当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY期刊下所有文献 > Reduced [125I]-Bolton Hunter substance P binding (NK1 receptors) in the basal forebrain nuclei of aged rats.

Reduced [125I]-Bolton Hunter substance P binding (NK1 receptors) in the basal forebrain nuclei of aged rats.

Abstract：

:1. Quantitative autoradiography and homogenate radioligand binding of [125I]-Bolton Hunter substance P ([125I]-BHSP) were used to compare brain NK1 receptors in young (2 months) and aged (18-20 months) rats. 2. The autoradiographic distribution and density of [125I]-BHSP binding sites was similar in all cortical regions of young and aged rats. In contrast, the density of [125I]-BHSP binding sites was significantly (P < 0.05) lower in the basal forebrain nuclei (intermediate part of the lateral septal nuclei, medial septal nucleus and horizontal and vertical nuclei of the diagonal band) of aged rats. In all other brain regions examined, binding densities were almost identical in young and aged rats. 3. Because a population of NK1 receptors ([125I]-BHSP binding sites) in the basal forebrain nuclei is associated with cholinergic neurons, the decrease in NK1 receptors in aged rats may reflect degeneration of cholinergic neurons and contribute to the motor and cognitive deficiencies that occur with ageing.

journal_name

Clin Exp Pharmacol Physiol

journal_title

Clinical and experimental pharmacology & physiology

authors

Geraghty DP,Maguire CM

doi

10.1046/j.1440-1681.2002.03781.x

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1112-5

issue

12

eissn

0305-1870

issn

1440-1681

pii

3781

journal_volume

29

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY文献大全
  • The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors.

    abstract：:The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GAB...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2008.04948.x

    authors： Parker DA,Marino V,Ong J,Puspawati NM,Prager RH

    更新日期：2008-09-01 00:00:00

  • Renal blood flow in obstructive jaundice: an experimental study in baboons.

    abstract：:1. The distribution of intrarenal blood flow has been measured using the 133Xe-washout technique in thirteen baboons 2 weeks after ligation of the common bile duct. 2. In comparison with eight sham-operated baboons, there was a signifigant decrease in the percentage distribution of blood to the cortex, although the ra...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1976.tb00624.x

    authors： Bloom DS,Bomzon L,Rosendorff C,Kew MC

    更新日期：1976-09-01 00:00:00

  • Structure of human renin and expression of the renin gene.

    abstract：:The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1984.tb00281.x

    authors： Morris BJ,Catanzaro DF,Hardman J,Mesterovic N,Tellam J,Hort Y,Bennetts BH,Shine J

    更新日期：1984-07-01 00:00:00

  • Molecular regulation of skeletal muscle mass.

    abstract：:1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1681.2009.05265.x

    authors： Russell AP

    更新日期：2010-03-01 00:00:00

  • Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women.

    abstract：:Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 信件

    doi：10.1111/1440-1681.12655

    authors： Figueroa A,Alvarez-Alvarado S,Jaime SJ,Johnson SA,Campbell JC,Feresin RG,Elam ML,Navaei N,Pourafshar S,Arjmandi BH

    更新日期：2016-12-01 00:00:00

  • Uric acid permeability coefficient in the rat papillary collecting duct.

    abstract：:1. While it is believed that the mammalian distal nephron is not involved in uric acid transport, this has not been directly evaluated. Nevertheless, some studies are consistent with significant distal nephron transport. 2. As uric acid transport in man may be similar to the rat, undirectional uric acid permeability w...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1997.tb02123.x

    authors： Ray C,Carney S,Morgan T

    更新日期：1997-09-01 00:00:00

  • Effects of locally administered argatroban on restenosis after balloon angioplasty: experimental and clinical study.

    abstract：:1. This study was undertaken to evaluate the preventive effects of locally administered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on restenosis after balloon angioplasty. 2. A hydrogel-coated balloon catheter was immersed three times in argatroban/saline solution (1 mg/mL) for 60 s, ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1997.tb02694.x

    authors： Imanishi T,Arita M,Tomobuchi Y,Hamada M,Hano T,Nishio I

    更新日期：1997-11-01 00:00:00

  • Growth inhibitory effect of β-eudesmol on cholangiocarcinoma cells and its potential suppressive effect on heme oxygenase-1 production, STAT1/3 activation, and NF-κB downregulation.

    abstract：:Cholangiocarcinoma (CCA) is a progressively fatal form of cancer originating from the malignant transformation of hepatic biliary cholangiocytes. The present study reports for the first time in vitro growth inhibitory activities of β-eudesmol, the bioactive sesquiterpenoid present in the rhizome of Atractylodes lancea...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.12818

    authors： Mathema VB,Chaijaroenkul W,Karbwang J,Na-Bangchang K

    更新日期：2017-11-01 00:00:00

  • Dopamine D1 receptors induce apoptosis of osteosarcoma cells via changes of MAPK pathway.

