Abstract:
BACKGROUND:Infection by Staphylococcus aureus (S. aureus) is a major cause of morbidity and mortality. Colonization by S. aureus increases the risk of infection. Little is known about decolonization strategies for S. aureus beyond antibiotics, however probiotics represent a promising alternative. A randomized controlled trial was conducted to determine the efficacy of Lactobacillus rhamnosus (L. rhamnosus) HN001 in reducing carriage of S. aureus at multiple body sites. METHODS:One hundred thirteen subjects, positive for S. aureus carriage, were recruited from the William S. Middleton Memorial Medical Center, Madison, WI, USA, and randomized by initial site of colonization, either gastrointestinal (GI) or extra-GI, to 4-weeks of oral L. rhamnosus HN001 probiotic, or placebo. Nasal, oropharyngeal, and axillary/groin swabs were obtained, and serial blood and fecal samples were collected. Differences in prevalence of S. aureus carriage at the end of the 4-weeks of treatment were assessed. RESULTS:The probiotic and placebo groups were similar in age, gender, and health history at baseline. S. aureus colonization within the stool samples of the extra-GI group was 15% lower in the probiotic than placebo group at the endpoint of the trial. Those in the probiotic group compared to the placebo group had 73% reduced odds (OR 0.27, 95% CI 0.07-0.98) of methicillin-susceptible S. aureus presence, and 83% reduced odds (OR 0.17, 95% CI 0.04-0.73) of any S. aureus presence in the stool sample at endpoint. CONCLUSION:Use of daily oral L. rhamnosus HN001 reduced odds of carriage of S. aureus in the GI tract, however it did not eradicate S. aureus from other body sites. TRIAL REGISTRATION:ClinicalTrials.gov Identifier: NCT01321606 . Registered March 21, 2011.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Eggers S,Barker AK,Valentine S,Hess T,Duster M,Safdar Ndoi
10.1186/s12879-018-3028-6subject
Has Abstractpub_date
2018-03-14 00:00:00pages
129issue
1issn
1471-2334pii
10.1186/s12879-018-3028-6journal_volume
18pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The prevalence of healthcare-acquired infections (HAI) and rising levels of antimicrobial resistance places significant economic and public health burdens on modern healthcare systems. A group of highly drug resistant pathogens known as the ESKAPE pathogens, along with C. difficile, are the leading causes of...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05121-4
更新日期:2020-06-12 00:00:00
abstract:INTRODUCTION:Late presentation to HIV/AIDS care which is attended by problems like, poor treatment outcomes, early development of opportunistic infections, increased healthcare costs, and mortality is a major problem in Ethiopia. Although evidences are available on the prevalence and associated factors of late presenta...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-019-4156-3
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Community-genotype methicillin-resistant Staphylococcus aureus (CG-MRSA) clones are a global concern due to their resistance and increased virulence and their ability to cause infections both hospitalized patients and healthy people in the community. Here, we characterize 32 isolates of a new CG-MRSA clone. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2193-3
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:Over 80% of morbidity due to soil-transmitted helminthiasis (STH) occurs in low-income countries. Children under 5 account for 20-30% of the burden in endemic areas. This study assessed the prevalence, intensity and factors associated with STH infections among preschool-age children (PSAC) in Hoima district,...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3289-0
更新日期:2018-08-17 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNF-α) plays a key role in the containment of tuberculosis. The relationship between the TNF -238G/A polymorphism and tuberculosis susceptibility remains inconclusive. A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them. MET...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2334-12-328
更新日期:2012-11-28 00:00:00
abstract:BACKGROUND:War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of first-line antibiotics resistant bacteria (FLAR) among PTO cases in civilians from Syria, Iraq and Yemen admitted to the reconstructive s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3741-9
更新日期:2019-01-31 00:00:00
abstract:BACKGROUND:Streptococcus pneumoniae (Pnc), nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are the most important bacterial pathogens associated with otitis media (OM). Previous studies have suggested that early upper respiratory tract (URT) bacterial carriage may increase risk of subsequent ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-366
更新日期:2012-12-21 00:00:00
abstract:BACKGROUND:The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2061-6
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) markedly reduces HIV transmission, and testing and treatment programs have been advocated as a method for decreasing transmission at the population level. Little is known, however, about the extent to which sexually transmitted infections (STIs), which increase the HIV infectious...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12879-015-0961-5
更新日期:2015-06-30 00:00:00
abstract:BACKGROUND:Staphylococcus aureus strains are now regarded as zoonotic agents. In pastoral settings where human-animal interaction is intimate, multi-drug resistant microorganisms have become an emerging zoonotic issue of public health concern. The study of S. aureus prevalence, antimicrobial resistance and clonal linea...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2524-4
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:Brucellosis is a zoonotic disease caused by brucella. It has been an increasing trend in recent years (Wang H, Xu WM, Zhu KJ, Zhu SJ, Zhang HF, Wang J, Yang Y, Shao FY, Jiang NM, Tao ZY, Jin HY, Tang Y, Huo LL, Dong F, Li ZJ, Ding H, Liu ZG, Emerg Microbes Infect 9:889-99, 2020). Brucellosis is capable to in...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05358-z
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:Drug resistant tuberculosis is a major public health problem in Morocco and worldwide. Treatment outcome of drug resistant tuberculosis is poor and requires a long period of treatment with many toxic and expensive antituberculosis drugs. The aim of this study is to evaluate treatment outcomes of drug resista...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3931-5
