Random allocation software for parallel group randomized trials.

abstract：BACKGROUND:Greater transparency and, in particular, sharing of patient-level data for further scientific research is an increasingly important topic for the pharmaceutical industry and other organisations who sponsor and conduct clinical trials as well as generally in the interests of patients participating in studies....

journal_title：BMC medical research methodology

authors： Tucker K,Branson J,Dilleen M,Hollis S,Loughlin P,Nixon MJ,Williams Z

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:Self-administered questionnaires are becoming increasingly common in general practice. Much research has explored methods to increase response rates but comparatively few studies have explored the effect of questionnaire administration on reported answers. METHODS:The aim of this study was to determine the ...

journal_title：BMC medical research methodology

authors： Desborough JA,Butters P,Bhattacharya D,Holland RC,Wright DJ

更新日期：2008-06-27 00:00:00

abstract：BACKGROUND:Information and theory beyond copula concepts are essential to understand the dependence relationship between several marginal covariates distributions. In a therapeutic trial data scheme, most of the time, censoring occurs. That could lead to a biased interpretation of the dependence relationship between ma...

journal_title：BMC medical research methodology

authors： Fontaine C,Daurès JP,Landais P

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Cancer relapses may be useful to predict the risk of death. To take into account relapse information, the Landmark approach is popular. As an alternative, we propose the joint frailty model for a recurrent event and a terminal event to derive dynamic predictions of the risk of death. METHODS:The proposed pr...

journal_title：BMC medical research methodology

authors： Mauguen A,Rachet B,Mathoulin-Pélissier S,Lawrence GM,Siesling S,MacGrogan G,Laurent A,Rondeau V

更新日期：2015-04-01 00:00:00

abstract：:The quality of a consultation provided by a physician can have a profound impact on the quality of care and patient engagement in treatment decisions. When the COPD Assessment Test (CAT) was developed, one of its aims was to aid the communication between physician and patient about the impact of COPD. We developed a n...

journal_title：BMC medical research methodology

authors： Gruffydd-Jones K,Marsden H,Holmes S,Kardos P,Escamilla R,Dal Negro R,Roberts J,Nadeau G,Leather D,Jones P

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way to quantify the update of the risk prediction due to the knowledge of the marker value. The LR has be...

journal_title：BMC medical research methodology

authors： Smith AM,Christodouleas JP,Hwang WT

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:The COVID-19 pandemic has evolved into one of the most impactful health crises in modern history, compelling researchers to explore innovative ways to efficiently collect public health data in a timely manner. Social media platforms have been explored as a research recruitment tool in other settings; however...

journal_title：BMC medical research methodology

authors： Ali SH,Foreman J,Capasso A,Jones AM,Tozan Y,DiClemente RJ

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear dynamical systems, which may make linear statistical techniques less suitable to analyze their dyna...

journal_title：BMC medical research methodology

authors： Toonen RB,Wardenaar KJ,Bos EH,van Ockenburg SL,de Jonge P

更新日期：2018-03-21 00:00:00

abstract：BACKGROUND:Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent variable. One reason for the unclarity is that traditional factor analytic techniques have trouble estim...

journal_title：BMC medical research methodology

authors： Forkmann T,Teismann T,Stenzel JS,Glaesmer H,de Beurs D

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Evidence suggests that differences exist in physical activity (PA) participation among Culturally and Linguistically Diverse (CALD) children and adolescents. It is possible that these differences could be influenced by variations in measurement technique and instrument reliability. However, culturally sensit...

journal_title：BMC medical research methodology

authors： Strugnell C,Renzaho A,Ridley K,Burns C

更新日期：2011-08-25 00:00:00

abstract：BACKGROUND:To describe how frequently harm is reported in the abstract of high impact factor medical journals. METHODS: DESIGN AND POPULATION:We carried out a blinded structured review of a random sample of 363 Randomised Controlled Trials (RCTs) carried out on human beings, and published in high impact factor medica...

journal_title：BMC medical research methodology

authors： Bernal-Delgado E,Fisher ES

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:Outcomes in observational studies may not best estimate those expected in the HIV vaccine efficacy trials. We compared retention in Simulated HIV Vaccine Efficacy Trials (SiVETs) and observational cohorts drawn from two key populations in Uganda. METHODS:Two SiVETs were nested within two observational cohor...

journal_title：BMC medical research methodology

authors： Abaasa A,Todd J,Nash S,Mayanja Y,Kaleebu P,Fast PE,Price M

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:One of the biggest challenges for population health studies is the recruitment of participants. Questions that investigators have asked are "who volunteers for studies?" and "does recruitment method influence characteristics of the samples?" The purpose of this paper was to compare sample characteristics of ...

journal_title：BMC medical research methodology

authors： Leung BM,McDonald SW,Kaplan BJ,Giesbrecht GF,Tough SC

更新日期：2013-12-06 00:00:00

abstract：BACKGROUND:Two most important considerations in evaluation of survival prediction models are 1) predictability - ability to predict survival risks accurately and 2) reproducibility - ability to generalize to predict samples generated from different studies. We present approaches for assessment of reproducibility of sur...

journal_title：BMC medical research methodology

authors： Chen HC,Chen JJ

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:Available methods for the joint modelling of longitudinal and time-to-event outcomes have typically only allowed for a single longitudinal outcome and a solitary event time. In practice, clinical studies are likely to record multiple longitudinal outcomes. Incorporating all sources of data will improve the p...

journal_title：BMC medical research methodology

authors： Hickey GL,Philipson P,Jorgensen A,Kolamunnage-Dona R

更新日期：2016-09-07 00:00:00

abstract：BACKGROUND:When conducting a meta-analysis of a continuous outcome, estimated means and standard deviations from the selected studies are required in order to obtain an overall estimate of the mean effect and its confidence interval. If these quantities are not directly reported in the publications, they must be estima...