    abstract：:This study explored the effects and mechanisms of dopamine D1 receptors (DR1) activation on the apoptosis of osteosarcoma cells (OS732).The DR1 agonist SKF-38393 decreased the viability of OS732 cells and increased their rate of apoptosis, whereas the DR1 antagonist SCH-23390 abolished the effects of SKF-38393. In OS7...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 信件

    doi：10.1111/1440-1681.12814

    authors： Gao J,Gao F

    更新日期：2017-11-01 00:00:00

  • The effects of calcium antagonists on blood pressure and responses to alpha-adrenoceptor agonists in hypertensive rabbits.

    abstract：:The effects of the calcium antagonists verapamil and nifedipine on mean arterial blood pressure, heart rate and pressor responses to a range of alpha-adrenoceptor agonists were examined in male normotensive New Zealand white rabbits and in rabbits with perinephritis hypertension. Verapamil and nifedipine caused a grea...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1987.tb00960.x

    authors： Hamilton CA,Jardine E,Sumner DJ,Reid JL

    更新日期：1987-02-01 00:00:00

  • Stretch-activated channels in stretch-induced muscle damage: role in muscular dystrophy.

    abstract：:1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystr...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type：

    doi：10.1111/j.1440-1681.2004.04027.x

    authors： Yeung EW,Allen DG

    更新日期：2004-08-01 00:00:00

  • Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice.

    abstract：:1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis. In the present study, we tested the hypothesis that emodin may attenuate the development of pulmonary fibrosis. 2. Mice...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2008.05048.x

    authors： Chen XH,Sun RS,Hu JM,Mo ZY,Yang ZF,Jin GY,Guan WD,Zhong NS

    更新日期：2009-02-01 00:00:00

  • Shift in the baroreflex-renal noradrenaline spillover curve during the development of congestive heart failure in the rabbit.

    abstract：:1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1990.tb01325.x

    authors： McGrath BP,Sano N,Way D

    更新日期：1990-04-01 00:00:00

  • Effect of ATP on Ca2+ uptake in the presence of high glucose in renal proximal tubule cells.

    abstract：:1. Calcium regulation has been reported to be associated with the development of diabetic nephropathy. Thus, changes in Ca2+ uptake induced by ATP, an important regulator of Ca2+ uptake, in the diabetic condition and related signal pathways were examined in primary cultures of rabbit renal proximal tubule cells (PTC)....

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1681.2003.03895.x

    authors： Han HJ,Park SH,Lee YJ,Lee JC,Lee JH

    更新日期：2003-09-01 00:00:00

  • Enzymatic bioremediation: from enzyme discovery to applications.

    abstract：:1. Enzymatic bioremediation is potentially a rapid method of removing environmental pesticide residues. Applications include the treatment of residues resulting from agricultural production and processing industries, such as the treatment of irrigation waters, surface-contaminated fruit and vegetables and spent dip li...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type：

    doi：10.1111/j.1440-1681.2004.04088.x

    authors： Sutherland TD,Horne I,Weir KM,Coppin CW,Williams MR,Selleck M,Russell RJ,Oakeshott JG

    更新日期：2004-11-01 00:00:00

  • From 'captive' agonism to insurmountable antagonism: demonstrating the power of analytical pharmacology.

    abstract：:1. Mathematical modelling is useful in pharmacology, allowing the investigator to obtain insights into the biological processes under study that may not always be intuitively obvious. Examples are presented in this review using the pharmacology of the muscarinic acetylcholine receptor (mAChR) agonist xanomeline. 2. Xa...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1681.2001.03376.x

    authors： Christopoulos A

    更新日期：2001-03-01 00:00:00

  • Visfatin is associated with lipid metabolic abnormalities in Lyon hypertensive rats.

    abstract：:1. Visfatin (also known as nicotinamide phosphoribosyltransferase or Nampt) is a novel adipokine associated with metabolic abnormalities in obesity and diabetes. The aim of the present study was to determine whether visfatin levels in the circulation and visfatin expression in fat tissues are altered in Lyon hypertens...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2010.05402.x

    authors： Wang P,Bai C,Xu QY,Xu TY,Su DF,Sassard J,Miao CY

    更新日期：2010-09-01 00:00:00

  • Indomethacin abolishes core temperature, but not cardiovascular or renal, responses to lipopolysaccharide in conscious lambs.

    abstract：:1. Core temperature (Tc), cardiovascular and renal responses to lipopolysaccharide (LPS), as well as the role of endogenously produced prostaglandins (PG) in influencing these responses, were investigated in the present study in conscious, chronically instrumented lambs. 2. Core temperature, mean arterial pressure, he...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2011.05536.x

    authors： Smith FG,Fewell JE,Qi W

    更新日期：2011-08-01 00:00:00

  • Effect of stress on serotonin, norepinephrine, epinephrine and corticosterone contents in the soft-shelled turtle.

    abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1991.tb01386.x

    authors： Mahapatra MS,Mahata SK,Maiti B

    更新日期：1991-10-01 00:00:00

  • Possible participation of NMDA and glycine receptors but not GABAA receptors in enflurane-induced opisthotonus in mice.

