Abstract:
BACKGROUND:An ongoing outbreak of coronavirus disease 2019 (COVID-19) is spreading globally. Recently, several articles have mentioned that the early acute respiratory distress syndrome (ARDS) caused by COVID-19 significantly differ from those of ARDS due to other causes. Actually, we newly observed that some mechanically ventilated COVID-19 patients recovering from severe ARDS (more than 14 days after invasive ventilation) often experienced evidently gradual increases in CO2 retention and minute ventilation. However, the underlying mechanics remain unclear. CASE PRESENTATION:To explain these pathophysiological features and discuss the ventilatory strategy during the late phase of severe ARDS in COVID-19 patients, we first used a metabolic module on a General Electric R860 ventilator (Engstrom Carestation; GE Healthcare, USA) to monitor parameters related to gas metabolism, lung mechanics and physiological dead space in two COVID-19 patients. We found that remarkably decreased ventilatory efficiency (e.g., the ratio of dead space to tidal volume 70-80%, arterial to end-tidal CO2 difference 18-23 mmHg and ventilatory ratio 3-4) and hypermetabolism (oxygen consumption 300-400 ml/min, CO2 elimination 200-300 ml/min) may explain why these patients experienced more severe respiratory distress and CO2 retention in the late phase of ARDS caused by COVID-19. CONCLUSION:During the recovery period of ARDS among mechanically-ventilated COVID-19 patients, attention should be paid to the monitoring of physiological dead space and metabolism. Tidal volume (8-9 ml/kg) could be increased appropriately under the limited plateau pressure; however, barotrauma should still be kept in mind.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Xia J,Feng Y,Li M,Yu X,Zhang Y,Duan J,Zhan Qdoi
10.1186/s12879-020-05360-5subject
Has Abstractpub_date
2020-08-27 00:00:00pages
637issue
1issn
1471-2334pii
10.1186/s12879-020-05360-5journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Yersinia pestis is the pathogen of the plague and caused three pandemics worldwide. Pneumonic plague is rarer than bubonic and septicemic plague. We report detailed clinical and pathogenic data for all the three sporadic cases of pneumonic plagues in China in 2014. CASE PRESENTATION:All the three patients a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1403-8
更新日期:2016-02-19 00:00:00
abstract:BACKGROUND:Implant-related infections, including those of peri-prosthetic joint (PJIs), osteosynthesis and other biomaterials, are biofilm-related. Pathogen identification is considered the diagnostic benchmark; however, the presence of bacterial biofilms makes pathogen detection with traditional microbiological techni...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3050-8
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda. METHODS:HIV-negative, high-risk women were seen q...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-333
更新日期:2011-12-02 00:00:00
abstract:BACKGROUND:Early insights into the timing of the start, peak, and intensity of the influenza season could be useful in planning influenza prevention and control activities. To encourage development and innovation in influenza forecasting, the Centers for Disease Control and Prevention (CDC) organized a challenge to pre...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1669-x
更新日期:2016-07-22 00:00:00
abstract:BACKGROUND:There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment. With the increasing availability of the potentially nephrotixic drug, tenofov...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-143
更新日期:2009-08-28 00:00:00
abstract:BACKGROUND:In resource-limited settings, such as Kenya, access to CD4 testing is limited. Therefore, evaluation of less expensive laboratory diagnostics is urgently needed to diagnose immuno-suppression in children. OBJECTIVES:To evaluate utility of total lymphocyte count (TLC) as surrogate marker for CD4 count in HIV...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-259
更新日期:2011-09-30 00:00:00
abstract:BACKGROUND:Fatigue is a common symptom of chronic hepatitis C virus (HCV) infection and a frequent side-effect of peginterferon/ribavirin (PR) therapy for HCV. This study evaluated the impact of adding the oral HCV NS3/4A protease inhibitor simeprevir to PR on patient-reported fatigue and health status among patients w...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-14-465
更新日期:2014-08-26 00:00:00
abstract:BACKGROUND:Dengue virus (DENV) infection is an emerging arboviral infection in tropical and sub-tropical countries in South-East Asia, the Western Pacific and South and Central America. Secondary DENV infection is the most widely accepted risk factor for the development of severe forms. Methods to discriminate primary ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1022-9
更新日期:2015-07-21 00:00:00
abstract:BACKGROUND:While the prevalence of multidrug-resistant (MDR) tuberculosis (TB) is high among children in the Western Cape of South Africa, the psychosocial implications of treatment for children with MDR-TB remain poorly understood. We sought to explore how MDR-TB and its treatment impact children on an individual, fam...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-426
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determining regions of M. genitalium in Johannesburg, South Africa, and ascertained their association wit...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3797-6
更新日期:2019-02-13 00:00:00
abstract:BACKGROUND:Trichosporon mycotoxinivorans is a recently described yeast-like fungal organism and its association as a pathogen for patients with cystic fibrosis (CF) was reported previously. We show the clinical course of a CF patient over 9 years as well as the applications of modern molecular and proteomic identificat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1910-7
更新日期:2016-10-25 00:00:00
abstract:BACKGROUND:The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C patients with advanced fibrosis (AF) is limited. The aim of this study is to assess its role in predi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0888-x
更新日期:2015-03-26 00:00:00
abstract:BACKGROUND:Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions. Increased reliability and technical efficiency of quantitative PCR (qPCR) makes it a promising tool for early diagnosis of leprosy. Inde...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3056-2
