Abstract:
:Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Intramaxillary ATP infusions increased CBF to an extent greater than that required for increases seen in CMRO2. Hypercapnia increased CBF without a significant change in CMRO2. Results suggest that increases in cerebral metabolism may mediate most, some and none of the cerebrovascular changes produced by bradykinin, ATP or hypercapnia, respectively.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Hoffman WE,Miletich DJ,Volkman PH,Albrecht RFdoi
10.1111/j.1440-1681.1983.tb00177.xsubject
Has Abstractpub_date
1983-03-01 00:00:00pages
115-24issue
2eissn
0305-1870issn
1440-1681journal_volume
10pub_type
杂志文章abstract::1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1977.tb02683.x
更新日期:1977-11-01 00:00:00
abstract::Although 7,8-dihydroxyflavone (7,8-DHF), a synthetic agonist specific for tyrosine kinase receptor B (TrkB), has been reported to promote intestinal dynamics, its effect on gastric dynamics has not been studied as yet. In this study, we explored how 7,8-DHF affected the carbachol (CCh)-induced contraction of rat gastr...
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1998.tb02229.x
更新日期:1998-06-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1983.tb00210.x
更新日期:1983-05-01 00:00:00
abstract::1. Trophoblast invasion during embryo implantation in some aspects resembles tumour cell invasion but, unlike tumour cells, trophoblast cells are able to differentiate and establish a placenta. Because direct cell-cell communication is believed to be involved in growth control and differentiation, we have investigated...
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pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1992.tb00475.x
更新日期:1992-05-01 00:00:00
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更新日期:2018-05-21 00:00:00
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更新日期:1995-06-01 00:00:00
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更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.2008.04887.x
更新日期:2008-04-01 00:00:00
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doi:10.1111/j.1440-1681.1994.tb02515.x
更新日期:1994-04-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1994.tb02521.x
更新日期:1994-04-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1989-04-01 00:00:00
abstract::1. The aim of the present study was to determine the effects of prolonged prostaglandin E2 (PGE2) administration on the function of the foetal kidneys and lungs in order to gain a greater understanding of the role played by PGE2 in the control of foetal fluid balance. By studying the effects of PGE2 at two gestational...
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1998.tb02157.x
更新日期:1998-10-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1986.tb00942.x
更新日期:1986-08-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/1440-1681.12321
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1993.tb03015.x
更新日期:1993-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1046/j.1440-1681.2002.03641.x
更新日期:2002-04-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1046/j.1440-1681.1999.03062.x
更新日期:1999-05-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1976.tb00607.x
更新日期:1976-07-01 00:00:00