Abstract:
:Lutein is the predominant carotenoid in the developing primate brain and retina, and may have important functional roles. However, its bioaccumulation pattern during early development is not understood. In this pilot study, we investigated whether carotenoid supplementation of infant formula enhanced lutein tissue deposition in infant rhesus macaques. Monkeys were initially breastfed; from 1 to 3 months of age they were fed either a formula supplemented with lutein, zeaxanthin, β-carotene and lycopene, or a control formula with low levels of these carotenoids, for 4 months (n = 2/group). All samples were analyzed by high pressure liquid chromatography (HPLC). Final serum lutein in the supplemented group was 5 times higher than in the unsupplemented group. All brain regions examined showed a selective increase in lutein deposition in the supplemented infants. Lutein differentially accumulated across brain regions, with highest amounts in occipital cortex in both groups. β-carotene accumulated, but zeaxanthin and lycopene were undetectable in any brain region. Supplemented infants had higher lutein concentrations in peripheral retina but not in macular retina. Among adipose sites, abdominal subcutaneous adipose tissue exhibited the highest lutein level and was 3-fold higher in the supplemented infants. The supplemented formula enhanced carotenoid deposition in several other tissues. In rhesus infants, increased intake of carotenoids from formula enhanced their deposition in serum and numerous tissues and selectively increased lutein in multiple brain regions.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Jeon S,Neuringer M,Johnson EE,Kuchan MJ,Pereira SL,Johnson EJ,Erdman JWdoi
10.3390/nu9010051subject
Has Abstractpub_date
2017-01-10 00:00:00issue
1issn
2072-6643pii
nu9010051journal_volume
9pub_type
杂志文章相关文献
Nutrients文献大全abstract::Environmental factors such as food availability and variety can function as cues for overeating in individuals susceptible to overweight or obesity, but relatively little is known about other types of environmental factors that may also be important. This qualitative study compared and contrasted categories of interna...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11061365
更新日期:2019-06-18 00:00:00
abstract::Oleuropein (OLE) is the major phenolic secoiridoid of olive tree leaves, and its antioxidant and anti-inflammatory activities have been demonstrated in in vitro and in vivo animal models. The aim of this study was to investigate the activity of OLE in the colonic mucosa from patients with ulcerative colitis (UC). Biop...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu9040391
更新日期:2017-04-15 00:00:00
abstract::The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an adequ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12061718
更新日期:2020-06-08 00:00:00
abstract::Rheumatoid arthritis (RA) is a debilitating, chronic, inflammatory, autoimmune disease associated with cachexia. The substitutive therapy of gut hormone ghrelin has been pointed at as a potential countermeasure for the management of metabolic and inflammatory complications in RA. The recent discovery of liver-expresse...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu12041006
更新日期:2020-04-06 00:00:00
abstract::Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is as...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113528
更新日期:2020-11-17 00:00:00
abstract::Fruit and vegetables (F&V) are imperative for good health, yet less than one per cent of Australian children consume these food groups in sufficient quantities. As guided by Social Cognitive Theory (SCT), this paper aimed to: (i) understand key informant perspectives of the amount, types and quality of F&V consumed by...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111603
更新日期:2018-11-01 00:00:00
abstract::Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited. In this study, we determined the cancer chemopreventive potentials of 10 representative ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu4111679
更新日期:2012-11-08 00:00:00
abstract::Postprandial inflammation and endotoxaemia are determinants of cardiovascular and metabolic disease risk which are amplified by high fat meals. We aimed to examine the determinants of postprandial inflammation and endotoxaemia in older and younger adults following a high fat mixed meal. In a randomised cross-over tria...
journal_title:Nutrients
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3390/nu9040354
更新日期:2017-04-02 00:00:00
abstract::This is the first study to evaluate vitamin K status in relation to dietary intake and phenylalanine dietary compliance in patients with phenylketonuria (PKU). The dietary and PKU formula intake of vitamin K was calculated in 34 PKU patients, with vitamin K status determined by the measurement of prothrombin induced b...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061772
更新日期:2020-06-14 00:00:00
abstract::Mechanical, microstructural properties, mineral content and bone mineral density (BMD) of the femur were evaluated in growing rats fed with Opuntia ficus indica (L.) Mill. (Cactaceae) cladodes at different maturity stages as calcium source. Male weanling rats were fed with cladodes at early maturity stage (25 and 60 d...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9020108
更新日期:2017-02-04 00:00:00
abstract::Increases in the number of food outlets have been proposed as a key factor driving obesity. This study aimed to investigate the association between the densities of food establishments serving meals (excluding supermarkets and grocery stores), with body mass index (BMI), waist to hip ratio (WHR) and percentage of body...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040890
更新日期:2020-03-25 00:00:00
abstract::Decreased renal function, elevated circulating levels of urea, intestinal levels of urea-degrading bacteria, and gut-derived uremic metabolites are present in end-stage renal disease (ESRD), a cohort that has reduced muscle mass and physical function, and poor muscle composition. This phenotype, defined as the kidney-...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010106
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. METHODS:We p...
