Abstract：
:Human milk oligosaccharides (HMOs) are multifunctional carbohydrates naturally present in human milk that act as prebiotics, prevent pathogen binding and infections, modulate the immune system and may support brain development in infants. HMOs composition is very individualized and differences in HMOs concentrations may affect the infant's health. HMOs variability can be partially explained by the activity of Secretor (Se) and Lewis (Le) genes in the mother, but non-genetic maternal factors may also be involved. In this cross-sectional, observational study, 78 single human milk samples ranging from 17 to 76 days postpartum (median: 32 days, IQR: 25-46 days) were collected from breastfeeding Brazilian women, analyzed for 16 representative HMOs by liquid chromatography coupled to mass spectrometry and associations between maternal and infant factors with HMOs concentrations were investigated. HMOs concentrations presented a high variability even in women with the same SeLe phenotype and associations with maternal allergic disease, time postpartum and with infant's weight, weight gain and sex. Overall, we present unprecedented data on HMOs concentrations from breastfeeding Brazilian women and novel associations of maternal allergic disease and infant's sex with HMOs concentrations. Differences in HMOs composition attributed to maternal SeLe phenotype do not impact infant growth, but higher concentrations of specific HMOs may protect against excessive weight gain.
journal_name
Nutrientsjournal_title
Nutrientsauthors
M Tonon K,B de Morais M,F V Abrão AC,Miranda A,B Morais Tdoi
10.3390/nu11061358subject
Has Abstractpub_date
2019-06-17 00:00:00issue
6issn
2072-6643pii
nu11061358journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Low diet quality is a driver of general and micronutrient malnutrition in urban and rural areas. The objective was to compare malnutrition and micronutrient deficiencies linked to dietary intake among urban and rural schoolchildren from food insecure settings in Kenya. The cross-sectional study was conducted among urb...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010207
更新日期：2020-01-13 00:00:00
abstract：:Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods-including fruits, vegetables, tea, wine, as well as other dietary supplements-and is responsible for various health benefits. Numerous pharmacological effects of que...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8090529
更新日期：2016-08-29 00:00:00
abstract：:Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18-80 years) measured their own capillary...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5125114
更新日期：2013-12-16 00:00:00
abstract：:Many Americans are attempting to lose weight with the help of healthcare professionals. Clinicians can improve weight loss results by using technology. Accurate dietary assessment is crucial to effective weight loss. The aim of this study was to validate a computer-led dietary assessment method in overweight/obese wom...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu9030218
更新日期：2017-03-01 00:00:00
abstract：:While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-a...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11061436
更新日期：2019-06-25 00:00:00
abstract：:The treatment of Pediatric Crohn's Disease (CD) requires attention both to achieve mucosal healing and to optimize growth, while also maintaining proper bone health. Exclusive Enteral Nutrition (EEN) is recommended as first-line treatment in luminal CD. The therapeutic mechanisms of EEN are being discovered by advance...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123793
更新日期：2020-12-10 00:00:00
abstract：:Some rural areas of Ecuador, including the Imbabura Province of the Andes Highlands, are experiencing a double burden of malnutrition where micronutrient deficiencies persist at the same time obesity is increasing as many traditional home-grown foods are being replaced with more commercially prepared convenience foods...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082454
更新日期：2020-08-15 00:00:00
abstract：BACKGROUND:The C57BL/6 mouse fed a high fat diet is a common and valuable model in experimental studies of obesity and type 2 diabetes (T2D). Different high fat diets are used and in order to determine which diet produces a model most accurately resembling human T2D, they need to be compared head-to-head. METHODS:Four...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4101367
更新日期：2012-09-28 00:00:00
abstract：UNLABELLED:Reduced physical activity and almost unlimited availability of food are major contributors to the development of obesity. With the decline of strenuous work, energy expenditure due to spontaneous physical activity has attracted increasing attention. Our aim was to assess changes in energy expenditure, physic...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7075256
更新日期：2015-07-16 00:00:00
abstract：:Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model known to induce re...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061624
更新日期：2020-06-01 00:00:00
abstract：:High sugar intake in childhood has been linked to obesity. However, the role of macronutrient substitutions and associations with metabolic health remain unclear. We examined associations of carbohydrate intake and its subtypes with body composition and metabolic health among 3573 children participating in a populatio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12071940
更新日期：2020-06-30 00:00:00
abstract：:We performed an external cross-validation study of 10 equations to estimate resting energy expenditure (REE) in 2037 children with and 389 without obesity. Inclusion criteria were Caucasian ethnicity, age ≤ 18 years, and availability of REE. REE was measured using indirect calorimetry. The correct classification fract...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051421
更新日期：2020-05-14 00:00:00
abstract：:Glutamine plays a protective role in colitis and colitis-associated colorectal cancer (CAC); however, the protective mechanisms are largely unknown to date. DEP domain-containing mTOR-interacting protein (DEPTOR)/mammalian Target of Rapamycin (mTOR) signaling plays an important role in carcinogenesis. The present stud...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8050261
更新日期：2016-05-02 00:00:00
abstract：:Osteoporosis and associated low energy fractures are a significant clinical problem, especially in the elderly population. The occurrence of a hip fracture is associated with significant mortality and a high risk of disability. For this, apart from the treatment of osteoporosis, effective prevention of both the develo...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12082394
更新日期：2020-08-10 00:00:00
abstract：:The aim of the present study was to report the usual nutrient intakes of sixteen micronutrients by schoolchildren, adults and the elderly in Greece and to further explore the role of age, sex and socio-economic status (SES) on meeting the recommended nutrient intakes. Dietary intake, demographic and SES data from thre...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6104073
更新日期：2014-10-03 00:00:00
abstract：BACKGROUND:Nitrate (NO3-)-rich beetroot (BR) juice supplementation has been shown to improve cardiovascular function via reduction to nitrite (NO2-) and then to the bioactive molecule nitric oxide (NO). However, limited research exists for the role of inorganic NO2- that is contained naturally within BR. OBJECTIVE:As ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13020281
更新日期：2021-01-20 00:00:00
abstract：:Dear Editors and Authors, I had the pleasure to read the published article entitled [1] "Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis" [...]. ...
