The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development.

abstract：Aims:Commonly performed unicompartmental knee arthroplasty (UKA) is not designed for the lateral compartment. Additionally, the anatomical medial and lateral tibial plateaus have asymmetrical geometries, with a slightly dished medial plateau and a convex lateral plateau. Therefore, this study aims to investigate the na...

journal_title：Bone & joint research

authors： Koh YG,Lee JA,Lee HY,Kim HJ,Chung HS,Kang KT

更新日期：2020-01-08 00:00:00

abstract：OBJECTIVES:To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS:Osteogenic cell sheets were prepared by culturing rat bone marrow stromal c...

journal_title：Bone & joint research

authors： Akahane M,Shimizu T,Kira T,Onishi T,Uchihara Y,Imamura T,Tanaka Y

更新日期：2016-11-01 00:00:00

abstract：Objectives:The primary stability of the cementless Oxford Unicompartmental Knee Replacement (OUKR) relies on interference fit (or press fit). Insufficient interference may cause implant loosening, whilst excessive interference could cause bone damage and fracture.The aim of this study was to identify the optimal interf...

journal_title：Bone & joint research

authors： Campi S,Mellon SJ,Ridley D,Foulke B,Dodd CAF,Pandit HG,Murray DW

更新日期：2018-05-05 00:00:00

abstract：:The treatment of osteochondral lesions and osteoarthritis remains an ongoing clinical challenge in orthopaedics. This review examines the current research in the fields of cartilage regeneration, osteochondral defect treatment, and biological joint resurfacing, and reports on the results of clinical and pre-clinical s...

journal_title：Bone & joint research

authors： Myers KR,Sgaglione NA,Grande DA

更新日期：2013-09-16 00:00:00

abstract：:Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. Controversy exists regarding the optimal treatment for patients with unstable trochanteric proximal femoral fractures. The recognised treatment alternatives are extramed...

journal_title：Bone & joint research

authors： Griffin XL,McArthur J,Achten J,Parsons N,Costa ML

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of resveratrol on normal and osteoarthritic (OA) human chondr...

journal_title：Bone & joint research

authors： Kim HJ,Braun HJ,Dragoo JL

更新日期：2014-03-10 00:00:00

abstract：OBJECTIVES:As tumours of bone and soft tissue are rare, multicentre prospective collaboration is essential for meaningful research and evidence-based advances in patient care. The aim of this study was to identify barriers and facilitators encountered in large-scale collaborative research by orthopaedic oncological sur...

journal_title：Bone & joint research

authors： Rendon JS,Swinton M,Bernthal N,Boffano M,Damron T,Evaniew N,Ferguson P,Galli Serra M,Hettwer W,McKay P,Miller B,Nystrom L,Parizzia W,Schneider P,Spiguel A,Vélez R,Weiss K,Zumárraga JP,Ghert M

更新日期：2017-05-01 00:00:00

abstract：AIMS:This study aimed to investigate the effect of solute carrier family 20 member 2 (SLC20A2) gene mutation (identified from a hereditary multiple exostoses family) on chondrocyte proliferation and differentiation. METHODS:ATDC5 chondrocytes were cultured in insulin-transferrin-selenium medium to induce differentiati...

journal_title：Bone & joint research

authors： Li Y,Lin X,Zhu M,Xun F,Li J,Yuan Z,Liu Y,Xu H

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:We aimed to examine the characteristics of deep venous flow in the leg in a cast and the effects of a wearable neuromuscular stimulator (geko; FirstKind Ltd) and also to explore the participants' tolerance of the stimulator. METHODS:This is an open-label physiological study on ten healthy volunteers. Duplex...

journal_title：Bone & joint research

authors： Warwick DJ,Shaikh A,Gadola S,Stokes M,Worsley P,Bain D,Tucker AT,Gadola SD

更新日期：2013-09-02 00:00:00

abstract：OBJECTIVES:We aimed to determine the effect of surgical approach on the histology of the femoral head following resurfacing of the hip. METHODS:We performed a histological assessment of the bone under the femoral component taken from retrieval specimens of patients having revision surgery following resurfacing of the ...

