Incorporating nonlinearity into mediation analyses.

abstract：BACKGROUND:Systematic reviews often require substantial resources, partially due to the large number of records identified during searching. Although artificial intelligence may not be ready to fully replace human reviewers, it may accelerate and reduce the screening burden. Using DistillerSR (May 2020 release), we eva...

journal_title：BMC medical research methodology

authors： Hamel C,Kelly SE,Thavorn K,Rice DB,Wells GA,Hutton B

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Cancer relapses may be useful to predict the risk of death. To take into account relapse information, the Landmark approach is popular. As an alternative, we propose the joint frailty model for a recurrent event and a terminal event to derive dynamic predictions of the risk of death. METHODS:The proposed pr...

journal_title：BMC medical research methodology

authors： Mauguen A,Rachet B,Mathoulin-Pélissier S,Lawrence GM,Siesling S,MacGrogan G,Laurent A,Rondeau V

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Evidence-based health care is informed by results of randomized clinical trials (RCTs) and their syntheses in meta-analyses. When the trial outcomes measured are not clearly described in trial publications, knowledge synthesis, translation, and decision-making may be impeded. While heterogeneity in outcomes ...

journal_title：BMC medical research methodology

authors： Monsour A,Mew EJ,Patel S,Chee-A-Tow A,Saeed L,Santos L,Courtney DB,Watson PN,Monga S,Szatmari P,Offringa M,Butcher NJ

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:The construction of prediction intervals (PIs) for future body mass index (BMI) values of individual children based on a recent German birth cohort study with n = 2007 children is problematic for standard parametric approaches, as the BMI distribution in childhood is typically skewed depending on age. METHO...

journal_title：BMC medical research methodology

authors： Mayr A,Hothorn T,Fenske N

更新日期：2012-01-25 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether awareness of being monitored by an accelerometer has an effect on physical activity in young people. METHODS:Eighty healthy participants aged 10-18 years were randomized between blinded and nonblinded groups. The blinded participants were informed that we were testing...

journal_title：BMC medical research methodology

authors： Vanhelst J,Béghin L,Drumez E,Coopman S,Gottrand F

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:The mechanisms and pathways to impacts from public health research in the UK have not been widely studied. Through the lens of one funder (NIHR), our aims are to map the diversity of public health research, in terms of funding mechanisms, disciplinary contributions, and public health impacts, identify exampl...

journal_title：BMC medical research methodology

authors： Boulding H,Kamenetzky A,Ghiga I,Ioppolo B,Herrera F,Parks S,Manville C,Guthrie S,Hinrichs-Krapels S

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Video stimulated recall (VSR) is a method of enhancing participants' accounts of the consultation using a video recording of the event to encourage and prompt recall in a post consultation interview. VSR is used in education and education research, and to a lesser extent in medical and nursing research. Litt...

journal_title：BMC medical research methodology

authors： Paskins Z,McHugh G,Hassell AB

更新日期：2014-08-30 00:00:00

abstract：BACKGROUND:Biomarkers of exposures such as infection or environmental chemicals can be measured in small volumes of blood extracted from newborn dried blood spots (DBS) underscoring their potential utility for population-based research. However, few studies have evaluated the feasibility and utility of this resource; p...

journal_title：BMC medical research methodology

authors： Yeung EH,Louis GB,Lawrence D,Kannan K,McLain AC,Caggana M,Druschel C,Bell E

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban no...

journal_title：BMC medical research methodology

authors： O'Toole JE,Sinclair MI,Leder K

更新日期：2009-11-09 00:00:00

abstract：BACKGROUND:Syntheses of qualitative studies can inform health policy, services and our understanding of patient experience. Meta-ethnography is a systematic seven-phase interpretive qualitative synthesis approach well-suited to producing new theories and conceptual models. However, there are concerns about the quality ...

journal_title：BMC medical research methodology

authors： France EF,Ring N,Thomas R,Noyes J,Maxwell M,Jepson R

更新日期：2014-11-19 00:00:00

abstract：BACKGROUND:The Health Care Module of the European Health Interview Survey (EHIS) is aimed to obtain comparable information on the use of inpatient and ambulatory care in all EU member states. In this study we assessed the validity of self-reported information on the use of health care, collected through this instrument...

journal_title：BMC medical research methodology

authors： Van der Heyden J,Charafeddine R,De Bacquer D,Tafforeau J,Van Herck K

更新日期：2016-08-16 00:00:00

abstract：:The quality of a consultation provided by a physician can have a profound impact on the quality of care and patient engagement in treatment decisions. When the COPD Assessment Test (CAT) was developed, one of its aims was to aid the communication between physician and patient about the impact of COPD. We developed a n...

journal_title：BMC medical research methodology

authors： Gruffydd-Jones K,Marsden H,Holmes S,Kardos P,Escamilla R,Dal Negro R,Roberts J,Nadeau G,Leather D,Jones P

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available but rarely used. This lack of use could be attributed to a lack of need or to a lack of awareness of ...

journal_title：BMC medical research methodology

authors： Farzanfar D,Abumuamar A,Kim J,Sirotich E,Wang Y,Pullenayegum E

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence of the disease in the study population, and also for studying the risk factors for the disease. ME...

journal_title：BMC medical research methodology

authors： Zhang N,Cheng S,Ambroggio L,Florin TA,Macaluso M

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:How overall physical activity relates to specific activities and how reported activity changes over time may influence interpretation of observed associations between physical activity and health. We examine the relationships between various physical activities self-reported at different times in a large coh...

journal_title：BMC medical research methodology

authors： Armstrong ME,Cairns BJ,Green J,Reeves GK,Beral V,Million Women Study Collaborators.