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Middle East Respiratory Syndrome (MERS) is caused by MERS coronavirus (MERS-CoV). More than 80% of reported cases have occurred in Saudi Arabia, with a mortality exceeding 50%. Health-care workers (HCWs) are at risk of acquiring and transmitting this virus, so the concerns of HCWs in Saudi Arabia regarding M...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2096-8
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:The incidence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) has risen dramatically in the U.S., particularly among children. Although Streptococcus pneumoniae colonization has been inversely associated with S. aureus colonization in unvaccinated children, this and other risk fact...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-110
更新日期:2009-07-11 00:00:00
abstract:BACKGROUND:The technique most frequently used to genotype HCV is quantitative RT-PCR. This technique is unable to provide an accurate genotype/subtype for many samples; we decided to develop an in-house method with the goal of accurately identifying the genotype of all samples. As a Belgium National Centre of reference...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4386-4
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:Brucellosis is endemic in many areas in China. The current diagnosis of Brucellosis predominantly relies on the traditional bacterial culture and serum agglutination test. In this study, we aimed to explore the value of ELISA in the diagnosis of Brucellosis in Chinese population. METHODS:We recruited 235 pa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4729-1
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Device-associated health care-associated infections (DA-HAIs) in intensive care unit (ICU) patients constitute a major therapeutic issue complicating the regular hospitalisation process and having influence on patients' condition, length of hospitalisation, mortality and therapy cost. METHODS:The study invo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05482-w
更新日期:2020-10-16 00:00:00
abstract:BACKGROUND:The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current molecular methods to detect MTB resistance to second-line drugs either do not cover an extended spectr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-240
更新日期:2013-05-24 00:00:00
abstract:BACKGROUND:China faces a serious HIV epidemic among men who have sex with men (MSM), and a large proportion of new infections are attributed to their regular male sex partners (RP). The objective of this study was to investigate the association between intimate relationship characteristics and HIV-related behaviors amo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3044-6
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Intracranial infection after puncture of cerebral hematoma in patients with intracerebral hemorrhage is very common in the department of neurosurgery, yet the relevant risks remain unknown. We attempted to analyze the risk factors of intracranial infection after puncture of cerebral hematoma, to provide insi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05630-2
更新日期:2020-12-11 00:00:00
abstract:BACKGROUND:Compliance to anti-TB treatment is crucial in achieving cure and avoiding the emergence of drug resistance. Electronic health (eHealth) interventions are included in the strategy to end the global Tuberculosis (TB) epidemic by 2035. Evidences showed that mobile messaging systems could improve patient adheren...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-020-4765-x
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Yeasts, mostly Candida, are important causes of bloodstream infections (BSI), responsible for significant mortality and morbidity among hospitalized patients. The epidemiology and species distribution vary from different regions. The goals of this study were to report the current epidemiology of Candida BSI ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-241
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Globally, prison inmates are a high-risk population for tuberculosis (TB), but the specific drivers of disease and impact of mass screening interventions are poorly understood. METHODS:We performed a prospective cohort study to characterize the incidence and risk factors for tuberculosis infection and disea...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1868-5
更新日期:2016-10-03 00:00:00
abstract:BACKGROUND:Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative a...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-014-0635-8
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Hemodialysis (HD) patients are susceptible to extended spectrum beta-lactamase (ESBL)-producing bacterial infections. Because the optimal treatment and clinical significance of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) HD access-related bacteremia remain unclear, we conducted this retrospective study to...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-206
更新日期:2012-09-05 00:00:00
abstract:BACKGROUND:Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical are...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1704-y
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Since correct maintenance of intravascular catheters is an effective strategy for preventing central-line infections, the aim of this study was to assess the level of adherence to guidelines for CVC maintenance amongst Italian HCWs. METHODS:From July 2016 thru January 2017, a cross sectional survey was carr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3514-x
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Diabetes is a risk factor for infection with coronaviruses. This study describes the demographic, clinical data, and outcomes of critically ill patients with diabetes and Middle East Respiratory Syndrome (MERS). METHODS:This retrospective cohort study was conducted at 14 hospitals in Saudi Arabia (September...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-021-05771-y
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Guidelines from the Infectious Diseases Society of America/The American Thoracic Society (IDSA/ATS) provide recommendations for diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the mere presence of guidelines is rarely sufficient to promote widespread adoption and uptake. Using the ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1665-1
更新日期:2016-07-22 00:00:00