Application of colour Doppler in encircling constriction of the superficial femoral vein in primary deep venous insufficiency of the lower limbs.

abstract：:1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

更新日期：2010-12-01 00:00:00

abstract：:The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joels N,Humphreys PW

更新日期：1985-11-01 00:00:00

abstract：:1. The effects of ATP and some of its more stable analogues have been examined upon preparations of epididymal and prostatic halves of vasa deferentia and of cauda epididymides from rats that had undergone vasectomy by medial transection of the vas deferens. 2. After unilateral vasectomy, the potencies of ATP, beta, g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,DeGaris RM,Stead CK,Pennefather JN

更新日期：1990-08-01 00:00:00

abstract：:1. Glucuronidation is the major route of metabolism of dihydrocodeine (DHC) and accounts for 25-30% of an oral dose in urine. The kinetics of DHC-6-glucuronide formation in liver microsomes from five human donors and the effect of a number of potential inhibitor drugs were examined using a newly developed and validate...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kirkwood LC,Nation RL,Somogyi AA

更新日期：1998-03-01 00:00:00

abstract：:1. Mathematical modelling is useful in pharmacology, allowing the investigator to obtain insights into the biological processes under study that may not always be intuitively obvious. Examples are presented in this review using the pharmacology of the muscarinic acetylcholine receptor (mAChR) agonist xanomeline. 2. Xa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christopoulos A

更新日期：2001-03-01 00:00:00

abstract：:1. The aim of the present study was to produce a mathematical model that describes the way dynamic changes in renal sympathetic nerve activity affect renal, cortical and medullary blood flow. 2. Cortical blood flow (CBF) and medullary blood flow (MBF) were measured using laser-Doppler flowmetry and (total) renal blood...

journal_title：Clinical and experimental pharmacology & physiology

authors： Navakatikyan MA,Leonard BL,Evans RG,Malpas SC

更新日期：2000-08-01 00:00:00

abstract：:1. Adrenocorticotrophin (ACTH) administration to sheep produces a rapid adrenally dependent hypertension which is maximal after 3 days and associated with increased cardiac output (CO) and heart rate (HR), while calculated total peripheral resistance remains unchanged. 2. This study investigated the proposal that a ce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Mathai M,Mills EH,Coghlan JP,Whitworth JA,Scoggins BA

更新日期：1989-07-01 00:00:00

abstract：:The anti-acetylcholinesterase (AChEase) activity of 15 opioids, namely morphine, nalorphine, oxymorphone, naloxone, naltrexone, N-methylnaloxone, levorphanol, levallophan, dextrorphan, dextrallophan, levo-methadone, dextro-methadone, pethidine, leu-enkephalin and U-50,488H was investigated. Among the opioids, the morp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sim MK,Chua ME

更新日期：1986-02-01 00:00:00

abstract：:Non-cystic fibrosis (non-CF) bronchiectasis is a chronic pulmonary disease that can lead to malnutrition. Serum prealbumin and albumin level are related to inflammatory and nutritional status. Thus, we aimed to confirm our hypothesis that low serum albumin and prealbumin level, as well as body mass index (BMI), is cor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Li Z,Bi J,Li H,Wang S,Shao C,Song Y

更新日期：2020-09-01 00:00:00

abstract：:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomlinson B

更新日期：1997-12-01 00:00:00

abstract：:1. In an isolated right atrial preparation, an increase in right atrial pressure (RAP) produces an increase in atrial rate. This rate response is larger and occurs faster when there is background vagal or muscarinic stimulation. 2. We hypothesized that in the latter situation, an increase in RAP antagonizes the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Han S,Wilson SJ,Bolter CP

更新日期：2010-09-01 00:00:00

abstract：:1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

更新日期：2001-11-01 00:00:00

abstract：:Pressor responsiveness to angiotensin II (AII) and phenylephrine (PE) was examined before and after 5 days of ACTH (1 mg, i.m., daily) or hydrocortisone (200 mg, orally, daily) in six normotensive men. Pulse pressure was higher prior to PE than AII infusion, presumably due to feeding. Systolic blood pressure (SBP) was...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whitworth JA,Connell JM,Lever AF,Fraser R

更新日期：1986-04-01 00:00:00

abstract：:Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), a downstream target of Ras and c-Myc, has been implicated in the development of multiple tumours, but its role in melanoma remains unclear. In the present study, the role of AEG-1 in melanoma was explored through AEG-1 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Peng G,Wang Y,Cui L,Wu W,Wang L,Liu C,Han X

更新日期：2017-07-01 00:00:00

abstract：:1. We tested the effects of intravenous infusions of angiotensin II (AngII; 300 ng/kg per min) and the vasopressin V1 receptor agonist [Phe2,Ile3,Orn8]-vasopressin (30 ng/kg per min) on regional kidney perfusion in an extracorporeal circuit model in anaesthetized rabbits in which renal artery pressure (RAP) can be set...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evans RG,Correia AG,Weekes SR,Madden AC

