The use of rats and mice as animal models in ex vivo bone growth and development studies.

abstract：OBJECTIVES:This study aimed to characterise and qualitatively grade the severity of the corrosion particles released into the hip joint following taper corrosion. METHODS:The 26 cases examined were CoC/ABG Modular (n = 13) and ASR/SROM (n = 13). Blood serum metal ion levels were collected before and after revision sur...

journal_title：Bone & joint research

authors： Munir S,Oliver RA,Zicat B,Walter WL,Walter WK,Walsh WR

更新日期：2016-09-01 00:00:00

abstract：Aims:To evaluate graft healing of decellularized porcine superflexor tendon (pSFT) xenograft in an ovine anterior cruciate ligament (ACL) reconstruction model using two femoral fixation devices. Also, to determine if pSFT allows functional recovery of gait as compared with the preoperative measurements. Methods:A tota...

journal_title：Bone & joint research

authors： Hexter AT,Hing KA,Haddad FS,Blunn G

更新日期：2020-07-23 00:00:00

abstract：OBJECTIVES:To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. METHODS:CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimic...

journal_title：Bone & joint research

authors： Sallent A,Vicente M,Reverté MM,Lopez A,Rodríguez-Baeza A,Pérez-Domínguez M,Velez R

更新日期：2017-10-01 00:00:00

abstract：Aims:Induction heating is a noninvasive, nonantibiotic treatment modality that can potentially be used to cause thermal damage to the bacterial biofilm on the metal implant surface. The purpose of this study was to determine the effectiveness of induction heating on killing Staphylococcus epidermidis from biofilm and t...

journal_title：Bone & joint research

authors： Pijls BG,Sanders IMJG,Kujiper EJ,Nelissen RGHH

更新日期：2020-05-16 00:00:00

abstract：OBJECTIVES:Evidence -based medicine (EBM) is designed to inform clinical decision-making within all medical specialties, including orthopaedic surgery. We recently published a pilot survey of the Canadian Orthopaedic Association (COA) membership and demonstrated that the adoption of EBM principles is variable among Can...

journal_title：Bone & joint research

authors： Thornley P,de Sa D,Evaniew N,Farrokhyar F,Bhandari M,Ghert M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-load...

journal_title：Bone & joint research

authors： Kwon YM,Mellon SJ,Monk P,Murray DW,Gill HS

更新日期：2012-04-01 00:00:00

abstract：Objectives:We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection. Materials and Methods:Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pre...

journal_title：Bone & joint research

authors： Beverly M,Mellon S,Kennedy JA,Murray DW

更新日期：2018-09-15 00:00:00

abstract：Objectives:The aim of this study was to investigate the biomechanical effect of the anterolateral ligament (ALL), anterior cruciate ligament (ACL), or both ALL and ACL on kinematics under dynamic loading conditions using dynamic simulation subject-specific knee models. Methods:Five subject-specific musculoskeletal mod...

journal_title：Bone & joint research

authors： Kang KT,Koh YG,Park KM,Choi CH,Jung M,Shin J,Kim SH

更新日期：2019-12-03 00:00:00

abstract：OBJECTIVES:An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum joint space width (mJSW). This requires accurate alignment of the x-ray beam with the tibial plateau, which may not be accomplished in practice. We investigate the feasibility of a new mJSW measurement method from ste...

journal_title：Bone & joint research

authors： van IJsseldijk EA,Valstar ER,Stoel BC,Nelissen RG,Baka N,Van't Klooster R,Kaptein BL

更新日期：2016-08-01 00:00:00

abstract：Objectives:The paradoxical migration of the femoral neck element (FNE) superomedially against gravity, with respect to the intramedullary component of the cephalomedullary device, is a poorly understood phenomenon increasingly seen in the management of pertrochanteric hip fractures with the intramedullary nail. The aim...

