A novel transcription factor UvCGBP1 regulates development and virulence of rice false smut fungus Ustilaginoidea virens.

abstract：:In 1965, Dr. Alexander Tomasz identified a critical component of the DNA uptake mechanism used by competent Streptococcus pneumoniae: the pneumococci secrete a polypeptide that induces the expression of proteins to allow foreign DNA to pass through the bacterium's cell wall. This hormone-like substance was the first o...

journal_title：Virulence

authors： Rollins SM,Schuch R

更新日期：2010-03-01 00:00:00

abstract：:Activation of innate and adaptive immune mechanisms in response to infection is necessary to control and clear infections. However, chronic immune activation in human immunodeficiency virus 1 (HIV-1) infection has a series of detrimental effects and is a major driving force in HIV-1 disease progression. We recently fo...

journal_title：Virulence

authors： Sandberg JK,Falconer K,Gonzalez VD

更新日期：2010-05-01 00:00:00

abstract：:Bacterial corneal infections threaten vision. With the widespread use of contact lenses and the increasing number of vision-correction (refractive) surgeries, the number of bacterial corneal infection (keratitis) cases has dramatically increased over the past decade. These infections are often blinding, as bacteria mu...

journal_title：Virulence

authors： Callegan MC

更新日期：2010-07-01 00:00:00

abstract：:The Us3 serine threonine kinases perform multiple roles in alphaherpesvirus infection and can localize to distinct subcellular compartments. Transient expression of Us3 in cells results in two dramatic alterations of the actin cytoskeleton: production of actin-based filamentous processes (FPs); and breakdown of actin ...

journal_title：Virulence

authors： Finnen RL,Banfield BW

更新日期：2010-07-01 00:00:00

abstract：:One of the most critical issues in epidemiology revolves around the bridging of the diverse space and time scales stretching from the microscopic scale, where detailed knowledge on the immune mechanisms, host-microbe and host-host interactions is often available, to the macroscopic population-scale where the epidemic ...

journal_title：Virulence

authors： Reppas AI,Spiliotis KG,Siettos CI

更新日期：2010-07-01 00:00:00

abstract：:Despite that basophils represent less than 0.5% of circulating leukocytes, recent studies have begun to unveil their potent immunoregulatory functions, i.e., induction of Th2 immunity. It is believed that basophils are capable of doing so primarily by secreting key Th2-inducing cytokines, namely IL-4 and Thymic Stroma...

journal_title：Virulence

authors： Min B

更新日期：2010-09-01 00:00:00

abstract：:Invasive aspergillosis has long been recognized as one of the most significant and often fatal opportunistic fungal infections in liver transplant recipients. We report a case of a liver transplant recipient who developed an Aspergillus fumigatus brain abscess that produced significant neurologic symptoms. The patient...

journal_title：Virulence

authors： Tsitsopoulos PP,Tsoulfas G,Tsonidis C,Imvrios G,Papanikolaou V,Giakoustidis D,Marinopoulos D,Takoudas D,Tsitsopoulos PD

更新日期：2010-09-01 00:00:00

abstract：:Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This fur...

journal_title：Virulence

authors： Evans SE,Leventakos K,Ben-Ami R,You D,Thakkar SG,Lewis RE,Kontoyiannis DP

更新日期：2010-11-01 00:00:00

abstract：:Fusarium is the second most frequent mold involved in fungal infections and is particularly important among immunocompromised patients. Culture methods and microscopy are still routinely used in clinical laboratories to identify Fusarium spp, and more sophisticated, timely, and effective methods for detecting Fusarium...

journal_title：Virulence

authors： Muhammed M,Coleman JJ,Carneiro HA,Mylonakis E

更新日期：2011-03-01 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen that also causes economically important infections of livestock. In a recent paper, we employed a population genomic approach to investigate the molecular basis of ruminant host adaptation by S. aureus. The data suggest that the common pathogenic clone associated wi...

