Understanding human functioning using graphical models.

Abstract:

BACKGROUND:Functioning and disability are universal human experiences. However, our current understanding of functioning from a comprehensive perspective is limited. The development of the International Classification of Functioning, Disability and Health (ICF) on the one hand and recent developments in graphical modeling on the other hand might be combined and open the door to a more comprehensive understanding of human functioning. The objective of our paper therefore is to explore how graphical models can be used in the study of ICF data for a range of applications. METHODS:We show the applicability of graphical models on ICF data for different tasks: Visualization of the dependence structure of the data set, dimension reduction and comparison of subpopulations. Moreover, we further developed and applied recent findings in causal inference using graphical models to estimate bounds on intervention effects in an observational study with many variables and without knowing the underlying causal structure. RESULTS:In each field, graphical models could be applied giving results of high face-validity. In particular, graphical models could be used for visualization of functioning in patients with spinal cord injury. The resulting graph consisted of several connected components which can be used for dimension reduction. Moreover, we found that the differences in the dependence structures between subpopulations were relevant and could be systematically analyzed using graphical models. Finally, when estimating bounds on causal effects of ICF categories on general health perceptions among patients with chronic health conditions, we found that the five ICF categories that showed the strongest effect were plausible. CONCLUSIONS:Graphical Models are a flexible tool and lend themselves for a wide range of applications. In particular, studies involving ICF data seem to be suited for analysis using graphical models.

journal_name

BMC Med Res Methodol

authors

Kalisch M,Fellinghauer BA,Grill E,Maathuis MH,Mansmann U,Bühlmann P,Stucki G

doi

10.1186/1471-2288-10-14

subject

Has Abstract

pub_date

2010-02-11 00:00:00

pages

14

issn

1471-2288

pii

1471-2288-10-14

journal_volume

10

pub_type

杂志文章
  • Effectiveness of motivational interviewing, health education and brief advice in a population of smokers who are not ready to quit.

    abstract:BACKGROUND:Motivational Interviewing (MI), Brief Advice (BA) and Health Education (HE) are established smoking cessation induction methods for smokers with low desire to quit. Although randomized controlled trials (RCT's) have been frequently used to assess these interventions the temporal efficacy and effectiveness of...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12874-018-0511-0

    authors: Bani-Yaghoub M,Elhomani A,Catley D

    更新日期:2018-06-13 00:00:00

  • Random allocation software for parallel group randomized trials.

    abstract:BACKGROUND:Typically, randomization software should allow users to exert control over the different aspects of randomization including block design, provision of unique identifiers and control over the format and type of program output. While some of these characteristics have been addressed by available software, none...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-4-26

    authors: Saghaei M

    更新日期:2004-11-09 00:00:00

  • Understanding the predictive value of continuous markers for censored survival data using a likelihood ratio approach.

    abstract:BACKGROUND:The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way to quantify the update of the risk prediction due to the knowledge of the marker value. The LR has be...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0721-0

    authors: Smith AM,Christodouleas JP,Hwang WT

    更新日期:2019-05-22 00:00:00

  • Validity of the International Physical Activity Questionnaire (IPAQ) for assessing moderate-to-vigorous physical activity and sedentary behaviour of older adults in the United Kingdom.

    abstract:BACKGROUND:In order to accurately measure and monitor levels of moderate-to-vigorous physical activity (MVPA) and sedentary behaviour (SB) in older adults, cost efficient and valid instruments are required. To date, the International Physical Activity Questionnaire (IPAQ) has not been validated with older adults (aged ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12874-018-0642-3

    authors: Cleland C,Ferguson S,Ellis G,Hunter RF

    更新日期:2018-12-22 00:00:00

  • Recruitment strategies and yields for the Pathobiology of Prediabetes in a Biracial Cohort: a prospective natural history study of incident dysglycemia.

    abstract:BACKGROUND:The Pathobiology of Prediabetes in A Biracial Cohort study is a prospective evaluation of the transition from normal to impaired glucose regulation among African American and Caucasian adults with parental type 2 diabetes. This report describes recruitment strategies and relative yields for the 376 enrolled ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-13-64

    authors: Ebenibo S,Edeoga C,Ammons A,Egbuonu N,Dagogo-Jack S,Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) Research Group.

