Novel study design to assess the utility of the copd assessment test in a primary care setting.

abstract：BACKGROUND:One of the biggest challenges for population health studies is the recruitment of participants. Questions that investigators have asked are "who volunteers for studies?" and "does recruitment method influence characteristics of the samples?" The purpose of this paper was to compare sample characteristics of ...

journal_title：BMC medical research methodology

authors： Leung BM,McDonald SW,Kaplan BJ,Giesbrecht GF,Tough SC

更新日期：2013-12-06 00:00:00

abstract：BACKGROUND:Disease registers aim to collect information about all instances of a disease or condition in a defined population of individuals. Traditionally methods of operating disease registers have required that notifications of cases be identified by unique identifiers such as social security number or national iden...

journal_title：BMC medical research methodology

authors： Churches T

更新日期：2003-01-06 00:00:00

abstract：BACKGROUND:Multilevel models for non-normal outcomes are widely used in medical and health sciences research. While methods for interpreting fixed effects are well-developed, methods to quantify and interpret random cluster variation and compare it with other sources of variation are less established. Random cluster va...

journal_title：BMC medical research methodology

authors： Glorioso TJ,Grunwald GK,Ho PM,Maddox TM

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:A key component of the implementation process is identifying potential barriers and facilitators that need to be addressed. The Theoretical Domains Framework (TDF) is one of the most commonly used frameworks for this purpose. When applying the TDF, it is critical to understand the context in which behaviours...

journal_title：BMC medical research methodology

authors： Etherington N,Rodrigues IB,Giangregorio L,Graham ID,Hoens AM,Kasperavicius D,Kelly C,Moore JE,Ponzano M,Presseau J,Sibley KM,Straus S

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Interventions in occupational health often target worksites rather than individuals. The objective of this paper is to describe the (lack of) stability in units of analysis in occupational health and safety intervention projects directed toward worksites. METHODS:A case study approach is used to describe na...

journal_title：BMC medical research methodology

authors： Olsen O,Albertsen K,Nielsen ML,Poulsen KB,Gron SM,Brunnberg HL

更新日期：2008-06-13 00:00:00

abstract：BACKGROUND:In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available. There is currently a lack of a systematically developed and evaluated tool for the assessment of diagnostic accuracy studies. The aim of this project was to combine empiri...

journal_title：BMC medical research methodology

authors： Whiting P,Rutjes AW,Reitsma JB,Bossuyt PM,Kleijnen J

更新日期：2003-11-10 00:00:00

abstract：BACKGROUND:We demonstrate an application of Group-Based Trajectory Modeling (GBTM) based on the beta distribution. It is offered as an alternative to the normal distribution for modeling continuous longitudinal data that are poorly fit by the normal distribution even with censoring. The primary advantage of the beta di...

journal_title：BMC medical research methodology

authors： Elmer J,Jones BL,Nagin DS

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Growth Mixture Modeling (GMM) is commonly used to group individuals on their development over time, but convergence issues and impossible values are common. This can result in unreliable model estimates. Constraining variance parameters across classes or over time can solve these issues, but can also serious...

journal_title：BMC medical research methodology

authors： Sijbrandij JJ,Hoekstra T,Almansa J,Peeters M,Bültmann U,Reijneveld SA

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Various papers have addressed pros and cons of the stepped wedge cluster randomized trial design (SWD). However, some issues have not or only limitedly been addressed. Our aim was to provide a comprehensive overview of all merits and limitations of the SWD to assist researchers, reviewers and medical ethics ...

journal_title：BMC medical research methodology

authors： de Hoop E,van der Tweel I,van der Graaf R,Moons KG,van Delden JJ,Reitsma JB,Koffijberg H

更新日期：2015-10-30 00:00:00

abstract：BACKGROUND:Cross-cultural research with patient-reported outcomes measures (PROMs) assumes that the PROM in the target language will measure the same construct in the same way as the PROM in the source language. Yet translation methods are rarely used to qualitatively maximise construct equivalence or to describe the i...

journal_title：BMC medical research methodology

authors： Hawkins M,Cheng C,Elsworth GR,Osborne RH

更新日期：2020-05-26 00:00:00

abstract：BACKGROUND:General Practitioners (GPs) respond poorly to postal surveys. Consequently there is potential for reduced data quality and bias in the findings. In general population surveys, response to postal questionnaires may be improved by reducing their length and offering incentives. The aim of this study was to inve...

journal_title：BMC medical research methodology

authors： Cottrell E,Roddy E,Rathod T,Thomas E,Porcheret M,Foster NE

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:When investigating subgroup effects in meta-analysis, it is unclear whether accounting in meta-regression for between-trial variation in treatment effects, but not between-trial variation in treatment interaction effects when such effects are present, leads to biased estimates, coverage problems, or wrong st...

journal_title：BMC medical research methodology

authors： da Costa BR,Sutton AJ

更新日期：2019-10-26 00:00:00

abstract：BACKGROUND:Variation in counts between subjects at a given speed or work rate are the most important source of error in physical activity (PA) measurements with accelerometers. The aim of this study was to explore how the use of individual accelerometer cut points (ICPs) affected the analysis of PA field data. METHODS...

journal_title：BMC medical research methodology

authors： Aadland E,Steene-Johannessen J

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:With the increasing implementation of web-based, mobile health interventions in clinical trials, it is crucial for researchers to address the security and privacy concerns of patient information according to high ethical standards. The full process of meeting these standards is often made more complicated du...

journal_title：BMC medical research methodology

authors： Eagleson R,Altamirano-Diaz L,McInnis A,Welisch E,De Jesus S,Prapavessis H,Rombeek M,Seabrook JA,Park T,Norozi K

