From 'captive' agonism to insurmountable antagonism: demonstrating the power of analytical pharmacology.

abstract：:1. Heparan sulfate proteoglycan in the basal lamina of smooth muscle cells is important in the maintenance of the 'contractile', high volume fraction of myofilaments (Vvmyo) phenotype. The mechanism by which this occurs may involve the continuous internalization of heparan sulfate by the smooth muscle cells themselves...

journal_title：Clinical and experimental pharmacology & physiology

authors： Campbell JH,Campbell GR

更新日期：1991-02-01 00:00:00

abstract：:1. It has previously been shown that perfusion with high O2-affinity-erythrocytes decreases venous PO2 (PVO2) and decreases O2 uptake (VO2) in contracting muscle at the same O2 delivery (arterial O2 concentration x flow). A linear VO2-PVO2 relationship has been obtained with a VO2-axis intercept, suggesting that, duri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kohzuki H,Misawa H,Kishi T,Ohga Y,Sakata S,Takaki M

更新日期：1999-08-01 00:00:00

abstract：:1. The Type 2C protein phosphatases (PP2C) represent a highly conserved gene family in the mammalian genome. Recent studies have revealed that PP2C isoforms possess unique patterns of tissue and subcellular distribution associated with diverse functionalities. 2. The functional importance of PP2C isoforms has been sho...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lu G,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:1. This paper reports on the in vitro and in vivo characteristics of a non-peptide vasopressin V1 receptor antagonist 1-(1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl)-3,4-dihydro-2( 1H)- quinolinone (OPC-21268). 2. OPC-21268 caused a concentration-dependent displacement of the selective V1 receptor antagonist radio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Burrell LM,Phillips PA,Stephenson J,Risvanis J,Hutchins AM,Johnston CI

更新日期：1993-05-01 00:00:00

abstract：:1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stevenson KM,Gibson KJ,Lumbers ER

更新日期：1996-02-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered by its ability to produce seizures. Nerispirdine, an analogue of 4-AP, is currently under clinical inve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Smith C,Kongsamut S,Wang H,Ji J,Kang J,Rampe D

更新日期：2009-11-01 00:00:00

abstract：:1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

更新日期：2006-07-01 00:00:00

abstract：:1. Adenosine A(1) receptors (A(1)R) play an important role in cardioprotection against hypoxic damage and the opening of mitochondrial permeability transition pores (MPTP) is central to the regulation of cell apoptosis and necrosis. However, it is still unclear whether A(1)R open MPTP in hypoxic cardiomyocytes. 2. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang F,Huang YS,Zhang DX,Chu ZG,Zhang JP,Zhang Q

更新日期：2010-03-01 00:00:00

abstract：:The effector mechanisms responsible for the bradycardia evoked by bilateral lesions of the brainstem coinciding with the A1 catecholamine cells were analyzed in four groups of rabbits. Sham or lesion operations were carried out in animals with intact cardiac effectors, with cardiac sympathetic block induced by propran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denoroy L,West MJ,Chalmers J

更新日期：1984-03-01 00:00:00

abstract：:1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR

更新日期：1979-01-01 00:00:00

abstract：:1. Hyperhomocysteinaemia (HHcy) is associated with endothelial dysfunction and has been recognized as a risk factor of cardiovascular disease. The present study aimed to investigate the effect of homocysteine (Hcy) on endothelial function in vivo and in vitro, and the underlying signalling pathways. 2. The HHcy animal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan TT,Li Q,Zhang XH,Wu WK,Sun J,Li L,Zhang Q,Tan HM

更新日期：2010-11-01 00:00:00

abstract：:This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 ± 0.38 μmol/L and a Hill coefficient (n) of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li H,Seo MS,An JR,Jung HS,Ha KS,Han ET,Hong SH,Bae YM,Ryu DR,Park WS

更新日期：2019-11-01 00:00:00

abstract：:1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iser JH,Packer JS,Smallwood RA,Hoffman NE

更新日期：1976-01-01 00:00:00

abstract：:1. The low molecular weight heparin (LMWH) dalteparin is used, for example, to prevent primary venous thromboembolism in patients undergoing surgery or in medically ill patients. The anticoagulant activity of dalteparin can be monitored by measuring anti-factor Xa levels and activated partial thromboplastin time (aPTT...

journal_title：Clinical and experimental pharmacology & physiology

authors： Feuring M,Wehling M,Schultz A

更新日期：2011-11-01 00:00:00

abstract：:Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many ti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu WW,Xiao F,Tang YY,Zou W,Li X,Zhang P,Wang AP,Tang XQ

