Resveratrol supplementation reduces ACE2 expression in human adipose tissue.

Abstract:

:Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we investigated the effects of 30-days resveratrol supplementation on RAS components in AT and skeletal muscle in men with obesity in a placebo-controlled cross-over study. Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components. These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19.

journal_name

Adipocyte

journal_title

Adipocyte

authors

de Ligt M,Hesselink MKC,Jorgensen J,Hoebers N,Blaak EE,Goossens GH

doi

10.1080/21623945.2021.1965315

keywords:

["ACE2","Covid-19","Resveratrol","SARS-CoV-2","leptin","renin-angiotensin-system"]

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

408-411

issue

1

eissn

2162-3945

issn

2162-397X

journal_volume

10

pub_type

杂志文章

相关文献

文献大全
  • Distinct roles for alpha-beta hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling.

    abstract::Catabolism of stored triacylglycerol (TAG) from cytoplasmic lipid droplets is critical for providing energy substrates, membrane building blocks, and signaling lipids in most cells of the body. However, the lipolytic machinery dictating TAG hydrolysis varies greatly among different cell types. Within the adipocyte, TA...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.20035

    authors: Lord CC,Brown JM

    更新日期:2012-01-01 00:00:00

  • Proteomic analysis of protein palmitoylation in adipocytes.

    abstract::Protein palmitoylation, by modulating the dynamic interaction between protein and cellular membrane, is involved in a wide range of biological processes, including protein trafficking, sorting, sub-membrane partitioning, protein-protein interaction and cell signaling. To explore the role of protein palmitoylation in a...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.22117

    authors: Ren W,Jhala US,Du K

    更新日期:2013-01-01 00:00:00

  • Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential.

    abstract::Obesity is currently a global pandemic, and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, decreased energy expenditure, or both. While white adipose tissue is specialized for energy st...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.18951

    authors: Townsend K,Tseng YH

    更新日期:2012-01-01 00:00:00

  • Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis.

    abstract::Adipocytes differentiate and function in environments rich in extracellular matrix (ECM) proteins. The phenotypes of genetically modified mice have aided in recognizing the importance of ECM proteins and their modifiers, e.g., proteinases, in the regulation of obesity and metabolism. Most of the molecular mechanisms t...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.19752

    authors: Chun TH

    更新日期:2012-04-01 00:00:00

  • Muscle-to-organ cross talk mediated by myokines.

    abstract::Cytokines and other peptides are secreted from skeletal muscles in response to exercise and function as hormones either locally within the muscle or by targeting distant organs. Such proteins are recognized as myokines, with the prototype myokine being IL-6. Several studies have established a role of these muscle-deri...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.20344

    authors: Pedersen L,Hojman P

    更新日期:2012-07-01 00:00:00

  • Seeking the source of adipocytes in adult white adipose tissues.

    abstract::Adipocyte progenitors are thought to play a fundamental role in white adipose tissue (WAT) plasticity, which enables dynamic modulation of WAT metabolic and cellular characteristics in response to various stimuli. In general, two main strategies have been used to identify adipocyte progenitor cells: fluorescence-activ...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.20804

    authors: Lee YH,Granneman JG

    更新日期:2012-10-01 00:00:00

  • New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis.

    abstract::The mitochondrial quality control system is essential for the preservation and regulation of mitochondrial function. This system is formed by a complex machinery that controls and maintains protein function and regulates mitochondrial morphology through a coordinated system of continual fusion and fission events. Impa...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.21999

    authors: Quirós PM,Ramsay AJ,López-Otín C

    更新日期:2013-01-01 00:00:00

  • Heart hormones fueling a fire in fat.

    abstract::Our view of how adipose tissue metabolism is regulated recently experienced a change in focus and breadth, meaning that some of the key controlling factors were not fully in the picture. The catecholamines of the sympathetic nervous system are well-known activators of β-adrenergic receptors in adipocytes to increase l...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.22515

    authors: Collins S,Bordicchia M

    更新日期:2013-04-01 00:00:00

  • Dedifferentiated adipocyte-derived progeny cells (DFAT cells): Potential stem cells of adipose tissue.