journal_title：Bone & joint research

authors： Law GW,Wong YR,Yew AK,Choh ACT,Koh JSB,Howe TS

更新日期：2019-08-02 00:00:00

abstract：OBJECTIVES:To investigate psychosocial and biomedical outcomes following total hip replacement (THR) and to identify predictors of recovery from THR. METHODS:Patients with osteoarthritis (OA) on the waiting list for primary THR in North West England were assessed pre-operatively and at six and 12 months post-operative...

journal_title：Bone & joint research

authors： McHugh GA,Campbell M,Luker KA

更新日期：2013-11-27 00:00:00

abstract：OBJECTIVES:The radiographic union score for tibial (RUST) fractures was developed by Whelan et al to assess the healing of tibial fractures following intramedullary nailing. In the current study, the repeatability and reliability of the RUST score was evaluated in an independent centre (a) using the original descriptio...

journal_title：Bone & joint research

authors： Leow JM,Clement ND,Tawonsawatruk T,Simpson CJ,Simpson AH

更新日期：2016-04-01 00:00:00

abstract：Objectives:The primary stability of the cementless Oxford Unicompartmental Knee Replacement (OUKR) relies on interference fit (or press fit). Insufficient interference may cause implant loosening, whilst excessive interference could cause bone damage and fracture.The aim of this study was to identify the optimal interf...

journal_title：Bone & joint research

authors： Campi S,Mellon SJ,Ridley D,Foulke B,Dodd CAF,Pandit HG,Murray DW

更新日期：2018-05-05 00:00:00

abstract：:Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and ...

journal_title：Bone & joint research

authors： Stewart S,Darwood A,Masouros S,Higgins C,Ramasamy A

更新日期：2020-05-16 00:00:00

abstract：AIMS:The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). METHODS:TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (UAC) procedure. Mouse ...

journal_title：Bone & joint research

authors： Zhang A,Ma S,Yuan L,Wu S,Liu S,Wei X,Chen L,Ma C,Zhao H

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:Lengthening osteotomies of the calcaneus in children are in general grafted with bone from the iliac crest. Artificial bone grafts have been introduced, however, their structural and clinical durability has not been documented. Radiostereometric analysis (RSA) is a very accurate and precise method for measur...

journal_title：Bone & joint research

authors： Martinkevich P,Rahbek O,Møller-Madsen B,Søballe K,Stilling M

更新日期：2015-05-01 00:00:00

abstract：:Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. Controversy exists regarding the optimal treatment for patients with unstable trochanteric proximal femoral fractures. The recognised treatment alternatives are extramed...

journal_title：Bone & joint research

authors： Griffin XL,McArthur J,Achten J,Parsons N,Costa ML

更新日期：2013-10-02 00:00:00

abstract：Objectives:Different criteria for assessing the reduction quality of trochanteric fractures have been reported. The Baumgaertner reduction quality criteria (BRQC) are relatively common and the Chang reduction quality criteria (CRQC) are relatively new. The objectives of the current study were to compare the reliability...

journal_title：Bone & joint research

authors： Mao W,Ni H,Li L,He Y,Chen X,Tang H,Dong Y

更新日期：2019-11-02 00:00:00

abstract：Objectives:The aim of this study was to analyze drain fluid, blood, and urine simultaneously to follow the long-term release of vancomycin from a biphasic ceramic carrier in major hip surgery. Our hypothesis was that there would be high local vancomycin concentrations during the first week with safe low systemic trough...

journal_title：Bone & joint research

authors： Stravinskas M,Nilsson M,Vitkauskiene A,Tarasevicius S,Lidgren L

更新日期：2019-03-02 00:00:00

abstract：OBJECTIVES:Osteophytes are products of active endochondral and intramembranous ossification, and therefore could theoretically provide significant efficacy as bone grafts. In this study, we compared the bone mineralisation effectiveness of osteophytes and cancellous bone, including their effects on secretion of growth ...

