Abstract:
BACKGROUND:After antibiotic treatment of Lyme borreliosis, a subset of patients report persistent symptoms, also referred to as post-treatment Lyme disease syndrome. The reported prevalence of persistent symptoms varies considerably, and its pathophysiology is under debate. The LymeProspect study has been designed to investigate the prevalence, severity, and a wide range of hypotheses on the etiology of persistent symptoms among patients treated for Lyme borreliosis in the Netherlands. METHODS:LymeProspect is a prospective, observational cohort study among adults with proven or probable Lyme borreliosis, either erythema migrans or disseminated manifestations, included at the start of antibiotic treatment. During one year of follow-up, participants are subjected to questionnaires every three months and blood is collected repeatedly during the first three months. The primary outcome is the prevalence of persistent symptoms after treatment, assessed by questionnaires online focusing on fatigue (CIS, subscale fatigue severity), pain (SF-36, subscale pain) and neurocognitive dysfunction (CFQ). Potential microbiological, immunological, genetic, epidemiological and cognitive-behavioral determinants for persistent symptoms are secondary outcome measures. Control cohorts include patients with long-lasting symptoms and unconfirmed Lyme disease, population controls, and subjects having reported a tick bite not followed by Lyme borreliosis. DISCUSSION:This article describes the background and design of the LymeProspect study protocol. This study is characterized by a prospective, explorative and multifaceted design. The results of this study will provide insights into the prevalence and determinants of persistent symptoms after treatment for Lyme borreliosis, and may provide a rationale for preventive and treatment recommendations. TRIAL REGISTRATION:NTR4998 (Netherlands Trial Register). Date of registration: 13 February 2015.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Vrijmoeth HD,Ursinus J,Harms MG,Zomer TP,Gauw SA,Tulen AD,Kremer K,Sprong H,Knoop H,Vermeeren YM,van Kooten B,Joosten LAB,Kullberg BJ,Hovius JWR,van den Wijngaard CCdoi
10.1186/s12879-019-3949-8subject
Has Abstractpub_date
2019-04-15 00:00:00pages
324issue
1issn
1471-2334pii
10.1186/s12879-019-3949-8journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce. METHODS:21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to imm...
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pub_type: 杂志文章
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