Role of folinic acid in methotrexate-based prophylaxis of graft-versus-host disease following hematopoietic stem cell transplantation.

abstract：:Bone marrow and peripheral blood are heterogeneous tissues containing cells of different hematopoietic lineages. It is possible to detect leukemic cells by flow cytometry using a gating strategy, which combines CD45 expression on the cell surface with right angle light scatter (SS). This approach was applied to 15 cas...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Deptala A,Halicka HD,Salomon T,Gorczyca W,Seiter K,Feldman EJ,Traganos F,Darzynkiewicz Z

更新日期：1999-01-01 00:00:00

abstract：:Nucleoli were studied in lymphoblasts of children (untreated with cytostatic therapy) suffering from acute lymphoblastic leukemias (ALL) by means of a simple cytochemical procedure for the demonstration of RNA to provide information on the incidence of the main nucleolar types and the number of nucleoli in these cells...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Smetana K,Jirásková I I,Starý J

更新日期：1999-01-01 00:00:00

abstract：:This paper summarizes data from a haematological, biochemical, and clinical study carried out in 73 patients of Greek origin (38 non-splenectomized children and 35 adults; 17 splenectomized) with Hereditary Spherocytosis (HS). Mean haemoglobin levels in the non-splenectomized patients were significantly lower (122 +/-...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Premetis E,Stamoulakatou A,Loukopoulos D

更新日期：1999-01-01 00:00:00

abstract：:Hypochromic and microcytic erythrocytes, resulting from absolute iron deficiency, have a shortened survival due to ineffective production coupled with accelerated reticuloendothelial cell sequestration once released into the circulation. To explore the contribution of diminished deformability and increased fragility t...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Anderson C,Aronson I,Jacobs P

更新日期：2000-01-01 00:00:00

abstract：:The autosomal recessive disorder Fanconi anaemia (FA) has been the subject of intense study for over a decade. The genes mutated in FA patients are being cloned, but so far, the sequences of these genes have not given any clear indication of their function. Various models for the function of the FA proteins have been ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Tipping AJ,Mathew CG

更新日期：2000-01-01 00:00:00

abstract：:Lymphocytosis is the main biomarker predicting the efficacy of subcutaneous IL-2 anticancer immunotherapy. In addition, it has been demonstrated the fundamental role of dendritic cells (DC) in the generation of an effective anticancer immunity. However, the relation between IL-2 and DC system needs to be further under...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lissoni P,Bonfanti A,Bordin V,Barni S,Vigore L,Ferrante R,Rovelli F,Fumagalli L

更新日期：2000-01-01 00:00:00

abstract：:Fifteen cancer patients, deemed blood HSC "mobilization failures" due to CD34 + cell yields of < 0.5 x 10(6) /kg from two consecutive daily cytaphereses, underwent G-CSF primed autologous bone marrow harvest in an attempt to obtain adequate hematopoietic support for subsequent autotransplantation. CD34 + cell yields f...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Phillips GL,Hale GA,Howard DS,Nath R,Munn RK,Marshall KW,Reece DE,Reed E,Van Zant G

更新日期：2000-01-01 00:00:00

abstract：:Granulocyte-macrophage colony stimulating factor (GM-CSF) and Interleukin-3 (IL-3) are increasingly used to stimulate granulopoiesis in neutropenic patients but these are rarely used in the lights of knowledge of the endogenous CSF-levels. In this study we measured serum levels of GM-CSF and IL-3 at diagnosis and afte...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Elbaz O,Shaltout A

更新日期：2001-01-01 00:00:00

abstract：:Seven cases of thromboembolism were found amongst 23 patients treated with thalidomide for myeloma over a total of 141.5 patient treatment months. Five thromboembolic events were venous (two severe) and two arterial. A historical control of 18 similar patients not given thalidomide had one thromboembolism over 289 mon...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Bowcock SJ,Rassam SM,Ward SM,Turner JT,Laffan M

更新日期：2002-02-01 00:00:00

abstract：:Allogeneic bone marrow transplantation (BMT) is an effective treatment for some severe hematologic or nonhematologic diseases. The blood group antigen mismatch between donor and recipient may cause immunohematological complications during or after BMT. In this review, we analyze the ABO, Rh and other red cell antigen ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Gandini G,Franchini M,Vassanelli A,De Gironcoli M,Ferro I,Bertuzzo D,Antonello O,Aprili G