    更新日期:2013-05-10 00:00:00

  • An exploration of how developers use qualitative evidence: content analysis and critical appraisal of guidelines.

    abstract:BACKGROUND:Clinical practice guidelines have become increasingly widely used to guide quality improvement of clinical practice. Qualitative research may be a useful way to improve the quality and implementation of guidelines. The methodology for qualitative evidence used in guidelines development is worthy of further r...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-01041-8

    authors: Wang YY,Liang DD,Lu C,Shi YX,Zhang J,Cao Y,Fang C,Huang D,Jin YH

    更新日期:2020-06-17 00:00:00

  • Study protocol: the empirical investigation of methods to correct for measurement error in biobanks with dietary assessment.

    abstract:BACKGROUND:The Public Population Project in Genomics (P3G) is an organisation that aims to promote collaboration between researchers in the field of population-based genomics. The main objectives of P3G are to encourage collaboration between researchers and biobankers, optimize study design, promote the harmonization o...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-11-135

    authors: Bennett DA,Little J,Masson LF,Minelli C

    更新日期:2011-10-05 00:00:00

  • Variance constraints strongly influenced model performance in growth mixture modeling: a simulation and empirical study.

    abstract:BACKGROUND:Growth Mixture Modeling (GMM) is commonly used to group individuals on their development over time, but convergence issues and impossible values are common. This can result in unreliable model estimates. Constraining variance parameters across classes or over time can solve these issues, but can also serious...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-01154-0

    authors: Sijbrandij JJ,Hoekstra T,Almansa J,Peeters M,Bültmann U,Reijneveld SA

    更新日期:2020-11-12 00:00:00

  • A system for rating the stability and strength of medical evidence.

    abstract:BACKGROUND:Methods for describing one's confidence in the available evidence are useful for end-users of evidence reviews. Analysts inevitably make judgments about the quality, quantity consistency, robustness, and magnitude of effects observed in the studies identified. The subjectivity of these judgments in several a...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-6-52

    authors: Treadwell JR,Tregear SJ,Reston JT,Turkelson CM

    更新日期:2006-10-19 00:00:00

  • Bayes factors for superiority, non-inferiority, and equivalence designs.

    abstract:BACKGROUND:In clinical trials, study designs may focus on assessment of superiority, equivalence, or non-inferiority, of a new medicine or treatment as compared to a control. Typically, evidence in each of these paradigms is quantified with a variant of the null hypothesis significance test. A null hypothesis is assume...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0699-7

    authors: van Ravenzwaaij D,Monden R,Tendeiro JN,Ioannidis JPA

    更新日期:2019-03-29 00:00:00

  • Writing a discussion section: how to integrate substantive and statistical expertise.

    abstract:BACKGROUND:When discussing results medical research articles often tear substantive and statistical (methodical) contributions apart, just as if both were independent. Consequently, reasoning on bias tends to be vague, unclear and superficial. This can lead to over-generalized, too narrow and misleading conclusions, es...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,评审

    doi:10.1186/s12874-018-0490-1

    authors: Höfler M,Venz J,Trautmann S,Miller R

    更新日期:2018-04-17 00:00:00

  • Imputation by the mean score should be avoided when validating a Patient Reported Outcomes questionnaire by a Rasch model in presence of informative missing data.

    abstract:BACKGROUND:Nowadays, more and more clinical scales consisting in responses given by the patients to some items (Patient Reported Outcomes - PRO), are validated with models based on Item Response Theory, and more specifically, with a Rasch model. In the validation sample, presence of missing data is frequent. The aim of...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-11-105

    authors: Hardouin JB,Conroy R,Sébille V

    更新日期:2011-07-14 00:00:00

  • The use of fasting vs. non-fasting triglyceride concentration for estimating the prevalence of high LDL-cholesterol and metabolic syndrome in population surveys.