    abstract::Analyses of mature adipocytes have shown that they possess a reprogramming ability in vitro, which is associated with dedifferentiation. The subsequent dedifferentiated fat cells (DFAT cells) are multipotent and can differentiate into adipocytes and other cell types as well. Mature adipocytes can be easily obtained by...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.23784

    authors: Wei S,Zan L,Hausman GJ,Rasmussen TP,Bergen WG,Dodson MV

    更新日期:2013-07-01 00:00:00

  • Does chronic low-grade endotoxemia define susceptibility of obese humans to insulin resistance via dietary effects on gut microbiota?

    abstract::Recent studies, including one from our own lab, report that different subpopulations of obese individuals display a variable inflammatory signature in their visceral adipose tissue that may contribute significantly to their risk for developing insulin resistance, type 2 diabetes, and other metabolic diseases. Understa...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.24776

    authors: Kemp DM

    更新日期:2013-07-01 00:00:00

  • Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity.

    abstract::Adiponectin is an insulin sensitizing fat cell (FC) hormone whose levels are related to adipose tissue (AT) mass and depot distribution. We hypothesized that the nature of AT expansion (hypertrophy vs. hyperplasia) contributes to obesity-related reductions in serum adiponectin and that this effect is influenced by the...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.24953

    authors: Meyer LK,Ciaraldi TP,Henry RR,Wittgrove AC,Phillips SA

    更新日期:2013-10-01 00:00:00

  • Identification of a novel interorgan mechanism favoring energy storage in overnutrition.

    abstract::While body weight is essentially determined by the balance of energy intake and energy consumption, it is not necessarily the case that changes in daily food intakes and exercise directly reflect changes in body weight. In recent years, it has been revealed that numerous metabolic interactions between organs, which ar...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.25499

    authors: Yamada T,Tsukita S,Katagiri H

    更新日期:2013-10-01 00:00:00

  • Adiponectin and IL-6: Mediators of inflammation in progression of healthy to type 2 diabetes in Indian population.

    abstract::Aim The objective of the study was to identify the association if any, of inflammatory markers (adiponectin and IL-6) with fasting glucose in normoglycemic (healthy), prediabetic (impaired fasting glucose), and hyperglycemic (diabetic) people in Indian population. Methods Total 162 volunteers were distributed into 3 g...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.26553

    authors: Upadhyaya S,Kadamkode V,Mahammed R,Doraiswami C,Banerjee G

    更新日期:2014-01-01 00:00:00

  • Cross-tissue comparisons of leptin and adiponectin: DNA methylation profiles.

    abstract::DNA methylation has been mostly studied in circulating blood cells. Although being readily accessible, metabolically active tissues such as adipose tissue would be more informative for the study of metabolic disorders. However, whether or not the blood DNA methylation profile correlates with that of adipose tissue rem...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.28308

    authors: Houde AA,Légaré C,Hould FS,Lebel S,Marceau P,Tchernof A,Vohl MC,Hivert MF,Bouchard L

    更新日期:2014-04-01 00:00:00

  • Characterization of Cre recombinase models for the study of adipose tissue.

    abstract::The study of adipose tissue in vivo has been significantly advanced through the use of genetic mouse models. While the aP2-Cre(BI) and aP2-Cre(Salk) lines have been widely used to target adipose tissue, the specificity of these lines for adipocytes has recently been questioned. Here we characterize Cre recombinase act...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.29674

    authors: Jeffery E,Berry R,Church CD,Yu S,Shook BA,Horsley V,Rosen ED,Rodeheffer MS

    更新日期:2014-07-01 00:00:00

  • Insights into Brown Adipose Tissue Physiology as Revealed by Imaging Studies.