journal_title：Bone & joint research

authors： Ishihara K,Okazaki K,Akiyama T,Akasaki Y,Nakashima Y

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:In order to ensure safety of the cell-based therapy for bone regeneration, we examined in vivo biodistribution of locally or systemically transplanted osteoblast-like cells generated from bone marrow (BM) derived mononuclear cells. METHODS:BM cells obtained from a total of 13 Sprague-Dawley (SD) green fluor...

journal_title：Bone & joint research

authors： Okabe YT,Kondo T,Mishima K,Hayase Y,Kato K,Mizuno M,Ishiguro N,Kitoh H

更新日期：2014-03-20 00:00:00

abstract：Objectives:We investigated the reliability of the cobalt-chromium (CoCr) synovial joint fluid ratio (JFR) in identifying the presence of a severe aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) response and/or suboptimal taper performance (SOTP) following metal-on-metal (MoM) hip arthroplasty. We then...

journal_title：Bone & joint research

authors： Langton DJ,Natu S,Harrington CF,Bowsher JG,Nargol AVF

更新日期：2019-04-02 00:00:00

abstract：:The treatment of osteochondral lesions and osteoarthritis remains an ongoing clinical challenge in orthopaedics. This review examines the current research in the fields of cartilage regeneration, osteochondral defect treatment, and biological joint resurfacing, and reports on the results of clinical and pre-clinical s...

journal_title：Bone & joint research

authors： Myers KR,Sgaglione NA,Grande DA

更新日期：2013-09-16 00:00:00

abstract：AIMS:Treatment of chronic osteomyelitis (COM) for young patients remains a challenge. Large bone deficiencies secondary to COM can be treated using induced membrane technique (IMT). However, it is unclear which type of bone graft is optimal. The goal of the study was to determine the clinical effectiveness of bone marr...

journal_title：Bone & joint research

authors： Shen J,Sun D,Yu S,Fu J,Wang X,Wang S,Xie Z

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Small animal models of fracture repair primarily investigate indirect fracture healing via external callus formation. We present the first described rat model of direct fracture healing. METHODS:A rat tibial osteotomy was created and fixed with compression plating similar to that used in patients. The proce...

journal_title：Bone & joint research

authors： Savaridas T,Wallace RJ,Muir AY,Salter DM,Simpson AH

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to explore dimensionality of the Oxford Hip Score (OHS) and examine whether self-reported pain and functioning can be distinguished in the form of subscales. METHODS:This was a secondary data analysis of the UK NHS hospital episode statistics/patient-reported outcome measures ...

journal_title：Bone & joint research

authors： Harris KK,Price AJ,Beard DJ,Fitzpatrick R,Jenkinson C,Dawson J

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:A patient-centred approach, usually achieved through shared decision making, has the potential to help improve decision making around knee arthroplasty surgery. However, such an approach requires an understanding of the factors involved in patient decision making. This review's objective is to systematically...

journal_title：Bone & joint research

authors： Barlow T,Griffin D,Barlow D,Realpe A

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The number of surgical procedures performed each year to treat femoroacetabular impingement (FAI) continues to rise. Although there is evidence that surgery can improve symptoms in the short-term, there is no evidence that it slows the development of osteoarthritis (OA). We performed a feasibility study to d...

journal_title：Bone & joint research

authors： Palmer AJ,Thomas GE,Pollard TC,Rombach I,Taylor A,Arden N,Beard DJ,Andrade AJ,Carr AJ,Glyn-Jones S

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. T...

journal_title：Bone & joint research

authors： Arnold M,Zhao S,Ma S,Giuliani F,Hansen U,Cobb JP,Abel RL,Boughton O

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS:Osteogenic cell sheets were prepared by culturing rat bone marrow stromal c...

journal_title：Bone & joint research

authors： Akahane M,Shimizu T,Kira T,Onishi T,Uchihara Y,Imamura T,Tanaka Y

更新日期：2016-11-01 00:00:00