Abstract:
:Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding the pathogenesis of asbestos-induced DMM, which may be summarized as follows: (1) the "oxidative stress theory" is based on the fact that phagocytic cells that engulf asbestos fibers produce large amounts of free radicals due to their inability to digest the fibers, and epidemiological studies indicating that iron-containing asbestos fibers appear more carcinogenic; (2) the "chromosome tangling theory" postulates that asbestos fibers damage chromosomes when cells divide; and (3) the "theory of adsorption of many specific proteins as well as carcinogenic molecules" states that asbestos fibers in vivo concentrate proteins or chemicals including the components of cigarette smoke. Elucidation of the major mechanisms underlying DMM would be helpful for the development of novel strategies to prevent DMM induction in people who have already been exposed to asbestos.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Toyokuni Ssubject
Has Abstractpub_date
2009-02-01 00:00:00pages
1-10issue
1-2eissn
0027-7622issn
2186-3326journal_volume
71pub_type
杂志文章,评审abstract::Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underl...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.4.629
更新日期:2019-11-01 00:00:00
abstract::Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.Z-Lepr...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::The distribution of nerve fibers containing either calcitonin gene-related peptide (CGRP) and substance P (SP) was investigated in rat skin with special reference to their relationship to the lymphatic vessels. These nerve fibers exhibited a similar distribution pattern but the former were more numerous than the latte...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::To evaluate the circulatory disturbances, sensory disturbances and damage to muscles and joints by chain saw vibration exposure, the process of the deterioration of the symptoms with chain saw operating time was studied. Subjects were classified into eight groups according to TOT (Total Operating Time): Group 0, 46 co...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Disorientation responses of animals exposed to microgravity produced by parabolic aircraft flights and also in-space experiments were reviewed. Disoriented postures in floating are largely species-dependent. Reflexive lowered tone of gravity-bearing extensor muscles by labyrinthectomy is not seen in mammals (hamster a...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::Thoracoscopic lobectomy has recently become a widely used surgical treatment for congenital cystic lung disease, but significant issues can arise in some cases, such as a limited working space in neonates, a limited view in cases involving large cystic lesions. We reviewed the treatment outcomes of neonates that under...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.78.4.447
更新日期:2016-12-01 00:00:00
abstract::The aim of this study was to determine the clinical safety and efficacy of preoperative embolization of meningiomas with low-concentration n-butyl cyanoacrylate (NBCA). Nineteen cases of hypervascular intracranial meningiomas were treated by preoperative embolization with 14% NBCA, using a wedged superselective cathet...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::We conducted a study of the effect of intravitreal plasmin on retinal thickness in rabbits. Forty rabbit eyes were injected with 0.4, 1, 2, and 5 IU of plasmin (8 eyes/group). The same volume of BSS-plus(®) was injected in control eyes. Four eyes in each group underwent vitrectomy 60 minutes after the injections. The ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::Dialysis-induced hypotension, the sharp decrease in blood pressure occurring during hemodialysis, remains one of the most difficult problems associated with hemodialysis even today. However, there is yet no established theory to explain the mechanism triggering dialysis-induced hypotension. This review attempts to off...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::Autologous nerve transplantation has been the gold standard in the treatment of facial nerve injury, however it has not been achieved satisfactory result and needs donor sacrifice. A polyglycolic acid collagen conduit (Nerbridge, Toyobo Co., Japan) has the potential to compare to or exceed autologous nerve grafts in p...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.1.123
更新日期:2020-02-01 00:00:00
abstract::Since smoking is implicated in many diseases, medical professionals are expected to contribute to the reduction of smoking rates in their practice. Medical students are also expected to learn the importance of practical measures against smoking. This study surveyed the smoking rates and attitudes to smoking among medi...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::Being homebound has been reported to be associated with a number of conditions. In the current study, the incidence of homebound individuals was surveyed in an urban city area in Japan. The city office randomly enrolled 5,000 residents of Nagoya City aged 65 and over. A questionnaire was sent to their principal caregi...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::The influence of total ischemia on the formation of products of anaerobic metabolism was investigated in canine hearts in vitro. Contents of organic acids were quantitatively analyzed by gas chromatography-mass spectrometry, and high energy phosphate compounds were determined using the luciferin-luciferase enzyme syst...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1994-03-01 00:00:00
