The rise of multiple imputation: a review of the reporting and implementation of the method in medical research.

abstract：BACKGROUND:Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of ...

journal_title：BMC medical research methodology

authors： Marshall A,Altman DG,Holder RL,Royston P

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Outcomes collected in randomized clinical trials are observations of random variables that should be independent and identically distributed. However, in some trials, the patients are randomized more than once thus violating both of these assumptions. The probability of an event is not always the same when a...

journal_title：BMC medical research methodology

authors： Hozo I,Djulbegovic B,Clark O,Lyman GH

更新日期：2005-05-10 00:00:00

abstract：BACKGROUND:Clinical practice guidelines have become increasingly widely used to guide quality improvement of clinical practice. Qualitative research may be a useful way to improve the quality and implementation of guidelines. The methodology for qualitative evidence used in guidelines development is worthy of further r...

journal_title：BMC medical research methodology

authors： Wang YY,Liang DD,Lu C,Shi YX,Zhang J,Cao Y,Fang C,Huang D,Jin YH

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:The weighted estimators generally used for analyzing case-cohort studies are not fully efficient and naive estimates of the predictive ability of a model from case-cohort data depend on the subcohort size. However, case-cohort studies represent a special type of incomplete data, and methods for analyzing inc...

journal_title：BMC medical research methodology

authors： Marti H,Carcaillon L,Chavance M

更新日期：2012-03-09 00:00:00

abstract：BACKGROUND:The BSI-18 contains the three six-item scales somatization, depression, and anxiety as well as the Global Severity Index (GSI), including all 18 items. The BSI-18 is the latest and shortest of the multidimensional versions of the Symptom-Checklist 90-R, but its psychometric properties have not been sufficien...

journal_title：BMC medical research methodology

authors： Franke GH,Jaeger S,Glaesmer H,Barkmann C,Petrowski K,Braehler E

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:Due to limited duration of follow up in clinical trials of cancer treatments, estimates of lifetime survival benefits are typically derived using statistical extrapolation methods. To justify the method used, a range of approaches have been proposed including statistical goodness-of-fit tests and comparing e...

journal_title：BMC medical research methodology

authors： Bullement A,Willis A,Amin A,Schlichting M,Hatswell AJ,Bharmal M

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:The mechanisms and pathways to impacts from public health research in the UK have not been widely studied. Through the lens of one funder (NIHR), our aims are to map the diversity of public health research, in terms of funding mechanisms, disciplinary contributions, and public health impacts, identify exampl...

journal_title：BMC medical research methodology

authors： Boulding H,Kamenetzky A,Ghiga I,Ioppolo B,Herrera F,Parks S,Manville C,Guthrie S,Hinrichs-Krapels S

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Evidence mapping describes the quantity, design and characteristics of research in broad topic areas, in contrast to systematic reviews, which usually address narrowly-focused research questions. The breadth of evidence mapping helps to identify evidence gaps, and may guide future research efforts. The Globa...

journal_title：BMC medical research methodology

authors： Bragge P,Clavisi O,Turner T,Tavender E,Collie A,Gruen RL

更新日期：2011-06-17 00:00:00

abstract：BACKGROUND:Physical activity is an important determinant of health. Walking is the most common physical activity performed by adults and the presence of sidewalks along roads is a determinant of walking. Geographic information systems (GIS) can be used to measure sidewalks; however, GIS sidewalk data are difficult to a...

journal_title：BMC medical research methodology

authors： Janssen I,Rosu A

更新日期：2012-03-29 00:00:00

abstract：BACKGROUND:Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, to ensure it continues to reflect current indications, doses, routes and formulations, as well as upd...

journal_title：BMC medical research methodology

authors： Cooney L,Loke YK,Golder S,Kirkham J,Jorgensen A,Sinha I,Hawcutt D

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance, and could lead to a better understanding of the impact of treatments on the everyday life and care ...

journal_title：BMC medical research methodology

authors： Barbieri A,Peyhardi J,Conroy T,Gourgou S,Lavergne C,Mollevi C

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that have potentially broad application in evaluating treatments and capturing burden of respiratory-related...

journal_title：BMC medical research methodology

authors： Lin FJ,Pickard AS,Krishnan JA,Joo MJ,Au DH,Carson SS,Gillespie S,Henderson AG,Lindenauer PK,McBurnie MA,Mularski RA,Naureckas ET,Vollmer WM,Lee TA,CONCERT Consortium.

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Randomised controlled trials (RCTs) are the gold standard for evidence-based practice. However, RCTs can have limitations. For example, translation of findings into practice can be limited by design features, such as inclusion criteria, not accurately reflecting clinical populations. In addition, it is expen...

journal_title：BMC medical research methodology

authors： Lemanska A,Byford RC,Cruickshank C,Dearnaley DP,Ferreira F,Griffin C,Hall E,Hinton W,de Lusignan S,Sherlock J,Faithfull S

更新日期：2020-07-25 00:00:00

abstract：BACKGROUND:Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for clustering. These inflation factors are valid under the assumption that randomisation is stratified by...

journal_title：BMC medical research methodology

authors： Martin JT,Hemming K,Girling A

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent by an intervening, mediator variable M. Methods for addressing mediation have been available for ...

journal_title：BMC medical research methodology

authors： Knafl GJ,Knafl KA,Grey M,Dixon J,Deatrick JA,Gallo AM

更新日期：2017-03-21 00:00:00

abstract：BACKGROUND:Family members are increasingly involved in the care of cancer patients, however many are not prepared for this challenging role. Intervention-based studies are valuable to inform the most appropriate and effective support for caregivers. Barriers in the recruitment of patient/caregiver dyads exist but the r...