    abstract:BACKGROUND:For practical reasons it is not easy to obtain fasting samples in large population health surveys. Non-fasting triglyceride (Tg) values are difficult to interpret. The authors compared the accuracy of statistically corrected non-fasting Tg values with true fasting values and estimated the misclassification o...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-11-63

    authors: Sundvall J,Leiviskä J,Laatikainen T,Peltonen M,Salomaa V,Vanhala M,Korpi-Hyövälti E,Lauronen J,Alfthan G

    更新日期:2011-05-10 00:00:00

  • Getting messier with TIDieR: embracing context and complexity in intervention reporting.

    abstract:BACKGROUND:The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is now widely used in health research. The aim of this paper is to describe the experience of using TIDi...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-017-0461-y

    authors: Cotterill S,Knowles S,Martindale AM,Elvey R,Howard S,Coupe N,Wilson P,Spence M

    更新日期:2018-01-18 00:00:00

  • A multi-country comparison of stochastic models of breast cancer mortality with P-splines smoothing approach.

    abstract:BACKGROUND:Precise predictions of incidence and mortality rates due to breast cancer (BC) are required for planning of public health programs as well as for clinical services. A number of approaches has been established for prediction of mortality using stochastic models. The performance of these models intensely depen...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-01187-5

    authors: Mubarik S,Hu Y,Yu C

    更新日期:2020-12-09 00:00:00

  • Using the Beta distribution in group-based trajectory models.

    abstract:BACKGROUND:We demonstrate an application of Group-Based Trajectory Modeling (GBTM) based on the beta distribution. It is offered as an alternative to the normal distribution for modeling continuous longitudinal data that are poorly fit by the normal distribution even with censoring. The primary advantage of the beta di...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-018-0620-9

    authors: Elmer J,Jones BL,Nagin DS

    更新日期:2018-11-26 00:00:00

  • Attempting rigour and replicability in thematic analysis of qualitative research data; a case study of codebook development.

    abstract:BACKGROUND:Navigating the world of qualitative thematic analysis can be challenging. This is compounded by the fact that detailed descriptions of methods are often omitted from qualitative discussions. While qualitative research methodologies are now mature, there often remains a lack of fine detail in their descriptio...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0707-y

    authors: Roberts K,Dowell A,Nie JB

    更新日期:2019-03-28 00:00:00

  • Relative performance of different exposure modeling approaches for sulfur dioxide concentrations in the air in rural western Canada.

    abstract:BACKGROUND:The main objective of this paper is to compare different methods for predicting the levels of SO2 air pollution in oil and gas producing area of rural western Canada. Month-long average air quality measurements were collected over a two-year period (2001-2002) at multiple locations, with some side-by-side me...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-8-43

    authors: Burstyn I,Cherry NM,Yasui Y,Kim HM

    更新日期:2008-07-04 00:00:00

  • Estimation of colorectal adenoma recurrence with dependent censoring.

    abstract:BACKGROUND:Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial. The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimati...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-9-66

    authors: Hsu CH,Long Q,Alberts DS

    更新日期:2009-09-29 00:00:00

  • Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form.

    abstract:BACKGROUND:The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that have potentially broad application in evaluating treatments and capturing burden of respiratory-related...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2288-14-78

    authors: Lin FJ,Pickard AS,Krishnan JA,Joo MJ,Au DH,Carson SS,Gillespie S,Henderson AG,Lindenauer PK,McBurnie MA,Mularski RA,Naureckas ET,Vollmer WM,Lee TA,CONCERT Consortium.

    更新日期:2014-06-16 00:00:00

  • Understanding health management and safety decisions using signal processing and machine learning.

    abstract:BACKGROUND:Small group research in healthcare is important because it deals with interaction and decision-making processes that can help to identify and improve safer patient treatment and care. However, the number of studies is limited due to time- and resource-intensive data processing. The aim of this study was to e...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0756-2

    authors: Aufegger L,Bicknell C,Soane E,Ashrafian H,Darzi A

    更新日期:2019-06-13 00:00:00

  • Cross-cultural validation of the Functional Vision Questionnaire for Children and Young People (FVQ_CYP) with visual impairment in the Dutch population: challenges and opportunities.

