Abstract:
BACKGROUND:Seroreactivity, processes of seroconversion and seroreversion, in the context of HPV infection has been investigated in numerous studies. However, the data resulting from these studies are usually not accounted for in mathematical transmission models of various HPV types due to gaps in our understanding of the nature of seroreactivity and its implications for HPV natural history. METHODS:In this study we selected a number of simple but plausible compartmental transmission models of HPV-16, differing in assumptions regarding the relation between seropositivity and immunity, and attempted to calibrate them to Australian HPV seroprevalence data for females and males, as well as DNA prevalence data for females, using a Bayesian model comparison procedure. We ranked the models according to both their simplicity and ability to be fitted to the data. RESULTS:Our results demonstrate that models with seroreversion where seropositivity indicates only a partial or very short-term full protection against re-infection generate age-specific HPV DNA prevalence most consistent with the observed data when compared with other models. CONCLUSIONS:Models supporting the notion that seropositive individuals are fully immune to reinfection demonstrated consistently inferior fits to the data than other models making no such assumption.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Korostil IA,Garland SM,Law MG,Regan DGdoi
10.1186/1471-2334-13-83subject
Has Abstractpub_date
2013-02-13 00:00:00pages
83issn
1471-2334pii
1471-2334-13-83journal_volume
13pub_type
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