Abstract:
OBJECTIVES:Local corticosteroid infiltration is a common practice of treatment for lateral epicondylitis. In recent studies no statistically significant or clinically relevant results in favour of corticosteroid injections were found. The injection of autologous blood has been reported to be effective for both intermediate and long-term outcomes. It is hypothesised that blood contains growth factors, which induce the healing cascade. METHODS:A total of 60 patients were included in this prospective randomised study: 30 patients received 2 ml autologous blood drawn from contralateral upper limb vein + 1 ml 0.5% bupivacaine, and 30 patients received 2 ml local corticosteroid + 1 ml 0.5% bupivacaine at the lateral epicondyle. Outcome was measured using a pain score and Nirschl staging of lateral epicondylitis. Follow-up was continued for total of six months, with assessment at one week, four weeks, 12 weeks and six months. RESULTS:The corticosteroid injection group showed a statistically significant decrease in pain compared with autologous blood injection group in both visual analogue scale (VAS) and Nirschl stage at one week (both p < 0.001) and at four weeks (p = 0.002 and p = 0.018, respectively). At the 12-week and six-month follow-up, autologous blood injection group showed statistically significant decrease in pain compared with corticosteroid injection group (12 weeks: VAS p = 0.013 and Nirschl stage p = 0.018; six months: VAS p = 0.006 and Nirschl p = 0.006). At the six-month final follow-up, a total of 14 patients (47%) in the corticosteroid injection group and 27 patients (90%) in autologous blood injection group were completely relieved of pain. CONCLUSIONS:Autologous blood injection is efficient compared with corticosteroid injection, with less side-effects and minimum recurrence rate.
journal_name
Bone Joint Resjournal_title
Bone & joint researchauthors
Dojode CMdoi
10.1302/2046-3758.18.2000095subject
Has Abstractpub_date
2012-08-01 00:00:00pages
192-7issue
8issn
2046-3758pii
2000095journal_volume
1pub_type
杂志文章abstract:OBJECTIVES:The radiographic union score for tibial (RUST) fractures was developed by Whelan et al to assess the healing of tibial fractures following intramedullary nailing. In the current study, the repeatability and reliability of the RUST score was evaluated in an independent centre (a) using the original descriptio...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.54.2000628
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. METHODS:CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimic...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.610.BJR-2017-0094.R1
更新日期:2017-10-01 00:00:00
abstract:AIMS:The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). METHODS:TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (UAC) procedure. Mouse ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.910.BJR-2020-0140.R1
更新日期:2020-10-01 00:00:00
abstract:Aims:Induction heating is a noninvasive, nonantibiotic treatment modality that can potentially be used to cause thermal damage to the bacterial biofilm on the metal implant surface. The purpose of this study was to determine the effectiveness of induction heating on killing Staphylococcus epidermidis from biofilm and t...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.94.BJR-2019-0274.R1
更新日期:2020-05-16 00:00:00
abstract:Objectives:The paradoxical migration of the femoral neck element (FNE) superomedially against gravity, with respect to the intramedullary component of the cephalomedullary device, is a poorly understood phenomenon increasingly seen in the management of pertrochanteric hip fractures with the intramedullary nail. The aim...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.87.BJR-2018-0271.R1
更新日期:2019-08-02 00:00:00
abstract:OBJECTIVES:Pedicle-lengthening osteotomy is a novel surgery for lumbar spinal stenosis (LSS), which achieves substantial enlargement of the spinal canal by expansion of the bilateral pedicle osteotomy sites. Few studies have evaluated the impact of this new surgery on spinal canal volume (SCV) and neural foramen dimens...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.56.2000469
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Osteophytes are products of active endochondral and intramembranous ossification, and therefore could theoretically provide significant efficacy as bone grafts. In this study, we compared the bone mineralisation effectiveness of osteophytes and cancellous bone, including their effects on secretion of growth ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.62.BJR-2016-0199.R1
更新日期:2017-02-01 00:00:00
abstract::Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4) is the most well-characterized member of the HDAC class IIa fami...
