Abstract:
INTRODUCTION:Mechanical ventilators are increasingly used in critical care units. However, they can cause lung injury, including pulmonary edema. Our previous studies indicated that γ-aminobutyric acid (GABA) receptors are involved in alveolar-fluid homeostasis. The present study investigated the role of GABA receptors in ventilator-induced lung injury. METHODS:Adult female Sprague-Dawley rats were subjected to high-tidal-volume ventilation of 40 ml/kg body weight for 1 hour, and lung injuries were assessed. RESULTS:High-tidal-volume ventilation resulted in lung injury, as indicated by an increase in total protein in bronchoalveolar fluid, wet-to-dry ratio (indication of pulmonary edema), and Evans Blue dye extravasation (indication of vascular damage). Intratracheal administration of GABA before ventilation significantly reduced the wet-to-dry ratio. Further, histopathologic analysis indicated that GABA reduced ventilator-induced lung injury and apoptosis. GABA-mediated reduction was effectively blocked by the GABAA-receptor antagonist, bicuculline. The GABA-mediated effect was not due to the vascular damage, because no differences in Evans Blue dye extravasation were noted. However, the decrease in alveolar fluid clearance by high-tidal-volume ventilation was partly prevented by GABA, which was blocked by bicuculline. CONCLUSIONS:These results suggest that GABA reduces pulmonary edema induced by high-tidal-volume ventilation via its effects on alveolar fluid clearance and apoptosis.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Chintagari NR,Liu Ldoi
10.1186/cc11298subject
Has Abstractpub_date
2012-12-12 00:00:00pages
R55issue
2eissn
1364-8535issn
1466-609Xpii
cc11298journal_volume
16pub_type
杂志文章相关文献
CRITICAL CARE文献大全abstract::Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepleted RBC transfusion may reduce the incidence of infection and organ dysfunction. However, the influence of le...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13811
更新日期:2014-04-01 00:00:00
abstract::Bacterial pathogens possess an array of specific mechanisms that confer virulence and the capacity to avoid host defence mechanisms. Mechanisms of virulence are often mediated by the subversion of normal aspects of host biology. In this way the pathogen modifies host function so as to promote the pathogen's survival o...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7091
更新日期:2008-01-01 00:00:00
abstract::Base deficit has frequently been utilized as an informal adjunct in the initial evaluation of trauma patients to assess the extent of their physiologic derangements. However, the current Advanced Trauma Life Support (ATLS) classification system for hypovolemic shock does not include base-deficit measurements and relie...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc12513
更新日期:2013-03-13 00:00:00
abstract::Ventilator-induced lung injury (VILI) consists of tissue damage and a biological response resulting from the application of inappropriate mechanical forces to the lung parenchyma. The current paradigm attributes VILI to overstretching due to very high-volume ventilation (volutrauma) and cyclic changes in aeration due ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc10052
更新日期:2011-04-07 00:00:00
abstract:INTRODUCTION:Mortality and disability following ischemic stroke (IS) remains unacceptably high with respect to the conventional therapies. This study tested the effect of erythropoietin (EPO) on long-term neurological outcome in patients after acute IS. This study aimed to evaluate the safety and efficacy of two consec...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-015-0761-8
更新日期:2015-02-25 00:00:00
abstract:INTRODUCTION:Expanding the criteria for deceased organ donors increases the risk of delayed graft function (DGF) and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocalin (NGAL), a novel biomarker for acute kidney injury, could predict DGF after transplantation. MET...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10220
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Protocols using high levels of positive end-expiratory pressure (PEEP) in combination with low tidal volumes have been shown to reduce mortality in patients with severe acute respiratory distress syndrome (ARDS). However, the optimal method for setting PEEP is yet to be defined. It has been shown that resp...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10236
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Epidemiological studies have provided inconsistent results on whether intensive care unit (ICU) discharge at night and on weekends is associated with an increased risk of mortality. This systematic review and meta-analysis aimed to determine whether ICU discharge time was associated with hospital mortality. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s13054-016-1569-x
更新日期:2016-12-01 00:00:00
abstract::The European Clinical Trials Directive requires an informed consent from the patient or a proxy in drug trials. Although informed consent is a valuable tool to protect patients' rights in clinical trials, this requirement largely impedes research in critical care settings, and if pursued in this context, it does not p...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10113
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Appropriate care for patients with tracheostomies in hospital settings is an important issue. Each year more than 7000 patients receive tracheostomies in Australia and New Zealand alone. Many of these tracheostomy patients commence their care in the intensive care unit (ICU) and once stabilised are then tr...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8159
更新日期:2009-01-01 00:00:00