    abstract:BACKGROUND:To assess cross-cultural validity between Dutch and English versions of the FVQ_CYP, a patient-reported outcome measure developed in the United Kingdom (UK) for children and adolescents with (severe) visual impairment or blindness (VI for brevity) to measure functional vision. METHODS:The 36-item FVQ_CYP wa...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0875-9

    authors: Elsman EBM,Tadić V,Peeters CFW,van Rens GHMB,Rahi JS,van Nispen RMA

    更新日期:2019-12-03 00:00:00

  • Assessment of reproducibility of cancer survival risk predictions across medical centers.

    abstract:BACKGROUND:Two most important considerations in evaluation of survival prediction models are 1) predictability - ability to predict survival risks accurately and 2) reproducibility - ability to generalize to predict samples generated from different studies. We present approaches for assessment of reproducibility of sur...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2288-13-25

    authors: Chen HC,Chen JJ

    更新日期:2013-02-20 00:00:00

  • Prediction intervals for future BMI values of individual children: a non-parametric approach by quantile boosting.

    abstract:BACKGROUND:The construction of prediction intervals (PIs) for future body mass index (BMI) values of individual children based on a recent German birth cohort study with n = 2007 children is problematic for standard parametric approaches, as the BMI distribution in childhood is typically skewed depending on age. METHO...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-12-6

    authors: Mayr A,Hothorn T,Fenske N

    更新日期:2012-01-25 00:00:00

  • Norm values and psychometric properties for the German health regulatory focus scale - results of a representative survey.

    abstract:BACKGROUND:The health regulatory focus is an application of Higgins' regulatory focus theory to a health-specific context. It explains individual differences in health motivation, strategies, and behavior. Previous research found the Health Regulatory Focus Scale (HRFS) to be a reliable and valid measure for the constr...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-00927-x

    authors: Schmalbach B,Zenger M,Brähler E,Petrowski K

    更新日期:2020-03-02 00:00:00

  • Using a social marketing framework to evaluate recruitment of a prospective study of genetic counseling and testing for the deaf community.

    abstract:BACKGROUND:Recruiting deaf and hard-of-hearing participants, particularly sign language-users, for genetics health service research is challenging due to communication barriers, mistrust toward genetics, and researchers' unfamiliarity with deaf people. Feelings of social exclusion and lack of social cohesion between re...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-13-145

    authors: Kobayashi Y,Boudreault P,Hill K,Sinsheimer JS,Palmer CG

    更新日期:2013-11-25 00:00:00

  • Onset of persistent pseudomonas aeruginosa infection in children with cystic fibrosis with interval censored data.

    abstract:BACKGROUND:Persistent Pseudomonas aeruginosa (PPA) infection promotes lung function deterioration in children with cystic fibrosis (CF). Although early CF diagnosis through newborn screening (NBS) has been shown to provide nutritional/growth benefit, it is unclear whether NBS lowers the risk of PPA infection and how th...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-016-0220-5

    authors: Wang W,Chen MH,Chiou SH,Lai HC,Wang X,Yan J,Zhang Z

    更新日期:2016-09-17 00:00:00

  • Simulation-based estimation of mean and standard deviation for meta-analysis via Approximate Bayesian Computation (ABC).

    abstract:BACKGROUND:When conducting a meta-analysis of a continuous outcome, estimated means and standard deviations from the selected studies are required in order to obtain an overall estimate of the mean effect and its confidence interval. If these quantities are not directly reported in the publications, they must be estima...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-015-0055-5

    authors: Kwon D,Reis IM

    更新日期:2015-08-12 00:00:00

  • Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium.

    abstract:BACKGROUND:Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery. Our goal in this study was to evaluate the use of different methods to correct for the effects of practice or retest on repeated test a...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-018-0530-x

    authors: Racine AM,Gou Y,Fong TG,Marcantonio ER,Schmitt EM,Travison TG,Inouye SK,Jones RN

    更新日期:2018-07-03 00:00:00

  • Bikeability and methodological issues using the active commuting route environment scale (ACRES) in a metropolitan setting.

    abstract:BACKGROUND:Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the pop...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-11-6

    authors: Wahlgren L,Schantz P

    更新日期:2011-01-17 00:00:00