更新日期：2011-06-22 00:00:00

abstract：BACKGROUND:Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear dynamical systems, which may make linear statistical techniques less suitable to analyze their dyna...

journal_title：BMC medical research methodology

authors： Toonen RB,Wardenaar KJ,Bos EH,van Ockenburg SL,de Jonge P

更新日期：2018-03-21 00:00:00

abstract：BACKGROUND:Available methods for the joint modelling of longitudinal and time-to-event outcomes have typically only allowed for a single longitudinal outcome and a solitary event time. In practice, clinical studies are likely to record multiple longitudinal outcomes. Incorporating all sources of data will improve the p...

journal_title：BMC medical research methodology

authors： Hickey GL,Philipson P,Jorgensen A,Kolamunnage-Dona R

更新日期：2016-09-07 00:00:00

abstract：BACKGROUND:Multiple Imputation as usually implemented assumes that data are Missing At Random (MAR), meaning that the underlying missing data mechanism, given the observed data, is independent of the unobserved data. To explore the sensitivity of the inferences to departures from the MAR assumption, we applied the meth...

journal_title：BMC medical research methodology

authors： Héraud-Bousquet V,Larsen C,Carpenter J,Desenclos JC,Le Strat Y

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting ...

journal_title：BMC medical research methodology

authors： Bhatti P,Kampa D,Alexander BH,McClure C,Ringer D,Doody MM,Sigurdson AJ

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Generic quality of life (QoL) instruments provide important measures of self-reported wellbeing that can be compared across healthy and clinical populations. The aim of this analysis is to validate the ten-item QoL instrument "QOL10", as well as to confirm the validity of the embedded "QOL5" questionnaire an...

journal_title：BMC medical research methodology

authors： Muller AE,Skurtveit S,Clausen T

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in many developed countries appears to be increasing. There is some evidence from Latin America that COPD is a growing cause of death, but information on prevalence is scant. It is possible that, due to the high frequency of smoking in these coun...

journal_title：BMC medical research methodology

authors： Menezes AM,Victora CG,Perez-Padilla R,PLATINO Team.

更新日期：2004-06-17 00:00:00

abstract：BACKGROUND:Administrative databases offer vast amounts of data that provide opportunities for cost-effective insights. They simultaneously pose significant challenges to statistical analysis such as the redaction of data because of privacy policies and the provision of data that may not be at the level of detail requir...

journal_title：BMC medical research methodology

authors： Rosychuk RJ,Bachman JWN,Chen A,Hu XJ

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Disease registers aim to collect information about all instances of a disease or condition in a defined population of individuals. Traditionally methods of operating disease registers have required that notifications of cases be identified by unique identifiers such as social security number or national iden...

journal_title：BMC medical research methodology

authors： Churches T

更新日期：2003-01-06 00:00:00

abstract：BACKGROUND:Although in health services survey research we strive for a high response rate, this must be balanced against the need to recruit participants ethically and considerately, particularly in surveys with a sensitive nature. In survey research there are no established recommendations to guide recruitment approac...

journal_title：BMC medical research methodology

authors： Hunt KJ,Shlomo N,Addington-Hall J

更新日期：2013-01-11 00:00:00

abstract：BACKGROUND:In clinical trials, study designs may focus on assessment of superiority, equivalence, or non-inferiority, of a new medicine or treatment as compared to a control. Typically, evidence in each of these paradigms is quantified with a variant of the null hypothesis significance test. A null hypothesis is assume...

journal_title：BMC medical research methodology

authors： van Ravenzwaaij D,Monden R,Tendeiro JN,Ioannidis JPA

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:Evidence mapping describes the quantity, design and characteristics of research in broad topic areas, in contrast to systematic reviews, which usually address narrowly-focused research questions. The breadth of evidence mapping helps to identify evidence gaps, and may guide future research efforts. The Globa...

journal_title：BMC medical research methodology

authors： Bragge P,Clavisi O,Turner T,Tavender E,Collie A,Gruen RL

更新日期：2011-06-17 00:00:00

abstract：BACKGROUND:The main objective of this paper is to compare different methods for predicting the levels of SO2 air pollution in oil and gas producing area of rural western Canada. Month-long average air quality measurements were collected over a two-year period (2001-2002) at multiple locations, with some side-by-side me...

journal_title：BMC medical research methodology

authors： Burstyn I,Cherry NM,Yasui Y,Kim HM

更新日期：2008-07-04 00:00:00

abstract：BACKGROUND:Disease incidence and prevalence are both core indicators of population health. Incidence is generally not as readily accessible as prevalence. Cohort studies and electronic health record systems are two major way to estimate disease incidence. The former is time-consuming and expensive; the latter is not av...

journal_title：BMC medical research methodology

authors： Hu XF,Young K,Chan HM

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Outcomes collected in randomized clinical trials are observations of random variables that should be independent and identically distributed. However, in some trials, the patients are randomized more than once thus violating both of these assumptions. The probability of an event is not always the same when a...

journal_title：BMC medical research methodology

authors： Hozo I,Djulbegovic B,Clark O,Lyman GH

更新日期：2005-05-10 00:00:00

abstract：BACKGROUND:The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance, and could lead to a better understanding of the impact of treatments on the everyday life and care ...

journal_title：BMC medical research methodology

authors： Barbieri A,Peyhardi J,Conroy T,Gourgou S,Lavergne C,Mollevi C

更新日期：2017-09-26 00:00:00