更新日期：2017-03-17 00:00:00

abstract：BACKGROUND:Systematic reviewers seek to comprehensively search for relevant studies and summarize these to present the most valid estimate of intervention effectiveness. The more resources searched, the higher the yield, and thus time and costs required to conduct a systematic review. While there is an abundance of evi...

journal_title：BMC medical research methodology

authors： Crumley ET,Wiebe N,Cramer K,Klassen TP,Hartling L

更新日期：2005-08-10 00:00:00

abstract：BACKGROUND:In prognostic studies model instability and missing data can be troubling factors. Proposed methods for handling these situations are bootstrapping (B) and Multiple imputation (MI). The authors examined the influence of these methods on model composition. METHODS:Models were constructed using a cohort of 58...

journal_title：BMC medical research methodology

authors： Vergouw D,Heymans MW,Peat GM,Kuijpers T,Croft PR,de Vet HC,van der Horst HE,van der Windt DA

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:The most commonly used survey methods are self-administered questionnaires, telephone interviews, and a mixture of both. But until now evidence out of randomised controlled trials as to whether patient responses differ depending on the survey mode is lacking. Therefore this study assessed whether patient res...

journal_title：BMC medical research methodology

authors： Lungenhausen M,Lange S,Maier C,Schaub C,Trampisch HJ,Endres HG

更新日期：2007-11-22 00:00:00

abstract：BACKGROUND:The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance, and could lead to a better understanding of the impact of treatments on the everyday life and care ...

journal_title：BMC medical research methodology

authors： Barbieri A,Peyhardi J,Conroy T,Gourgou S,Lavergne C,Mollevi C

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:The Behavioral Risk Factor Surveillance System (BRFSS) is a network of health-related telephone surveys--conducted by all 50 states, the District of Columbia, and participating US territories-that receive technical assistance from CDC. Data users often aggregate BRFSS state samples for national estimates wit...

journal_title：BMC medical research methodology

authors： Iachan R,Pierannunzi C,Healey K,Greenlund KJ,Town M

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Identifying and assessing degree and type of frailty among older persons is a major challenge when targeting high risk populations to identify preventive interventions. The Vulnerable Elders Survey-(VES-13) is a simple instrument to identify frailty defined as risk for death, functional decline or institutio...

journal_title：BMC medical research methodology

authors： Belmin J,Khellaf L,Pariel S,Jarzebowski W,Valembois L,Zeisel J,Lafuente-Lafuente C

更新日期：2020-02-05 00:00:00

abstract：BACKGROUND:Biomarkers of exposures such as infection or environmental chemicals can be measured in small volumes of blood extracted from newborn dried blood spots (DBS) underscoring their potential utility for population-based research. However, few studies have evaluated the feasibility and utility of this resource; p...

journal_title：BMC medical research methodology

authors： Yeung EH,Louis GB,Lawrence D,Kannan K,McLain AC,Caggana M,Druschel C,Bell E

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of ...

journal_title：BMC medical research methodology

authors： Marshall A,Altman DG,Holder RL,Royston P

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the most widely used tool for investigating the methodological quality of SRs and is currently undergoing r...

journal_title：BMC medical research methodology

authors： Wegewitz U,Weikert B,Fishta A,Jacobs A,Pieper D

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Diabetes-related lower limb amputations are associated with considerable morbidity and mortality and are usually preceded by foot ulceration. The available systematic reviews of aggregate data are compromised because the primary studies report both adjusted and unadjusted estimates. As adjusted meta-analyses...

journal_title：BMC medical research methodology

authors： Crawford F,Anandan C,Chappell FM,Murray GD,Price JF,Sheikh A,Simpson CR,Maxwell M,Stansby GP,Young MJ,Abbott CA,Boulton AJ,Boyko EJ,Kastenbauer T,Leese GP,Monami M,Monteiro-Soares M,Rith-Najarian SJ,Veves A,Coates N

更新日期：2013-02-15 00:00:00

abstract：BACKGROUND:Recruitment to clinical trials can be challenging. Methods that improve the efficiency of trial recruitment are needed to increase successful study completions. The aim of this study was to ascertain whether sending an audio-visual presentation on a digital versatile disc (DVD), along with usual study invita...

journal_title：BMC medical research methodology

authors： Rogers A,Flynn RWV,Mackenzie IS,MacDonald TM

更新日期：2019-01-30 00:00:00

abstract：BACKGROUND:The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way to quantify the update of the risk prediction due to the knowledge of the marker value. The LR has be...

journal_title：BMC medical research methodology

authors： Smith AM,Christodouleas JP,Hwang WT

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity such as participant recruitment and retention, identifying a meaningful...

journal_title：BMC medical research methodology

authors： Hall CL,Brown S,James M,Martin JL,Brown N,Selby K,Clarke J,Williams L,Sayal K,Hollis C,Groom MJ

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in many developed countries appears to be increasing. There is some evidence from Latin America that COPD is a growing cause of death, but information on prevalence is scant. It is possible that, due to the high frequency of smoking in these coun...

journal_title：BMC medical research methodology

authors： Menezes AM,Victora CG,Perez-Padilla R,PLATINO Team.

更新日期：2004-06-17 00:00:00

abstract：BACKGROUND:Family members are increasingly involved in the care of cancer patients, however many are not prepared for this challenging role. Intervention-based studies are valuable to inform the most appropriate and effective support for caregivers. Barriers in the recruitment of patient/caregiver dyads exist but the r...

journal_title：BMC medical research methodology

authors： Heckel L,Gunn KM,Livingston PM

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban no...

journal_title：BMC medical research methodology

authors： O'Toole JE,Sinclair MI,Leder K

更新日期：2009-11-09 00:00:00