Abstract：
:We determined whether ring-2 carbon of histidine is folate-dependently transferred to carbons 8 (C8) and/or 2 (C2) in urinary uric acid in humans. Two adults collected each urine void for four days. Aliquots of urine for the first day were used for baseline values; then the subjects ingested 0.7 g (3.3 mmol) of l-[ring-2-13C]histidine and collected urine for three experimental days. Aliquots were analyzed for percentage 13C-content at C2 and C8 by a liquid-chromatography-mass spectrometry method. Percentage enrichment was determined by subtracting time-of-day paired baseline percentage 13C-content from experimental percentage 13C-content for each void. C2 was predominantly 13C-enriched in the majority of voids. The percentage enrichments at C2 for two subjects were 0.14 (±0.028 [SEM], n = 26) and 0.18 (±0.049, n = 21), whereas at C8, they were 0.008 (±0.006) and -0.005 (±0.008), respectively. The mean C2-enrichments were significantly greater than zero (p < 0.01), whereas those of C8 were not (p > 0.2). The enrichment had a diurnal rhythm peaking in the morning. Our results may be useful in the estimation of the timing for the administration of drugs that interfere with purine nucleotide biosynthesis in the treatment of cancer and autoimmune disease.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Tamura T,Baggott JEdoi
10.3390/nu7010697subject
Has Abstractpub_date
2015-01-20 00:00:00pages
697-705issue
1issn
2072-6643pii
nu7010697journal_volume
7pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Animal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these syndromes. Knowing that different diets can precipitate different metabolic disease phenotypes, herein we characterized several hypercaloric rat models of obesi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061197
更新日期：2019-05-28 00:00:00
abstract：:To determine whether elevated intra-abdominal pressure (IAP) is associated with a higher rate of enteral nutrition-related gastrointestinal (GI) complications; to assess the value of IAP as a predictor of enteral nutrition (EN) intolerance. Intensive Care Unit (ICU) patients on mechanical ventilation requiring at leas...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu11112616
更新日期：2019-11-01 00:00:00
abstract：:Thermogenic adipocytes burn nutrients in order to produce heat. Upon activation, brown adipose tissue (BAT) clears vast amounts of lipids and glucose from the circulation and thus substantially lowers plasma lipid levels. As a consequence, BAT activation protects from the development of atherosclerosis. However, it is...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020463
更新日期：2019-02-23 00:00:00
abstract：:Mothers who underwent bariatric surgery (BS) before pregnancy have worrisome eating habits, but little is known about the eating habits of their offspring. EFFECTOR is a cross-sectional, long-term follow-up study of 4-11-year-old children born from mothers that underwent bariatric surgery before pregnancy (n = 36), mo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092577
更新日期：2020-08-25 00:00:00
abstract：:Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This stu...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030518
更新日期：2019-02-28 00:00:00
abstract：:Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we reported that eggplant was rich in choline esters, including acetylcholine (ACh), and had an antihypertensive effect in spontaneously hypertensive rats. Her...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11112797
更新日期：2019-11-16 00:00:00
abstract：:Carotenoids are diet-dependent milk components that are important for the visual and cognitive development of an infant. This study determined β-carotene, lycopene and lutein + zeaxanthin in breastmilk and its associations with dietary intake from healthy Polish mothers in the first six months of lactation. Concentrat...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11010193
更新日期：2019-01-18 00:00:00
abstract：:Differences in postprandial insulin, glucose, and/or free fatty acid concentrations, following the consumption of breakfast, have been demonstrated to be dependent on habitual breakfast patterns. This study examined the effects of habitual breakfast patterns on postprandial appetite, satiety, and hormonal responses al...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11061223
更新日期：2019-05-29 00:00:00
abstract：:The present study aimed to evaluate the effects of paeoniflorin on insulin resistance and hepatic steatosis induced by fructose. Male Sprague-Dawley rats were fed 20% fructose drink for eight weeks. The insulin sensitivity, serum lipid profiles, and hepatic lipids contents were measured. The results showed that paeoni...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10081024
更新日期：2018-08-05 00:00:00
abstract：:The relationship between alcohol consumption and the prevalence of metabolic syndrome is not consistent and may vary between populations, depending on age, sex, ethnicity, cultural traditions and lifestyle. We have hypothesized that moderate alcohol consumption will be associated with the lowest risk of the syndrome. ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112764
更新日期：2019-11-14 00:00:00
abstract：:Harman and norharman, two neuroactive β-carbolines, are present in several plants and in thermally processed foods. They exhibited a wide spectrum of biological and pharmacological effects, including antioxidant, neuroprotective, and anti-inflammatory effects. In this article, we review the progress of recent research...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11040814
更新日期：2019-04-11 00:00:00
abstract：:Eicosapentaenoic and docosahexaenoic acids have been reported to have a variety of beneficial effects on cardiovascular disease risk factors. However, a large inter-individual variability in the plasma lipid response to an omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation is observed in different studies...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4081026
更新日期：2012-08-01 00:00:00