journal_title：Bone & joint research

authors： Amarasekera HW,Campbell PC,Parsons N,Achten J,Masters J,Griffin DR,Costa ML

更新日期：2013-09-18 00:00:00

abstract：OBJECTIVES:Lengthening osteotomies of the calcaneus in children are in general grafted with bone from the iliac crest. Artificial bone grafts have been introduced, however, their structural and clinical durability has not been documented. Radiostereometric analysis (RSA) is a very accurate and precise method for measur...

journal_title：Bone & joint research

authors： Martinkevich P,Rahbek O,Møller-Madsen B,Søballe K,Stilling M

更新日期：2015-05-01 00:00:00

abstract：:Cartilage repair in terms of replacement, or regeneration of damaged or diseased articular cartilage with functional tissue, is the 'holy grail' of joint surgery. A wide spectrum of strategies for cartilage repair currently exists and several of these techniques have been reported to be associated with successful clin...

journal_title：Bone & joint research

authors： Cook JL,Hung CT,Kuroki K,Stoker AM,Cook CR,Pfeiffer FM,Sherman SL,Stannard JP

更新日期：2014-04-02 00:00:00

abstract：Aims:To evaluate graft healing of decellularized porcine superflexor tendon (pSFT) xenograft in an ovine anterior cruciate ligament (ACL) reconstruction model using two femoral fixation devices. Also, to determine if pSFT allows functional recovery of gait as compared with the preoperative measurements. Methods:A tota...

journal_title：Bone & joint research

authors： Hexter AT,Hing KA,Haddad FS,Blunn G

更新日期：2020-07-23 00:00:00

abstract：OBJECTIVES:An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum joint space width (mJSW). This requires accurate alignment of the x-ray beam with the tibial plateau, which may not be accomplished in practice. We investigate the feasibility of a new mJSW measurement method from ste...

journal_title：Bone & joint research

authors： van IJsseldijk EA,Valstar ER,Stoel BC,Nelissen RG,Baka N,Van't Klooster R,Kaptein BL

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:The goals of this study were: 1) to determine if high-fat diet (HFD) feeding in female mice would negatively impact biomechanical and histologic consequences on the Achilles tendon and quadriceps muscle; and 2) to investigate whether exercise and branched-chain amino acid (BCAA) supplementation would affect ...

journal_title：Bone & joint research

authors： Boivin GP,Platt KM,Corbett J,Reeves J,Hardy AL,Elenes EY,Charnigo RJ,Hunter SA,Pearson KJ

更新日期：2013-09-10 00:00:00

abstract：:Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and ...

journal_title：Bone & joint research

authors： Stewart S,Darwood A,Masouros S,Higgins C,Ramasamy A

更新日期：2020-05-16 00:00:00

abstract：OBJECTIVES:Small animal models of fracture repair primarily investigate indirect fracture healing via external callus formation. We present the first described rat model of direct fracture healing. METHODS:A rat tibial osteotomy was created and fixed with compression plating similar to that used in patients. The proce...

journal_title：Bone & joint research

authors： Savaridas T,Wallace RJ,Muir AY,Salter DM,Simpson AH

更新日期：2012-11-01 00:00:00

abstract：:Osteoporosis (OP) is a chronic metabolic bone disease characterized by the decrease of bone tissue per unit volume under the combined action of genetic and environmental factors, which leads to the decrease of bone strength, makes the bone brittle, and raises the possibility of bone fracture. However, the exact mechan...

journal_title：Bone & joint research

authors： Li S,Mao Y,Zhou F,Yang H,Shi Q,Meng B

更新日期：2020-08-02 00:00:00

abstract：OBJECTIVES:Evidence -based medicine (EBM) is designed to inform clinical decision-making within all medical specialties, including orthopaedic surgery. We recently published a pilot survey of the Canadian Orthopaedic Association (COA) membership and demonstrated that the adoption of EBM principles is variable among Can...

journal_title：Bone & joint research

authors： Thornley P,de Sa D,Evaniew N,Farrokhyar F,Bhandari M,Ghert M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. METHODS:CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimic...

journal_title：Bone & joint research

authors： Sallent A,Vicente M,Reverté MM,Lopez A,Rodríguez-Baeza A,Pérez-Domínguez M,Velez R