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:In this study, we evaluated the genetic relatedness of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KPN) isolates from an outbreak in a neonatal intensive care unit (NICU) in August 2017, We implemented an active countermeasure to control this outbreak successfully. METHODS:The inc...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4889-z
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:We sought to assess reporting in China's Pneumonia of Unknown Etiology (PUE) passive surveillance system for emerging respiratory infections and to identify ways to improve the PUE surveillance system's detection of respiratory infections of public health significance. METHODS:From February 29-May 29, 2016,...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4345-0
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information on XDR TB is available. Hence, the eval...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3009-9
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Diagnosis of bloodstream infections (BSI) in neonates is usually difficult due to minimal symptoms at presentation; thus early empirical therapy guided by local antibiotic susceptibility profile is necessary to improve therapeutic outcomes. METHODS:A review of neonatal blood cultures submitted to the microb...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1913-4
更新日期:2016-10-24 00:00:00
abstract:BACKGROUND:Migrants are considered a key population at risk for sexually transmitted and blood-borne diseases in Europe. Prevalence data to support the design of infectious diseases screening protocols are scarce. We aimed to estimate the prevalence of hepatitis B and C, human immunodefiency virus (HIV) infection and s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3041-9
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:As most data on hepatitis in resource-poor countries relate to urban communities, surveys in the rural environment are necessary to determine the 'true' prevalence of these viral infections. We undertook a survey to determine the prevalence of hepatitis B virus (HBV) infection in an apparently healthy rural ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-286
更新日期:2013-06-24 00:00:00
abstract:BACKGROUND:Cryptococcus gattii is known to be an etiologic agent of human cryptococcosis, particularly in immunocompetent persons. C. gattii infection usually involves the central nervous system, the respiratory tract, or may be disseminated. Here we report an atypical manifestation of C. gattii infection in a patient ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-018-3165-y
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mu...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1285-1
更新日期:2015-12-03 00:00:00
abstract:BACKGROUND:The outbreak of the 2009 H1N1 influenza pandemic (H1N1pdm) affected thousands of people in Mexico and the United States, and spread rapidly throughout the world from April 2009 to July 2010. To explore the age-specific prevalence of seroprotection against H1N1pdm infection, we estimated pre-existing humoral ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2215-1
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to estimate influenza vaccine effectiveness (VE) among individuals aged 60+ years over three seasons a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0882-3
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2567-6
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Children in developing country suffer the highest burden of pneumonia. However, few studies have evaluated associations between poverty and pneumonia. METHODS:A prospective population-based study on pneumonia was carried out as part of the Latin America Epidemiological Assessment of Pneumococcus (LEAP study...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-180
更新日期:2011-06-22 00:00:00
abstract:BACKGROUND:Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013-2017. METHODS:Acquisition of two pseudonymized case-based data sources (national TB notification data a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05467-9
更新日期:2020-10-17 00:00:00
abstract:BACKGROUND:The current low access to virological testing to confirm chronic viraemic HCV infection in low- and middle-income countries (LMIC) is limiting the rollout of hepatitis C (HCV) care. Existing tests are complex, costly and require sophisticated laboratory infrastructure. Diagnostic manufacturers need guidance ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2770-5
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The emerging resistance to the extended-spectrum cephalosporins (ESCs) in Neisseria gonorrhoeae together with increasing incidence of gonorrhoea cases in many countries have been global public health concerns. However, in recent years the levels of ESC resistance have decreased in several regions worldwide. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1013-x
更新日期:2015-08-11 00:00:00
abstract:BACKGROUND:The China-Myanmar border is a particularly interesting region that has very high prevalence of and considerable diversity of HIV-1 recombinants. Due to the transient nature of their work, long-distance truck drivers (LDTDs) have a comparatively high potential to become infected with HIV-1 and further spread ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-463
更新日期:2014-08-26 00:00:00
abstract:BACKGROUND:A Q-fever outbreak occurred in an urban area in the south of the Netherlands in May 2008. The distribution and timing of cases suggested a common source. We studied the spatial relationship between the residence locations of human cases and nearby small ruminant farms, of which one dairy goat farm had experi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-69
更新日期:2010-03-16 00:00:00
abstract:BACKGROUND:Human rotavirus A (human RV-A) is the most common cause of viral gastroenteritis in infants. The objective of the study was to characterize the G and P genotypes among clinical rotavirus isolates from children with acute diarrhea admitted to a tertiary care hospital in Riyadh, Saudi Arabia. METHODS:From 201...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0923-y
更新日期:2015-04-17 00:00:00