Abstract:
BACKGROUND:This article describes the design and baseline sample of a single-site trial comparing Individual Placement and Support (IPS) supported employment delivered within a Veterans Health Administration (VHA) primary care Patient Aligned Care Team (PACT) to treatment-as-usual vocational rehabilitation (TAU-VR) that includes transitional work. METHODS:Unemployed U.S. military veterans receiving care in a VHA PACT who were seeking competitive work, otherwise eligible for vocational rehabilitation, and diagnosed with a mental health condition other than a psychotic or bipolar I disorder were prospectively randomized to receive either IPS or TAU-VR. Employment outcomes and measures of quality of life, self-esteem, and community reintegration are being collected for 12 months. RESULTS:The participant sample (n = 119) is comprised of 17.6% female, 73.1% African-Americans, and 1.7% Hispanic. Average age is 38.2 (SD ± 8.41) years; 80.7% served in the military since 2001; 78% are receiving or applying for U.S. Department of Veterans Affairs (VA) service-connected disability; 26.9% have not held a competitive job in the past 3 years; and the average length of pre-randomization unemployment is 1.4 (SD ± 2.3) years. CONCLUSIONS:Unique design features include evaluating the efficacy of evidenced-based IPS within the primary care setting, having broad diagnostic eligibility, and defining the primary outcome criterion as "steady employment", i.e. holding a competitive job for ≥26 weeks of the 12-month follow-up period. The findings illustrate the characteristics of a primary care veteran sample in need of employment services. TRIAL REGISTRATION:www.clinicaltrials.gov Identifier: NCT02400736.
journal_name
BMC Med Res Methodoljournal_title
BMC medical research methodologyauthors
Davis LL,Blansett CM,Mumba MN,MacVicar D,Toscano R,Pilkinton P,Gay W,Bartolucci Adoi
10.1186/s12874-020-0919-1subject
Has Abstractpub_date
2020-02-17 00:00:00pages
33issue
1issn
1471-2288pii
10.1186/s12874-020-0919-1journal_volume
20pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The mechanisms and pathways to impacts from public health research in the UK have not been widely studied. Through the lens of one funder (NIHR), our aims are to map the diversity of public health research, in terms of funding mechanisms, disciplinary contributions, and public health impacts, identify exampl...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-0905-7
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:Multiple Imputation as usually implemented assumes that data are Missing At Random (MAR), meaning that the underlying missing data mechanism, given the observed data, is independent of the unobserved data. To explore the sensitivity of the inferences to departures from the MAR assumption, we applied the meth...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-12-73
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:This study aimed to investigate whether awareness of being monitored by an accelerometer has an effect on physical activity in young people. METHODS:Eighty healthy participants aged 10-18 years were randomized between blinded and nonblinded groups. The blinded participants were informed that we were testing...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12874-017-0378-5
更新日期:2017-07-11 00:00:00
abstract:BACKGROUND:Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,实务指引
doi:10.1186/1471-2288-9-57
更新日期:2009-07-28 00:00:00
abstract:BACKGROUND:Primary-care based randomized controlled trials (RCTs) build an important evidence base for general practice but little evidence exists about barriers to recruitment which often hamper such trials. We investigated the issues that impeded and facilitated recruitment to a clinical trial in general practice. M...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-015-0012-3
更新日期:2015-03-12 00:00:00
abstract:BACKGROUND:The health regulatory focus is an application of Higgins' regulatory focus theory to a health-specific context. It explains individual differences in health motivation, strategies, and behavior. Previous research found the Health Regulatory Focus Scale (HRFS) to be a reliable and valid measure for the constr...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-00927-x
更新日期:2020-03-02 00:00:00
abstract:BACKGROUND:A recent paper found that terminal digits of statistical values in Nature deviated significantly from an equiprobable distribution, indicating errors or inconsistencies in rounding. This finding, as well as the discovery that a large percentage of p values were inconsistent with reported test statistics, led...
journal_title:BMC medical research methodology
pub_type: 评论,杂志文章
doi:10.1186/1471-2288-6-45
更新日期:2006-09-13 00:00:00
abstract:BACKGROUND:Data on lifetime exposures are often self-reported in epidemiologic studies, sometimes many years after the relevant age. Validity of self-reported data is usually inferred from their agreement with measured values, but few studies directly quantify the likely effects of reporting errors in body size and rep...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-11-7
更新日期:2011-01-17 00:00:00
abstract:BACKGROUND:Models of hepatitis C virus (HCV) kinetics are increasingly used to estimate and to compare in vivo drug's antiviral effectiveness of new potent anti-HCV agents. Viral kinetic parameters can be estimated using non-linear mixed effect models (NLMEM). Here we aimed to evaluate the performance of this approach ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-13-60
更新日期:2013-04-25 00:00:00
abstract:BACKGROUND:Diagnostic problems in clinical trials are sometimes ordinal. For example, colon tumor staging was performed according to the TNM classification. However, clinical data are limited by markedly small sample sizes in some stage. METHODS:We propose a distribution-free test for detecting ordered alternatives in...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-13-148
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:Clinical study reports (CSRs) have been increasingly utilised within academic research in recent years. European Medicines Agency (EMA) Policy 0070 'Phase 1,' which came into effect in January 2015, requires the publication of regulatory documents such as CSRs from central applications in an anonymised forma...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/s12874-019-0836-3
更新日期:2019-11-05 00:00:00
abstract:BACKGROUND:To describe how frequently harm is reported in the abstract of high impact factor medical journals. METHODS: DESIGN AND POPULATION:We carried out a blinded structured review of a random sample of 363 Randomised Controlled Trials (RCTs) carried out on human beings, and published in high impact factor medica...
