P2X7 receptor in cardiovascular disease: The heart side.

abstract：:In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneous beating and in the release of noradrenaline produced by field stimulation of sympathetic nerves. In rat isolated caudal artery preparations, both angiotensin I and angiotensin II had dir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ziogas J,Story DF,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:1. Cholestatic liver disease is associated with nitric oxide (NO) overproduction and bradycardia. Nitric oxide has a dual effect on sinoatrial node and its effects depend on its concentration. Nitric oxide can increase heart rate by activating hyperpolarization-activated pacemaker current (If) but, at high concentrati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mani AR,Nahavandi A,Moosavi M,Safarinejad R,Dehpour AR

更新日期：2002-10-01 00:00:00

abstract：:1. We have studied the role of kallikrein (KK) in the maintenance of renal function in chronic hypoxic rats (high altitude; HA), compared with control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (198-290 g) in an altitude chamber (5500 m) 15 h/day for 4 weeks. Experiments were also c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

更新日期：1996-09-01 00:00:00

abstract：:1. We tested the hypothesis that increasing myocardial cyclic GMP levels would reduce myocardial O2 consumption and areas of low O2 supply/consumption balance, using zaprinast, a selective cyclic GMP-phosphodiesterase inhibitor. 2. The study was conducted in three groups (vehicle, 10(-3) and 3 x 10(-3) mol/L zaprinast...

journal_title：Clinical and experimental pharmacology & physiology

authors： Weiss HR,Rodriguez E,Tse J,Scholz PM

更新日期：1994-08-01 00:00:00

abstract：:The activation of inactive renin during incubation of human plasma with puff adder venom at pH 7.4 was found to be a complex process. Gel filtration on Sephacryl S-200 indicated that the venom contains a major peak of caseinolytic and renin-activating activity of low molecular weight. This enzyme was a metalloproteina...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris BJ,Lawrence CH,Catanzaro DF

更新日期：1980-09-01 00:00:00

abstract：:Receptors for parathyroid hormone (PTH) in the renal tubule are coupled to adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from cells of the proximal convoluted tubule. The effects of alpha-adrenergic agonists ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Woodcock EA,McLeod JK,Johnston CI

更新日期：1984-07-01 00:00:00

abstract：:Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joksić J,Sopić M,Spasojević-Kalimanovska V,Gojković T,Zeljković A,Vekić J,Andjelkovic K,Kalimanovska-Oštrić D,Jelić-Ivanović Z

更新日期：2016-01-01 00:00:00

abstract：:1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post-ganglionic sympathetic neuronal development. 2. Endothelin is produced by post-ganglionic neurons and by cells adjacent to these neurons. 3. Post-ganglionic sympathetic neurons express functional receptors for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Damon DH

更新日期：1999-12-01 00:00:00

abstract：:The effect of pancuronium in the rabbit ear artery was investigated in order to measure the inhibition it produces at the prejunctional muscarinic receptor on sympathetic nerve endings in this tissue. Pancuronium (0.1-0.2 mmol/l) produced an enhancement of responses to transmural electrical stimulation but this effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Leung E,Mitchelson F

更新日期：1983-11-01 00:00:00

abstract：:1. The neurotrophins play an important role during development to stimulate and guide axonal growth for the establishment of a correctly wired and functional neural system. Neurotrophins can also regulate adult nervous system plasticity by promoting neuronal survival and stimulating nerve regrowth following injury. 2....

journal_title：Clinical and experimental pharmacology & physiology

authors： Gillespie LN

更新日期：2003-10-01 00:00:00

abstract：:1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

更新日期：2001-05-01 00:00:00

abstract：:1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Piller NB

更新日期：1976-11-01 00:00:00

abstract：:1. The role of arginine vasopressin (AVP) was examined in adrenocorticotrophin (ACTH)-induced hypertension in Sprague-Dawley rats using the non-peptide AVP V1a receptor antagonist OPC 21268. 2. In an acute study, six rats were pretreated with ACTH for 11 days and direct arterial blood pressure (4 h), plasma osmolality...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fraser TB,Turner SW,Wen C,Li M,Burrell LM,Whitworth JA

更新日期：2000-11-01 00:00:00

abstract：:1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bennet L,Booth L,Malpas SC,Quaedackers JS,Jensen E,Dean J,Gunn AJ

更新日期：2006-04-01 00:00:00

abstract：:The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GAB...