abstract：:Breakfast cereals are present on the market as different types and, in general, are one of the food categories in which voluntary information, such as nutrition or health claims (NHC) or gluten free (GF) declarations, have the largest distribution. The aims of the present study were to compare (i) the nutritional decl...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112827
更新日期：2019-11-19 00:00:00
abstract：:Globally, zinc deficiency is widespread, despite decades of research highlighting its negative effects on health, and in particular upon child health in low-income countries. Apart from inadequate dietary intake of bioavailable zinc, other significant contributors to zinc deficiency include the excessive intestinal lo...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7010572
更新日期：2015-01-14 00:00:00
abstract：:Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well a...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11010025
更新日期：2018-12-22 00:00:00
abstract：:Infant dietary patterns tend to be insufficient sources of fruits, vegetables, and fiber, as well as excessive in salt, added sugars, and overall energy. Despite the serious long-term health risks associated with suboptimal fruit and vegetable intake, a large percentage of infants and toddlers in the U.S. do not consu...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8050316
更新日期：2016-05-21 00:00:00
abstract：:Alu hypomethylation promotes genomic instability and is associated with aging and age-related diseases. Dietary factors affect global DNA methylation, leading to changes in genomic stability and gene expression with an impact on longevity and the risk of disease. This preliminary study aims to investigate the relation...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11122986
更新日期：2019-12-06 00:00:00
abstract：:Micronutrient Powder (MNP) is beneficial to control anemia, but some iron-related side-effects are common. A high level of iron in the groundwater used for drinking may exacerbate the side-effects among MNP users. We conducted a randomized controlled trial examining the effect of a low-dose iron MNP compared with the ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11112756
更新日期：2019-11-13 00:00:00
abstract：:The sex differences in malnutrition and hypertension during adolescence is largely inconclusive. There is also a paucity of data on the sex-specific correlates of malnutrition and hypertension for adolescents. Hence, this study aimed to assess the association between malnutrition, pre-hypertension/hypertension (PHH) a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092737
更新日期：2020-09-08 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus type (SARS-CoV2, also known as COVID-19), which is the latest pandemic infectious disease, constitutes a serious risk to human health. SARS-CoV2 infection causes immune activation and systemic hyperinflammation which can lead to respiratory distress syndrome (ARDS). ARDS v...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12113512
更新日期：2020-11-14 00:00:00
abstract：OBJECTIVE:To investigate dietary habits, sleep and psychological well-being of adolescents and medical students during COVID-19 lockdown in Split, Croatia. METHODS:We surveyed 1326 students during 2018 and 2019, and compared their responses with 531 students enrolled in May 2020. Perceived stress, quality of life (QoL...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010097
更新日期：2020-12-30 00:00:00
abstract：BACKGROUND:Fruits and vegetables are key to a healthy diet, particularly in children; however, parents may be concerned about contaminants found in fruits and vegetables. Making informed food choices for children requires understanding and balancing the risks of contaminant exposure with the importance of providing a h...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111572
更新日期：2018-10-24 00:00:00
abstract：:As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum lev...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112748
更新日期：2019-11-12 00:00:00
abstract：:In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients receive...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123873
更新日期：2020-12-18 00:00:00
abstract：BACKGROUND:Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development. OBJECTIVE:The main aim was to evaluate the effect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidney disease (CKD) children. METHODS:A randomized-trial mult...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3390/nu11112671
更新日期：2019-11-05 00:00:00
abstract：:Vitamin D deficiency is a common issue, particularly in obese populations, and is tested by assessing serum 25(OH)D concentrations. This study aimed to identify factors that contribute to the vitamin D status in fifty morbidly obese individuals recruited prior to bariatric surgery. Data collected included serum 25(OH)...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9101094
更新日期：2017-10-04 00:00:00
abstract：:This study aimed to compare calculated nutrient intakes from two different food composition databases using data from the European prospective investigation into cancer and nutrition (EPIC) cohort. Dietary intake data of the EPIC cohort was recently matched to 150 food components from the U.S. nutrient database (USNDB...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102906
更新日期：2020-09-23 00:00:00
abstract：:Although the association of vitamin D levels with cardiovascular risk profiles among Hispanics/Latinos has been studied, little is known about this association among Hispanics/Latinos with chronic conditions. This pilot study determined serum vitamin D and parathyroid hormone (PTH) levels in a sample of participants f...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081959
更新日期：2019-08-20 00:00:00
abstract：BACKGROUND:The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozoto...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112720
更新日期：2019-11-09 00:00:00
abstract：:Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations of genetic variants in the Syndecan-4 (SDC4) gene with intra-abdominal fat, fasting plasma glucose levels, and insulin sensitivity index in children, and with f...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112810
更新日期：2019-11-18 00:00:00