abstract::Women are generally under-represented in many academic medical settings. Through a brief commentary on this issue, the present article discusses possible explanations for this under-representation as well as potential solutions. Issues examined include women in leadership positions, attrition out of academic medicine,...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11915
更新日期:2013-01-29 00:00:00
abstract:INTRODUCTION:Diclofenac, a nonsteroidal antiinflammatory drug, is commonly used as antipyretic therapy in intensive care. The purpose of this study was to investigate the effects of parenteral diclofenac infusion on brain homeostasis, including brain-tissue oxygen tension (PbtO2) and brain metabolism after aneurysmal s...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12714
更新日期:2013-05-12 00:00:00
abstract:INTRODUCTION:There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved. METHODS:We interrogated the Australian New Zealand Intensive Care Society Adult Patient Database to obtain data ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5949
更新日期:2007-01-01 00:00:00
abstract::Climate change and environmental stewardship are phrases that have been defining the past few decades and promoting change in our societies. The sensitivities of intensive care as a specialty make the process of greening an intensive care unit a challenge, but not one that is insurmountable. This paper discusses oppor...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9409
更新日期:2011-01-01 00:00:00
abstract::Type 2 diabetes has reached epidemic proportions in many parts of the world. The disease is projected to continue to increase and double within the foreseeable future. Dysglycaemia develops in the form of hyperglycaemia, hypoglycaemia and marked glucose variability in critically ill adults whether they are known to ha...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9266
更新日期:2010-01-01 00:00:00
abstract::Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypas...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-2743-8
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis. METHODS:This was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13054-018-2240-5
更新日期:2018-11-20 00:00:00
abstract:INTRODUCTION:Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieved is still not clearly defined. The aim of the present study was to evaluate the dynamics of the a...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc3774
更新日期:2005-10-05 00:00:00
abstract:BACKGROUND:Neurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in healthcare costs and long-term outcome for different forms of neurocritical illnesses treated in the intensive care unit (ICU). METHODS:We used the prospective Finnish Intensive Care Consort...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-018-2151-5
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcircula...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2418-5
更新日期:2019-04-11 00:00:00
abstract::The burden of chronic obstructive pulmonary disease on intensive care is heavy, but newer modalities of treatment are now available to improve outcomes. Cardiac-based research continues to generate new drugs and tests to better outcome and aid in early diagnosis. And how do various intensive care interventions compare...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8130
更新日期:2009-01-01 00:00:00
abstract::Emergency departments (EDs) face several challenges in maintaining consistent quality care in the face of steadily increasing public demand. Improvements in the survival rate of critically ill patients in the ED are directly related to the advancement of early recognition and treatment. Frequent episodes of overcrowdi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0692-9
更新日期:2014-12-08 00:00:00
abstract:BACKGROUND:Simvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13054-017-1695-0
更新日期:2017-05-17 00:00:00
abstract:INTRODUCTION:The interdependence between endotoxemia, gram negative (GN) bacteremia and mortality has been extensively studied. Underlying patient risk and GN bacteremia types are possible confounders of the relationship. METHODS:Published studies with ≥ 10 patients in either ICU or non-ICU settings, endotoxemia detec...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc11462
更新日期:2012-08-07 00:00:00
abstract::In sepsis, inflammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets), endothelial and smooth muscle cells. Microparticles are proinflammatory and procoagulant fragments originating from plasma membrane generated after cellular activation a...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9231
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission. METHODS:We conducted a prospective observational study enrolling patients admitted to the ICU with severe se...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1000-z
更新日期:2015-08-27 00:00:00
abstract:INTRODUCTION:The accurate assessment of intravascular volume status for the therapy of severe hypovolemia and shock is difficult and critical to critically ill patients. Non-invasive evaluation of fluid responsiveness by the rapid infusion of a very limited amount of volume is an important clinical goal. This study aim...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13891
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2623-2
更新日期:2019-11-09 00:00:00
abstract:INTRODUCTION:Severe hypoglycemia (blood glucose concentration (BG) < 40 mg/dL) is independently associated with an increased risk of mortality in critically ill patients. The association of milder hypoglycemia (BG < 70 mg/dL) with mortality is less clear. METHODS:Prospectively collected data from two observational coh...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc10322
更新日期:2011-07-25 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-2776-z
更新日期:2020-03-24 00:00:00