当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Prevalence and metabolic characteristics of adrenal androgen excess in hyperandrogenic women with different phenotypes.

Prevalence and metabolic characteristics of adrenal androgen excess in hyperandrogenic women with different phenotypes.

Abstract：

BACKGROUND:Serum DHEAS has been found to be elevated in some women with polycystic ovary syndrome (PCOS). We wished to determine whether this prevalence is different in women with androgen excess who have different phenotypes and to correlate these findings with various cardiovascular and metabolic parameters. METHODS:Two hundred and thirty-eight young hyperandrogenic women categorized into various diagnostic groups were evaluated for elevations in serum DHEAS, testosterone, glucose, insulin, quantitative insulin-sensitivity check index (QUICKI), cholesterol, HDL-C, LDL-C, triglycerides and C-reactive protein (CRP). Data were stratified based on elevations in DHEAS. RESULTS:Serum DHEAS was elevated in 39.5% for the entire group [36.7% in PCOS and 48.3% in idiopathic hyperandrogenism (IHA)]. In classic (C)-PCOS, the prevalence was 39.6% and in ovulatory (OV) PCOS it was 29.1%. These differences were not statistically significant. Women with elevated DHEAS had higher testosterone but lower insulin, higher QUICKI, lower total and LDL-cholesterol and higher HDL-cholesterol, p<0.01. Triglycerides and CRP were not different. This trend was greatest in women with C-PCOS. CONCLUSIONS:The prevalence of adrenal hyperandrogenism, as determined by elevations in DHEAS, appears to be statistically similar in IHA, C-PCOS and compared to OV-PCOS. Metabolic and cardiovascular parameters were noted to be more favorable in those women who have higher DHEAS levels.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Carmina E,Lobo RA

doi

10.1007/BF03347408

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

111-6

issue

2

eissn

0391-4097

issn

1720-8386

pii

3473

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Response of Paget's disease to human calcitonin in patients resistant to porcine calcitonin.

    abstract：:Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hC...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348394

    authors： Lo Cascio V,Adami S,Galvanini G,Lazzaretto R,Ferrari M,Tartarotti D,Scuro LA

    更新日期：1984-04-01 00:00:00

  • Does kidney transplantation normalise cortisol metabolism in apparent mineralocorticoid excess syndrome?

    abstract：:The syndrome of apparent mineralocorticoid syndrome (AME) results from defective 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). This enzyme is co-expressed with the mineralocorticoid receptor (MR) in the kidney and converts cortisol to its inactive metabolite cortisone. Its deficiency allows the unmetabolized co...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343755

    authors： Palermo M,Delitala G,Sorba G,Cossu M,Satta R,Tedde R,Pala A,Shackleton CH

    更新日期：2000-07-01 00:00:00

  • Primary hyperparathyroidism-associated polyostotic fibrous dysplasia: absence of McCune-Albright syndrome mutations.

    abstract：:Several cases of sporadic primary hyperparathyroidism in association with fibrous dysplasia of the bone have been reported in the English literature. Since fibrous dysplasia is a major feature and hyperparathyroidism is occasionally found in the McCune-Albright syndrome, we hypothesized that such cases may represent a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348018

    authors： Hammami MM,al-Zahrani A,Butt A,Vencer LJ,Hussain SS

    更新日期：1997-10-01 00:00:00

  • Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men.

    abstract：PURPOSE:Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship betw...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01140-4

    authors： D'Elia L,Giaquinto A,Cappuccio FP,Iacone R,Russo O,Strazzullo P,Galletti F

    更新日期：2020-05-01 00:00:00

  • Actions of calcium ions and a calcium-influx blocker on basal and TRH- and GnRH-stimulated hormone release in patients with pituitary adenomas.

    abstract：:We investigated the influence of calcium ions on the secretion of anterior pituitary hormones basally and in response to exogenous hypothalamic releasing factors in 6 men with pituitary tumors. To this end, concentrations of LH, FSH, TSH, growth hormone and prolactin were measured in blood collected at 10-min interval...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03348164

    authors： Davis M,Nassberg B,Borges JL,Iranmanesh A,Lizzaralde G,Santen RJ,Drake C,Rogol AD,Kaiser DL,Thorner MO

