Abstract:
:Proteinuria is an established risk factor for diabetic nephropathy. Recent studies indicate that some xanthine oxidase inhibitors have a renoprotective effect. The aim of this study was to assess whether topiroxostat reduces albuminuria in hyperuricemic patients with diabetic nephropathy and overt proteinuria. The ETUDE study is an ongoing 24-week, multicenter, open-label, randomized (1:1), parallel group study involving hyperuricemic patients with diabetic nephropathy (estimated glomerular filtration rate [eGFR] ≥ 20 mL/min/1.73 m(2)) and overt proteinuria (0.3 ≤ urine protein to creatinine ratio (UPCR) < 3.5 g/g Cr). Patients are randomly assigned to high dose (topiroxostat 160 mg daily) or low dose (topiroxostat 40 mg daily) on top of standard of care. The primary endpoint is the change in albuminuria indicated by urine albumin-to-creatinine ratio after 24 treated weeks relative to the baseline values. This trial was registered at the Japanese University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR: UMIN 000015403). The background, rationale, and study design of this trial are presented here. Seventy-six patients from four registered facilities have already been enrolled and received at least one dose of topiroxostat. This trial will end in 2017. The ETUDE trial is the first randomized controlled study of topiroxostat in hyperuricemic patients with diabetic nephropathy and overt proteinuria. We will clarify the pleiotropic function of topiroxostat including an anti-albumiuric effect as well as its effects on safely decreasing serum uric acid levels.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Kato S,Ando M,Mizukoshi T,Nagata T,Katsuno T,Kosugi T,Tsuboi N,Maruyama Ssubject
Has Abstractpub_date
2016-05-01 00:00:00pages
135-42issue
2eissn
0027-7622issn
2186-3326journal_volume
78pub_type
杂志文章,随机对照试验abstract::The Japanese Orthopaedic Association has proposed the term "locomotive syndrome" to designate a condition that places a person at high risk for long-term care. However, in daily clinical practice, even when a diagnosis of locomotive syndrome is made, exercise therapy often cannot be successfully performed in some pati...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.1.43
更新日期:2017-02-01 00:00:00
abstract::Wrapping and graft replacement are two optional procedures for the treatment of dilated ascending aorta at the time of aortic valve replacement (AVR). Wrapping is considered less invasive. The aim of this study was to compare the short- and long-term clinical outcomes as well as the long-term quality of life in patien...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.4.443
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to determine the clinical safety and efficacy of preoperative embolization of meningiomas with low-concentration n-butyl cyanoacrylate (NBCA). Nineteen cases of hypervascular intracranial meningiomas were treated by preoperative embolization with 14% NBCA, using a wedged superselective cathet...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::As molecular biology has developed, several new diagnostic techniques have found application in the clinical setting. The use of the polymerase chain reaction (PCR) assay to study the molecular biology of microbial organisms has led to unparalleled advances, largely due to the rapidity with which results can be obtain...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
abstract::Metabolic syndrome (MetS) is characterized by the presence of atherogenic risk factors, and is associated with a marked increase in the risk of cardiovascular disease. Recently, the criteria of MetS were newly defined in Japan. We examined the relationship between MetS and the various metabolic parameters in Japanese ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::Thoracoscopic lobectomy has recently become a widely used surgical treatment for congenital cystic lung disease, but significant issues can arise in some cases, such as a limited working space in neonates, a limited view in cases involving large cystic lesions. We reviewed the treatment outcomes of neonates that under...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.78.4.447
更新日期:2016-12-01 00:00:00
abstract::Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing, β-hydroxy-β-methylbutyrate (HMB) is important for collagen biosynthesis...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.1.33
更新日期:2020-02-01 00:00:00
abstract::Surgeons focus on the period of absence from work during the initial treatment of breast cancer. The aim of this study was to determine surgeons' perceptions and awareness regarding the necessary period of absence from work during breast cancer treatment. We created a questionnaire for all surgeons involved in breast ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
abstract::This study aimed to evaluate the efficacy of interventions to reduce patient misidentification incidents classified as level 2 and over (adverse events occurred for patients) with the step-by-step problem-solving method. All incidents related to patient misidentification were selected, and relevant information was col...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.2.315
更新日期:2020-05-01 00:00:00
abstract::Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous st...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:10.18999/nagjms.78.4.349
更新日期:2016-12-01 00:00:00
abstract::Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is the standard regimen for patients with primary breast cancer. Among the taxanes, conventional paclitaxel (PTX) and docetaxel have usually been adopted in the neoadjuvant or adjuvant setting. Nanoparticle albumin-bound paclitaxel (nab-...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.3.457
更新日期:2020-08-01 00:00:00
abstract::A total of 483 hips treated by primary total hip arthroplasty (THA) were investigated to evaluate the surgical skill of the performing surgeon. Surgical trainees operated on 259 hips and instructors on 224 hips. The average age of the patients at the time of THA in the trainee and instructor group was 61.9 and 60.8 ye...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-02-01 00:00:00
