Molecular genetics in clinical practice: evolution of a DNA diagnostic service.

Abstract:

:The development of a molecular genetics diagnostic service over a three year period was studied in a National Health Service region with a population of three million. Starting from a time when few diagnostic applications were possible, the number of disorders and the overall demand had grown rapidly. Conditions for which molecular genetic diagnosis had been provided included Duchenne and Becker muscular dystrophy, myotonic dystrophy, Huntington's disease, and cystic fibrosis. Of 405 requests for diagnosis, 151 (37%) related to determination of carrier state, 187 (46%) to determining the feasibility of future prenatal diagnosis, and 67 (17%) were prenatal diagnostic biopsy samples, almost exclusively of first trimester chorion. DNA samples for future diagnostic use with a wide range of genetic disorders had also been banked. The study showed a need for close integration with clinical genetics services to allow satisfactory genetic counselling and interpretation of risks.

journal_name

BMJ

authors

Meredith AL,Upadhyaya M,Harper PS

doi

10.1136/bmj.297.6652.843

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

843-6

issue

6652

eissn

0959-8138

issn

1756-1833

journal_volume

297

pub_type

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