Abstract:
:Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding the pathogenesis of asbestos-induced DMM, which may be summarized as follows: (1) the "oxidative stress theory" is based on the fact that phagocytic cells that engulf asbestos fibers produce large amounts of free radicals due to their inability to digest the fibers, and epidemiological studies indicating that iron-containing asbestos fibers appear more carcinogenic; (2) the "chromosome tangling theory" postulates that asbestos fibers damage chromosomes when cells divide; and (3) the "theory of adsorption of many specific proteins as well as carcinogenic molecules" states that asbestos fibers in vivo concentrate proteins or chemicals including the components of cigarette smoke. Elucidation of the major mechanisms underlying DMM would be helpful for the development of novel strategies to prevent DMM induction in people who have already been exposed to asbestos.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Toyokuni Ssubject
Has Abstractpub_date
2009-02-01 00:00:00pages
1-10issue
1-2eissn
0027-7622issn
2186-3326journal_volume
71pub_type
杂志文章,评审abstract::Meningiomas are common spinal tumor and mostly located at intradura. Recurrence rate after surgery for extradural meningioma was higher than intradural meningioma. A patient with intra and extradural spinal meningioma was treated and discussed its features and clinical management. A 41-year-old woman noted numbness of...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.1.115
更新日期:2017-02-01 00:00:00
abstract::The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.4.559
更新日期:2018-11-01 00:00:00
abstract::Curved intertrochanteric varus osteotomy (CVO) is one of the good surgical procedures for avascular necrosis of the femoral head (ANFH) patients. However, some patients with failed CVO are converted to total hip arthroplasty (THA) as a salvage operation. We compared the clinical and radiographic outcomes of 10 hips co...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2016-02-01 00:00:00
abstract::A new hypothesis for the origin of metastases is presented. It assumes that a cancer-transformed gene in a primary tumour is incorporated in its identical form via a virus-vector function into biologically potent recipient cells in other organs, such as stem cells, multipotent cells or cells in an early phase of divis...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2013-02-01 00:00:00
abstract::Metabolic syndrome (MetS) is characterized by the presence of atherogenic risk factors, and is associated with a marked increase in the risk of cardiovascular disease. Recently, the criteria of MetS were newly defined in Japan. We examined the relationship between MetS and the various metabolic parameters in Japanese ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::The cutoff values of fractional flow reserve (FFR) to detect physiological myocardial ischemia are still controversial. Some studies have reported that left ventricular (LV) dyssynchrony occurs in patients with coronary artery disease (CAD). The purpose of this study was to investigate LV dyssynchrony in patients with...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-02-01 00:00:00
abstract::Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.Z-Lepr...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::The distribution of nerve fibers containing either calcitonin gene-related peptide (CGRP) and substance P (SP) was investigated in rat skin with special reference to their relationship to the lymphatic vessels. These nerve fibers exhibited a similar distribution pattern but the former were more numerous than the latte...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Patients with intestinal ischemia associated with acute aortic dissection often require emergent bowel resection, which results in serious complications. We present a case of successful surgical management of extensive bowel necrosis caused by acute aortic dissection. A 42-year-old man underwent emergent subtotal rese...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.81.4.711
更新日期:2019-11-01 00:00:00
abstract::Accessibility to health care services in Thailand is generally good, but a few areas in the country are difficult to reach. The purpose of this study was to investigate the accessibility of health care services in rural and remote areas of Thailand. It was conducted in 16 remote villages within a catchment area with a...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2013-08-01 00:00:00
abstract::Being homebound has been reported to be associated with a number of conditions. In the current study, the incidence of homebound individuals was surveyed in an urban city area in Japan. The city office randomly enrolled 5,000 residents of Nagoya City aged 65 and over. A questionnaire was sent to their principal caregi...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::API2-MALT1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma is thought to transform to diffuse large B-cell lymphoma (DLBCL) rarely. A 69-year-old man presented with epigastralgia. Esophagogastroduodenoscopy showed multiple ulcerations in the stomach. Endoscop...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.2.251
更新日期:2017-02-01 00:00:00
abstract::We retrospectively reviewed 12 patients (3 men and 9 women, with a mean age of 72 years) who were surgically treated for carpal tunnel syndrome associated with Kienböck disease. All patients except 1 were incidentally diagnosed with Kienböck disease and had little or no wrist pain. Radiographic tests revealed advanced...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2016-08-01 00:00:00
abstract::Dermal sinus tracts (DSTs) of the cervical and thoracic spine are extremely rare, particularly in adult patients because diagnosis is typically made in the early stage after birth by pediatricians. These cases should be treated surgically as soon as possible to prevent neurological sequelae. This report describes two ...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.3.567
更新日期:2020-08-01 00:00:00
abstract::Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's d...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.4.451
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS:Twenty-two helical CT scans of the lung were obtained in 11 health...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::As molecular biology has developed, several new diagnostic techniques have found application in the clinical setting. The use of the polymerase chain reaction (PCR) assay to study the molecular biology of microbial organisms has led to unparalleled advances, largely due to the rapidity with which results can be obtain...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
abstract::A study was conducted to clarify the prognostic factors related to recurrence of craniopharyngioma and to improve the quality of life of patients by the treatment with intentional partial removal and gamma knife radiosurgery. One hundred cases of craniopharyngioma have been treated at Komaki City Hospital since 1991. ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::This study was aimed to evaluate the relationship between serum interleukin-23 (IL-23) levels and ankylosing spondylitis (AS).Twenty male patients diagnosed with ankylosing spondylitis according to the 1984 modified New York criteria for AS and twenty male healthy controls were included in this study.The demographic c...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-11-01 00:00:00
abstract::The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) is a long-term cohort study to investigate the interactions among genotypes, lifestyles, and lifestyle-related diseases, especially cancer. This article reports the outline of the baseline survey of the Daiko Study, one site of the J-MICC Study. T...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract::The immunohistochemical localization of basic fibroblast growth factor (FGF-2) in the submandibular glands of the rat was investigated by use of an antiserum to FGF-2. Nerve fiber bundles with FGF-2-immunoreactivity were found in association with interlobular ducts and blood vessels; they dissociated into single immun...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::We investigated the differences in Japanese and United States medical and legal professional opinions on ethical support for clinical ethical issues using the refusal of blood transfusions on the grounds of religious principles as an example of a clinical ethical issue. In ethical support systems for medical instituti...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.2.193
更新日期:2020-05-01 00:00:00
abstract::Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the m...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.3.397
更新日期:2019-08-01 00:00:00
abstract::The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psyc...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:10.18999/nagjms.80.3.309
更新日期:2018-08-01 00:00:00
abstract::Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::The purpose of this study was to demonstrate the characteristics of the Instrumental Activities of Daily Living (IADL) ability, evaluated by the Assessment of Motor and Process Skills (AMPS), and everyday memory functions (the memory necessary for daily life), assessed by the Rivermead Behavioral Memory Test (RBMT) in...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 micrograms/kg/mi...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::A 47-year-old woman diagnosed with Marfan syndrome underwent valve-sparing aortic root replacement for aortic regurgitation and annulo-aortic ectasia. Her cardiac function was normal. Preoperative coronary angiography did not demonstrate any stenosis. The David reimplantation procedure with a 28-mm Valsalva graft was ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::Dialysis-induced hypotension, the sharp decrease in blood pressure occurring during hemodialysis, remains one of the most difficult problems associated with hemodialysis even today. However, there is yet no established theory to explain the mechanism triggering dialysis-induced hypotension. This review attempts to off...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00