    abstract::There has been resurgence in interest in brown adipose tissue (BAT) following radiological and histological identification of metabolically active BAT in adult humans. Imaging enables BAT to be studied non-invasively and therefore imaging studies have contributed a significant amount to what is known about BAT functio...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/21623945.2014.965609

    authors: Izzi-Engbeaya C,Salem V,Atkar RS,Dhillo WS

    更新日期:2014-11-14 00:00:00

  • Insights into an adipocyte whitening program.

    abstract::White adipose tissue plays a critical role in regulating systemic metabolism and can remodel rapidly in response to changes in nutrient availability. Nevertheless, little is known regarding the metabolic changes occurring in adipocytes during obesity. Our laboratory recently addressed this issue in a commonly used, hi...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/21623945.2014.960351

    authors: Hill BG

    更新日期:2015-01-28 00:00:00

  • Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat.

    abstract::Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. Since the discovery that BAT and brite/beige cells are functional in adult humans, many studies have been focusing on the physiology and functionality of this organ. The brain is contro...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/21623945.2014.983752

    authors: López M,Diéguez C,Nogueiras R

    更新日期:2015-01-07 00:00:00

  • Adipose depots differ in cellularity, adipokines produced, gene expression, and cell systems.

    abstract::The race to manage the health concerns related to excess fat deposition has spawned a proliferation of clinical and basic research efforts to understand variables including dietary uptake, metabolism, and lipid deposition by adipocytes. A full appreciation of these variables must also include a depot-specific understa...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/adip.28321

    authors: Dodson MV,Du M,Wang S,Bergen WG,Fernyhough-Culver M,Basu U,Poulos SP,Hausman GJ

    更新日期:2014-12-10 00:00:00

  • The proliferation and differentiation of primary pig preadipocytes is suppressed when cultures are incubated at 37°Celsius compared to euthermic conditions in pigs.

    abstract::Given similarities in metabolic parameters and cardiovascular physiology, the pig is well positioned as a biomedical model for metabolic disease and obesity in humans. Better understanding molecular mechanisms governing porcine adipocyte hyperplasia may provide insight into the regulation of adipose tissue development...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.4161/21623945.2014.981434

    authors: Bohan AE,Purvis KN,Bartosh JL,Brandebourg TD

    更新日期:2014-12-10 00:00:00

  • Effect of alcohol on adipose tissue: a review on ethanol mediated adipose tissue injury.

    abstract:BACKGROUND:Alcohol consumption has been in existence in the world for many centuries and it is the major cause of death and injury worldwide. Alcoholic liver disease (ALD) is caused due to excess and chronic alcohol intake. Studies across the globe have identified several pathways leading to ALD. Adipose tissue which h...

    journal_title:Adipocyte

    pub_type: 杂志文章,评审

    doi:10.1080/21623945.2015.1017170

    authors: Kema VH,Mojerla NR,Khan I,Mandal P

    更新日期:2015-04-02 00:00:00

  • Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat.

    abstract::Brown fat has gained widespread attention as a potential therapeutic target to treat obesity and associated metabolic disorders. Indeed, the anti-obesity potential of multiple targets to stimulate both brown adipocyte differentiation and recruitment have been verified in rodent models. However, their therapeutic poten...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.1080/21623945.2015.1042192

    authors: Seiler SE,Xu D,Ho JP,Lo KA,Buehrer BM,Ludlow YJ,Kovalik JP,Sun L

    更新日期:2015-04-20 00:00:00

  • Human cytomegalovirus infection of human adipose-derived stromal/stem cells restricts differentiation along the adipogenic lineage.

    abstract::Human adipose-derived stromal/stem cells (ASCs) display potential to be used in regenerative stem cell therapies and as treatments for inflammatory and autoimmune disorders. Despite promising use of ASCs as therapeutics, little is known about their susceptibility to infectious agents. In this study, we demonstrate tha...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.1080/21623945.2015.1119957

    authors: Zwezdaryk KJ,Ferris MB,Strong AL,Morris CA,Bunnell BA,Dhurandhar NV,Gimble JM,Sullivan DE

