Changes in redox ratio and protein glycation in precataractous lens from fructose-fed rats: effects of exogenous L-carnitine.

abstract：:1. We have studied the role of kallikrein (KK) in the maintenance of renal function in chronic hypoxic rats (high altitude; HA), compared with control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (198-290 g) in an altitude chamber (5500 m) 15 h/day for 4 weeks. Experiments were also c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

更新日期：1996-09-01 00:00:00

abstract：:The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

journal_title：Clinical and experimental pharmacology & physiology

authors： Howe PR,Rogers PF,King RA,Smith RM

更新日期：1983-05-01 00:00:00

abstract：:1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2009-12-01 00:00:00

abstract：:1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Aydogdu N,Atmaca G,Yalcin O,Taskiran R,Tastekin E,Kaymak K

更新日期：2006-01-01 00:00:00

abstract：:β-Glucans have been reported to be potent adjuvants in stimulating innate and adaptive immune responses. The aim of the present study was to determine the immunohematopoietic effects of Imunoglucan (HEBRON) following its oral administration to normal and Ehrlich ascites tumour (EAT)-bearing mice. Mice were treated wit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Torello CO,Souza-Queiroz J,Queiroz ML

更新日期：2012-03-01 00:00:00

abstract：:1. The aim of the present study was to evaluate the usefulness and reliability of a portable indirect calorimeter (Metavine; Vine, Tokyo, Japan). 2. We measured energy expenditure (EE) of elderly people (n = 191) at nursing homes using both Metavine and an authorized indirect calorimeter (Deltatrac Metabolic Monitor; ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kato M,Tajika M,Miwa Y,Moriwaki H

更新日期：2002-10-01 00:00:00

abstract：:1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA,Krause L,Julius S

更新日期：1994-01-01 00:00:00

abstract：:1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sundaresan P,Lykos D,Daher A,Morris R,Diamond T,Howes LG

更新日期：1998-02-01 00:00:00

abstract：:1. Previous clinical and experimental reports have suggested that the systemic administration of ethyl alcohol permits lower body temperatures before the onset of hypothermic cardiac arrest. 2. In the investigations described here, the effect of ethyl alcohol on the temperature at which cardiac arrest occurred in rats...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duthie AM,White JF

更新日期：1977-07-01 00:00:00

abstract：:1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

更新日期：1989-04-01 00:00:00

abstract：:Mutations of αB-crystallin (CryαB), a small heat shock protein abundantly expressed in cardiac and skeletal muscles, are known to cause desmin-related myopathies. The CryαB R120G allele has been linked to a familial desminopathy and, in transgenic mice, causes a sudden death at about 28 weeks of age. To investigate th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiao Q,Sanbe A,Zhang X,Liu JP,Minamisawa S

更新日期：2014-08-01 00:00:00

abstract：:1. The diffusional permeability of collecting ducts to 22Na+ and 36Cl- was measured in rat papillae in vitro. 2. The permeability of the collecting duct to 36Cl- was 0.72 (s.e.m. = 0.01; n = 356) microns/sec which was significantly higher than the value of 0.51 (s.e.m. = 0.01; n = 356) microns/sec measured for 22Na+. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morgan T,Ray C

更新日期：1982-11-01 00:00:00

abstract：:1. The present study investigated whether the somatostatin receptor (SSTR) agonist, octreotide, could inhibit the activation of dorsal skin afferent fibres induced by local injection of capsaicin in the rat. 2. Single unit activity from Aδ mechano-heat sensitive (AMH; n = 41) and C mechano-heat sensitive (CMH; n = 30)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Cao DY,Guo Y,Ma SJ,Luo R,Pickar JG,Zhao Y

更新日期：2011-08-01 00:00:00

abstract：:Lamotrigine (LTG) is one of the most widely used antiepileptic drugs. Confusion still exists in the literature as to the relative influence of age, body weight, and concomitant drug therapy on LTG pharmacokinetics. So, the objective of this study is to evaluate the influence of patient-related factors and comedication...

journal_title：Clinical and experimental pharmacology & physiology

authors： Baldoni AO,Freitas-Lima P,de Santi Ferreira FI,Martinez EZ,Queiroz RH,Sakamoto AC,Alexandre V,Perucca E,Pereira LR

更新日期：2016-07-01 00:00:00

abstract：:A high-salt diet in rats has been shown to result in enhanced vasoconstrictor and/or reduced vasodilator responses of isolated arteries to agonists. The present experiments were designed to investigate the effects of dietary salt on the responses of the pressurized mesenteric resistance artery of the dog to constricto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sofola O,Knill A,Myers D,Hainsworth R,Drinkhill M

更新日期：2004-10-01 00:00:00

abstract：:1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Piller NB

更新日期：1976-11-01 00:00:00

abstract：:1. Subpressor calcium infusion for 1 h, which raised calcium levels to the upper limit of normal in normal subjects, increased plasma and urinary levels of atrial natriuretic peptide (ANP). 2. Heart rate fell, presumably due to carotid baroreflex stimulation (supported by the fall in noradrenaline) and the resultant f...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Gordon RD,Seneviratne BI,Tunny TJ,Klemm SA

更新日期：1992-05-01 00:00:00

abstract：:1. Telomeres (ends of chromosomes) undergo constant remodelling during cell development, proliferation and differentiation, as well as in neoplastic cell immortalization and transformation. How the cellular microenvironment influences telomere remodelling (lengthening or shortening) remains largely unknown. 2. Recentl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu JP,Nicholls C,Chen SM,Li H,Tao ZZ