journal_title:Bone & joint research
pub_type: 杂志文章,评审
doi:10.1302/2046-3758.92.BJR-2019-0172.R1
更新日期:2020-05-16 00:00:00
abstract:BACKGROUND:Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of resveratrol on normal and osteoarthritic (OA) human chondr...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.33.2000226
更新日期:2014-03-10 00:00:00
abstract:OBJECTIVES:To study the measurement properties of a joint specific patient reported outcome measure, a measure of capability and a general health-related quality of life (HRQOL) tool in a large cohort of patients with a hip fracture. METHODS:Responsiveness and associations between the Oxford Hip Score (a hip specific ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.33.2000250
更新日期:2014-03-19 00:00:00
abstract:OBJECTIVES:To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS:Osteogenic cell sheets were prepared by culturing rat bone marrow stromal c...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.511.BJR-2016-0013.R1
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. T...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.69.BJR-2016-0317.R2
更新日期:2017-09-01 00:00:00
abstract::Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. Controversy exists regarding the optimal treatment for patients with unstable trochanteric proximal femoral fractures. The recognised treatment alternatives are extramed...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.210.2000183
更新日期:2013-10-02 00:00:00
abstract:AIMS:Treatment of chronic osteomyelitis (COM) for young patients remains a challenge. Large bone deficiencies secondary to COM can be treated using induced membrane technique (IMT). However, it is unclear which type of bone graft is optimal. The goal of the study was to determine the clinical effectiveness of bone marr...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.101.BJR-2020-0229.R1
更新日期:2021-01-01 00:00:00
abstract:Aims:Commonly performed unicompartmental knee arthroplasty (UKA) is not designed for the lateral compartment. Additionally, the anatomical medial and lateral tibial plateaus have asymmetrical geometries, with a slightly dished medial plateau and a convex lateral plateau. Therefore, this study aims to investigate the na...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.812.BJR-2019-0114.R1
更新日期:2020-01-08 00:00:00
abstract::In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led t...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.512.BJR-2016-0102.R2
更新日期:2016-12-01 00:00:00
abstract:Objectives:Recently, the field of tissue engineering has made numerous advances towards achieving artificial tendon substitutes with excellent mechanical and histological properties, and has had some promising experimental results. The purpose of this systematic review is to assess the efficacy of tissue engineering in...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.74.BJR-2017-0326
更新日期:2018-05-05 00:00:00
abstract:OBJECTIVES:Evidence -based medicine (EBM) is designed to inform clinical decision-making within all medical specialties, including orthopaedic surgery. We recently published a pilot survey of the Canadian Orthopaedic Association (COA) membership and demonstrated that the adoption of EBM principles is variable among Can...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.54.2000578
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-load...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.14.2000019
更新日期:2012-04-01 00:00:00
abstract:Aims:To evaluate graft healing of decellularized porcine superflexor tendon (pSFT) xenograft in an ovine anterior cruciate ligament (ACL) reconstruction model using two femoral fixation devices. Also, to determine if pSFT allows functional recovery of gait as compared with the preoperative measurements. Methods:A tota...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.96.BJR-2020-0030.R2
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVES:An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum joint space width (mJSW). This requires accurate alignment of the x-ray beam with the tibial plateau, which may not be accomplished in practice. We investigate the feasibility of a new mJSW measurement method from ste...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.58.2000626
更新日期:2016-08-01 00:00:00
abstract::Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and ...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.91.BJR-2019-0043.R2
更新日期:2020-05-16 00:00:00
abstract:OBJECTIVES:In order to ensure safety of the cell-based therapy for bone regeneration, we examined in vivo biodistribution of locally or systemically transplanted osteoblast-like cells generated from bone marrow (BM) derived mononuclear cells. METHODS:BM cells obtained from a total of 13 Sprague-Dawley (SD) green fluor...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.33.2000257
更新日期:2014-03-20 00:00:00
abstract:Objectives:The aim of this study was to analyze drain fluid, blood, and urine simultaneously to follow the long-term release of vancomycin from a biphasic ceramic carrier in major hip surgery. Our hypothesis was that there would be high local vancomycin concentrations during the first week with safe low systemic trough...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.82.BJR-2018-0174.R2
更新日期:2019-03-02 00:00:00
abstract:Objectives:The primary stability of the cementless Oxford Unicompartmental Knee Replacement (OUKR) relies on interference fit (or press fit). Insufficient interference may cause implant loosening, whilst excessive interference could cause bone damage and fracture.The aim of this study was to identify the optimal interf...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.73.BJR-2017-0193.R1
更新日期:2018-05-05 00:00:00
abstract:Objectives:The aim of this study was to investigate the biomechanical effect of the anterolateral ligament (ALL), anterior cruciate ligament (ACL), or both ALL and ACL on kinematics under dynamic loading conditions using dynamic simulation subject-specific knee models. Methods:Five subject-specific musculoskeletal mod...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.811.BJR-2019-0103.R1
更新日期:2019-12-03 00:00:00
abstract:OBJECTIVES:We aimed to examine the characteristics of deep venous flow in the leg in a cast and the effects of a wearable neuromuscular stimulator (geko; FirstKind Ltd) and also to explore the participants' tolerance of the stimulator. METHODS:This is an open-label physiological study on ten healthy volunteers. Duplex...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.29.2000176
更新日期:2013-09-02 00:00:00
abstract:Objectives:We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection. Materials and Methods:Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pre...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.78.BJR-2017-0343.R2
更新日期:2018-09-15 00:00:00
abstract:OBJECTIVES:A patient-centred approach, usually achieved through shared decision making, has the potential to help improve decision making around knee arthroplasty surgery. However, such an approach requires an understanding of the factors involved in patient decision making. This review's objective is to systematically...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.410.2000420
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Small animal models of fracture repair primarily investigate indirect fracture healing via external callus formation. We present the first described rat model of direct fracture healing. METHODS:A rat tibial osteotomy was created and fixed with compression plating similar to that used in patients. The proce...
journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.111.2000087
更新日期:2012-11-01 00:00:00