Abstract:
BACKGROUND:Surveillance of current changes in the epidemiology of Invasive Fungal Diseases (IFDs) as an important component of the antifungal stewardship programs (ASP), requires careful regular monitoring, especially in high-risk settings such as oncology centers. This study aimed to examine Candida colonization status and corresponding current changes in children with malignancy during repeated admissions and also investigate the possible epidemiological shifts after the implementation of ASP. METHODS:In this prospective observational study, all eligible patients younger than 18 years were recruited during 2016-2017 at Amir Medical Oncology Center (AMOC) in Shiraz, Iran. Totally, 136 patients were enrolled and 482 samples were collected from different sites (oral/nasal discharges, urine and stool). Weekly regular sampling was carried out during hospitalization. Candida colonization status and epidemiological changes were monitored during repeated admissions. Samples were cultivated on Sabouraud Dextrose agar medium and identified by Polymerase Chain Reaction -Restriction Fragment Length Polymorphism (PCR-RFLP). RESULTS:Estimated Candida colonization incidence was 59.9% (82/136) in our patients. Candida colonization was found to be higher in oral cavity and rectum than that in nasal cavity. Among those long-term follow ups and repetitive hospitalizations, a significant number of patients exhibited changes in their colonization patterns (37.7%). Candida colonization did not reveal any significant relationship with age, sex, oncologic diseases and degree of neutropenia. C. albicans (72.0%) was found as the most common Candida species in colonized patients, followed by C. krusei, C. kefyr, C. glabrata and C. parapsilosis. CONCLUSION:Given the high incidence of Candida infections in children with cancers, close monitoring of epidemiologic changes is essential for judicious management, based on local surveillance data and improvement of overall quality of care in high risk patients.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hamzavi SS,Amanati A,Badiee P,Kadivar MR,Jafarian H,Ghasemi F,Haghpanah S,Dehghani M,Norouzian Baghani Adoi
10.1186/s12879-019-4372-xsubject
Has Abstractpub_date
2019-08-30 00:00:00pages
759issue
1issn
1471-2334pii
10.1186/s12879-019-4372-xjournal_volume
19pub_type
杂志文章abstract:BACKGROUND:Healthy condition and chronic diseases may be associated with microbiota composition and its properties. The prevalence of respiratory haemophili with respect to their phenotypes including the ability to biofilm formation in patients with sarcoidosis was assayed. METHODS:Nasopharynx and sputum specimens wer...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1793-7
更新日期:2016-08-26 00:00:00
abstract:BACKGROUND:Dengue is a common illness in the tropics. Equally common are neurological complications that stem from dengue infection. However, to date, parkinsonism following dengue has not been reported in medical literature. CASE PRESENTATION:A previously well 18-year old man developed parkinsonism, in addition to ot...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-179
更新日期:2013-04-18 00:00:00
abstract:BACKGROUND:Kazakhstan remains a high-burden TB prevalence country with a concomitent high-burden of multi-drug resistant tuberculosis. For this reason, we performed an in depth genetic diversity and population structure characterization of Mycobacterium tuberculosis complex (MTC) genetic diversity in Kazakhstan with bo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4201-2
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:Procalcitonin (PCT) has become a commonly used serum inflammatory marker. Our aim was to describe the kinetics and usefulness of serial post-operative PCT measurements to detect bacterial infection in a cohort of children immediately after pediatric liver transplantation (pLT). METHODS:We performed a retros...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2234-y
更新日期:2017-02-15 00:00:00
abstract:BACKGROUND:After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the dev...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3690-3
更新日期:2019-01-16 00:00:00
abstract:BACKGROUND:Pneumocystis pneumonia (PCP) may develop as a clinical manifestation of nosocomial pneumonia by means of either reactivation of resident P. jirovecii or de novo infection. However, there have been no studies describing the clinical characteristics of hospital-onset PCP. METHODS:A retrospective review of med...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0847-6
更新日期:2015-02-26 00:00:00
abstract:BACKGROUND:Bedaquiline was recently introduced into World Health Organization (WHO)-recommended regimens for treatment of drug resistant tuberculosis. There is limited data on the long-term safety of bedaquiline. Because bedaquiline prolongs the QT interval, there are concerns regarding cardiovascular safety. The Weste...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4197-7
更新日期:2019-06-20 00:00:00
abstract:BACKGROUND:Immunization policymakers at global and local levels need to establish priorities among new vaccines competing for limited resources. However, comparison of the potential impact of single vaccination programs is challenging, primarily due to the limited number of vaccine analyses as well as their differing a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-174
更新日期:2011-06-16 00:00:00
abstract:BACKGROUND:The mobility of female sex workers (FSWs) is a factor in the geographic spread of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). This study describes FSW mobility patterns in a high risk area of China to identify factors associated with increased mobility, and to study t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-198
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Clostridium difficile infection (CDI) has an increasing pediatric prevalence worldwide. However, molecular characteristics of C. difficile in Chinese children with acute gastroenteritis have not been reported. METHODS:A five-year cross-sectional study was conducted in a tertiary children's hospital in Zheji...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05030-6
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3127-4
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:This randomized controlled trial aimed to evaluate whether the serum procalcitonin (PCT) level can be utilized to guide the use of antibiotics in the treatment of acute exacerbations of asthma. METHODS:A total of 293 consecutive patients with suspected asthma attacks from February 2005 to July 2010 particip...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-13-596
更新日期:2013-12-17 00:00:00
abstract:BACKGROUND:Malaria remains a major tropical vector-borne disease of immense public health concern owing to its debilitating effects in sub-Saharan Africa. Over the past 30 years, the high altitude areas in Eastern Africa have been reported to experience increased cases of malaria. Governments including that of the Repu...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05158-5