journal_title：Virulence

authors： Guinane CM,Penadés JR,Fitzgerald JR

更新日期：2011-05-01 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. typhi), is a human restricted pathogen and the causal agent of typhoid fever. Although the use of antimicrobial drugs or vaccines has served as an effective therapeutics strategy against typhoid fever, the recent surge in multidrug resistant strains of S. typhi presents a major he...

journal_title：Virulence

authors： Mian MF,Pek EA,Chenoweth MJ,Coombes BK,Ashkar AA

更新日期：2011-05-01 00:00:00

abstract：:Cryptococcus neoformans is unusual among melanotic fungi in that it requires an exogenous supply of precursor to synthesize melanin. C. neoformans melanizes during mammalian infection in a process that presumably uses host-supplied compounds such as catecholamines. L-3,4-dihydroxyphenylalanine (L-DOPA) is a natural ca...

journal_title：Virulence

authors： Eisenman HC,Chow SK,Tsé KK,McClelland EE,Casadevall A

更新日期：2011-07-01 00:00:00

abstract：:Tripartite motif-containing (TRIM) E3 ligases are a recently identified family of proteins with potent antiviral activity in mammalian cells. The prototype TRIM E3 ligase, TRIM5α was initially identified as a species-specific antiviral restriction factor but subsequent studies suggest some antiviral activity by severa...

journal_title：Virulence

authors： Ndung'u T

更新日期：2011-07-01 00:00:00

abstract：:Biofilms are masses of microorganisms that bind to and multiply on a solid surface, typically with a fluid bathing the microbes. The microorganisms that are not attached but are free floating in an aqueous environment are termed planktonic cells. Traditionally, microbiology research has addressed results from plankton...

journal_title：Virulence

authors： Huang R,Li M,Gregory RL

更新日期：2011-09-01 00:00:00

abstract：:The treatment and prevention of infectious diseases is a major part of both clinical and investigative medicine. As the use of conventional antibiotics rises, antimicrobial resistance patterns develop, necessitating the continuous need for newer and more effective therapies. Nanotechnology, defined as the production a...

journal_title：Virulence

authors： Blecher K,Nasir A,Friedman A

更新日期：2011-09-01 00:00:00

abstract：:Proteus mirabilis inhabits the environment and causes a number of infections including those of the skin, respiratory tract, wounds and urinary tract. These organisms express virulence factors associated with adhesion, motility, immunoavoidance, nutrient acquisition, host damage, as well as biofilm formation. P. mirab...

journal_title：Virulence

authors： Jacobsen SM,Shirtliff ME

更新日期：2011-09-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is abundant in hospitals and in the United States is a leading cause of mortality due to infectious agents. Community-associated MRSA (CA-MRSA) strains such as USA300, which typically cause disease outside of healthcare settings, are also prevalent in the United State...

journal_title：Virulence

authors： Malachowa N,DeLeo FR

更新日期：2011-11-01 00:00:00

abstract：:The yeast Candida parapsilosis has emerged as a major human pathogen. The fungus is found in diverse environments as well as in different mammalian hosts, indicative of a successful adaptation to various niches. Fatty acids are the building blocks of cell membranes. Thus, the yeast must have evolved efficient ways to ...

journal_title：Virulence

authors： Nguyen LN,Gacser A,Nosanchuk JD

更新日期：2011-11-01 00:00:00

abstract：:The emergence of Candida strains carrying FKS1 hotspot mutations associated with resistance to echinocandins is cause for concern. However, to assess the potential of such strains to spread within the community and cause lethal infection, the impact of FKS1 mutations on Candida fitness must be determined. We present e...

journal_title：Virulence

authors： Ben-Ami R,Kontoyiannis DP

更新日期：2012-01-01 00:00:00

abstract：:Escherichia coli represents a major cause of morbidity and mortality worldwide. The treatment of E. coli infections is now threatened by the emergence of antimicrobial resistance. The dissemination of resistance is associated with genetic mobile elements, such as plasmids, that may also carry virulence determinants. A...

journal_title：Virulence

authors： Da Silva GJ,Mendonça N

更新日期：2012-01-01 00:00:00

abstract：:Diverse fungal species are the cause of devastating agricultural and human diseases. As successful pathogenesis is dependent upon the ability of the fungus to adapt to the nutritional and chemical environment of the host, the understanding of signaling pathways required for such adaptation will provide insights into t...