journal_title：BMC medical research methodology

authors： Kwon D,Reis IM

更新日期：2015-08-12 00:00:00

abstract：BACKGROUND:Disease registers aim to collect information about all instances of a disease or condition in a defined population of individuals. Traditionally methods of operating disease registers have required that notifications of cases be identified by unique identifiers such as social security number or national iden...

journal_title：BMC medical research methodology

authors： Churches T

更新日期：2003-01-06 00:00:00

abstract：BACKGROUND:Missing data present a challenge to many research projects. The problem is often pronounced in studies utilizing self-report scales, and literature addressing different strategies for dealing with missing data in such circumstances is scarce. The objective of this study was to compare six different imputatio...

journal_title：BMC medical research methodology

authors： Shrive FM,Stuart H,Quan H,Ghali WA

更新日期：2006-12-13 00:00:00

abstract：BACKGROUND:Sleeping under a long-lasting insecticidal net (LLIN) is recommended for all pregnant women in sub-Saharan Africa, due to the high prevalence of malaria infection and its associated complications in the region. Despite this, LLIN use has still remained sub-optimal among pregnant women in Maiduguri, Nigeria. ...

journal_title：BMC medical research methodology

authors： Balami AD,Said SM,Zulkefli NAM,Bachok N,Balami EL

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:With the increasing implementation of web-based, mobile health interventions in clinical trials, it is crucial for researchers to address the security and privacy concerns of patient information according to high ethical standards. The full process of meeting these standards is often made more complicated du...

journal_title：BMC medical research methodology

authors： Eagleson R,Altamirano-Diaz L,McInnis A,Welisch E,De Jesus S,Prapavessis H,Rombeek M,Seabrook JA,Park T,Norozi K

更新日期：2017-03-17 00:00:00

abstract：BACKGROUND:Claims databases are generally considered inadequate for obesity research due to suboptimal capture of body mass index (BMI) measurements. This might not be true for bariatric surgery because of reimbursement requirements and changes in coding systems. We assessed the availability and validity of claims-base...

journal_title：BMC medical research methodology

authors： Li X,Lewis KH,Callaway K,Wharam JF,Toh S

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Spiritual care is defined as recognizing and responding to the needs of the human spirit when the individual is facing trauma, illness, or sadness. Providing spiritual care is one of the core aspects of holistic care, as it is significantly associated with patients' quality of life. The provision of optimal ...

journal_title：BMC medical research methodology

authors： Hu Y,Tiew LH,Li F

更新日期：2019-01-23 00:00:00

abstract：BACKGROUND:It has been demonstrated that the enclosure of money with a mailed questionnaire increases the response rate significantly. We evaluated scratch lottery tickets as an alternative to cash. METHODS:1500 randomly selected Norwegians between the ages of 40 and 65 years were sent a short questionnaire. 250 recei...

journal_title：BMC medical research methodology

authors： Finsen V,Storeheier AH

更新日期：2006-04-28 00:00:00

abstract：BACKGROUND:Nowadays, more and more clinical scales consisting in responses given by the patients to some items (Patient Reported Outcomes - PRO), are validated with models based on Item Response Theory, and more specifically, with a Rasch model. In the validation sample, presence of missing data is frequent. The aim of...

journal_title：BMC medical research methodology

authors： Hardouin JB,Conroy R,Sébille V

更新日期：2011-07-14 00:00:00

abstract：BACKGROUND:This article describes the design and baseline sample of a single-site trial comparing Individual Placement and Support (IPS) supported employment delivered within a Veterans Health Administration (VHA) primary care Patient Aligned Care Team (PACT) to treatment-as-usual vocational rehabilitation (TAU-VR) tha...

journal_title：BMC medical research methodology

authors： Davis LL,Blansett CM,Mumba MN,MacVicar D,Toscano R,Pilkinton P,Gay W,Bartolucci A

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitment and increased generalisability of results. Mixed models can be applied to account for potential cl...

journal_title：BMC medical research methodology

authors： Harden M,Friede T

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:There is increasing awareness that meta-analyses require a sufficiently large information size to detect or reject an anticipated intervention effect. The required information size in a meta-analysis may be calculated from an anticipated a priori intervention effect or from an intervention effect suggested b...

journal_title：BMC medical research methodology

authors： Wetterslev J,Thorlund K,Brok J,Gluud C

更新日期：2009-12-30 00:00:00

abstract：BACKGROUND:In Routine Outcome Monitoring (ROM) there is a high demand for short assessments. Computerized Adaptive Testing (CAT) is a promising method for efficient assessment. In this article, the efficiency of a CAT version of the Mood and Anxiety Symptom Questionnaire, - Anhedonic Depression scale (MASQ-AD) for use ...

journal_title：BMC medical research methodology

authors： Smits N,Zitman FG,Cuijpers P,den Hollander-Gijsman ME,Carlier IV

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Clinical practice guidelines have become increasingly widely used to guide quality improvement of clinical practice. Qualitative research may be a useful way to improve the quality and implementation of guidelines. The methodology for qualitative evidence used in guidelines development is worthy of further r...

journal_title：BMC medical research methodology

authors： Wang YY,Liang DD,Lu C,Shi YX,Zhang J,Cao Y,Fang C,Huang D,Jin YH

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Methods for describing one's confidence in the available evidence are useful for end-users of evidence reviews. Analysts inevitably make judgments about the quality, quantity consistency, robustness, and magnitude of effects observed in the studies identified. The subjectivity of these judgments in several a...

journal_title：BMC medical research methodology

authors： Treadwell JR,Tregear SJ,Reston JT,Turkelson CM

更新日期：2006-10-19 00:00:00