Markers of activation of coagulation and fibrinolysis in patients with Cushing's syndrome.

Abstract:

:Patients with active Cushing's syndrome have an increased thrombotic tendency. We chose to reassess the mechanism underlying the thrombophilic state associated with this clinical condition using sensitive markers of coagulation and fibrinolysis activation in 17 patients with active disease. The results were compared with those obtained in 12 Cushing's patients successfully treated by surgery and in 20 normal individuals. The general pattern of results in patients with active disease was the finding of increased levels of von Willebrand factor (VWF: Ag), a marker of enhanced metabolic function of endothelial cells (VWF:Ag 181 +/- 42 vs 110 +/- 43, p<0.001 in normal subjects), accompanied by signs of heightened thrombin and plasmin generation, expressed by high levels of thrombin-antithrombin (TAT 5.59+/-3.6 vs 3.06+/-0.92 ng/ml in controls, p<0.01) and plasmin-antiplasmin complexes (PAP 407+/-176 vs 245+/-67 ng/ml in controls, p<0.01). VWF:Ag and TAT values were significantly higher in hypertensive than in normotensive patients with active disease (205+/-40 vs 155+/-26 U/dl, p<0.05 and 7.49+/-3.7 vs 3.45+/-1.8, p<0.01, respectively). Plasma levels of plasminogen activator inhibitor type 1 were higher, though not to a statistically significant extent, in patients with active disease compared to controls (12.8+/-12.3 vs 5.6+/-7.4 IU/ml, NS) and positively correlated with body mass index (r=0.66, p<0.01). After surgical control of Cushing's syndrome, there was a partial or complete reversal of the abnormalities to values similar to those found in normal individuals. Our data suggest that the thrombophilic state present in patients with active Cushing's syndrome is related to an enhanced metabolic function of endothelial cells; this in turn may be caused by an heightened production of thrombin with secondary hyperfibrinolysis. Primary prophylaxis with anticoagulants is recommended in these patients when they are exposed to a thrombophilic condition such as surgery.

journal_name

J Endocrinol Invest

authors

Fatti LM,Bottasso B,Invitti C,Coppola R,Cavagnini F,Mannucci PM

doi

10.1007/BF03343697

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

145-50

issue

3

eissn

0391-4097

issn

1720-8386

journal_volume

23

pub_type

临床试验,杂志文章
  • Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines.

    abstract:BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expre...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346542

    authors: Sponziello M,Scipioni A,Durante C,Verrienti A,Maranghi M,Giacomelli L,Ferretti E,Celano M,Filetti S,Russo D

    更新日期:2010-01-01 00:00:00

  • Metabolic syndrome is the key determinant of impaired vaginal lubrication in women with chronic spinal cord injury.

    abstract:PURPOSE:Spinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01185-w

    authors: D'Andrea S,Castellini C,Paladino V,Totaro M,Felzani G,Francavilla S,Francavilla F,Barbonetti A

    更新日期:2020-07-01 00:00:00

  • Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism.

    abstract::The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormon...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348554

    authors: Cavaliere H,Medeiros-Neto GA,Rosner W,Kourides IA

    更新日期:1985-12-01 00:00:00

  • Long-term follow-up of patients with hyperthyroidism due to Graves' disease treated with methimazole. Comparison of usual treatment schedule with drug discontinuation vs continuous treatment with low methimazole doses: a retrospective study.

    abstract::Antithyroid drugs may be proposed as the firstline therapy for hyperthyroidism due to Graves' disease since some patients undergo prolonged remission after drug withdrawal. On the other hand, some studies, though controversial, indicated that methimazole (MMI) has some immunomodulating activity. We retrospectively ana...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346433

    authors: Mazza E,Carlini M,Flecchia D,Blatto A,Zuccarini O,Gamba S,Beninati S,Messina M

    更新日期:2008-10-01 00:00:00

  • Twenty-four-hour prolactin secretory patterns in women with galactorrhea, normal menses, normal random prolacting levels and abnormal sellar tomograms.

    abstract::During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348450

    authors: Kapcala LP,Molitch ME,Arno J,King LW,Reichlin S,Wolpert SM

    更新日期:1984-10-01 00:00:00

  • Effects of opioid receptor blockade on luteinizing hormone (LH) pulses and interpulse LH concentrations in normal women during the early phase of the menstrual cycle.