更新日期：2017-10-01 00:00:00

abstract：Objectives:Different criteria for assessing the reduction quality of trochanteric fractures have been reported. The Baumgaertner reduction quality criteria (BRQC) are relatively common and the Chang reduction quality criteria (CRQC) are relatively new. The objectives of the current study were to compare the reliability...

journal_title：Bone & joint research

authors： Mao W,Ni H,Li L,He Y,Chen X,Tang H,Dong Y

更新日期：2019-11-02 00:00:00

abstract：OBJECTIVES:Local corticosteroid infiltration is a common practice of treatment for lateral epicondylitis. In recent studies no statistically significant or clinically relevant results in favour of corticosteroid injections were found. The injection of autologous blood has been reported to be effective for both intermed...

journal_title：Bone & joint research

authors： Dojode CM

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:A patient-centred approach, usually achieved through shared decision making, has the potential to help improve decision making around knee arthroplasty surgery. However, such an approach requires an understanding of the factors involved in patient decision making. This review's objective is to systematically...

journal_title：Bone & joint research

authors： Barlow T,Griffin D,Barlow D,Realpe A

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:To investigate the differences of open reduction and internal fixation (ORIF) of complex AO Type C distal radius fractures between two different models of a single implant type. METHODS:A total of 136 patients who received either a 2.4 mm (n = 61) or 3.5 mm (n = 75) distal radius locking compression plate (...

journal_title：Bone & joint research

authors： von Recum J,Matschke S,Jupiter JB,Ring D,Souer JS,Huber M,Audigé L

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:To study the measurement properties of a joint specific patient reported outcome measure, a measure of capability and a general health-related quality of life (HRQOL) tool in a large cohort of patients with a hip fracture. METHODS:Responsiveness and associations between the Oxford Hip Score (a hip specific ...

journal_title：Bone & joint research

authors： Parsons N,Griffin XL,Achten J,Costa ML

更新日期：2014-03-19 00:00:00

abstract：OBJECTIVES:In order to ensure safety of the cell-based therapy for bone regeneration, we examined in vivo biodistribution of locally or systemically transplanted osteoblast-like cells generated from bone marrow (BM) derived mononuclear cells. METHODS:BM cells obtained from a total of 13 Sprague-Dawley (SD) green fluor...

journal_title：Bone & joint research

authors： Okabe YT,Kondo T,Mishima K,Hayase Y,Kato K,Mizuno M,Ishiguro N,Kitoh H

更新日期：2014-03-20 00:00:00

abstract：OBJECTIVE:The objective of this study was to explore dimensionality of the Oxford Hip Score (OHS) and examine whether self-reported pain and functioning can be distinguished in the form of subscales. METHODS:This was a secondary data analysis of the UK NHS hospital episode statistics/patient-reported outcome measures ...

journal_title：Bone & joint research

authors： Harris KK,Price AJ,Beard DJ,Fitzpatrick R,Jenkinson C,Dawson J

更新日期：2014-11-01 00:00:00

abstract：Objectives:We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection. Materials and Methods:Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pre...

journal_title：Bone & joint research

authors： Beverly M,Mellon S,Kennedy JA,Murray DW

更新日期：2018-09-15 00:00:00

abstract：OBJECTIVES:To investigate psychosocial and biomedical outcomes following total hip replacement (THR) and to identify predictors of recovery from THR. METHODS:Patients with osteoarthritis (OA) on the waiting list for primary THR in North West England were assessed pre-operatively and at six and 12 months post-operative...

journal_title：Bone & joint research

authors： McHugh GA,Campbell M,Luker KA

更新日期：2013-11-27 00:00:00

abstract：OBJECTIVES:Osteophytes are products of active endochondral and intramembranous ossification, and therefore could theoretically provide significant efficacy as bone grafts. In this study, we compared the bone mineralisation effectiveness of osteophytes and cancellous bone, including their effects on secretion of growth ...

journal_title：Bone & joint research

authors： Ishihara K,Okazaki K,Akiyama T,Akasaki Y,Nakashima Y

更新日期：2017-02-01 00:00:00