Abstract:
Aims:Induction heating is a noninvasive, nonantibiotic treatment modality that can potentially be used to cause thermal damage to the bacterial biofilm on the metal implant surface. The purpose of this study was to determine the effectiveness of induction heating on killing Staphylococcus epidermidis from biofilm and to determine the possible synergistic effect of induction heating and antibiotics. Methods:S. epidermidis biofilms were grown on titanium alloy (Ti6Al4V) coupons for 24 hours (young biofilm) and seven days (mature biofilm). These coupons with biofilm were heated to temperatures of 50°C, 55°C, 60°C, 65°C, 70°C, 80°C, and 90°C for 3.5 minutes and subsequently exposed to vancomycin and rifampicin at clinically relevant concentrations. Results:For the young biofilm, total eradication was observed at 65°C or higher for 3.5 minutes followed by 24 hours of vancomycin 10 mg/l and rifampicin 1 mg/l. For the mature biofilm, total eradication was observed at 60°C for 3.5 minutes followed by 24 hours of vancomycin 10 mg/l and rifampicin 1 mg/l. Total eradication was also observed at 60°C for 3.5 minutes followed by 24 hours of vancomycin 1 mg/l and rifampicin 1 mg/l followed by another thermal shock of 60°C for 3.5 minutes (two thermal shocks). Conclusion:Induction heating of Ti6Al4V coupons is effective in reducing bacterial load in vitro for S. epidermidis biofilms. Induction heating and antibiotics have a synergistic effect resulting in total eradication of the biofilm at 60°C or higher for clinically relevant concentrations of vancomycin and rifampicin.Cite this article:Bone Joint Res. 2020;9(4):192-199.
journal_name
Bone Joint Resjournal_title
Bone & joint researchauthors
Pijls BG,Sanders IMJG,Kujiper EJ,Nelissen RGHHdoi
10.1302/2046-3758.94.BJR-2019-0274.R1subject
Has Abstractpub_date
2020-05-16 00:00:00pages
192-199issue
4issn
2046-3758pii
10.1302_2046-3758.94.BJR-2019-0274.R1journal_volume
9pub_type
杂志文章abstract::Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. Controversy exists regarding the optimal treatment for patients with unstable trochanteric proximal femoral fractures. The recognised treatment alternatives are extramed...
journal_title:Bone & joint research
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更新日期:2020-07-23 00:00:00
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doi:10.1302/2046-3758.29.2000176
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doi:10.1302/2046-3758.16.2000008
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journal_title:Bone & joint research
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doi:10.1302/2046-3758.29.2000196
更新日期:2013-09-10 00:00:00
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更新日期:2020-10-01 00:00:00
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更新日期:2016-06-01 00:00:00
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更新日期:2019-08-02 00:00:00
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更新日期:2017-05-01 00:00:00