    更新日期：1987-10-01 00:00:00

  • Changes of circulating thyroid autoantibody levels during and after the therapy with methimazole in patients with Graves' disease.

    abstract：:The changes occurring in the levels of circulating thyroid microsomal antibody (M-Ab) and antithyroglobulin antibody (Tg-Ab) during antithyroid drug therapy were studied in 32 patients receiving methimazole for Graves' disease. M-Ab was determined by competitive binding radioassay and Tg-Ab by a sandwich radiometric m...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350476

    authors： Marcocci C,Chiovato L,Mariotti S,Pinchera A

    更新日期：1982-01-01 00:00:00

  • Resistance to somatostatin analogs in acromegaly: an evolving concept?

    abstract：:The aim of acromegaly treatment is to control the disease by suppressing GH hyperactivity and reducing the size or impeding the growth of the pituitary GH secreting mass. Over recent years, many studies have emphasized the role of SS analogs in the treatment of acromegaly. In fact, SS analogs have been demonstrated to...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03349183

    authors： Gola M,Bonadonna S,Mazziotti G,Amato G,Giustina A

    更新日期：2006-01-01 00:00:00

  • Effects of metabolic abnormalities, hyperandrogenemia and clomiphene on liver function parameters among Chinese women with polycystic ovary syndrome: results from a randomized controlled trial.

    abstract：PURPOSE:To investigate the effects of metabolic abnormalities, hyperandrogenemia and ovulation induction by clomiphene/acupuncture on liver function parameters among women with polycystic ovary syndrome (PCOS). METHODS:This is a secondary analysis of a randomized controlled trial. All 1000 subjects were diagnosed as P...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0953-6

    authors： Cai WY,Gao JS,Luo X,Ma HL,Ge H,Liu N,Xia Q,Wang Y,Han BW,Wu XK

    更新日期：2019-05-01 00:00:00

  • Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.

    abstract：OBJECTIVE:The aims of the present study were to examine gene and protein expression of the vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzyme in human papillary thyroid cancer (PTC), furthermore, to investigate the association between CYP24A1 expression and numerous c...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0165-7

    authors： Balla B,Tobiás B,Kósa JP,Podani J,Horváth P,Nagy Z,Horányi J,Járay B,Székely E,Krenács L,Árvai K,Dank M,Putz Z,Szabó B,Szili B,Valkusz Z,Vasas B,Győri G,Lakatos P,Takács I

    更新日期：2015-03-01 00:00:00

  • A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased nuclear triiodothyronine receptors.

    abstract：:A 52-year-old male presented himself with tachycardia crises which appeared first during childhood, increased in frequency without goiter or exophthalmos. Cardiac and adrenergic diseases were excluded. The thyroid function was normal regarding T4, free T4 and T3, TBG, radioiodine uptake, TSH and T3 suppressibility; ho...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349636

    authors： Jaffiol C,Baldet L,Torresani J,Bismuth J,Papachristou C

    更新日期：1990-11-01 00:00:00

  • The age of patients with thyrotoxicosis factitia in Italy from 1973 to 1996.

    abstract：:Thyrotoxicosis factitia, a syndrome due to the surreptitious ingestion of excess thyroid hormones, has generally been diagnosed in young or middle-aged women with psychopathological disturbances. We reviewed all the cases seen at our Institution over a 24-yr period, from 1973 to 1996. All 25 patients were women. Analy...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350892

    authors： Bogazzi F,Bartalena L,Scarcello G,Campomori A,Rossi G,Martino E

    更新日期：1999-02-01 00:00:00

  • Primary hypothyroidism-associated TSH-secreting pituitary adenoma/hyperplasia presenting as a bleeding nasal mass and extremely elevated TSH level.

    abstract：:A 41-year-old male with primary hypothyroidism and a huge TSH-secreting pituitary tumor presented with a bleeding nasal mass that was initially misdiagnosed as a paraganglioma. Other unique features of the case include lack of complaints related to hypothyroidism, an extremely elevated TSH level of 3474 mU/l, and a lo...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343584

    authors： Ghannam NN,Hammami MM,Muttair Z,Bakheet SM

    更新日期：1999-06-01 00:00:00

  • Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus.

