Abstract:
:Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is the standard regimen for patients with primary breast cancer. Among the taxanes, conventional paclitaxel (PTX) and docetaxel have usually been adopted in the neoadjuvant or adjuvant setting. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a solvent-free formulation that can be delivered to cancer cells at higher doses than conventional PTX. This study is a retrospective observational study in a single institution. We evaluated the efficacy and safety of nab-PTX followed by 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) in the neoadjuvant setting. In this study, 50 patients with primary breast cancer received nab-PTX (q3w, 260 mg/m2 ± trastuzumab 6 mg/kg) followed by FEC (q3w, 5-fluorouracil 500 mg/m2, epirubicin 100 mg/m2, and cyclophosphamide 500 mg/m2) prior to surgery. The efficacy was evaluated using the clinical response rate (CRR), pathological complete response (pCR) rate, and Ki67 labeling index. Safety was evaluated using the frequency of treatment-related adverse events and relative dose intensity (RDI). All patients received at least one course of chemotherapy. The CRR and pCR rate were 88.0% and 40.0%, respectively. The mean Ki67 labeling index was significantly decreased from 47.7% to 24.6% after NAC. The safety profiles were comparable with previously reported regimens, and high RDIs were obtained (97.2% for nab-PTX and 95.5% for FEC). This study illustrated the efficacy and tolerability of a neoadjuvant regimen of nab-PTX followed by FEC.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Shizuku M,Shibata M,Shimizu Y,Takeuchi D,Mizuno Ydoi
10.18999/nagjms.82.3.457subject
Has Abstractpub_date
2020-08-01 00:00:00pages
457-467issue
3eissn
0027-7622issn
2186-3326journal_volume
82pub_type
杂志文章abstract::The purpose of this matched case-control study was to investigate the social correlates of primary infertility among females aged 35 years or less. The study was conducted in the Clinics of Samarkand Medical Institute, Uzbekistan, among 120 infertile and 120 healthy women matched by age, residential area, and occupati...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That's why an association between genetic background and PSA levels should be ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,多中心研究
doi:
更新日期:2013-02-01 00:00:00
abstract::We report a patient with a multicystic kidney treated successfully by continuous percutaneous drainage. This method may be an alternative to surgical resection of a multicystic kidney that has not involved after one year of follow-up. ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::The Japanese Orthopaedic Association has proposed the term "locomotive syndrome" to designate a condition that places a person at high risk for long-term care. However, in daily clinical practice, even when a diagnosis of locomotive syndrome is made, exercise therapy often cannot be successfully performed in some pati...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.1.43
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abstract::Over the last two decades, many attempts have been made to record electroretinograms (ERG) of human macula by several investigators. However, previous ERG responses were not informative enough, because each ERG component could not be evaluated independently. However, we have developed a new system for recording focal ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
abstract::The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.4.559
更新日期:2018-11-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2013-02-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:2009-02-01 00:00:00
abstract::As molecular biology has developed, several new diagnostic techniques have found application in the clinical setting. The use of the polymerase chain reaction (PCR) assay to study the molecular biology of microbial organisms has led to unparalleled advances, largely due to the rapidity with which results can be obtain...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.81.4.711
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2016-08-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:2011-08-01 00:00:00
abstract::Since smoking is implicated in many diseases, medical professionals are expected to contribute to the reduction of smoking rates in their practice. Medical students are also expected to learn the importance of practical measures against smoking. This study surveyed the smoking rates and attitudes to smoking among medi...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psyc...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:10.18999/nagjms.80.3.309
更新日期:2018-08-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.3.411
更新日期:2018-08-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::The biological effects of static magnetic fields, and their combined effects with ionizing radiation, were studied using a cultured mammalian cell line (FM3A). The three different modes of magnetic fields evaluated in this report were the 0.3 Tesla (T) field with a gradient of 0.3T/m, the 0.7T field with a gradient of...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.78.4.447
更新日期:2016-12-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
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journal_title:Nagoya journal of medical science
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doi:
更新日期:2011-08-01 00:00:00
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journal_title:Nagoya journal of medical science
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journal_title:Nagoya journal of medical science
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更新日期:2014-02-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
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journal_title:Nagoya journal of medical science
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abstract::Disorientation responses of animals exposed to microgravity produced by parabolic aircraft flights and also in-space experiments were reviewed. Disoriented postures in floating are largely species-dependent. Reflexive lowered tone of gravity-bearing extensor muscles by labyrinthectomy is not seen in mammals (hamster a...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
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journal_title:Nagoya journal of medical science
pub_type: 杂志文章
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