Abstract:
BACKGROUND:E1684 was the pivotal adjuvant melanoma trial for establishment of high-dose interferon (IFN) as effective therapy of high-risk melanoma patients. E1690 was an intriguing effort to corroborate E1684, and the differences between the outcomes of these trials have embroiled the field in controversy over the past several years. The analyses of E1684 and E1690 were carried out separately when the results were published, and there were no further analyses trying to perform a single analysis of the combined trials. METHOD:In this paper, we consider such a joint analysis by carrying out a Bayesian analysis of these two trials, thus providing us with a consistent and coherent methodology for combining the results from these two trials. RESULTS:The Bayesian analysis using power priors provided a more coherent flexible and potentially more accurate analysis than a separate analysis of these data or a frequentist analysis of these data. The methodology provides a consistent framework for carrying out a single unified analysis by combining data from two or more studies. CONCLUSIONS:Such Bayesian analyses can be crucial in situations where the results from two theoretically identical trials yield somewhat conflicting or inconsistent results.
journal_name
BMC Med Res Methodoljournal_title
BMC medical research methodologyauthors
Ibrahim JG,Chen MH,Chu Hdoi
10.1186/1471-2288-12-183subject
Has Abstractpub_date
2012-11-29 00:00:00pages
183issn
1471-2288pii
1471-2288-12-183journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Interventions in occupational health often target worksites rather than individuals. The objective of this paper is to describe the (lack of) stability in units of analysis in occupational health and safety intervention projects directed toward worksites. METHODS:A case study approach is used to describe na...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-8-39
更新日期:2008-06-13 00:00:00
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journal_title:BMC medical research methodology
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journal_title:BMC medical research methodology
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journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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