Abstract:
OBJECTIVE:To determine patient, institution, and machine characteristics that contribute to variation in radiation doses used for computed tomography (CT). DESIGN:Prospective cohort study. SETTING:Data were assembled and analyzed from the University of California San Francisco CT International Dose Registry. PARTICIPANTS:Standardized data from over 2.0 million CT examinations of adults who underwent CT between November 2015 and August 2017 from 151 institutions, across seven countries (Switzerland, Netherlands, Germany, United Kingdom, United States, Israel, and Japan). MAIN OUTCOME MEASURES:Mean effective doses and proportions of high dose examinations for abdomen, chest, combined chest and abdomen, and head CT were determined by patient characteristics (sex, age, and size), type of institution (trauma center, care provision 24 hours per day and seven days per week, academic, private), institutional practice volume, machine factors (manufacturer, model), country, and how scanners were used, before and after adjustment for patient characteristics, using hierarchical linear and logistic regression. High dose examinations were defined as CT scans with doses above the 75th percentile defined during a baseline period. RESULTS:The mean effective dose and proportion of high dose examinations varied substantially across institutions. The doses varied modestly (10-30%) by type of institution and machine characteristics after adjusting for patient characteristics. By contrast, even after adjusting for patient characteristics, wide variations in radiation doses across countries persisted, with a fourfold range in mean effective dose for abdomen CT examinations (7.0-25.7 mSv) and a 17-fold range in proportion of high dose examinations (4-69%). Similar variation across countries was observed for chest (mean effective dose 1.7-6.4 mSv, proportion of high dose examinations 1-26%) and combined chest and abdomen CT (10.0-37.9 mSv, 2-78%). Doses for head CT varied less (1.4-1.9 mSv, 8-27%). In multivariable models, the dose variation across countries was primarily attributable to institutional decisions regarding technical parameters (that is, how the scanners were used). CONCLUSIONS:CT protocols and radiation doses vary greatly across countries and are primarily attributable to local choices regarding technical parameters, rather than patient, institution, or machine characteristics. These findings suggest that the optimization of doses to a consistent standard should be possible. STUDY REGISTRATION:Clinicaltrials.gov NCT03000751.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Smith-Bindman R,Wang Y,Chu P,Chung R,Einstein AJ,Balcombe J,Cocker M,Das M,Delman BN,Flynn M,Gould R,Lee RK,Yellen-Nelson T,Schindera S,Seibert A,Starkey J,Suntharalingam S,Wetter A,Wildberger JE,Miglioretti DLdoi
10.1136/bmj.k4931subject
Has Abstractpub_date
2019-01-02 00:00:00pages
k4931eissn
0959-8138issn
1756-1833journal_volume
364pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To determine whether fibrinogen and lipid concentrations are risk factors for ischaemic stroke. DESIGN:Case-control study with a population based comparison within the overall study. SETTING:Oxfordshire community stroke project and a neurology clinic. SUBJECTS:105 patients who had a transient ischaemic at...
journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章
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更新日期:1991-09-14 00:00:00
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journal_title:BMJ (Clinical research ed.)
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journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章
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abstract::The opportunities for international public health collaboration through joint business ventures between the USSR and Western nations, an arrangement that would benefit the public, industry, and the medical community, are discussed. Evidence indicates that the state of health of the Soviet population is declining rapi...
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更新日期:2016-04-06 00:00:00
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更新日期:2014-01-13 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-10-01 00:00:00
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更新日期:2003-05-03 00:00:00
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更新日期:1988-10-01 00:00:00
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更新日期:2002-05-04 00:00:00
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更新日期:2000-06-03 00:00:00
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更新日期:2014-08-26 00:00:00
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更新日期:2003-03-01 00:00:00
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更新日期:1996-07-06 00:00:00
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更新日期:2016-03-02 00:00:00
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更新日期:2007-11-03 00:00:00