journal_title：Nutrients
pub_type： 评论,信件
doi：10.3390/nu10030312
更新日期：2018-03-06 00:00:00
abstract：:Many of the health benefits associated with dietary fiber are attributed to their fermentation by microbiota and production of short chain fatty acids (SCFA). The aim of this study was to investigate the fermentability of the functional fiber PolyGlyopleX® (PGX®) in vitro. A validated dynamic, computer-controlled in v...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6031115
更新日期：2014-03-14 00:00:00
abstract：:This study examined the relationship between diet quality scores and cardiometabolic risk factors in regionally-dwelling older Australian adults with increased cardiovascular risk. This study was a cross-sectional analysis of demographic, anthropometric, and cardiometabolic risk factor data from 458 participants of th...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12030860
更新日期：2020-03-23 00:00:00
abstract：:The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5030725
更新日期：2013-03-07 00:00:00
abstract：:Metabolic syndrome (MetS) is defined as a cluster of metabolic alterations such as abdominal obesity, dyslipidemias, elevated fasting glucose, and hypertension. Studies on the association between egg consumption and MetS are limited and inconsistent. A cross-sectional analysis was conducted to examine the association ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9070687
更新日期：2017-07-02 00:00:00
abstract：:The microclimate of an airline cabin consists of dry, recirculated, and cool air, which is maintained at lower pressure than that found at sea level. Being exposed to this distinctive, encapsulated environment for prolonged durations, together with the short-term chair-rest immobilization that occurs during long-haul ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092574
更新日期：2020-08-25 00:00:00
abstract：:As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum lev...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112748
更新日期：2019-11-12 00:00:00
abstract：:Inula japonica Thunb. (Asteraceae) is a flowering plant that grows mainly in Korea, Japan, and China and its flower extract has diverse biological effects such as anti-inflammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010017
更新日期：2018-12-20 00:00:00
abstract：:Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strate...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11040894
更新日期：2019-04-20 00:00:00
abstract：:To address the problem of malnutrition in poor rural areas of China, this study aims to examine the effects of social-psychological factors in food consumption of rural residents in poor counties of Southwest China. In addition, it investigates the role of perceived need and habit within the theory of planned behavior...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041203
更新日期：2020-04-24 00:00:00
abstract：:Studies suggest that haem, non-haem iron and total iron intake may be related to non-communicable diseases, especially metabolic syndrome. This study was undertaken to investigate the association of haem, non-haem iron and total iron intake with metabolic syndrome and its components. A cross-sectional population-based...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10030314
更新日期：2018-03-07 00:00:00
abstract：:Some temporary double enterostomies (DES) or entero-atmospheric fistulas (EAF) have high output and are responsible for Type 2 intestinal failure. Intravenous supplementations (IVS) for parenteral nutrition and hydration compensate for intestinal losses. Chyme reinfusion (CR) artificially restores continuity pending s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051376
更新日期：2020-05-11 00:00:00
abstract：:We examined the evidence for intermittent fasting (IF) as a preventative tool to influence β-amyloid in animal models of Alzheimer's disease (AD). A Scopus, Ovid, PubMed, and Web of Science (WoS), search yielded 29 results using the keywords "amyloid beta", "intermittent fasting", "intermittent caloric restriction", "...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12103215
更新日期：2020-10-21 00:00:00
abstract：:We have identified a clinical association between self-reported non-celiac wheat sensitivity (NCWS) and Familial Mediterranean Fever (FMF). Objectives: A) To determine whether a 2-week double-blind placebo-controlled (DBPC) cross-over wheat vs. rice challenge exacerbates the clinical manifestations of FMF; B) to evalu...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041127
更新日期：2020-04-17 00:00:00
