Abstract：
:Proteinuria is an established risk factor for diabetic nephropathy. Recent studies indicate that some xanthine oxidase inhibitors have a renoprotective effect. The aim of this study was to assess whether topiroxostat reduces albuminuria in hyperuricemic patients with diabetic nephropathy and overt proteinuria. The ETUDE study is an ongoing 24-week, multicenter, open-label, randomized (1:1), parallel group study involving hyperuricemic patients with diabetic nephropathy (estimated glomerular filtration rate [eGFR] ≥ 20 mL/min/1.73 m(2)) and overt proteinuria (0.3 ≤ urine protein to creatinine ratio (UPCR) < 3.5 g/g Cr). Patients are randomly assigned to high dose (topiroxostat 160 mg daily) or low dose (topiroxostat 40 mg daily) on top of standard of care. The primary endpoint is the change in albuminuria indicated by urine albumin-to-creatinine ratio after 24 treated weeks relative to the baseline values. This trial was registered at the Japanese University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR: UMIN 000015403). The background, rationale, and study design of this trial are presented here. Seventy-six patients from four registered facilities have already been enrolled and received at least one dose of topiroxostat. This trial will end in 2017. The ETUDE trial is the first randomized controlled study of topiroxostat in hyperuricemic patients with diabetic nephropathy and overt proteinuria. We will clarify the pleiotropic function of topiroxostat including an anti-albumiuric effect as well as its effects on safely decreasing serum uric acid levels.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Kato S,Ando M,Mizukoshi T,Nagata T,Katsuno T,Kosugi T,Tsuboi N,Maruyama Ssubject
Has Abstractpub_date
2016-05-01 00:00:00pages
135-42issue
2eissn
0027-7622issn
2186-3326journal_volume
78pub_type
杂志文章,随机对照试验abstract：:Binding of epidermal growth factor (EGF) to its receptor was evaluated in the four cultured choriocarcinoma cell lines BeWo, NaUCC-1, NaUCC-2, and NaUCC-3. Also, the effect of the anti-tumor drugs actinomycin-D (Act-D) and methotrexate (MTX) on the EGF receptor binding was investigated in these cell lines. Incubation ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Experimental middle ear barotrauma was studied morphologically. White guinea pigs were placed in an experimental hyperbaric chamber, and middle ear barotrauma was created by increasing the pressure in the hyperbaric chamber from 1 atmosphere absolute (ATA) to 2 ATA using pure oxygen, maintaining the pressure at 2 ATA ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history...
journal_title：Nagoya journal of medical science
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更新日期：2014-02-01 00:00:00
abstract：:Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes...
journal_title：Nagoya journal of medical science
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doi：
更新日期：1993-03-01 00:00:00
abstract：:Argon-plasma coagulation, high-frequency electrosurgical snare, laser therapy, and microwave treatment are therapeutic options to reduce tumor-related stenosis of the central airway. These treatments may cause airway fire under a high concentration of oxygen, so FiO2 levels must be ≤40%. This restriction may be danger...
journal_title：Nagoya journal of medical science
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doi：10.18999/nagjms.80.3.411
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更新日期：2019-11-01 00:00:00
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journal_title：Nagoya journal of medical science
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doi：
更新日期：2015-11-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.3.351
更新日期：2017-08-01 00:00:00
abstract：:Autologous nerve transplantation has been the gold standard in the treatment of facial nerve injury, however it has not been achieved satisfactory result and needs donor sacrifice. A polyglycolic acid collagen conduit (Nerbridge, Toyobo Co., Japan) has the potential to compare to or exceed autologous nerve grafts in p...
journal_title：Nagoya journal of medical science
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doi：10.18999/nagjms.82.1.123
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.1.113
更新日期：2019-02-01 00:00:00
abstract：:Surgeons focus on the period of absence from work during the initial treatment of breast cancer. The aim of this study was to determine surgeons' perceptions and awareness regarding the necessary period of absence from work during breast cancer treatment. We created a questionnaire for all surgeons involved in breast ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2014-08-01 00:00:00
abstract：:The influence of total ischemia on the formation of products of anaerobic metabolism was investigated in canine hearts in vitro. Contents of organic acids were quantitatively analyzed by gas chromatography-mass spectrometry, and high energy phosphate compounds were determined using the luciferin-luciferase enzyme syst...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
abstract：:Wrapping and graft replacement are two optional procedures for the treatment of dilated ascending aorta at the time of aortic valve replacement (AVR). Wrapping is considered less invasive. The aim of this study was to compare the short- and long-term clinical outcomes as well as the long-term quality of life in patien...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.4.443
更新日期：2017-11-01 00:00:00
abstract：:In endovascular coil embolization for intracranial aneurysms, as coils are filled in the aneurysm and the stage of procedure is advanced, the force to push forward the coil delivery wire (insertion force) increases. However, the coil insertion force that interventionist's felt at his fingertips does not directly refle...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.2.217
更新日期：2019-05-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.81.4.629
更新日期：2019-11-01 00:00:00
abstract：:A case treated with onlay bone grafting and simultaneous osseointegrated implant insertion is reported. The patient had an oronasal fistula in the center of the premaxillary region due to failed repair of a bilateral cleft palate. Four fixtures were inserted with onlay bone grafting of the maxillary alveolar ridge. Tw...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:As molecular biology has developed, several new diagnostic techniques have found application in the clinical setting. The use of the polymerase chain reaction (PCR) assay to study the molecular biology of microbial organisms has led to unparalleled advances, largely due to the rapidity with which results can be obtain...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：:Syntrophins are the cytoplasmic peripheral proteins of dystrophin glycoprotein complex, of which five (alpha l, beta 1, beta 2, gamma 1 and gamma 2) isoforms have been identified so far. Respective syntrophin isoforms are encoded by different genes but have similar domain structures. At the sarcolemma of skeletal musc...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2008-08-01 00:00:00
abstract：:Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous st...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：:The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psyc...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:The biological effects of static magnetic fields, and their combined effects with ionizing radiation, were studied using a cultured mammalian cell line (FM3A). The three different modes of magnetic fields evaluated in this report were the 0.3 Tesla (T) field with a gradient of 0.3T/m, the 0.7T field with a gradient of...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.2.147
更新日期：2017-02-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：2011-08-01 00:00:00
abstract：:The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 micrograms/kg/mi...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Temporary threshold shifts (TSSs) in vibrotactile perception produced by continuous vibration and repetitive shocks having one complete cycle of a 100 Hz sine wave and exponential decays. The repetition rate of the cycles was 5, 25, 50, or 100/s, while the root-mean-square (r.m.s.) acceleration measured over exposure ...
journal_title：Nagoya journal of medical science
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更新日期：1994-05-01 00:00:00
abstract：:Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding th...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
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更新日期：2009-02-01 00:00:00
abstract：:Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph's nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old woman visited local clinics with complaints of an u...
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pub_type：
doi：10.18999/nagjms.81.2.325
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