abstract::Yokukansankachimpihange (YKSCH), a traditional Japanese medicine, is widely used for the amelioration of the behavioral and psychological symptoms of dementia with digestive dysfunction. Regardless of its successful use for digestive dysfunction, the effect of YKSCH on body weight was unknown. Furthermore, if YKSCH in...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.3.351
更新日期:2017-08-01 00:00:00
abstract::We investigated the differences in Japanese and United States medical and legal professional opinions on ethical support for clinical ethical issues using the refusal of blood transfusions on the grounds of religious principles as an example of a clinical ethical issue. In ethical support systems for medical instituti...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.2.193
更新日期:2020-05-01 00:00:00
abstract::Over the last two decades, many attempts have been made to record electroretinograms (ERG) of human macula by several investigators. However, previous ERG responses were not informative enough, because each ERG component could not be evaluated independently. However, we have developed a new system for recording focal ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1998-10-01 00:00:00
abstract::Dialysis-induced hypotension, the sharp decrease in blood pressure occurring during hemodialysis, remains one of the most difficult problems associated with hemodialysis even today. However, there is yet no established theory to explain the mechanism triggering dialysis-induced hypotension. This review attempts to off...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::A 67-year-old man underwent posterior cervical decompression surgery for ossification of the posterior longitudinal ligament (OPLL) with fixation using cervical pedicle screws (CPSs) guided by intraoperative 3D image-based navigation. Intraoperatively, while creating the screw hole using the navigation probe, the virt...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.4.799
更新日期:2020-11-01 00:00:00
abstract::The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 micrograms/kg/mi...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::The purpose of this matched case-control study was to investigate the social correlates of primary infertility among females aged 35 years or less. The study was conducted in the Clinics of Samarkand Medical Institute, Uzbekistan, among 120 infertile and 120 healthy women matched by age, residential area, and occupati...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::Communication errors are the most important cause of adverse events in healthcare. The current study aimed to improve hospital-wide employee teamwork and reduce adverse medical events for patients arising from miscommunication. In our hospital, when patient safety incidents and accidents occur, staff from various occu...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.4.697
更新日期:2020-11-01 00:00:00
abstract::Argon-plasma coagulation, high-frequency electrosurgical snare, laser therapy, and microwave treatment are therapeutic options to reduce tumor-related stenosis of the central airway. These treatments may cause airway fire under a high concentration of oxygen, so FiO2 levels must be ≤40%. This restriction may be danger...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.3.411
更新日期:2018-08-01 00:00:00
abstract::Patients with intestinal ischemia associated with acute aortic dissection often require emergent bowel resection, which results in serious complications. We present a case of successful surgical management of extensive bowel necrosis caused by acute aortic dissection. A 42-year-old man underwent emergent subtotal rese...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.81.4.711
更新日期:2019-11-01 00:00:00
abstract::A study was conducted to clarify the prognostic factors related to recurrence of craniopharyngioma and to improve the quality of life of patients by the treatment with intentional partial removal and gamma knife radiosurgery. One hundred cases of craniopharyngioma have been treated at Komaki City Hospital since 1991. ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract::Surgical intervention for the treatment of acetabular fracture non-union is often challenging. Here, we present a case of acetabular fracture non-union with pelvic discontinuity in a patient who underwent cemented total hip arthroplasty (THA) after intra- and extra-articular plate fixation. The case was a 70-year-old ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.1.113
更新日期:2019-02-01 00:00:00
abstract::The immunohistochemical localization of basic fibroblast growth factor (FGF-2) in the submandibular glands of the rat was investigated by use of an antiserum to FGF-2. Nerve fiber bundles with FGF-2-immunoreactivity were found in association with interlobular ducts and blood vessels; they dissociated into single immun...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's d...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.4.451
更新日期:2018-11-01 00:00:00
abstract::Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That's why an association between genetic background and PSA levels should be ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,多中心研究
doi:
更新日期:2013-02-01 00:00:00
abstract::Dermal sinus tracts (DSTs) of the cervical and thoracic spine are extremely rare, particularly in adult patients because diagnosis is typically made in the early stage after birth by pediatricians. These cases should be treated surgically as soon as possible to prevent neurological sequelae. This report describes two ...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.3.567
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS:Twenty-two helical CT scans of the lung were obtained in 11 health...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::Malignant lymphoma is a heterogeneous category embracing three major types of lymphoid neoplasms: B cell neoplasms, T and NK cell neoplasms, and Hodgkin lymphoma. Within each type, distinct disease entities are defined based on a combination of morphology, immunophenotype, genetic features and clinical syndromes, the ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00