更新日期：2002-04-01 00:00:00

abstract：:The traditional approach to allogeneic hematopoietic stem cell transplantation involves the administration of myeloablative preparative regimens. This form of conditioning is associated with a relatively high incidence of regimen-related toxicity. As a result, candidates for allogeneic stem cell transplantation may be...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Seftel MD,Lavoie J,Barnett MJ,Conneally E

更新日期：2002-06-01 00:00:00

abstract：:The myelodysplastic syndromes are increasingly recognised clinical entities reflecting a stem cell defect that gives rise to ineffective clonal haematopoiesis. The spectrum extends from relatively indolent refractory anaemia through varying combinations of leucopoenia and thrombocytopenia to acute leukaemia. Diagnosis...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Jacobs P,Wood L

更新日期：2002-12-01 00:00:00

abstract：:Patients with hematological malignancies who relapse after autologous stem cell transplantation (auto-SCT) generally have poor prognosis. Salvage treatment is often associated with severe toxicities. The aim of our study was to evaluate retrospectively the toxicity and outcome of rescue therapy in patients with acute ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Büchler T,Hermosilla M,Ferra C,Encuentra M,Gallardo D,Berlanga J,Sarra J,Grañena A

更新日期：2003-06-01 00:00:00

abstract：:The role of autologous peripheral blood stem cell transplantation (APBSCT) in acute myeloid leukaemia (AML) remains controversial. The current study evaluated the application of APBSCT in a large consecutive series of patients with untreated AML, and compared outcome with a predictive model based on MRC AML10 data. Of...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Ewing JC,Robertson JD,Kell WJ,Burnett AK,Ryder D,Chang J,Morgenstern GR,Scarffe JH,Chopra R

更新日期：2003-04-01 00:00:00

abstract：:A 9-year-old girl who had hepatitis-associated aplastic anemia was treated intermittently with methylprednisolone pulse therapy and growth factors (granulocyte-colony stimulating factor (G-CSF), recombinant human erythropoietin (rhEpo) and cyclosporin A (CyA) for over two years. At this time, there was hematological i...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Shibuya A,Ishii S,Obinata K

更新日期：2002-10-01 00:00:00

abstract：:The recent description of molecular markers in patients with myeloproliferative disorders (MPDs) has raised several questions: does the presence of multiple markers coincide in individual patients or can a patient acquire some markers selectively? Do the markers distinguish molecular categories of MPDs? Do these categ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Pahl HL

更新日期：2003-08-01 00:00:00

abstract：:Multiple myeloma (MM) is a malignant tumor of plasma cells in the bone marrow. Interleukin 6 (IL-6) is an indispensable growth factor for myeloma cells. The heterogeneity of myeloma cells are the characteristics of MM, categorized into five sub-populations, two immature cells, MPC-1

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journal_title：Hematology (Amsterdam, Netherlands)

authors： Tsuyama N,Ishikawa H,Abroun S,Liu S,Li FJ,Otsuyama K,Zheng X,Obata M,Taniguchi O,Kawano MM

更新日期：2003-12-01 00:00:00

abstract：:Multiple myeloma (MM) is a lymphoproliferative disorder that is characterized by a proliferation of clonal B cells in various stages of maturation that then infiltrate the bone marrow. MM has been reported to accompany various T cell abnormalities including quantitative and functional defects of CD4+ and CD8+ T cells....

journal_title：Hematology (Amsterdam, Netherlands)

authors： Murakami H,Ogawara H,Hiroshi H

更新日期：2004-02-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is an intriguing disorder characterized by the accumulation of specialized dendritic cells called Langerhans cells in several diverse tissues and body sites. It has been cited in numerous case reports to be associated with a wide variety of malignant neoplasms. Although many hypothe...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Sharma VR,Fleming DR,Yam LT

更新日期：2002-08-01 00:00:00

abstract：:Between March 1984 and December 1999, a total of 43 second related allogeneic BMT procedures after myeloablative conditioning were carried out in our institution, 37 following allogeneic, and 6 following autologous BMT. Thirty one patients were males (72%). At 1st BMT (BMT1), median age was 11.5 years (range, 0.16-45 ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Al-Qurashi F,Ayas M,Al Sharif F,Ibrahim E,Sahovic E,Al Mahr M,Chaudhri N,Al Mohareb F,Al Zahrani H,Al Jefri A,Al Omar H,Al Shanqeeti A,Seth P,Aslam M,El Solh H,Aljurf M

