The World Trade Center attack. Lessons for all aspects of health care.


:The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness has now been replaced by anger, fear, and the determination to be better prepared next time. This determination not only exists in politics but also in health care, and as with all attempts to enforce change there needs to be a period of collecting opinions and data. This article introduces nine reviews in Critical Care offering varied health care perspectives of the events of 11 September 2001 from people who were there and from experts in disaster management.


Crit Care


Tamber PS,Vincent JL





Has Abstract


2001-12-01 00:00:00












  • Hyperoncotic colloids and acute kidney injury: a meta-analysis of randomized trials.

    abstract:INTRODUCTION:It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear. METHODS:A meta-analysis was conducted of randomized controlled trials evaluating AKI after infusion of hyperoncotic albumin and hydroxyethyl starch (...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析


    authors: Wiedermann CJ,Dunzendorfer S,Gaioni LU,Zaraca F,Joannidis M

    更新日期:2010-01-01 00:00:00

  • Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study.

    abstract:BACKGROUND:Temperature management is used with increased frequency as a tool to mitigate neurological injury. Although frequently used, little is known about the optimal cooling methods for inducing and maintaining controlled normo- and hypothermia in the intensive care unit (ICU). In this study we compared the efficac...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Hoedemaekers CW,Ezzahti M,Gerritsen A,van der Hoeven JG

    更新日期:2007-01-01 00:00:00

  • Microvascular effects of intravenous esmolol in patients with normal cardiac function undergoing postoperative atrial fibrillation: a prospective pilot study in cardiothoracic surgery.

    abstract:BACKGROUND:Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic instability. Microcirculatory effects of POAF and esmolol have not yet been investigated. We hy...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Fornier W,Jacquet-Lagrèze M,Collenot T,Teixeira P,Portran P,Schweizer R,Ovize M,Fellahi JL

    更新日期:2017-12-12 00:00:00

  • Interest of low-dose hydrocortisone therapy during brain-dead organ donor resuscitation: the CORTICOME study.

    abstract:INTRODUCTION:Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration of steroid, thyroxine and vasopressin has been proposed to optimize the management of brain deceased donors before recovery of organs. However the single administration...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Pinsard M,Ragot S,Mertes PM,Bleichner JP,Zitouni S,Cook F,Pierrot M,Dube L,Menguy E,Lefèvre LM,Escaravage L,Dequin PF,Vignon P,Pichon N

    更新日期:2014-07-23 00:00:00

  • Changes in central venous saturation after major surgery, and association with outcome.

    abstract:INTRODUCTION:Despite recent interest in measurement of central venous oxygen saturation (ScvO2), there are no published data describing the pattern of ScvO2 changes after major general surgery or any relationship with outcome. METHODS:ScvO2 and other biochemical, physiological and demographic data were prospectively m...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Pearse R,Dawson D,Fawcett J,Rhodes A,Grounds RM,Bennett ED

    更新日期:2005-01-01 00:00:00

  • Clinical review: how to identify high-risk surgical patients.

    abstract::Postoperative outcome is mainly influenced by ventricular function. Tests designed to identify myocardial ischemia alone will fail to detect cardiac failure and are thus inadequate as a screening test for identification of cardiac risk in noncardiac surgical patients. We find that the degree of cardiac failure is the ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Older P,Hall A

    更新日期:2004-10-01 00:00:00

  • Significance of lipopolysaccharide-binding protein (an acute phase protein) in monitoring critically ill patients.

    abstract:INTRODUCTION:The present study was conducted to assess the value of serum concentration of lipopolysaccharide-binding protein (LBP) in patients with systemic inflammatory response syndrome (SIRS), sepsis and septic shock with respect to its ability to differentiate between infectious and noninfectious etiologies in SIR...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Prucha M,Herold I,Zazula R,Dubska L,Dostal M,Hildebrand T,Hyanek J

    更新日期:2003-12-01 00:00:00

  • Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients.

    abstract:BACKGROUND:Diaphragm dysfunction develops frequently in ventilated intensive care unit (ICU) patients. Both disuse atrophy (ventilator over-assist) and high respiratory muscle effort (ventilator under-assist) seem to be involved. A strong rationale exists to monitor diaphragm effort and titrate support to maintain resp...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Jansen D,Jonkman AH,Roesthuis L,Gadgil S,van der Hoeven JG,Scheffer GJ,Girbes A,Doorduin J,Sinderby CS,Heunks LMA

    更新日期:2018-09-27 00:00:00

  • Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study.

    abstract:INTRODUCTION:Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its imp...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

    更新日期:2014-08-12 00:00:00

  • Urinary output and fractional excretion of sodium and urea as indicators of transient versus intrinsic acute kidney injury during early sepsis.

    abstract:INTRODUCTION:The pathophysiology of acute kidney injury (AKI) in sepsis is ill defined. We investigated parameters associated with low glomerular filtration, and their predictive value to discriminate transient from intrinsic septic AKI. METHODS:In 107 sepsis patients, AKI was defined by the Risk, Injury, Failure, Los...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Vanmassenhove J,Glorieux G,Hoste E,Dhondt A,Vanholder R,Van Biesen W