journal_title:Nutrients
pub_type: 杂志文章,meta分析,评审
doi:10.3390/nu10060732
更新日期:2018-06-06 00:00:00
abstract::Common genetic variants of the fat mass and obesity associated (FTO) gene are strongly associated with obesity and type 2 diabetes. FTO is ubiquitously expressed. Earlier studies have focused on the role of hypothalamic FTO in the regulation of metabolism. However, recent studies suggest that expression of hepatic FTO...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111600
更新日期:2018-11-01 00:00:00
abstract::Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu8060338
更新日期:2016-06-02 00:00:00
abstract:BACKGROUND:With the rapid development of Shanghai's economy, diet habits have undergone great changes. The study aimed to examine the situation of out-of-home (OH) eating in Shanghai adults and the nutrition characteristics of eating in different dining places, and to assess the social demographic determinants of eatin...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10070951
更新日期:2018-07-23 00:00:00
abstract::Few studies have examined docosahexaenoic acid (DHA) in pregnant and lactating women in developing countries like China, where DHA-enriched supplements are increasingly popular. We aimed to assess the DHA status among Chinese pregnant and lactating women residing areas differing in the availability of aquatic products...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7105428
更新日期:2015-10-21 00:00:00
abstract::Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the management of neurodegenerative and neurological diseases. However, a discrepancy exists between the well-documented pharmacological activities that curcumin seems to possess in vivo and its poor aqueous solubility, bioavailabilit...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11102426
更新日期:2019-10-11 00:00:00
abstract::This study aimed to detect the association of the MADD-FOLH1 single nucleotide polymorphisms (SNPs) and their haplotypes with the risk of coronary heart disease (CHD) and ischemic stroke (IS) in a Chinese Han population. Six SNPs of rs7395662, rs326214, rs326217, rs1051006, rs3736101, and rs7120118 were genotyped in 5...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8040208
更新日期:2016-04-08 00:00:00
abstract::Postprandial blood glucose excursions are important for achieving optimal glycemic control. In normal-weight individuals, glucose tolerance is diminished in the evening compared to glucose tolerance in the morning. Wheat albumin (WA) has the potential to suppress the postprandial glucose response with a relatively sma...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11010187
更新日期:2019-01-17 00:00:00
abstract::The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, th...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10020219
更新日期:2018-02-16 00:00:00
abstract::Cherries are known for their nutraceutical properties, in particular for their antioxidant ability due to their polyphenol content, which causes a reduction of cardiovascular disease (CVD) risk factors. However, once ingested these molecules are degraded in the Gastrointestinal (GI) tract before reaching the blood, wh...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111598
更新日期:2018-11-01 00:00:00
abstract::The European population is only suboptimally supplied with the essential trace element selenium. Such a selenium status is supposed to worsen colitis while colitis-suppressive effects were observed with adequate or supplemented amounts of both organic selenomethionine (SeMet) and inorganic sodium selenite. In order to...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7042687
更新日期:2015-04-10 00:00:00
abstract::The aim of this review is to highlight current insights into the roles of choline and docosahexaenoic acid (DHA) in maternal and infant nutrition, with special emphasis on dietary recommendations, gaps in dietary intake, and synergistic implications of both nutrients in infant brain and eye development. Adequate choli...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11051125
更新日期:2019-05-21 00:00:00
abstract::Preschool Mexican children consume 7% of their total energy intake from processed breakfast cereals. This study characterized the nutritional quality and labelling (claims and Guideline Daily Amount (GDA)) of the packaged breakfast cereals available in the Mexican market. Photographs of all breakfast cereals available...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9080884
更新日期:2017-08-16 00:00:00
abstract::Galacto-oligosaccharides (GOS), functional oligosaccharides with natural characteristics, are important active substances in milk that play an important role in the development of intestinal microbiota and the immune system of newborns. The intestinal maturation of piglets resembles that of human newborns and infants....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081753
更新日期:2019-07-30 00:00:00
abstract:BACKGROUND:Fluid overload and protein-energy wasting (PEW) are common in patients with end-stage renal disease (ESRD) and lead to a poor prognosis. We aimed to evaluate the volume and nutritional status of ESRD patients and to determine the clinical significance of phase angle (PhA). METHODS:This study was a cross-sec...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091331
更新日期:2018-09-19 00:00:00
abstract::Gastroesophageal reflux disease (GERD) affects approximately 20% of Australians. Patients suffer a burning sensation known as heartburn due to the movement of acidic stomach content into the esophagus. There is anecdotal evidence of the effectiveness of prebiotic sugarcane flour in controlling symptoms of GERD. This p...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061813
更新日期:2020-06-18 00:00:00
abstract::The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 438...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122885
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with "moderate" hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. SUBJECTS/METHODS:We performed ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5051531
更新日期:2013-05-08 00:00:00