Abstract:
BACKGROUND:The effectiveness of multiple innovative recruitment strategies for enrolling Black/African American participants to the Adventist Health Study-2 (AHS-2) is described. The study's focus is diet and breast, prostate and colon cancer. METHODS:Promotions centered on trust, relationship building and incentives for increasing enrollment and questionnaire return rate. Of the sub-studies described, one had a randomized control group, and the others, informal controls. The subjects are from all states of the U.S. and some provinces of Canada. The offer of a Black art piece, follow-up calls, a competitive tournament as well as other strategies accounted for nearly 3,000 additional returns even though they were often used in small subsets. RESULTS:Flexibility and multiple strategies proved advantageous in gaining the cooperation of Blacks, who are usually reluctant to participate in research studies. CONCLUSIONS:Lessons learned during initial enrollment should help us retain our final Black cohort of 26,000, and obtain new information when required.
journal_name
BMC Med Res Methodoljournal_title
BMC medical research methodologyauthors
Herring P,Butler T,Hall S,Bennett H,Montgomery SB,Fraser Gdoi
10.1186/1471-2288-14-46subject
Has Abstractpub_date
2014-04-03 00:00:00pages
46issn
1471-2288pii
1471-2288-14-46journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Recruitment to clinical trials can be challenging. Methods that improve the efficiency of trial recruitment are needed to increase successful study completions. The aim of this study was to ascertain whether sending an audio-visual presentation on a digital versatile disc (DVD), along with usual study invita...
journal_title:BMC medical research methodology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12874-019-0663-6
更新日期:2019-01-30 00:00:00
abstract:BACKGROUND:Evidence-based health care is informed by results of randomized clinical trials (RCTs) and their syntheses in meta-analyses. When the trial outcomes measured are not clearly described in trial publications, knowledge synthesis, translation, and decision-making may be impeded. While heterogeneity in outcomes ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-01019-6
更新日期:2020-05-25 00:00:00
abstract:BACKGROUND:Given an observed test statistic and its degrees of freedom, one may compute the observed P value with most statistical packages. It is unknown to what extent test statistics and P values are congruent in published medical papers. METHODS:We checked the congruence of statistical results reported in all the ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-4-13
更新日期:2004-05-28 00:00:00
abstract:BACKGROUND:Glaucoma is a leading cause of avoidable blindness worldwide. Open angle glaucoma is the most common type of glaucoma. No randomised controlled trials have been conducted evaluating the effectiveness of glaucoma screening for reducing sight loss. It is unclear what the most appropriate intervention to be eva...
journal_title:BMC medical research methodology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2288-11-54
更新日期:2011-04-21 00:00:00
abstract:BACKGROUND:The Community Reintegration of Service Members (CRIS) is a new measure of community reintegration developed to measure veteran's participation in life roles. It consists of three sub-scales: Extent of Participation (Extent), Perceived Limitations with Participation (Perceived), and Satisfaction with Particip...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2288-11-98
更新日期:2011-06-25 00:00:00
abstract:BACKGROUND:Sero- prevalence studies often have a problem of missing data. Few studies report the proportion of missing data and even fewer describe the methods used to adjust the results for missing data. The objective of this review was to determine the analytical methods used for analysis in HIV surveys with missing ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-00944-w
更新日期:2020-03-14 00:00:00
abstract:BACKGROUND:Outcomes in observational studies may not best estimate those expected in the HIV vaccine efficacy trials. We compared retention in Simulated HIV Vaccine Efficacy Trials (SiVETs) and observational cohorts drawn from two key populations in Uganda. METHODS:Two SiVETs were nested within two observational cohor...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-00920-4
更新日期:2020-02-12 00:00:00
abstract:BACKGROUND:Syntheses of qualitative studies can inform health policy, services and our understanding of patient experience. Meta-ethnography is a systematic seven-phase interpretive qualitative synthesis approach well-suited to producing new theories and conceptual models. However, there are concerns about the quality ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/1471-2288-14-119
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:Video stimulated recall (VSR) is a method of enhancing participants' accounts of the consultation using a video recording of the event to encourage and prompt recall in a post consultation interview. VSR is used in education and education research, and to a lesser extent in medical and nursing research. Litt...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/1471-2288-14-101
更新日期:2014-08-30 00:00:00
abstract:BACKGROUND:Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design assuming that a control group already exists. METHODS:We propose and discuss an interim analysis step...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0763-3
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:Recruitment to health research remains a major challenge. Innovation is required to meet policy commitments to help patients take part in health research. One innovation that may help meet those policy goals is the development of 'consent to contact' systems, where people give generic consent to be contacted...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0843-4
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Two most important considerations in evaluation of survival prediction models are 1) predictability - ability to predict survival risks accurately and 2) reproducibility - ability to generalize to predict samples generated from different studies. We present approaches for assessment of reproducibility of sur...