journal_title：Clinical and experimental pharmacology & physiology

authors： Parker DA,Marino V,Ong J,Puspawati NM,Prager RH

更新日期：2008-09-01 00:00:00

abstract：:1. The present study examined the cytosolic Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0.01-100 micromol/L) to elucidate its vascular effects on isometric ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

更新日期：2010-03-01 00:00:00

abstract：:1. A rapid imaging technique with temporal resolution of about 1 ms was employed to describe cell-length changes during the isotonic contraction cycle of adult rat ventricular myocytes at 22 degrees C. 2. Parameters of cell contraction and relaxation were defined and values obtained under control conditions and after ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Delbridge LM,Harris PJ,Morgan TO

更新日期：1989-03-01 00:00:00

abstract：:1. Calcium regulation has been reported to be associated with the development of diabetic nephropathy. Thus, changes in Ca2+ uptake induced by ATP, an important regulator of Ca2+ uptake, in the diabetic condition and related signal pathways were examined in primary cultures of rabbit renal proximal tubule cells (PTC)....

journal_title：Clinical and experimental pharmacology & physiology

authors： Han HJ,Park SH,Lee YJ,Lee JC,Lee JH

更新日期：2003-09-01 00:00:00

abstract：:1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

更新日期：1980-07-01 00:00:00

abstract：:The currently available chemotherapeutic regimens against gastric cancer are not very effective, leading to high recurrence and poor survival. Resveratrol is a naturally occurring polyphenol with potent apoptosis-inducing activity. However, the mechanism underlying its actions remains unknown. In the present study, hu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Z,Li W,Meng X,Jia B

更新日期：2012-03-01 00:00:00

abstract：:1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1989-05-01 00:00:00

abstract：:The effector mechanisms responsible for the bradycardia evoked by bilateral lesions of the brainstem coinciding with the A1 catecholamine cells were analyzed in four groups of rabbits. Sham or lesion operations were carried out in animals with intact cardiac effectors, with cardiac sympathetic block induced by propran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denoroy L,West MJ,Chalmers J

更新日期：1984-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder with an incompletely defined aetiology that is associated with memory and cognitive impairment. Currently available therapeutics only provide temporary assistance with symptoms. In spite of plentiful research in the field and the generation of thousands of studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zamani E,Parviz M,Roghani M,Mohseni-Moghaddam P

更新日期：2019-01-01 00:00:00

abstract：:1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

更新日期：1999-01-01 00:00:00

abstract：:1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pisarenko OI

更新日期：1996-08-01 00:00:00

abstract：:1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

更新日期：2010-12-01 00:00:00

abstract：:1. Aldosterone is a hormone that affects both blood pressure and glucose homeostasis. We studied the association of the aldosterone synthase gene (CYP11B2) polymorphism -344T>C with essential hypertension (EH) and glucose homeostasis in people in China. 2. We investigated the polymorphism -344T>C in CYP11B2 using a ca...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li XM,Ling Y,Lu DR,Lu ZQ,Yi QL,Liu Y,Chen HY,Gao X

更新日期：2011-09-01 00:00:00

abstract：:1. Parathyroidectomy (PTX) lessens the development of hypertension in young spontaneously hypertensive rats (SHR) and the involved mechanisms remain to be elucidated. We have studied here the aortic vascular reactivity to both norepinephrine (NE) and acetylcholine in 10 week old male PTX SHR and Wistar-Kyoto (WKY) rat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boulebda N,Van Overloop B,Gairard A

更新日期：1993-12-01 00:00:00

abstract：:1. The endogenous production of and/or the bioavailability of nitric oxide (NO) is decreased in pulmonary hypertensive diseases. L-arginine (L-arg) is the substrate for NO synthase (NOS). L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui H,Chen B,Chicoine LG,Nelin LD

更新日期：2011-12-01 00:00:00

abstract：:Hepatic fibrosis is an outcome of chronic liver injury. Angiotensin II (ANG II) may play a role in the pathogenesis of hepatic fibrosis. Certain drugs such as ACE inhibitors, ANG II antagonists, and even statins could interfere with the renin angiotensin system and modulate its deleterious effects. This study was carr...

journal_title：Clinical and experimental pharmacology & physiology

authors： El-Ashmawy NE,El-Bahrawy HA,Shamloula MM,Ibrahim AO

更新日期：2015-09-01 00:00:00