更新日期：2018-08-01 00:00:00

abstract：:1. The aim of the present study was to investigate the mechanism underlying biochanin A-induced relaxation of the aorta in spontaneously hypertensive rats (SHR). 2. The tension in isolated ring preparations of thoracic aortas from normotensive (Wistar-Kyoto (WKY) rats) and SHR at 5 and 10 weeks of age was measured iso...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang HP,Gao Q,Mei RH,Zhao MH,Lu Y,Li XY,Bruce IC,Xia Q

更新日期：2006-09-01 00:00:00

abstract：:Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Walweel K,Oo YW,Laver DR

更新日期：2017-01-01 00:00:00

abstract：:1. The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction. 2. Japanese white rabbits underwent 30 min of coronary occlusion, followed by 48 h of reperfusion. Cilostazol (1 and 5 mg/kg) or vehicle was given intr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bai Y,Muqier,Murakami H,Iwasa M,Sumi S,Yamada Y,Ushikoshi H,Aoyama T,Nishigaki K,Takemura G,Uno B,Minatoguchi S

更新日期：2011-10-01 00:00:00

abstract：:1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Singh BN,Jewitt DE,Downey JM,Kirk ES,Sonnenblick EH

更新日期：1976-09-01 00:00:00

abstract：:1. Within the lung, endothelin (ET)-1 is synthesized and released by airway epithelial and vascular endothelial cells, as well as by inflammatory cells, such as macrophages. Following release, ET-1 can modulate the activities of a wide range of different cell types within the lung through the stimulation of specific e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Henry PJ

更新日期：1999-02-01 00:00:00

abstract：:1. The field of extracellular nucleotides and purinoceptors has undergone a resurgence of interest and enthusiasm in the past decade. More and more investigators are probing the physiological and pathophysiological roles of P2 receptors in virtually every organ system, including the kidney. 2. With this renewed intere...

journal_title：Clinical and experimental pharmacology & physiology

authors： Inscho EW

更新日期：2001-04-01 00:00:00

abstract：:The activity of dopamine-beta-hydroxylase (D beta H) in the serum was measured in patients with quadriplegia and in healthy subjects. We assume that the plasma D beta H levels reflect sympathetic tone. Quadriplegics had significantly lower D beta H levels at rest. After head-up tilting a significant decrease in D beta...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ohry A,Rabinowitz R,Korczyn AD

更新日期：1980-07-01 00:00:00

abstract：:1. The present study was carried out to determine whether rilmenidine, a recently introduced antihypertensive agent which acts on alpha 2-adrenoceptors, has partial agonist activity on prejunctional alpha 2-adrenoceptors in guinea-pig atria. 2. Isolated preparations of guinea-pig atria were incubated with [3H]-noradre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li CG,Rand MJ

更新日期：1988-10-01 00:00:00

abstract：:1. Two patients with angiotensin-responsive aldosterone-producing adenoma (APA) and one with adrenal cortical carcinoma demonstrated autonomous secretion of cortisol as well as of aldosterone. 2. The response of cortisol and of aldosterone to ACTH did not differentiate between the two APA which secreted cortisol and t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tunny TJ,Klemm SA,Gordon RD

更新日期：1990-03-01 00:00:00

abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oates HF,Stoker LM

更新日期：1980-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has been considered as a multi-factorial metabolic syndrome. MicroRNA-375 (MiR-375) was significantly up-regulated in serum of NAFLD patients and the role of miR-375 was addressed as a putative biomarker of NAFLD progression. However, the specific function of miR-375 in the pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lei L,Zhou C,Yang X,Li L

更新日期：2018-08-01 00:00:00

abstract：:1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang DY,Lumbers ER,Simonetta G

更新日期：1996-08-01 00:00:00

abstract：:1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied ...

journal_title：Clinical and experimental pharmacology & physiology

authors： McGrath BP,Sano N,Way D

更新日期：1990-04-01 00:00:00

abstract：:Responses of the toad isolated rectus abdominis muscle to cumulative doses of carbachol were recorded in the absence or presence of varying concentrations of cimetidine or ranitidine. The corresponding cumulative log concentration-response curves for carbachol were then plotted for each antagonist studied. Cimetidine ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gwee MC,Cheah LS,Shoon ML

更新日期：1986-08-01 00:00:00