    abstract：OBJECTIVE:Subcutaneous insulin absorption is one of the key factors affecting glycemic control in patients with diabetes mellitus under insulin therapy. Insulin-induced subcutaneous lipohypertrophy has been reported to impair insulin regular absorption and hence glycemic control. So far, lipohypertrophy diagnosis has o...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-017-0675-1

    authors： Bertuzzi F,Meneghini E,Bruschi E,Luzi L,Nichelatti M,Epis O

    更新日期：2017-10-01 00:00:00

  • Effects of hypothyroidism and endocrine disruptor-dependent non-thyroidal illness syndrome on the GnRH-gonadotroph axis of the adult male rat.

    abstract：:Effects of primary hypothyroidism (HYPO) on the male gonadal axis are controversial, with only scanty data on the gonadotroph cell response and no information on GnRH tuberoinfundibular neurons, even in animal models. HYPO has been reported to variably induce hypogonadotropic hypogonadism, a hypergonadotropic state, o...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Toni R,Della Casa C,Castorina S,Cocchi D,Celotti F

    更新日期：2005-01-01 00:00:00

  • Vitamin D levels in a paediatric population of normal weight and obese subjects.

    abstract：BACKGROUND:Vitamin D exerts pleiotropic effects and few studies are available in the Italian population. AIM:Aim of our study was to evaluate vitamin D status in children living in Northern Italy. METHODS:We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal an...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0108-3

    authors： Bellone S,Esposito S,Giglione E,Genoni G,Fiorito C,Petri A,Bona G,Prodam F

    更新日期：2014-09-01 00:00:00

  • A rapid procedure for the quantitation of natriuretic peptide RNAs by competitive RT-PCR in congenital heart defects.

    abstract：:We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343655

    authors： Iascone MR,Vittorini S,Collavoli A,Cupelli A,Kraft G,Biagini A,Clerico A

    更新日期：1999-12-01 00:00:00

  • Influence of the neonatal suppression of TSH production (neonatal hyperthyroidism) on response to TSH in adulthood.

    abstract：:Six-day treatment of neonatal rats with T3 or T4 resulted in a considerable depression of T4 production in response to exogenous TSH in adulthood. This supports the hypothetical conclusion that hormonal imprinting, i.e. the presence of the hormone and its interaction with the cell during the period of receptor maturat...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348561

    authors： Csaba G,Nagy SU

    更新日期：1985-12-01 00:00:00

  • Intracranial volume receptors: possible role on ADH homeostatic control.

    abstract：:Volume receptors are situated in many organs and are capable of modulating ADH secretion. We have evaluated the variation of plasma ADH concentration after an experimentally induced increase of cerebrospinal fluid (CSF) pressure (PCSF). The experiment was performed in controlled environmental conditions to avoid pain ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349891

    authors： Satta A,Palomba D,Demontis MP,Varoni MV,Faedda R,Ginanni A,Anania V

    更新日期：1996-07-01 00:00:00

  • Exercise-induced endocrine pathologies.

    abstract：:There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345238

    authors： Warren MP,Goodman LR

    更新日期：2003-09-01 00:00:00

  • Microvascular density and vascular endothelial growth factor expression in normal pituitary tissue and pituitary adenomas.

    abstract：:Microvessel density (MVD) represents a measure of angiogenesis and may be used as an indicator of neoplastic aggressiveness. Vascular endothelial growth factor (VEGF) plays a pivotal role as angiogenic promoter by stimulating endothelial cell proliferation and migration and enhancing vascular permeability. The aim of ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345118

    authors： Viacava P,Gasperi M,Acerbi G,Manetti L,Cecconi E,Bonadio AG,Naccarato AG,Acerbi F,Parenti G,Lupi I,Genovesi M,Martino E

    更新日期：2003-01-01 00:00:00

  • Effects of whole-body vibration exercise on the endocrine system of healthy men.

    abstract：:Whole-body vibration is reported to increase muscle performance, bone mineral density and stimulate the secretion of lipolytic and protein anabolic hormones, such as GH and testosterone, that might be used for the treatment of obesity. To date, as no controlled trial has examined the effects of vibration exercise on t...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03351056

    authors： Di Loreto C,Ranchelli A,Lucidi P,Murdolo G,Parlanti N,De Cicco A,Tsarpela O,Annino G,Bosco C,Santeusanio F,Bolli GB,De Feo P

