Abstract：
:The cutoff values of fractional flow reserve (FFR) to detect physiological myocardial ischemia are still controversial. Some studies have reported that left ventricular (LV) dyssynchrony occurs in patients with coronary artery disease (CAD). The purpose of this study was to investigate LV dyssynchrony in patients with moderate coronary stenosis and borderline FFR, using stress electrocardiographically-gated myocardial perfusion single-photon emission computed tomography (SPECT). The study population comprised 10 patients with moderate (50-75% diameter) stenosis and an FFR in the range 0.75-0.90, who were compared to 10 control subjects. All underwent stress myocardial (99m)Tc-sestamibi (MIBI) or tetrofosmin SPECT imaging. The regional time to end systole (TES), time to peak ejection (TPE), and time to peak filling (TPF) were obtained as indexes of perfusion and function, using gated SPECT (pFAST) in combination with Cardio Gated SPECT Regional Assessment for LV Function (cardioGRAF). The dyssynchrony index (DI) was also calculated. The DI of post-stress TES was significantly greater than that of rest in patients with moderate CAD (4.8 ± 2.8 vs. 2.7 ± 1.5, P = 0.01), but there were no significant differences in the control subjects (3.0 ± 1.7 vs. 2.9 ± 1.9, P = 0.99). There were no significant differences in TPE and TPF between the groups. In conclusion, LV dyssynchrony may occur after stress in patients with coronary stenosis and borderline FFR, even without a significant reduction in perfusion.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Shibata Y,Sone T,Tsuboi H,Isobe S,Ishii H,Suzuki S,Hayashi M,Murohara Tsubject
Has Abstractpub_date
2015-02-01 00:00:00pages
155-66issue
1-2eissn
0027-7622issn
2186-3326journal_volume
77pub_type
杂志文章abstract：:In the present study, we developed quantitative index for evaluating regional liver function using 99mTc diethylenetriamine-pentaacetic acid galactosyl human serum albumin (GSA). A three head SPECT equipped with a low energy high resolution parallel hole collimator was used. Used pre-filter was Butterworth and axial i...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:To evaluate the adaptability of children with cleft lip and/or palate to school, their mental images of the school environment were investigated in a semantic differential method survey using 23 pairs of adjectives. The following eight places on and off the school grounds were chosen as environmental factors; classroo...
journal_title：Nagoya journal of medical science
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
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journal_title：Nagoya journal of medical science
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pub_type： 杂志文章,随机对照试验
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journal_title：Nagoya journal of medical science
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.3.501
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.2.193
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
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journal_title：Nagoya journal of medical science
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doi：
更新日期：2010-08-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
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journal_title：Nagoya journal of medical science
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更新日期：1998-10-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.80.4.451
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journal_title：Nagoya journal of medical science
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journal_title：Nagoya journal of medical science
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journal_title：Nagoya journal of medical science
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journal_title：Nagoya journal of medical science
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更新日期：2015-02-01 00:00:00
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