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Galactosylhydroxylysine and pyridinium cross links in monitoring the bone response to hormone replacement therapy.

Abstract：

:Aim of the study was to compare urinary galactosyl-hydroxylysine (GHyl), deoxypyridinoline (D-Pyr) and pyridinoline (Pyr) before and after 5 to 9 months of hormone replacement therapy (HRT) in postmenopausal women. The urinary markers were measured by HPLC in the second void of fasting samples and were expressed as ratio to creatinine. GHyl was also expressed as a ratio to glucosylgalactolysyl-hydroxylysine (GGHyl). After short-term hormone replacement therapy, urinary D-Pyr fell significantly, but Pyr and GHyl, also when expressed as a ratio to GGHyl, remained unmodified. We conclude that GHyl and Pyr are not useful markers in monitoring the bone response to HRT in postmenopausal women.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Marabini R,Sirtori P,Chionna R,Barzizza L,Rubinacci A

doi

10.1007/BF03349858

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

154-8

issue

3

eissn

0391-4097

issn

1720-8386

journal_volume

19

pub_type

杂志文章

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