Abstract:
:1. It has previously been shown that perfusion with high O2-affinity-erythrocytes decreases venous PO2 (PVO2) and decreases O2 uptake (VO2) in contracting muscle at the same O2 delivery (arterial O2 concentration x flow). A linear VO2-PVO2 relationship has been obtained with a VO2-axis intercept, suggesting that, during this type of hypoxia, VO2 is composed of a PVO2-dependent and -independent VO2. However, the VO2-PVO2 relation during hypoxic hypoxia has not been examined. 2. To clarify this relation, PVO2 and VO2 have been measured in contracting gastrocnemius (1 Hz trains of 0.2 s isometric tetani) under both normoxic and hypoxic conditions during 5 min of stimulation. 3. Venous O2 changes proportionally with O2 delivery. Each VO2-PVO2 relation was linear, with the mean described by the equation VO2 = 5.06 + 0.41 x PVO2 (n = 6, r = 0.81, P < 0.05). The VO2-axis intercept was significantly different from zero (P < 0.05). 4. These results were similar to those obtained during hypoxia induced by high O2-affinity-erythrocytes. We conclude that there is a linear relationship between PVO2 and VO2 above the VO2-axis intercept, regardless of the type of hypoxia.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Kohzuki H,Misawa H,Kishi T,Ohga Y,Sakata S,Takaki Mdoi
10.1046/j.1440-1681.1999.03100.xkeywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
639-44issue
8eissn
0305-1870issn
1440-1681journal_volume
26pub_type
杂志文章abstract::1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...
journal_title:Clinical and experimental pharmacology & physiology
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更新日期:2010-02-01 00:00:00
abstract::1. Sodium (Na) depletion, due to uncompensated loss of parotid saliva, reduces the pressor responsiveness to angiotensin II (AII) in intact conscious sheep. 2. Inhibition of prostaglandin synthesis by indomethacin restored AII pressor responsiveness in Na-deplete sheep. 3. Indomethacin infusion also increased the pres...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1981.tb00131.x
更新日期:1981-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1975-03-01 00:00:00
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更新日期:2000-10-01 00:00:00
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doi:10.1111/j.1440-1681.1989.tb01618.x
更新日期:1989-08-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:2001-09-01 00:00:00
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更新日期:2019-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-09-01 00:00:00
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1991-01-01 00:00:00
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更新日期:1986-07-01 00:00:00