更新日期：2004-04-01 00:00:00

abstract：:Improved leukemia classification and tailoring of therapy have greatly improved patient outcome particularly for children with acute leukemia (AL). Using immunophenotyping, molecular genetics and cytogenetics the low hanging fruits of biomedical research have been successfully incorporated in routine diagnosis of leuk...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Te Kronnie G,Bicciato S,Basso G

更新日期：2004-06-01 00:00:00

abstract：:Angiogenesis is the hallmark of cancer. Growing evidence indicates that an imbalance between pro- and anti-angiogenic molecules triggers the angiogenic switch during tumor progression. Several molecules, able to affect vascular formation and function, are now beginning to be elucidated. Recent data indicate that angio...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Giuliani N,Colla S,Rizzoli V

更新日期：2004-10-01 00:00:00

abstract：:Gilbert's syndrome (GS) is a benign, familial condition characterized by recurrent asymptomatic non-hemolytic low-grade indirect hyper-bilirubinemia. Conditions related to fasting, stress or co-morbidity might reveal the disease in asymptomatic individuals. Seven patients who were treated for a hematological malignanc...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Ruiz-Argüelles GJ,Ruiz-Delgado GJ,David Gómez-Rangel J,Gómez-Almaguer D

更新日期：2005-02-01 00:00:00

abstract：:Cloning translocation breakpoints which cluster suspiciously to specific chromosomal loci has proved fruitful, leading to the identification of genes implicated in the onset of hematological malignancy. One of the most notable is BCL6, located on chromosome 3q27. The BCL6 is now known to encode a nuclear transcription...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Jardin F,Sahota SS

更新日期：2005-04-01 00:00:00

abstract：UNLABELLED:Type 2 (non-insulin-dependent) diabetes is associated with a marked increase in the risk of coronary heart disease. Platelets play a significant role in coronary artery disease. Soluble P-selectin is an index of platelets activation. In this study, Soluble P-selectin levels were measured by ELISA in the peri...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Aref S,Sakrana M,Hafez AA,Hamdy M

更新日期：2005-06-01 00:00:00

abstract：:Antiphospholipid syndrome is an autoimmune disorder characterized by the association between antiphospholipid antibodies and venous or arterial thrombosis or obstetric complications. In spite of the recent progresses, many aspects of this disease remain unclear. In this review, we briefly focus on the most important a...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Franchini M,Veneri D

更新日期：2005-08-01 00:00:00

abstract：:Staging and monitoring of multiple myeloma (MM) is mainly based on monoclonal component quantification; the absence of such a parameter renders difficult follow up of patients with nonsecretory MM (nsMM). In this study our aims were to determine the specificity and sensitivity of Tc99m-sestaMIBI scintigraphy at diagno...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Catalano L,Andretta C,Pace L,Del Vecchio S,Salvatore B,De Rosa G,Buonanno MT,Paone G,Rotoli B

更新日期：2005-08-01 00:00:00

abstract：:Despite the advances in automated blood cell counting, the blood film retains a crucial role in the diagnosis of red cell disorders. It is particularly important in haemolytic anaemias and in the differential diagnosis of macrocytic anaemia. However, all cases of anaemia in which the diagnosis is not immediately obvio...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Bain BJ

更新日期：2005-01-01 00:00:00

abstract：:Leukemia, a group of hematological malignancies characterized by clonal expansion of hematopoietic cells with uncontrolled proliferation, decreased apoptosis and blocked differentiation, is one of the most notorious enemies of mankind which accounts for some 300,000 new cases and 222,000 deaths each year worldwide. Le...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Zhou GB,Chen SJ,Chen Z

更新日期：2005-01-01 00:00:00

abstract：:This presentation begins to discuss the findings of an ongoing doctoral study that arose as the result of clinical experience, previous studies and ongoing reflection. Building on the work of Frankl this study explores the search for meaning in the context of living with cancer. In this study people with cancer share ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Quinn B

更新日期：2005-01-01 00:00:00