Abstract：
:Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes and on the binding ratio of postulated copper transfer proteins between the cytosol and lysosomes. Eight patients were in stage 1 with an initial accumulation of lysosomal cuproproteins, mediated by transfer proteins not saturated with copper. Two patients were in stage 2, in which transfer proteins were saturated with copper. The first two stages gave negative results for histochemical copper. The remaining eight patients were in stage 3, in which copper accumulation detected by histochemical included transfer proteins saturated with copper and large amounts of lysosomal cuproproteins. Five patients (one each in stages 1 and 2, and three in stage 3) underwent a second liver biopsy after treatment with 600 mg of ursodeoxycholic acid daily for 14 to 39 months. Results of blood chemistry tests improved, but liver histologic findings and copper accumulation were unchanged in all five patients. It seems likely that ursodeoxycholic acid does not affect the copper accumulation in hepatocyte lysosomes that reflects the state of cholestasis in patients with primary biliary cirrhosis.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Takeshima H,Yagi A,Yano M,Sakamoto N,Kato S,Kuriki J,Arao M,Takikawa T,Hayashi Hsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
115-23issue
1-4eissn
0027-7622issn
2186-3326journal_volume
55pub_type
杂志文章abstract：:We investigated the differences in Japanese and United States medical and legal professional opinions on ethical support for clinical ethical issues using the refusal of blood transfusions on the grounds of religious principles as an example of a clinical ethical issue. In ethical support systems for medical instituti...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.2.193
更新日期：2020-05-01 00:00:00
abstract：:Dialysis-induced hypotension, the sharp decrease in blood pressure occurring during hemodialysis, remains one of the most difficult problems associated with hemodialysis even today. However, there is yet no established theory to explain the mechanism triggering dialysis-induced hypotension. This review attempts to off...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
abstract：:Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph's nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old woman visited local clinics with complaints of an u...
journal_title：Nagoya journal of medical science
pub_type：
doi：10.18999/nagjms.81.2.325
更新日期：2019-05-01 00:00:00
abstract：:A 47-year-old woman diagnosed with Marfan syndrome underwent valve-sparing aortic root replacement for aortic regurgitation and annulo-aortic ectasia. Her cardiac function was normal. Preoperative coronary angiography did not demonstrate any stenosis. The David reimplantation procedure with a 28-mm Valsalva graft was ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2015-08-01 00:00:00
abstract：:Temporary threshold shifts (TSSs) in vibrotactile perception produced by continuous vibration and repetitive shocks having one complete cycle of a 100 Hz sine wave and exponential decays. The repetition rate of the cycles was 5, 25, 50, or 100/s, while the root-mean-square (r.m.s.) acceleration measured over exposure ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：PURPOSE:To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS:Twenty-two helical CT scans of the lung were obtained in 11 health...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:Communication errors are the most important cause of adverse events in healthcare. The current study aimed to improve hospital-wide employee teamwork and reduce adverse medical events for patients arising from miscommunication. In our hospital, when patient safety incidents and accidents occur, staff from various occu...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.4.697
更新日期：2020-11-01 00:00:00
abstract：:Meningiomas are common spinal tumor and mostly located at intradura. Recurrence rate after surgery for extradural meningioma was higher than intradural meningioma. A patient with intra and extradural spinal meningioma was treated and discussed its features and clinical management. A 41-year-old woman noted numbness of...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.1.115
更新日期：2017-02-01 00:00:00
abstract：:A new hypothesis for the origin of metastases is presented. It assumes that a cancer-transformed gene in a primary tumour is incorporated in its identical form via a virus-vector function into biologically potent recipient cells in other organs, such as stem cells, multipotent cells or cells in an early phase of divis...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：:Sixteen operative cases of parasagittal and falx meningioma were analyzed retrospectively. Parasagittal meningioma totaled 12 cases and falx meningioma numbered 4 cases. Preoperative symptoms were paresis of a lower extremity in 7 cases and disturbed consciousness or mentality in 6 cases. Paresis and/or consciousness ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:Experimental middle ear barotrauma was studied morphologically. White guinea pigs were placed in an experimental hyperbaric chamber, and middle ear barotrauma was created by increasing the pressure in the hyperbaric chamber from 1 atmosphere absolute (ATA) to 2 ATA using pure oxygen, maintaining the pressure at 2 ATA ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：:Curved intertrochanteric varus osteotomy (CVO) is one of the good surgical procedures for avascular necrosis of the femoral head (ANFH) patients. However, some patients with failed CVO are converted to total hip arthroplasty (THA) as a salvage operation. We compared the clinical and radiographic outcomes of 10 hips co...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:Proteinuria is an established risk factor for diabetic nephropathy. Recent studies indicate that some xanthine oxidase inhibitors have a renoprotective effect. The aim of this study was to assess whether topiroxostat reduces albuminuria in hyperuricemic patients with diabetic nephropathy and overt proteinuria. The ETU...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-05-01 00:00:00