    abstract::To determine the role of endogenous opioid peptides in regulating pulsatile luteinizing hormone (LH) release in the early follicular phase of the menstrual cycle of eumenorrheic women, we evaluated serum LH concentrations in blood collected every 10 min for 12 h in 27 women each studied during two menstrual cycles: (1...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348799

    authors: Evans WS,Weltman JY,Johnson ML,Weltman A,Veldhuis JD,Rogol AD

    更新日期:1992-07-01 00:00:00

  • There are no acute cardiac effects of a single iv dose of human ghrelin in severe growth hormone deficient patients.

    abstract::It has previously been suggested that ghrelin mediates GH-independent biologic activities on the heart. We investigated the acute effects on cardiac contraction of a single iv administration of human ghrelin (in a dose of 1 microg/kg) in severe untreated GH deficient subjects. Prior to the ghrelin infusion, an echocar...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03347499

    authors: Janssen JA,Poldermans D,Hofland LJ,Vourvouri EC,Muller AF,Bax JJ,Deghenghi R,Broglio F,Ghigo E,van der Lely AJ

    更新日期:2004-07-01 00:00:00

  • Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans.

    abstract:UNLABELLED:ABSTRACT. Several data show that meal intake and nutritional status regulate circulating ghrelin concentrations in humans. Ghrelin mainly circulates in two different forms: octanoyl and des-octanoyl ghrelin. Most circulating ghrelin is des-octanoyl ghrelin which is considered inactive because it lacks endocr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:

    authors: Lucidi P,Murdolo G,Di Loreto C,Parlanti N,De Cicco A,Ranchelli A,Fatone C,Taglioni C,Fanelli C,Santeusanio F,De Feo P

    更新日期:2004-05-01 00:00:00

  • Epigenetics: spotlight on type 2 diabetes and obesity.

    abstract::Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research area...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-016-0473-1

    authors: Desiderio A,Spinelli R,Ciccarelli M,Nigro C,Miele C,Beguinot F,Raciti GA

    更新日期:2016-10-01 00:00:00

  • Growth hormone insufficiency in a girl with the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

    abstract::Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disease which may comprise many endocrine and non-endocrine components. GH insufficiency has not been recognised as a classical manifestation of this syndrome. We describe the case of a girl with APECED, who presented with four end...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345481

    authors: Franzese A,Valerio G,Di Maio S,Iannucci MP,Bloise A,Tenore A

    更新日期:1999-01-01 00:00:00

  • Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model.

    abstract:BACKGROUND:Activation of the farnesoid X receptor (FXR), a member of the nuclear receptor steroid superfamily, leads to anti-inflammatory and anti-fibrotic effects in several tissues, including the lung. We have recently demonstrated a protective effect of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) i...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-019-1009-2

    authors: Comeglio P,Filippi S,Sarchielli E,Morelli A,Cellai I,Corno C,Adorini L,Vannelli GB,Maggi M,Vignozzi L

    更新日期:2019-08-01 00:00:00

  • Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.

    abstract::Circulating TSH bioactivity may vary in several clinical and experimental conditions. Since the reliability of the current methods for the measurement of TSH bioactivity is limited, a new bioassay based on cAMP accumulation in Chinese Hamster Ovary cells transfected with recombinant human TSH receptor (CHO-R) was set ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348894

    authors: Persani L,Tonacchera M,Beck-Peccoz P,Vitti P,Mammoli C,Chiovato L,Elisei R,Faglia G,Ludgate M,Vassart G

    更新日期:1993-07-01 00:00:00

  • Leptin, insulin and TNF-alpha in weight loss.

    abstract::Forty-eight morbidly obese patients were placed on a very low calorie (800 kcal) formula diet (OPTIFAST) for a 10-week period with the goal of achieving 10% weight loss within this time. Weekly serum leptin measurements were performed to determine whether changes in this adipose protein would serve as a useful marker ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343943

    authors: Xenachis C,Samojlik E,Raghuwanshi MP,Kirschner MA

    更新日期:2001-12-01 00:00:00

  • Presence of endothelin-1 in the normal and pathological human thyroid.