journal_title：Virulence

authors： Fuller KK,Rhodes JC

更新日期：2012-03-01 00:00:00

abstract：:The nematode C. elegans responds to infection by the fungus Drechmeria coniospora with a rapid increase in the expression of antimicrobial peptide genes. To investigate further the molecular basis of this innate immune response, we took a two-dimensional difference in-gel electrophoresis (2D-DIGE) approach to characte...

journal_title：Virulence

authors： Couillault C,Fourquet P,Pophillat M,Ewbank JJ

更新日期：2012-05-01 00:00:00

abstract：:Improving testing and uptake to care among highly impacted populations is a critical element of Seek, Test, Treat and Retain strategies for reducing HIV incidence in the community. HIV disproportionately impacts prisoners. Though, incarceration provides an opportunity to diagnose and initiate therapy, treatment is fre...

journal_title：Virulence

authors： Montague BT,Rosen DL,Solomon L,Nunn A,Green T,Costa M,Baillargeon J,Wohl DA,Paar DP,Rich JD,LINCS Study Group

更新日期：2012-05-01 00:00:00

abstract：:The lifestyle of intracellular pathogens has always questioned the skill of a microbiologist in the context of finding the permanent cure to the diseases caused by them. The best tool utilized by these pathogens is their ability to reside inside the host cell, which enables them to easily bypass the humoral immunity o...

journal_title：Virulence

authors： Garai P,Gnanadhas DP,Chakravortty D

更新日期：2012-07-01 00:00:00

abstract：:The encephalomyocarditis virus (EMCV) is a small non-enveloped single-strand RNA virus, the causative agent of not only myocarditis and encephalitis, but also neurological diseases, reproductive disorders and diabetes in many mammalian species. EMCV pathogenesis appears to be viral strain- and host-specific, and a bet...

journal_title：Virulence

authors： Carocci M,Bakkali-Kassimi L

更新日期：2012-07-01 00:00:00

abstract：:Larvae of Galleria mellonella are widely used to study the virulence of microbial pathogens and for assessing the potency of antimicrobial agents. This work examined the effect of nutritional deprivation on the ability of larvae to withstand infection in order to establish standardized conditions for the treatment of ...

journal_title：Virulence

authors： Banville N,Browne N,Kavanagh K

更新日期：2012-10-01 00:00:00

abstract：:Understanding the genetic and ecological factors which support the emergence of new clones of pathogenic bacteria is vital to develop preventive measures. Vibrio cholerae the causative agent of cholera epidemics represents a paradigm for this process in that this organism evolved from environmental non-pathogenic stra...

journal_title：Virulence

authors： Faruque SM,Mekalanos JJ

更新日期：2012-11-15 00:00:00

abstract：:It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew toward T(H)2 immunity, stimulate Treg cells while simultaneously inhibiting T(H)1 and T(H)17 responses. Additionally, they induce eosinophilia and extensive IgE release. The exact mechanism of ho...

journal_title：Virulence

authors： White RR,Artavanis-Tsakonas K

更新日期：2012-11-15 00:00:00

abstract：:Non-mammalian models have been used to investigate fungal virulence. In this work we have explored the use of Galleria mellonella as an infection model for the pathogenic dimorphic fungi Histoplasma capsulatum and Paracoccidioides lutzii. In mammalian models these fungi cause similar infections, and disease outcomes a...

journal_title：Virulence

authors： Thomaz L,García-Rodas R,Guimarães AJ,Taborda CP,Zaragoza O,Nosanchuk JD

更新日期：2013-02-15 00:00:00

abstract：:Enteric pathogens must not only survive passage through the gastrointestinal tract but must also coordinate expression of virulence determinants in response to localized microenvironments with the host. Enterohemorrhagic Escherichia coli (EHEC), a serious food and waterborne human pathogen, is well equipped with an ar...

journal_title：Virulence

authors： Barnett Foster D

更新日期：2013-05-15 00:00:00