    更新日期:2013-10-13 00:00:00

  • Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China.

    abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease s...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Zeng Z,Yu H,Chen H,Qi W,Chen L,Chen G,Yan W,Chen T,Ning Q,Han M,Wu D

    更新日期:2020-08-27 00:00:00

  • Feasibility and reliability of an automated controller of inspired oxygen concentration during mechanical ventilation.

    abstract:INTRODUCTION:Hypoxemia and high fractions of inspired oxygen (FiO2) are concerns in critically ill patients. An automated FiO2 controller based on continuous oxygen saturation (SpO2) measurement was tested. Two different SpO2-FiO2 feedback open loops, designed to react differently based on the level of hypoxemia, were ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Saihi K,Richard JC,Gonin X,Krüger T,Dojat M,Brochard L

    更新日期:2014-02-19 00:00:00

  • Blocking IL-1 to prevent respiratory failure in COVID-19.

    abstract::COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infe...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: van de Veerdonk FL,Netea MG

    更新日期:2020-07-18 00:00:00

  • Do we need new trials of procalcitonin-guided antibiotic therapy?

    abstract::Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect of a procalcitonin (PCT)-guided antibiotic treatment on outcomes in acute lower respiratory trac...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lisboa T,Salluh J,Povoa P

    更新日期:2018-01-27 00:00:00

  • Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis.

    abstract:INTRODUCTION:The purpose of this study was to investigate whether common variants across the nuclear factor erythroid 2-like 2 (NFE2L2) gene contribute to the development of the acute respiratory distress syndrome (ARDS) in patients with severe sepsis. NFE2L2 is involved in the response to oxidative stress, and it has ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Acosta-Herrera M,Pino-Yanes M,Blanco J,Ballesteros JC,Ambrós A,Corrales A,Gandía F,Subirá C,Domínguez D,Baluja A,Añón JM,Adalia R,Pérez-Méndez L,Flores C,Villar J,GRECIA and GEN-SEP networks.

    更新日期:2015-06-16 00:00:00

  • How the relationships between general practitioners and intensivists can be improved: the general practitioners' point of view.

    abstract:INTRODUCTION:The present study assessed the opinion of general practitioners (GPs) concerning their relationships with intensivists. METHODS:An anonymous questionnaire was mailed to 7,239 GPs. GPs were asked about their professional activities, postgraduate intensive care unit (ICU) training, the rate of patient admit...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Etesse B,Jaber S,Mura T,Leone M,Constantin JM,Michelet P,Zoric L,Capdevila X,Malavielle F,Allaouchiche B,Orban JC,Fabbro-Peray P,Lefrant JY,AzuRéa Group.

    更新日期:2010-01-01 00:00:00

  • Prolonged refractory status epilepticus following acute traumatic brain injury: a case report of excellent neurological recovery.

    abstract:INTRODUCTION:Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality. METHODS:This case report describes a 20 year old previously healthy woman who suffered a severe TBI as a result of a motor vehicle collision and...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Peets AD,Berthiaume LR,Bagshaw SM,Federico P,Doig CJ,Zygun DA

    更新日期:2005-01-01 00:00:00

  • Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study.

    abstract:INTRODUCTION:Bacterial meningitis (BM) is a severe complication in patients with aneurysmal subarachnoid haemorrhage (SAH). Clinical signs of meningitis are often masked by SAH-related symptoms, and routine cerebrospinal fluid (CSF) analysis fails to indicate BM. Microdialysis (MD) is a technique for monitoring cerebra...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Schlenk F,Frieler K,Nagel A,Vajkoczy P,Sarrafzadeh AS

    更新日期:2009-01-01 00:00:00

  • Translocation of bacterial NOD2 agonist and its link with inflammation.

    abstract:INTRODUCTION:The gut is often considered as the motor of critical illness through bacterial translocation, which amplifies the inflammatory response and alters the immune status. However, systemic bacterial translocation was rarely proven and endotoxin measurement only reflects translocation of Gram-negative-derived pr...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Kim OY,Monsel A,Bertrand M,Cavaillon JM,Coriat P,Adib-Conquy M

    更新日期:2009-01-01 00:00:00

  • Impact of intensive care on renal function before graft harvest: results of a monocentric study.

    abstract:BACKGROUND:The aim of life-support measures in brain-dead donors is to preserve the functional value of their organs. In renal transplantation, serum creatinine level is one of the criteria for graft harvest. The aim of this study was to assess the impact of intensive care on donor renal function through two criteria: ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Blasco V,Leone M,Bouvenot J,Geissler A,Albanèse J,Martin C

    更新日期:2007-01-01 00:00:00

  • Parenteral diclofenac infusion significantly decreases brain-tissue oxygen tension in patients with poor-grade aneurysmal subarachnoid hemorrhage.