abstract：:Binding of epidermal growth factor (EGF) to its receptor was evaluated in the four cultured choriocarcinoma cell lines BeWo, NaUCC-1, NaUCC-2, and NaUCC-3. Also, the effect of the anti-tumor drugs actinomycin-D (Act-D) and methotrexate (MTX) on the EGF receptor binding was investigated in these cell lines. Incubation ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The distribution of nerve fibers containing either calcitonin gene-related peptide (CGRP) and substance P (SP) was investigated in rat skin with special reference to their relationship to the lymphatic vessels. These nerve fibers exhibited a similar distribution pattern but the former were more numerous than the latte...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous st...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：10.18999/nagjms.78.4.349
更新日期：2016-12-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of interventions to reduce patient misidentification incidents classified as level 2 and over (adverse events occurred for patients) with the step-by-step problem-solving method. All incidents related to patient misidentification were selected, and relevant information was col...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.82.2.315
更新日期：2020-05-01 00:00:00
abstract：:Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That's why an association between genetic background and PSA levels should be ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,多中心研究
doi：
更新日期：2013-02-01 00:00:00
abstract：:We conducted a study of the effect of intravitreal plasmin on retinal thickness in rabbits. Forty rabbit eyes were injected with 0.4, 1, 2, and 5 IU of plasmin (8 eyes/group). The same volume of BSS-plus(®) was injected in control eyes. Four eyes in each group underwent vitrectomy 60 minutes after the injections. The ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：:Research into the molecular genetics and pathomechanisms of ichthyoses have advanced considerably, resulting in the identification of several causative genes and molecules underlying the disease. In 2009, the First Ichthyosis Consensus Conference was held to establish a consensus for the nomenclature and classificatio...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：2011-08-01 00:00:00
abstract：:In endovascular coil embolization for intracranial aneurysms, as coils are filled in the aneurysm and the stage of procedure is advanced, the force to push forward the coil delivery wire (insertion force) increases. However, the coil insertion force that interventionist's felt at his fingertips does not directly refle...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.2.217
更新日期：2019-05-01 00:00:00
abstract：:Wrapping and graft replacement are two optional procedures for the treatment of dilated ascending aorta at the time of aortic valve replacement (AVR). Wrapping is considered less invasive. The aim of this study was to compare the short- and long-term clinical outcomes as well as the long-term quality of life in patien...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.4.443
更新日期：2017-11-01 00:00:00
abstract：:Yokukansankachimpihange (YKSCH), a traditional Japanese medicine, is widely used for the amelioration of the behavioral and psychological symptoms of dementia with digestive dysfunction. Regardless of its successful use for digestive dysfunction, the effect of YKSCH on body weight was unknown. Furthermore, if YKSCH in...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.3.351
更新日期：2017-08-01 00:00:00
abstract：:The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) is a long-term cohort study to investigate the interactions among genotypes, lifestyles, and lifestyle-related diseases, especially cancer. This article reports the outline of the baseline survey of the Daiko Study, one site of the J-MICC Study. T...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：:The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.80.4.559
更新日期：2018-11-01 00:00:00
abstract：:Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underl...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.4.629
更新日期：2019-11-01 00:00:00
abstract：:The aim of this study was to identify the socio-demographic characteristics, knowledge, attitude and accessibility factors related to the utilization of antenatal care (ANC) service among pregnant women in the Kham District, Laos. Data for this cross-sectional study were collected in July 2008, using a two-stage clust...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：:Over the last two decades, many attempts have been made to record electroretinograms (ERG) of human macula by several investigators. However, previous ERG responses were not informative enough, because each ERG component could not be evaluated independently. However, we have developed a new system for recording focal ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：:The survey involves examining the applications from 142 institutions that have consented to make available all certification applications from 2015 and 2016 to a research project for building a certification system for an ethics committee run by the Agency for Medical Research and Development. The number of certified ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.3.501
更新日期：2019-08-01 00:00:00
