Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.

Abstract:

:Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China (approval No. AEWC-20140615-002) on June 15, 2014.

journal_name

Neural Regen Res

authors

Lin YT,Shi QQ,Zhang L,Yue CP,He ZJ,Li XX,He QJ,Liu Q,Du XB

doi

10.4103/1673-5374.317992

keywords:

["Alzheimer’s disease","amyloid-β","anti-inflammation","bioenergetics","gut microbiota","hydrogen therapy","neurodegenerative disease","neurofibrillary tangles\n"]

subject

Has Abstract

pub_date

2022-02-01 00:00:00

pages

409-417

issue

2

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2022_17_2_409_317992

journal_volume

17

pub_type

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