更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:Enterovirus 71 (EV-A71) shows a potential of rapid death, but the natural history of the infection is poorly known. This study aimed to examine the natural history of EV-A71 infection. METHODS:This was a prospective longitudinal observational study performed between January 1st and October 31st, 2012, at th...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-017-2228-9
更新日期:2017-02-17 00:00:00
abstract:BACKGROUND:Trichosporon mycotoxinivorans is a recently described yeast-like fungal organism and its association as a pathogen for patients with cystic fibrosis (CF) was reported previously. We show the clinical course of a CF patient over 9 years as well as the applications of modern molecular and proteomic identificat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1910-7
更新日期:2016-10-25 00:00:00
abstract:BACKGROUND:Previous controlled studies on the effect of non-pharmaceutical interventions (NPI) - namely the use of facemasks and intensified hand hygiene - in preventing household transmission of influenza have not produced definitive results. We aimed to investigate efficacy, acceptability, and tolerability of NPI in ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-12-26
更新日期:2012-01-26 00:00:00
abstract:BACKGROUND:An increased number of refractory mycoplasma pneumoniae (MP) pneumonia (MPP) cases have been reported. However the duration of MP infection in lower airway and the course of anti-MP treatment remains unclear. METHODS:We retrospectively reviewed the medical records of 94 MPP children. Patients were classifie...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4667-y
更新日期:2019-12-10 00:00:00
abstract:BACKGROUND:In the spring of 1918, the "War to End All Wars", which would ultimately claim more than 37 million lives, had entered into its final year and would change the global political and economic landscape forever. At the same time, a new global threat was emerging and would become one of the most devastating glob...
journal_title:BMC infectious diseases
pub_type: 历史文章,杂志文章,评审
doi:10.1186/s12879-019-3750-8
更新日期:2019-02-06 00:00:00
abstract:BACKGROUND:HIV-monoinfected patients may be at risk for significant liver fibrosis, but its prevalence and determinants in these patients are unknown. Since HIV-monoinfected patients do not routinely undergo liver biopsy, we evaluated the prevalence and risk factors of significant hepatic fibrosis in this group using t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-116
更新日期:2010-05-13 00:00:00
abstract:BACKGROUND:HIV-uninfected infants born to HIV-infected mothers (HIV-exposed uninfected, HEU) have been described to have immune alterations as compared to unexposed infants. This study sought to characterize T-cell populations after birth in HEU infants and unexposed infants living in a semirural area in southern Mozam...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0766-6
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:Hospital acquired pneumonia (HAP) is divided in two distinct groups, ventilator-associated pneumonia (VAP) and non-ventilator-associated HAP (nvHAP). Although nvHAP occurs more frequently than VAP and results in similar mortality and costs, prevention guidelines and prevention focus almost exclusively on VAP...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05271-5
更新日期:2020-08-17 00:00:00
abstract:BACKGROUND:Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes serious problems in immunocompromised or immunologically immature hosts. Vaccination is the preferred approach for prevention of HCMV infection, but so far no approved HCMV vaccine is available. In this study, we assessed the immunogenicity an...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-195
更新日期:2014-04-11 00:00:00
abstract:BACKGROUND:Bloodstream infections due to Candida species cause significant morbidity and mortality, and the epidemiology of Candida infection is changing. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. METHODS:The medical and electronic records of all patie...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-337
更新日期:2013-07-22 00:00:00
abstract:BACKGROUND:In Tashkent (Uzbekistan), TB treatment is provided in accordance with the DOTS strategy. Of 1087 pulmonary TB patients started on treatment in 2005, 228 (21%) defaulted. This study investigates who the defaulters in Tashkent are, when they default and why they default. METHODS:We reviewed the records of 126...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-97
更新日期:2008-07-22 00:00:00
abstract:BACKGROUND:Dose-response assessment is one step in quantitative microbial risk assessment (QMRA). Four infectious microbes capable of causing respiratory diseases important to public health, and for which dose-response functions have not been available are: Bordetella pertussis (whooping cough), group A Streptococcus (...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0832-0
更新日期:2015-02-24 00:00:00
abstract:BACKGROUND:Male partner HIV testing and counseling (HTC) is associated with enhanced uptake of prevention of mother-to-child HIV transmission (PMTCT), yet male HTC during pregnancy remains low. Identifying settings preferred by pregnant women and their male partners may improve male involvement in PMTCT. METHODS:Parti...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-015-1053-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:The purpose of this study was to further characterize the immune response to Mycobacterium tuberculosis (Mtb) antigens, in order to provide new insight into host-pathogen interactions in tuberculosis (TB), and to offer tools for a more accurate diagnosis of the different stages of TB. METHODS:T-cell respons...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-99
更新日期:2009-06-23 00:00:00
abstract:BACKGROUND:Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. Since clinical judgment is sometimes uncertain biomarkers could provide additional information likely to guide critical illness management. We evaluated the p...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1893-4
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:After the onset of HAART, some HIV-infected individuals under treatment present a exacerbated inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory syndrome (IRIS). Few reports of tegumentary leishmaniasis have been described in associat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0774-6
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:Brucella abortus is a highly pathogenic zoonotic agent, tempting for the development of a rapid diagnostic method to enable adequate treatment and prevent further spread. Enrichment of the bacteria is often used as a first step in diagnostics to increase the bacterial number above the detection limit of the ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3134-5
更新日期:2018-06-05 00:00:00