    abstract:INTRODUCTION:Diclofenac, a nonsteroidal antiinflammatory drug, is commonly used as antipyretic therapy in intensive care. The purpose of this study was to investigate the effects of parenteral diclofenac infusion on brain homeostasis, including brain-tissue oxygen tension (PbtO2) and brain metabolism after aneurysmal s...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Schiefecker AJ,Pfausler B,Beer R,Sohm F,Sabo J,Knauseder V,Fischer M,Dietmann A,Hackl WO,Thomé C,Schmutzhard E,Helbok R

    更新日期:2013-05-12 00:00:00

  • Mean glucose during ICU admission is related to mortality by a U-shaped curve in surgical and medical patients: a retrospective cohort study.

    abstract:INTRODUCTION:Lowering of hyperglycemia in the intensive care unit (ICU) is widely practiced. We investigated in which way glucose regulation, defined as mean glucose concentration during admission, is associated with ICU mortality in a medical and a surgical cohort. METHODS:Retrospective database cohort study includin...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Siegelaar SE,Hermanides J,Oudemans-van Straaten HM,van der Voort PH,Bosman RJ,Zandstra DF,DeVries JH

    更新日期:2010-01-01 00:00:00

  • Managing daily intensive care activities: an observational study concerning ad hoc decision making of charge nurses and intensivists.

    abstract:INTRODUCTION:Management of daily activities in ICUs is challenging. ICU shift leaders, charge nurses and intensivists have to make several immediate ad hoc decisions to enable the fluent flow of ICU activities. Even though the management of ICU activities is quite well delineated by international consensus guidelines, ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lundgrén-Laine H,Kontio E,Perttilä J,Korvenranta H,Forsström J,Salanterä S

    更新日期:2011-08-08 00:00:00

  • In vivo calibration of esophageal pressure in the mechanically ventilated patient makes measurements reliable.

    abstract:BACKGROUND:Esophageal pressure (Pes) can provide information to guide mechanical ventilation in acute respiratory failure. However, both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. We evaluated the feasibility...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Mojoli F,Iotti GA,Torriglia F,Pozzi M,Volta CA,Bianzina S,Braschi A,Brochard L

    更新日期:2016-04-11 00:00:00

  • Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis.

    abstract:INTRODUCTION:In transgenic animal models of sepsis, members of the Bcl-2 family of proteins regulate lymphocyte apoptosis and survival of sepsis. This study investigates the gene regulation of pro-apoptotic and anti-apoptotic members of the Bcl-2 family of proteins in patients with early stage severe sepsis. METHODS:I...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Weber SU,Schewe JC,Lehmann LE,Müller S,Book M,Klaschik S,Hoeft A,Stüber F

    更新日期:2008-01-01 00:00:00

  • Tight glycemic control: what do we really know, and what should we expect?

    abstract::Tight glycemic control has engendered large numbers of investigations, with conflicting results. The world has largely embraced intensive insulin as a practice, but applies this therapy with great variability in the manner of glucose control and measurement. The present commentary reviews what we actually know with ce...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章,评审


    authors: Nasraway SA Jr,Rattan R

    更新日期:2010-01-01 00:00:00

  • Bending the cost curve in the United States: the role of comparative effectiveness research.

    abstract::Owing to an increasing focus on the rising cost of medical care in the United States, bending the cost curve has become the central tenet of healthcare reform. The exact definition of this phrase, however, remains elusive. In order to affect change in the cost and quality of healthcare, the importance of comparative e...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Ghaferi AA

    更新日期:2010-01-01 00:00:00

  • Transpulmonary thermodilution for hemodynamic measurements in severely burned children.

    abstract:INTRODUCTION:Monitoring of hemodynamic and volumetric parameters after severe burns is of critical importance. Pulmonary artery catheters, however, have been associated with many risks. Our aim was to show the feasibility of continuous monitoring with minimally invasive transpulmonary thermodilution (TPTD) in severely ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Branski LK,Herndon DN,Byrd JF,Kinsky MP,Lee JO,Fagan SP,Jeschke MG

    更新日期:2011-01-01 00:00:00

  • A practical approach to goal-directed echocardiography in the critical care setting.

    abstract::Urgent cardiac ultrasound examination in the critical care setting is clinically useful. Application of goal-directed echocardiography in this setting is quite distinct from typical exploratory diagnostic comprehensive echocardiography, because the urgent critical care setting mandates a goal-directed approach. Goal-d...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Walley PE,Walley KR,Goodgame B,Punjabi V,Sirounis D

    更新日期:2014-12-01 00:00:00

  • The benefit of specialized team approaches in patients with acute kidney injury undergoing continuous renal replacement therapy: propensity score matched analysis.

    abstract:INTRODUCTION:Continuous renal replacement therapy (CRRT) has been widely used in critically ill acute kidney injury (AKI) patients. Moreover, some centers operate a specialized CRRT team (SCT) composed of physicians and nurses, but few studies have yet determined the superiority of SCT control. METHODS:A total of 334 ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Oh HJ,Lee MJ,Kim CH,Kim DY,Lee HS,Park JT,Na S,Han SH,Kang SW,Koh SO,Yoo TH

    更新日期:2014-08-13 00:00:00