    更新日期:2015-12-09 00:00:00

  • Morphogenetics in brown, beige and white fat development.

    abstract::Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and β-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat. The discovery of brown and brown-like adipocytes in adult humans has r...

    journal_title:Adipocyte

    pub_type: 杂志文章,评审

    doi:10.1080/21623945.2016.1140708

    authors: Lin JZ,Farmer SR

    更新日期:2016-02-18 00:00:00

  • Minor differences in the molecular machinery mediating regulated membrane fusion has major impact on metabolic health.

    abstract::The exocytosis of signaling molecules from neuronal, neuroendocrine and endocrine cells is regulated by membrane fusion involving SNAP-25 and associated SNARE proteins. The importance of this process for metabolic control recently became evident by studies of mouse mutants genetically engineered to only express one of...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.1080/21623945.2015.1137689

    authors: Valladolid-Acebes I,Daraio T,Brismar K,Hökfelt T,Bark C

    更新日期:2016-01-08 00:00:00

  • Recent advances in the understanding of how neuropeptide Y and α-melanocyte stimulating hormone function in adipose physiology.

    abstract::Communication between the brain and the adipose tissue has been the focus of many studies in recent years, with the "brain-fat axis" identified as a system that orchestrates the assimilation and usage of energy to maintain body mass and adequate fat stores. It is now well-known that appetite-regulating peptides that w...

    journal_title:Adipocyte

    pub_type: 杂志文章,评审

    doi:10.1080/21623945.2016.1208867

    authors: Shipp SL,Cline MA,Gilbert ER

    更新日期:2016-07-13 00:00:00

  • Form(ul)ation of adipocytes by lipids.

    abstract::Lipids have the potential to serve as bio-markers, which allow us to analyze and to identify cells under various experimental settings, and to serve as a clinical diagnostic tool. For example, diagnosis according to specific lipids that are associated with diabetes and obesity. The rapid development of mass-spectromet...

    journal_title:Adipocyte

    pub_type: 杂志文章,评审

    doi:10.1080/21623945.2017.1299298

    authors: Lapid K,Graff JM

    更新日期:2017-07-03 00:00:00

  • Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens.

    abstract::Upregulating the fatty acid oxidation capacity of white adipose tissue in mice protects against diet-induced obesity, inflammation and insulin resistance. Part of this capacity results from induction of brown-like adipocytes within classical white depots, making it difficult to determine the oxidative contribution of ...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.1080/21623945.2016.1263777

    authors: Torchon E,Ray R,Hulver MW,McMillan RP,Voy BH

    更新日期:2017-01-02 00:00:00

  • Elucidating the role of adipose tissue secreted factors in malignant transformation.

    abstract::Although there is a growing number of incidences of obesity and obesity-linked cancers, how excess adiposity actually causes cancer has not been fully explained. Our previous study showed that removal of visceral adipose tissue significantly reduced the number of ultraviolet radiation (UVR)-initiated, high-fat diet-pr...

    journal_title:Adipocyte

    pub_type: 杂志文章

    doi:10.1080/21623945.2017.1388971

    authors: Chakraborty D,Benham V,Bernard JJ

    更新日期:2018-01-02 00:00:00

  • Loading and firing the brown adipocyte.

    abstract::Brown adipose tissue (BAT) is specialized to both store and expend chemical energy making it an ideal therapeutic target for various metabolic diseases. Fatty acids derived from lipid droplets within brown adipocytes acting on mitochondrial uncoupling protein 1 (UCP1) were long thought to be essential for non-shiverin...

    journal_title:Adipocyte

    pub_type: 杂志文章,评审

    doi:10.1080/21623945.2017.1405879

    authors: Hankir MK

    更新日期:2018-01-02 00:00:00