journal_title:BMC medical research methodology
pub_type: 信件,评审
doi:10.1186/1471-2288-8-14
更新日期:2008-03-27 00:00:00
abstract:BACKGROUND:General Practitioners (GPs) respond poorly to postal surveys. Consequently there is potential for reduced data quality and bias in the findings. In general population surveys, response to postal questionnaires may be improved by reducing their length and offering incentives. The aim of this study was to inve...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-15-3
更新日期:2015-01-06 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the standard tasks performed by clinical research coordinators (CRCs) in oncology clinical trials. METHODS:Forty-one CRCs were anonymously surveyed, using a four-page self-administered questionnaire focused on demographics, qualifications, and professional experien...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-4-6
更新日期:2004-03-25 00:00:00
abstract:BACKGROUND:Estimating costs is essential to the economic analysis of health care programs. Health care costs are often captured from administrative databases or by patient report. Administrative records only provide a partial representation of health care costs and have additional limitations. Patient-completed questio...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-11-45
更新日期:2011-04-13 00:00:00
abstract:BACKGROUND:In the present article, we propose an alternative method for dealing with negative affectivity (NA) biases in research, while investigating the association between a deleterious psychosocial environment at work and poor mental health. First, we investigated how strong NA must be to cause an observed correlat...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-11-121
更新日期:2011-08-24 00:00:00
abstract:BACKGROUND:There is a recognised need to build primary care medication adherence services which are tailored to patients' needs. Continuous quality improvement of such services requires a regular working method of measuring adherence in order to monitor effectiveness. Self report has been considered the method of choic...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/1471-2288-11-149
更新日期:2011-11-03 00:00:00
abstract:BACKGROUND:Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-76
更新日期:2009-11-13 00:00:00
abstract:BACKGROUND:Patient-reported outcome (PRO) measures play a key role in the advancement of patient-centered care research. The accuracy of inferences, relevance of predictions, and the true nature of the associations made with PRO data depend on the validity of these measures. Errors inherent to self-report measures can ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-016-0161-z
更新日期:2016-05-26 00:00:00
abstract:BACKGROUND:Due to limited duration of follow up in clinical trials of cancer treatments, estimates of lifetime survival benefits are typically derived using statistical extrapolation methods. To justify the method used, a range of approaches have been proposed including statistical goodness-of-fit tests and comparing e...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-00997-x
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence of the disease in the study population, and also for studying the risk factors for the disease. ME...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-017-0447-9
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial. The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimati...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-66
更新日期:2009-09-29 00:00:00
abstract:BACKGROUND:Growth Mixture Modeling (GMM) is commonly used to group individuals on their development over time, but convergence issues and impossible values are common. This can result in unreliable model estimates. Constraining variance parameters across classes or over time can solve these issues, but can also serious...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-01154-0
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Recruitment to health research remains a major challenge. Innovation is required to meet policy commitments to help patients take part in health research. One innovation that may help meet those policy goals is the development of 'consent to contact' systems, where people give generic consent to be contacted...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0843-4
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Compliance is a critical issue for parental questionnaires in school based epidemiological surveys and high compliance is difficult to achieve. The objective of this study was to determine trends and factors associated with parental questionnaire compliance during respiratory health surveys of school childre...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-12-53
更新日期:2012-04-20 00:00:00
abstract:BACKGROUND:The occurrence of communicable diseases (CD) depends on exposure to contagious persons. The effects of exposure to CD are delayed in time and contagious persons remain contagious for several days during which their contagiousness varies. Moreover when multiple exposures occur, it is difficult to know which e...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-13-26
更新日期:2013-02-20 00:00:00
abstract:BACKGROUND:Nowadays, more and more clinical scales consisting in responses given by the patients to some items (Patient Reported Outcomes - PRO), are validated with models based on Item Response Theory, and more specifically, with a Rasch model. In the validation sample, presence of missing data is frequent. The aim of...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-11-105
更新日期:2011-07-14 00:00:00
abstract:BACKGROUND:Syntheses of qualitative studies can inform health policy, services and our understanding of patient experience. Meta-ethnography is a systematic seven-phase interpretive qualitative synthesis approach well-suited to producing new theories and conceptual models. However, there are concerns about the quality ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/1471-2288-14-119
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:Posttraumatic growth is the positive change resulting from traumatic experiences and is typically assessed with retrospective measures like the Posttraumatic Growth Inventory (PTGI). The PTGI was designed to include reference to a specific traumatic event, making it difficult to implement, without change, in...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-017-0344-2
更新日期:2017-04-20 00:00:00
abstract:BACKGROUND:Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design assuming that a control group already exists. METHODS:We propose and discuss an interim analysis step...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0763-3
更新日期:2019-07-16 00:00:00