journal_title：BMC medical research methodology

authors： Heckel L,Gunn KM,Livingston PM

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Technical advances following the Human Genome Project revealed that high-quality and -quantity DNA may be obtained from whole saliva samples. However, usability of previously collected samples and the effects of environmental conditions on the samples during collection have not been assessed in detail. In fi...

journal_title：BMC medical research methodology

authors： Nemoda Z,Horvat-Gordon M,Fortunato CK,Beltzer EK,Scholl JL,Granger DA

更新日期：2011-12-19 00:00:00

abstract：:Clinical Decision Support Systems (CDSS) provide aid in clinical decision making and therefore need to take into consideration human, data interactions, and cognitive functions of clinical decision makers. The objective of this paper is to introduce a high level reference model that is intended to be used as a foundat...

journal_title：BMC medical research methodology

authors： Zikos D,DeLellis N

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:Generic quality of life (QoL) instruments provide important measures of self-reported wellbeing that can be compared across healthy and clinical populations. The aim of this analysis is to validate the ten-item QoL instrument "QOL10", as well as to confirm the validity of the embedded "QOL5" questionnaire an...

journal_title：BMC medical research methodology

authors： Muller AE,Skurtveit S,Clausen T

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:The Public Population Project in Genomics (P3G) is an organisation that aims to promote collaboration between researchers in the field of population-based genomics. The main objectives of P3G are to encourage collaboration between researchers and biobankers, optimize study design, promote the harmonization o...

journal_title：BMC medical research methodology

authors： Bennett DA,Little J,Masson LF,Minelli C

更新日期：2011-10-05 00:00:00

abstract：BACKGROUND:Bias in adolescent self-reported height and weight is well documented. Given the importance and widespread use of the National Longitudinal Study of Adolescent to Adult Health (Add Health) data for obesity research, we developed and tested the feasibility and validity of an empirically derived statistical co...

journal_title：BMC medical research methodology

authors： Liechty JM,Bi X,Qu A

更新日期：2016-09-22 00:00:00

abstract：BACKGROUND:Studies have shown that industry-sponsored meta-analyses of drugs lack scientific rigour and have biased conclusions. However, these studies have been restricted to certain medical specialities. We compared all industry-supported meta-analyses of drug-drug comparisons with those without industry support. ME...

journal_title：BMC medical research methodology

authors： Jørgensen AW,Maric KL,Tendal B,Faurschou A,Gøtzsche PC

更新日期：2008-09-09 00:00:00

abstract：BACKGROUND:Thresholds for statistical significance are insufficiently demonstrated by 95% confidence intervals or P-values when assessing results from randomised clinical trials. First, a P-value only shows the probability of getting a result assuming that the null hypothesis is true and does not reflect the probabilit...

journal_title：BMC medical research methodology

authors： Jakobsen JC,Gluud C,Winkel P,Lange T,Wetterslev J

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:Cluster randomised controlled trials (CRCTs) are frequently used in health service evaluation. Assuming an average cluster size, required sample sizes are readily computed for both binary and continuous outcomes, by estimating a design effect or inflation factor. However, where the number of clusters are fix...

journal_title：BMC medical research methodology

authors： Hemming K,Girling AJ,Sitch AJ,Marsh J,Lilford RJ

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:With the increased empirical interest in the positive significance of improving nurses' sense of professional benefits, there is a requirement for measures of nurses' perceived professional benefit (NPPB). Our objective was to develop and psychometrically test a brief Nurses' Perceived Professional Benefit Q...

journal_title：BMC medical research methodology

authors： Hu Y,Hu J,Li L,Zhao B,Liu X,Li F

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:Diet plays an important role in chronic disease, and the use of dietary pattern analysis has grown rapidly as a way of deconstructing the complexity of nutritional intake and its relation to health. Pattern analysis methods, such as principal component analysis (PCA), have been used to investigate various di...

journal_title：BMC medical research methodology

authors： Zhang F,Tapera TM,Gou J

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Chemotherapy is expected to reduce cancer deaths (CD), while possibly being harmful in terms of non-cancer deaths (NCD) because of toxicity. Peto's log-rank test is popular in the medical literature, but its operating characteristics are barely known. We compared this test to the most common ones in the stat...

journal_title：BMC medical research methodology

authors： Rotolo F,Michiels S

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:There is a recognised need to build primary care medication adherence services which are tailored to patients' needs. Continuous quality improvement of such services requires a regular working method of measuring adherence in order to monitor effectiveness. Self report has been considered the method of choic...

journal_title：BMC medical research methodology

authors： Garfield S,Clifford S,Eliasson L,Barber N,Willson A

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is now widely used in health research. The aim of this paper is to describe the experience of using TIDi...

journal_title：BMC medical research methodology

authors： Cotterill S,Knowles S,Martindale AM,Elvey R,Howard S,Coupe N,Wilson P,Spence M

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:The occurrence of communicable diseases (CD) depends on exposure to contagious persons. The effects of exposure to CD are delayed in time and contagious persons remain contagious for several days during which their contagiousness varies. Moreover when multiple exposures occur, it is difficult to know which e...

journal_title：BMC medical research methodology

authors： Payet C,Voirin N,Vanhems P,Ecochard R

更新日期：2013-02-20 00:00:00