    abstract::An immunohistochemical study with two rabbit polyclonal antibodies I-AR76 and CA-08-351 against Endothelin-1 (ET-1) was performed in 133 human thyroid specimens: 5 normal thyroids, 30 multinodular goiters (15 toxic and 15 nontoxic), 20 Graves' diseases, 5 Hashimoto's thyroiditis, 26 adenomas (6 Hürthle cell, 16 toxic ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347834

    authors: Lenziardi M,Viacava P,Fiorini I,Castagna M,Nardini V,Pollina L,De Negri F,Goletti O,Di Coscio G,Bevilacqua G

    更新日期:1995-05-01 00:00:00

  • The effects of calcitonin on idiopathic nephrolithiasis. Evidence of bone involvement in fasting hypercalciuria.

    abstract::This study was performed to evaluate the antihypercalciuric effect of calcitonin (CT), a potent inhibitor of bone osteoclastic activity, on idiopathic hypercalciuria (IH). Forty-two stone formers were studied: 18 suffered from fasting hypercalciuria (FH), 12 from nonfasting hypercalciuria (NFH) and 12 were normocalciu...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350171

    authors: Filipponi P,Mannarelli C,Gubbiotti G,Blass A,Moretti I,Tini S,Giuseppetti N,Ballanti S,Morucci P

    更新日期:1988-07-01 00:00:00

  • The response of growth hormone and prolactin to oral diazepam in diabetics.

    abstract::We studied 8 insulin dependent stable young diabetics with a mean age of 20 yr. Each patient received 10 mg of diazepam orally after with drawing the baseline blood sample. Subsequent samples were obtained at 30 min intervals for 150 min. The oral administration of diazepam resulted in a significant increase in serum ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349471

    authors: Ajlouni K,El-Khateeb M,El-Zaheri MM,El-Najdawi A

    更新日期:1982-05-01 00:00:00

  • Sandwich-type enzyme immunoassay for human chorionic gonadotropin.

    abstract::We have developed a sandwich-type enzyme immunoassay for human chorionic gonadotropin (hCG), in which antibody Fab'-beta-D-galactosidase complex and an antibody-immobilized silicone rubber solid phase were used. Despite the fact this assay system crossreacted about 40% with human luteinizing hormone (LH) that contains...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349444

    authors: Sekiya T,Furuhashi Y,Goto S,Kaseki S,Tomoda Y,Kato K

    更新日期:1981-07-01 00:00:00

  • Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion.

    abstract::Several clinical signs might be related to the decline of DHEA secretion in aged people: sarcopenia, osteopenia, atherosclerosis progression, impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences. In addition, in aged people this clinical condition mig...

    journal_title:Journal of endocrinological investigation

    pub_type:

    doi:

    authors: Valenti G

    更新日期:2002-01-01 00:00:00

  • Premarin priming does not alter growth hormone release following exercise.

    abstract::We evaluated the usefulness of premarin priming on exercise induced growth hormone release and the value of combining several growth hormone screening agents in a large population of prepubertal children. Two hundred five short healthy prepubertal children growing below the 5th percentile in height were studied. One h...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346963

    authors: Lanes R,Lifshitz F,Sekaran C,Fort P,Recker B

    更新日期:1986-12-01 00:00:00

  • Intranasal and intramuscular human calcitonin in female osteoporosis and in Paget's disease of bones: a pilot study.

    abstract::It has been shown that human calcitonin (hCT) is absorbed through the nasal mucosa when administered together with promoters like sodium glycocholate (SGC) or dihydrofusinate. The aim of this study was to compare the clinical and metabolic effect of intranasal (in) and intramuscular (im) hCT in patients with osteoporo...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03350260

    authors: Pontiroli AE,Pajetta E,Calderara A,Alberetto M,Pozza G,Manganelli V,Resmini G,Tessari L,Maresca V

    更新日期:1991-01-01 00:00:00

  • Effects of PCSK9 inhibitors on LDL cholesterol, cardiovascular morbidity and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND AIMS:Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors determine a wide reduction of LDL cholesterol, greater than other lipid-lowering agents. The present meta-analysis is aimed at the assessment of PCSK9 inhibitors effect on LDL Cholesterol, cardiovascular morbidity and all-cause mortali...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,meta分析

    doi:10.1007/s40618-019-01019-4

    authors: Dicembrini I,Giannini S,Ragghianti B,Mannucci E,Monami M

    更新日期:2019-09-01 00:00:00

  • Transoral thyroidectomy: a viable surgical option with unprecedented complications-a case series.

