Abstract：
:The effect of cyclic GMP was investigated using guinea-pig tracheal smooth muscle. 8-Bromo-cyclic GMP showed a dose-dependent relaxation of spontaneous tension of tracheal smooth muscle. Administration of sodium nitroprusside induced dose-dependent relaxation of tracheal smooth muscle as well as an increase in tissue levels of cyclic GMP. Nicorandil, N-(2-hydroxyethyl) nicotinamide nitrate showed dose-dependent relaxation of tracheal smooth muscle and an increase in cyclic GMP levels in the tissue. N-(2-aminoethyl) nicotinamide dihydrochloride, which is a nicorandil derivative and differs minimally in its molecular structure (-NH2 vs -NO2), had neither a relaxant effect on tracheal smooth muscle nor did it increase the level of cyclic GMP in the tissue. The rise cyclic GMP levels preceded the relaxation of tracheal smooth muscle induced by sodium nitroprusside. These results suggest that cyclic GMP is one of the relaxant factors and that nitro-derivatives exhibit their relaxant effect on the smooth muscle mediated by an increase in cyclic GMP level.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Suzuki K,Takagi K,Satake T,Sugiyama S,Ozawa Tdoi
10.1111/j.1440-1681.1986.tb00313.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
39-46issue
1eissn
0305-1870issn
1440-1681journal_volume
13pub_type
杂志文章abstract：:1. Deviation supersensitivity and post-junctional supersensitivity are important determinants in the control of the response of smooth muscle. 2. Post-junctional supersensitivity is a process whereby effector cells have augmented responsiveness as a consequence of an impaired physiological stimulus. Deviation supersen...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1681.1989.tb01584.x
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1111/j.1440-1681.1982.tb00840.x
更新日期：1982-11-01 00:00:00
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doi：10.1111/j.1440-1681.1986.tb00936.x
更新日期：1986-07-01 00:00:00
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更新日期：1996-10-01 00:00:00
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