更新日期：2010-01-01 00:00:00

abstract：:1. The purpose of the present study was to investigate whether there was a cooperative interaction between substance P (SP) and glutamate (GLU) administered subcutaneously on Adelta and C primary afferent fibre activity in dorsal hairy skin of the rat in vivo. The single unit activities of Adelta and C afferent fibres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Q,Zhao Y,Guo Y,Cao DY,Tian YL,Yao FR,Wang HS

更新日期：2006-12-01 00:00:00

abstract：:1. The present experiments were performed in order to study the role of the sarcoplasmic reticulum (SR) in the altered action potential and contraction of ventricular myocardium obtained from myopathic Syrian hamster and explanted human hearts (n = 8). The hamsters included age-matched healthy hamsters (F1B; n = 18), ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wei J,Liu HC,Lee FY,Lee MS,Huang CY,Pan HP,Lin CI

更新日期：2003-04-01 00:00:00

abstract：:1. Piretanide is a new loop diuretic resembling furosemide. The effects of this diuretic on various parameters of renal function and on the excretion of the major ions were studied on anaesthetized, hydrated rats. 2. Piretanide induced a marked diuresis and increased sodium, potassium, chloride and calcium excretion. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nguyen-Simonnet H,Gauthier C,Pellet M

更新日期：1981-07-01 00:00:00

abstract：:1. In coronary artery disease, the typical atheromatous plaque consists of a lipid core containing various inflammatory cells and a fibrous cap composed mostly of extracellular matrix. Both matrix metalloproteinases (MMPs) and inflammation are involved in the initiation of atherosclerotic plaques and plaque instabilit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang W,Wang CH,Li F,Zhu WZ

更新日期：2008-03-01 00:00:00

abstract：:1. We studied the association between the level of the left ventricular ejection fraction and the severity of coronary atherosclerosis. 2. The study population consisted of 850 consecutive patients who underwent coronary angiography for suspected or known coronary atherosclerosis. Anthropometric measurements including...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jia EZ,Xu ZX,Yang ZJ,Zhu TB,Wang LS,Cao KJ,Ma WZ

更新日期：2011-02-01 00:00:00

abstract：:1. Anastomosis (vasovasostomy) of epididymal and prostatic halves of vasa deferentia was carried out in rats in which unilateral or bilateral medial transection (vasectomy) had been performed 4 weeks previously. 2. Noradrenaline levels in epididymal halves of vasa deferentia, 8 weeks after anastomosis with prostatic h...

journal_title：Clinical and experimental pharmacology & physiology

authors： DeGaris RM,Pennefather JN

更新日期：1987-05-01 00:00:00

abstract：:1. We have tested the effects of 2 month oral treatment with the KATP opener, nitric oxide (NO) donor and anti-oxidant molecule nicorandil (0.1 mg/kg per day) on major physiological parameters and heart function of 4-, 12- and 24-month-old rats. 2. Several methods were used: (i) measurement of blood pressure using a n...

journal_title：Clinical and experimental pharmacology & physiology

authors： Garnier-Raveaud S,Faury G,Mazenot C,Cand F,Godin-Ribuot D,Verdetti J

更新日期：2002-05-01 00:00:00

abstract：:1. Metformin is one of the most commonly used drugs for the treatment of Type 2 diabetes. Accumulating evidence suggests that metformin also has cardioprotective effects. In the present study, we investigated the cardioprotective effects of metformin and the mechanisms involved. 2. A rat model of chronic heart failure...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XF,Zhang JY,Li L,Zhao XY,Tao HL,Zhang L

更新日期：2011-02-01 00:00:00

abstract：:In the context of the ongoing debate on the mechanism of blood pressure (BP) regulation and pathophysiology of arterial hypertension ("renocentric" vs "neural" concepts), attention is focused on the putative regulatory role of changes in renal medullary blood flow (MBF). Experimental evidence is analysed with regard t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sadowski J,Bądzyńska B

更新日期：2020-08-01 00:00:00

abstract：:Repaglinide is a short-acting insulin secretagogue, which often results in considerable interindividual variability in therapeutic efficacy when widely used in a clinical setting. Among various reasons under discussion is genetic polymorphism, especially the genes related to insulin secretion and resistance. Recent st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Song JF,Wang T,Zhu J,Zhou XY,Lu Q,Guo H,Zhang F,Wang Y,Li W,Wang DD,Cui YW,Lv DM,Yin XX

更新日期：2015-01-01 00:00:00

abstract：:1. Investigations of the role of cAMP in the stimulation of the steroidogenesis of zona glomerulosa (ZG) cells by increased extracellular K+ concentration are reviewed. 2. Possible reasons for discrepancies in the results of different investigators on whether K+ increases the cAMP content or output of ZG tissue or dis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tait JF,Tait SA

更新日期：1999-12-01 00:00:00

abstract：:The kidney has a unique environment that results in relatively low tissue oxygen tension (Po2). However, recent studies have shown that renal hypoxia is more severe during hypertension and may reflect changes in the way O2 is used. The present review summarizes studies that explore the relationship between renal oxyge...

journal_title：Clinical and experimental pharmacology & physiology

authors： Welch WJ

更新日期：2006-10-01 00:00:00