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Correlation between plasma levels of ACTH and beta-endorphin in the first seven days of postnatal life.

Abstract：

:Plasma adrenocorticotropic hormone (ACTH) and beta-endorphin (beta-EP) concentrations were measured by radioimmunoassay in 122 newborns, born vaginally after spontaneous labor between the 38th and the 41st week of pregnancy. Blood samples were taken from umbilical cord in 10 newborns and from antecubital vein in the remaining 112 newborns, divided into 8 groups aged from 12 h to 7 days. The mean (+/- SE) ACTH concentrations in cord plasma were 81.87 +/- 10.16 pg/ml and decreased significantly (p less than 0.01) at the 24th h of life (49.09 +/- 6.93 pg/ml). Afterwards mean ACTH plasma concentrations fluctuated around the latter values. The mean (+/- SE) B-EP concentrations in cord plasma were 21.96 +/- 3.12 pmol/l and decreased significantly at the 24th h of life (13.43 +/- 2.08 pmol/l; p less than 0.01). From the 24th h to the 7th day the mean plasma concentrations of beta-EP were not significantly different. ACTH and beta-EP plasma levels were positively correlated (p less than 0.001) at delivery and during the first seven days of life.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Gemelli M,Mamì C,Manganaro R,De Luca F,Saja A,Costa G

doi

10.1007/BF03349064

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

395-8

issue

6

eissn

0391-4097

issn

1720-8386

journal_volume

11

pub_type

杂志文章

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