    abstract:PURPOSE:To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS:From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0808-6

    authors: Bakkar S,Al Hyari M,Naghawi M,Corsini C,Miccoli P

    更新日期:2018-07-01 00:00:00

  • Insulin receptor binding and degradation in IM-9 cultured human lymphocytes - importance of extracellular degradation.

    abstract::Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348223

    authors: Misbin RI,Mehl TD

    更新日期:1980-01-01 00:00:00

  • Growth hormone variants: a potential avenue for a better diagnostic characterization of growth hormone deficiency in children.

    abstract::Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different labor...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.3275/8647

    authors: Rigamonti AE,Bozzola M,Banfi G,Meazza C,Müller EE,Cella SG

    更新日期:2012-11-01 00:00:00

  • Bilateral testicular enlargement due to adrenal remnant in a patient with C11 hydroxylase deficiency congenital adrenal hyperplasia.

    abstract::The case of a 15-yr-old boy with C11 hydroxylase deficiency congenital adrenal hyperplasia is reported who was diagnosed and treated as true precocious puberty at the age of 2 yr because of virilization and bilateral testicular enlargement. He later developed hyperpigmentation, hypertension and short stature and becau...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345128

    authors: Ghazi AA,Hadayegh F,Khakpour G,Azizi F,Melby JC

    更新日期:2003-01-01 00:00:00

  • Hyperthyroidism due to familial pituitary resistance to thyroid hormone: successful control with 3, 5, 3' triiodothyroacetic associated to propranolol.

    abstract::We herein describe a family with thyroid hormone resistance. Thyroid hormones and basal TSH were elevated. Pituitary tumor or abnormality in thyroid hormone binding proteins were ruled out by appropriate tests. Mother and sister of the propositus presented similar abnormal hormonal features but no hyperthyroidism. Ini...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347890

    authors: Aguilar Diosdado M,Escobar-Jimenez L,Fernandez Soto ML,Garcia Curiel A,Escobar-Jimenez F

    更新日期:1991-09-01 00:00:00

  • Signals that determine the fate of osteoblastic cells.

    abstract::Signals that determine skeletal cell fate, function and apoptosis are critical to normal bone remodeling. Skeletal cells synthesize growth factors; some regulate cell replication, others regulate osteoblastic differentiation. Bone morphogenetic proteins (BMP) and Wnts induce the differentiation of mesenchymal cells to...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Canalis E,Deregowski V,Pereira RC,Gazzerro E

    更新日期:2005-01-01 00:00:00

  • The dynamics of 11-beta-hydroxy-androstenedione (11 OHAD) metabolism in man.

    abstract::The aim of the study was to determine the main metabolic parameters of 11-beta-hydroxy-androstenedione (11 OHAD) in man. Seven normal subjects were investigated at 1-3 months interval by 2 types of isotope dilution techniques using a tritiated tracer: constant infusion and bolus iv injection. 3H-11 OHAD and 3H-11-beta...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349485

    authors: Lejeune-Lenain C,Courtois P,Art G,Franckson JR

    更新日期:1984-12-01 00:00:00

  • Characterization of novel genes in AZF regions.

    abstract::The long arm of the Y chromosome contains genes mapped in loci involved in male infertility, short stature and gonadoblastoma. However, many of these genes have not been fully characterized, and are not currently investigated in patients affected by such diseases. We report a study aimed to the genomic characterizatio...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343790

    authors: Stuppia L,Gatta V,Fogh I,Gaspari AR,Grande R,Morizio E,Fantasia D,Pizzuti A,Calabrese G,Palka G

    更新日期:2000-11-01 00:00:00

  • The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines.

    abstract:PURPOSE:This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines. METHODS:In this comparative case-control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0650-x

    authors: Behboudi-Gandevani S,Ramezani Tehrani F,Bidhendi Yarandi R,Noroozzadeh M,Hedayati M,Azizi F

    更新日期:2017-08-01 00:00:00