    abstract：:1. We previously reported that volatile anaesthetics produce incidences of a transient opisthotonus in mice, a sign of CNS stimulation. This study was performed to investigate mechanisms by which enflurane-induced opisthotonus (EIO) occurs. 2. The effects of pretreatment of N-methyl-D-aspartate (NMDA) antagonists dizo...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1994.tb02546.x

    authors： Komatsu H,Nogaya J,Ueki M,Yokono S,Ogli K

    更新日期：1994-06-01 00:00:00

  • Effects of digoxin, furosemide, enalaprilat and metoprolol on endothelial function in young normotensive subjects.

    abstract：:1. Endothelial dysfunction is seen in patients with essential hypertension or congestive heart failure (CHF). The present study aimed to evaluate the direct effect on endothelium- dependent vasodilation (EDV) of different pharmacological drugs commonly used in the treatment of these conditions. 2. Forearm blood flow (...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1440-1681.2001.03465.x

    authors： Mühlen BV,Millgård J,Lind L

    更新日期：2001-05-01 00:00:00

  • Facilitation of noradrenergic transmission by locally generated angiotensin II in guinea-pig isolated atria and in the perfused caudal artery of the rat.

    abstract：:In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneous beating and in the release of noradrenaline produced by field stimulation of sympathetic nerves. In rat isolated caudal artery preparations, both angiotensin I and angiotensin II had dir...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1984.tb00290.x

    authors： Ziogas J,Story DF,Rand MJ

    更新日期：1984-07-01 00:00:00

  • Effect of phosphorylation on L-type calcium current in ventricular myocytes dialysed with proteolytic enzymes.

    abstract：:1. L-Type Ca2+ channels play important roles in cardiac excitation and conduction. The present study used the whole-cell patch-clamp technique to investigate properties of Ca2+ channels in guinea-pig isolated ventricular myocytes. The effects of internal application of the proteolytic enzymes trypsin and carboxypeptid...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1681.1999.02999.x

    authors： Dooley PC,Hancox JC,Chapman RA

    更新日期：1999-02-01 00:00:00

  • The relationship between tissue levels of cyclic GMP and tracheal smooth muscle relaxation in the guinea-pig.

    abstract：:The effect of cyclic GMP was investigated using guinea-pig tracheal smooth muscle. 8-Bromo-cyclic GMP showed a dose-dependent relaxation of spontaneous tension of tracheal smooth muscle. Administration of sodium nitroprusside induced dose-dependent relaxation of tracheal smooth muscle as well as an increase in tissue ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1986.tb00313.x

    authors： Suzuki K,Takagi K,Satake T,Sugiyama S,Ozawa T

    更新日期：1986-01-01 00:00:00

  • Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes.

    abstract：:1. Sulfur dioxide (SO(2) ) has recently been found to have various biological effects on the cardiovascular system. The present study was designed to explore the effects of SO(2) derivatives on the L-type calcium current (I (Ca, L) ) in isolated rat ventricular cardiomyocytes. 2. A Langendorf system was used to dissoc...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2011.05528.x

    authors： Zhang RY,Du JB,Sun Y,Chen S,Tsai HJ,Yuan L,Li L,Tang CS,Jin HF

    更新日期：2011-07-01 00:00:00

  • The anti-diabetic drug miglitol is protective against anginal ischaemia through a mechanism independent of regional myocardial blood flow in the dog.

    abstract：:1. In the present study, we attempted to clarify whether the antidiabetic drug miglitol, an alpha-glucosidase inhibitor, has a protective effect against anginal ischaemia. We had reported previously that miglitol reduces myocardial infarct size through inhibition of glycogenolysis during ischaemia in rabbits. However,...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2005.04269.x

    authors： Uno Y,Minatoguchi S,Arai M,Wang N,Chen XH,Hashimoto K,Lu C,Takemura G,Fujiwara H

    更新日期：2005-10-01 00:00:00

  • The isolated lung strip and single open tracheal ring: a convenient combination for characterizing Schultz Dale anaphylactic contractions in the peripheral and central airways of the guinea-pig.

    abstract：:1. The use of the isolated lung strip and single open tracheal ring for studying Schultz Dale anaphylactic contractions in both the peripheral and central airways is described. 2. This method is particularly relevant to studies of anaphylaxis because many preparations may be obtained from a single sensitized animal. 3...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1979.tb00046.x

    authors： Lulich KM,Papadimitriou JM,Paterson JW

    更新日期：1979-11-01 00:00:00

  • Increased Ca2+ sensitivity of myofibrillar tension in ischaemic vs dilated cardiomyopathy.

    abstract：:1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2010.05443.x

    authors： Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

    更新日期：2010-12-01 00:00:00

  • Paradoxical cardiovascular response to visceral afferent stimulation in the established spontaneously hypertensive rat.

    abstract：:Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that th...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1985.tb00300.x

    authors： Koyama S,Manning JW

    更新日期：1985-01-01 00:00:00

  • Dual activation of cardiac sympathetic and parasympathetic components during conditioned fear to context in the rat.

    abstract：:1. The present study investigates the contribution of the sympathetic and vagal parasympathetic systems to the tachycardic response of long-lasting (40 min) conditioned fear responses to context. 2. The conditioned fear response evoked by re-exposure to a footshock chamber was tested 10 min after intravenous injection...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2006.04519.x

    authors： Carrive P

    更新日期：2006-12-01 00:00:00