journal_title:BMC medical research methodology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2288-13-25
更新日期:2013-02-20 00:00:00
abstract:BACKGROUND:Diagnostic problems in clinical trials are sometimes ordinal. For example, colon tumor staging was performed according to the TNM classification. However, clinical data are limited by markedly small sample sizes in some stage. METHODS:We propose a distribution-free test for detecting ordered alternatives in...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-13-148
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:The intraclass correlation coefficient (ICC) is widely used in biomedical research to assess the reproducibility of measurements between raters, labs, technicians, or devices. For example, in an inter-rater reliability study, a high ICC value means that noise variability (between-raters and within-raters) is...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-14-121
更新日期:2014-11-22 00:00:00
abstract:BACKGROUND:We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete retrieval of such information may not be straightforward, for two reasons. First, not all clinical drug trials provide data on the fre...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-1-7
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:A zero-inflated continuous outcome is characterized by occurrence of "excess" zeros that more than a single distribution can explain, with the positive observations forming a skewed distribution. Mixture models are employed for regression analysis of zero-inflated data. Moreover, for repeated measures zero-i...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-10-55
更新日期:2010-06-14 00:00:00
abstract:BACKGROUND:Systematic reviews often require substantial resources, partially due to the large number of records identified during searching. Although artificial intelligence may not be ready to fully replace human reviewers, it may accelerate and reduce the screening burden. Using DistillerSR (May 2020 release), we eva...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-01129-1
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:The Computer Adaptive Test version of the Community Reintegration of Injured Service Members measure (CRIS-CAT) consists of three scales measuring Extent of, Perceived Limitations in, and Satisfaction with community integration. The CRIS-CAT was developed using item response theory methods. The purposes of t...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-12-145
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:Dynamic risk models, which incorporate disease-free survival and repeated measurements over time, might yield more accurate predictions of future health status compared to static models. The objective of this study was to develop and apply a dynamic prediction model to estimate the risk of developing type 2 ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0812-y
更新日期:2019-08-14 00:00:00
abstract:BACKGROUND:Interventions in occupational health often target worksites rather than individuals. The objective of this paper is to describe the (lack of) stability in units of analysis in occupational health and safety intervention projects directed toward worksites. METHODS:A case study approach is used to describe na...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-8-39
更新日期:2008-06-13 00:00:00
abstract:BACKGROUND:It is widely recognised that the pursuit of sustainable development cannot be accomplished without addressing inequality, or observed differences between subgroups of a population. Monitoring health inequalities allows for the identification of health topics where major group differences exist, dimensions of...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-016-0229-9
更新日期:2016-10-19 00:00:00
abstract:BACKGROUND:Patient-reported outcomes (PRO) are important as endpoints in clinical trials and epidemiological studies. Guidelines for the development of PRO instruments and analysis of PRO data have emphasized the need to report methods used for sample size planning. The Raschpower procedure has been proposed for sample...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-015-0011-4
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-76
更新日期:2009-11-13 00:00:00
abstract:BACKGROUND:Thresholds for statistical significance are insufficiently demonstrated by 95% confidence intervals or P-values when assessing results from randomised clinical trials. First, a P-value only shows the probability of getting a result assuming that the null hypothesis is true and does not reflect the probabilit...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-14-34
更新日期:2014-03-04 00:00:00
abstract:BACKGROUND:Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban no...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-72
更新日期:2009-11-09 00:00:00
abstract:BACKGROUND:The "real" effect size of a medical therapy is constant over time. In contrast, the effect size reported in randomised controlled trials (RCTs) may change over time because the sum of all kinds of bias influencing the reported effectiveness is not necessarily constant. As this would affect the validity of me...
journal_title:BMC medical research methodology
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2288-6-25
更新日期:2006-05-11 00:00:00
abstract:BACKGROUND:Researchers and policy makers have determined that accounting for productivity costs, or "indirect costs," may be as important as including direct medical expenditures when evaluating the societal value of health interventions. These costs are also important when estimating the global burden of disease. The ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-12-87
更新日期:2012-06-25 00:00:00
abstract:BACKGROUND:The mechanisms and pathways to impacts from public health research in the UK have not been widely studied. Through the lens of one funder (NIHR), our aims are to map the diversity of public health research, in terms of funding mechanisms, disciplinary contributions, and public health impacts, identify exampl...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-020-0905-7
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:Motivational Interviewing (MI), Brief Advice (BA) and Health Education (HE) are established smoking cessation induction methods for smokers with low desire to quit. Although randomized controlled trials (RCT's) have been frequently used to assess these interventions the temporal efficacy and effectiveness of...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12874-018-0511-0
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Modern modelling techniques may potentially provide more accurate predictions of binary outcomes than classical techniques. We aimed to study the predictive performance of different modelling techniques in relation to the effective sample size ("data hungriness"). METHODS:We performed simulation studies bas...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-14-137
更新日期:2014-12-22 00:00:00