    更新日期：2004-04-01 00:00:00

  • Some considerations about evolution of idiopathic primary aldosteronism.

    abstract：:The prevalence of primary aldosteronism has increased since many patients who were previously considered as being affected by low renin essential hypertension are actually satisfying the new diagnostic criteria using plasma aldosterone/ plasma renin activity (PRA) ratio. Many of these cases could be classified as subc...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346520

    authors： Armanini D,Fiore C

    更新日期：2009-07-01 00:00:00

  • Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: a meta-analysis from clinical studies.

    abstract：:Dopamine agonists have been associated with increased risk of cardiac valve regurgitation in patients with Parkinson's disease. Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled. Occasional case reports and 7 studies on the relationship between cabergoline and cardiac valve r...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/BF03345662

    authors： Bogazzi F,Manetti L,Raffaelli V,Lombardi M,Rossi G,Martino E

    更新日期：2008-12-01 00:00:00

  • Spying on organelle Ca²⁺ in living cells: the mitochondrial point of view.

    abstract：:Over the past years, the use of genetically encoded Ca(2+) indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca(2+) homeostasis in living cells leading to novel insights into functional aspects of Ca(2+) signalling. Particularly relevant for a deeper under...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40618-014-0178-2

    authors： Pendin D,Greotti E,Filadi R,Pozzan T

    更新日期：2015-01-01 00:00:00

  • Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?

    abstract：PURPOSE:Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0905-1

    authors： Demirpence M,Guler A,Yilmaz H,Sayin A,Pekcevik Y,Turkon H,Colak A,Ari EM,Aslanipour B,Kocabas GU,Calan M

    更新日期：2019-02-01 00:00:00

  • Lack of effect of the dopamine D1 antagonist, NNC 01-0687, on unstimulated and stimulated release of anterior pituitary hormones in males.

    abstract：:Dopamine in humans inhibits the secretion of luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH) and prolactin (PRL), and is a stimulator of growth hormone (GH) secretion. Dopamine-D1 receptor stimulation with fenoldopam increases basal PRL levels, suppresses TSH, and incr...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03350331

    authors： Grodum E,Andersen M,Hangaard J,Koldkjaer O,Hagen C

    更新日期：1998-05-01 00:00:00

  • Acute keratoconus induced by hypothyroxinemia during pregnancy.

    abstract：:Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pat...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345600

    authors： Gatzioufas Z,Thanos S

    更新日期：2008-03-01 00:00:00

  • Longitudinal study on goiter prevalence and goitrogen factors in northeastern Sicily.

    abstract：:A longitudinal study was carried out in an area of endemic goiter of north-eastern Sicily. Three different surveys (in 1977, 1983 and 1994) evaluated the epidemiological prevalence of goiter in schoolchildren of the endemic area (towns of Bronte, Troina and Maniaci) in comparison to an iodine sufficient control area (...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349031

    authors： Regalbuto C,Squatrito S,La Rosa GL,Cercabene G,Ippolito A,Tita P,Salamone S,Vigneri R

    更新日期：1996-10-01 00:00:00

  • Glucagon test in insulinoma: Is it useful?

    abstract：:Diagnosis of endogenous hyperinsulinism caused by insulinoma is based on confirmation of hypoglycemia during the symptoms associated to elevated insulin levels. Patients with insulinoma may demonstrate an excessive insulin response and subsequent hypoglycemia after 1 mg of glucagon iv injection. Glucagon test was perf...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/7879

    authors： Felício JS,Martins CL,Mileo KB,Semer M,Kalinin L,Nery M,Machado MC,Liberman B

    更新日期：2012-06-01 00:00:00

  • Hypoproteinemia in acromegaly.

    abstract：:Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypoglobulinemia has been observed in this endocrine disorder. In 28 acromegalic patients and 56 control subjects sera have been analyzed for total pro...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349317

    authors： Federspil G,Vettor R,Bossi A,Sicolo N

    更新日期：1979-04-01 00:00:00