abstract::A case treated with onlay bone grafting and simultaneous osseointegrated implant insertion is reported. The patient had an oronasal fistula in the center of the premaxillary region due to failed repair of a bilateral cleft palate. Four fixtures were inserted with onlay bone grafting of the maxillary alveolar ridge. Tw...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::In endovascular coil embolization for intracranial aneurysms, as coils are filled in the aneurysm and the stage of procedure is advanced, the force to push forward the coil delivery wire (insertion force) increases. However, the coil insertion force that interventionist's felt at his fingertips does not directly refle...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.2.217
更新日期:2019-05-01 00:00:00
abstract::Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous st...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:10.18999/nagjms.78.4.349
更新日期:2016-12-01 00:00:00
abstract::Surgeons focus on the period of absence from work during the initial treatment of breast cancer. The aim of this study was to determine surgeons' perceptions and awareness regarding the necessary period of absence from work during breast cancer treatment. We created a questionnaire for all surgeons involved in breast ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
abstract::Binding of epidermal growth factor (EGF) to its receptor was evaluated in the four cultured choriocarcinoma cell lines BeWo, NaUCC-1, NaUCC-2, and NaUCC-3. Also, the effect of the anti-tumor drugs actinomycin-D (Act-D) and methotrexate (MTX) on the EGF receptor binding was investigated in these cell lines. Incubation ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::API2-MALT1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma is thought to transform to diffuse large B-cell lymphoma (DLBCL) rarely. A 69-year-old man presented with epigastralgia. Esophagogastroduodenoscopy showed multiple ulcerations in the stomach. Endoscop...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.2.251
更新日期:2017-02-01 00:00:00
abstract::Dermal sinus tracts (DSTs) of the cervical and thoracic spine are extremely rare, particularly in adult patients because diagnosis is typically made in the early stage after birth by pediatricians. These cases should be treated surgically as soon as possible to prevent neurological sequelae. This report describes two ...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.3.567
更新日期:2020-08-01 00:00:00
abstract::Yokukansankachimpihange (YKSCH), a traditional Japanese medicine, is widely used for the amelioration of the behavioral and psychological symptoms of dementia with digestive dysfunction. Regardless of its successful use for digestive dysfunction, the effect of YKSCH on body weight was unknown. Furthermore, if YKSCH in...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.3.351
更新日期:2017-08-01 00:00:00
abstract::Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Vietnam is facing a problem of over-crowding in public hospitals. Long waiting time is a major dissatisfaction for patients. Reducing waiting time benefits not only patients but also hospitals in decreasing overall workload. To identify factors contributing to long waiting time in outpatient clinics, a cross-sectional...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.2.227
更新日期:2018-05-01 00:00:00
abstract::Visual dysfunction can be caused by several abnormalities, including dysfunctions in the visual cortex and retina. Our aim was to investigate changes in visual evoked brain responses in the primary visual cortex associated with Parkinson's disease (PD). Sixteen healthy control subjects and ten patients with PD partici...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.2.147
更新日期:2017-02-01 00:00:00
abstract::Over the last two decades, many attempts have been made to record electroretinograms (ERG) of human macula by several investigators. However, previous ERG responses were not informative enough, because each ERG component could not be evaluated independently. However, we have developed a new system for recording focal ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1998-10-01 00:00:00
abstract::Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the m...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.3.397
更新日期:2019-08-01 00:00:00
abstract::To evaluate the adaptability of children with cleft lip and/or palate to school, their mental images of the school environment were investigated in a semantic differential method survey using 23 pairs of adjectives. The following eight places on and off the school grounds were chosen as environmental factors; classroo...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::As molecular biology has developed, several new diagnostic techniques have found application in the clinical setting. The use of the polymerase chain reaction (PCR) assay to study the molecular biology of microbial organisms has led to unparalleled advances, largely due to the rapidity with which results can be obtain...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
abstract::The purpose of this matched case-control study was to investigate the social correlates of primary infertility among females aged 35 years or less. The study was conducted in the Clinics of Samarkand Medical Institute, Uzbekistan, among 120 infertile and 120 healthy women matched by age, residential area, and occupati...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00