更新日期：2000-12-01 00:00:00

abstract：:C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

更新日期：2020-06-01 00:00:00

abstract：:1. In order to find an anaesthesia with minimum perturbation to the metabolism of chylomicrons, the effects of seven different anaesthetic agents on clearance from plasma of chylomicron-like emulsions were compared. 2. Avertin, urethane, fentanyl, and a ketamine/xylazine mixture all slowed the removal from plasma of e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mortimer BC,Umeda Y,Elsegood CL,Redgrave TG

更新日期：1993-01-01 00:00:00

abstract：:1. Within the lung, endothelin (ET)-1 is synthesized and released by airway epithelial and vascular endothelial cells, as well as by inflammatory cells, such as macrophages. Following release, ET-1 can modulate the activities of a wide range of different cell types within the lung through the stimulation of specific e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Henry PJ

更新日期：1999-02-01 00:00:00

abstract：:1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu SP,Mao ZF,Huang J,Wang JY

更新日期：2009-08-01 00:00:00

abstract：:1. Mast cells cultured from human peripheral blood have been used as a cell model for functional studies of human mast cells, particularly human lung mast cells. However, the beta-adrenoceptor subtype expressed by these cultured cells has not been identified. The aim of the present study was to characterize pharmacolo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XS,Lau HY

更新日期：2006-08-01 00:00:00

abstract：:Opioids are effective analgaesic agents, but serious adverse effects such as tolerance and withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal is a common occurrence in human opiate addicts that is not life-threatening. Studies have shown that the mesocorticolimbic system, especially the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jafarova Demirkapu M,Yananlı HR,Kaleli M,Sakalli HE,Gören MZ,Topkara B

更新日期：2020-04-01 00:00:00

abstract：:1. Chromium picolinate (CrPic) has been recommended as an alternative therapeutic regimen for Type 2 diabetes mellitus (T2DM). However, the molecular mechanism underlying the action of CrPic is poorly understood. 2. Using normal and insulin-resistant 3T3-L1 adipocytes, we examined the effects of CrPic on the gene tran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang YQ,Dong Y,Yao MH

更新日期：2009-08-01 00:00:00

abstract：:1. It is a central thesis of this review that in clinical and experimental pharmacology and physiology the goal of statistical analysis should be to minimize the risk of making any false-positive inferences from the results of an experiment (experimentwise Type I error). 2. It is common in clinical and experimental ph...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J

更新日期：1991-06-01 00:00:00

abstract：:1. The intrinsic sympathomimetic activity of a range of beta-adrenoceptor antagonists and its relationship to beta-adrenoceptor blockade was studied in pentobarbitone-anaesthetized, vagotomized rats which had been depleted of catecholamines by pretreatment with syrosingopine. Dichlorisoprenaline, practolol, oxprenolol...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bilski A,Robertson HH,Wale JL

更新日期：1979-01-01 00:00:00

abstract：:1. In infants, promethazine has been implicated in the pathogenesis of sleep apnoea, apparent life threatening events (ALTE) and the Sudden Infant Death syndrome (SIDS). The aim of the present study was to investigate, in a neonatal animal, the effects of a commonly used promethazine-containing medication on airway pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： McKelvey GM,Post EJ,Wood AK,Jeffery HE

更新日期：2001-07-01 00:00:00

abstract：:1. Arterial baroreceptor denervation produces acute hypertension, but chronically denervated animals have an average arterial pressure that is similar to that of baroreceptor intact animals. 2. Although cardiopulmonary baroreceptors and renal compensations have been suggested to mediate the restoration of a normal ave...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sved AF,Schreihofer AM,Kost CK Jr

更新日期：1997-01-01 00:00:00

abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mahapatra MS,Mahata SK,Maiti B

更新日期：1991-10-01 00:00:00

abstract：:Excessive activation of the sympatho-adrenomedullary system plays a pathogenic role in triggering and sustaining essential hypertension. We previously reported that, in normotensive rats, intracerebroventricularly (i.c.v.) administered neuropeptides, corticotropin-releasing factor and bombesin induced activation of th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shimizu T,Yamamoto M,Zou S,Shimizu S,Higashi Y,Saito M

更新日期：2020-07-01 00:00:00

abstract：:1. To determine whether total interruption of the local cardiac renin-angiotensin system by angiotensin II (AngII) receptor antagonist limits myocardial ischaemia, intracoronary (i.c.) or intravenous (i.v.) infusion of AngII receptor antagonists was compared in ischaemic dogs. 2. Dogs subjected to 90 min coronary arte...

journal_title：Clinical and experimental pharmacology & physiology

authors： So T,Nakashima Y,Imamura M,Arakawa K

更新日期：1998-07-01 00:00:00

abstract：:1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Piller NB

更新日期：1976-11-01 00:00:00