Health Equity Assessment Toolkit (HEAT): software for exploring and comparing health inequalities in countries.

abstract：BACKGROUND:Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling a subject's disease progression, which is measured by the ALS Functional Rating Scale (ALSFRS), ver...

journal_title：BMC medical research methodology

authors： Karanevich AG,Statland JM,Gajewski BJ,He J

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Typically, randomization software should allow users to exert control over the different aspects of randomization including block design, provision of unique identifiers and control over the format and type of program output. While some of these characteristics have been addressed by available software, none...

journal_title：BMC medical research methodology

authors： Saghaei M

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Mean arterial pressure (MAP), bispectral index (BIS), and minimum alveolar concentration (MAC) represent valuable, yet dynamic intraoperative monitoring variables. They provide information related to poor outcomes when considered together, however their collective behavior across time has not been characteri...

journal_title：BMC medical research methodology

authors： Schnetz MP,Hochheiser HS,Danks DJ,Landsittel DP,Vogt KM,Ibinson JW,Whitehurst SL,McDermott SP,Duque MG,Kaynar AM

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent by an intervening, mediator variable M. Methods for addressing mediation have been available for ...

journal_title：BMC medical research methodology

authors： Knafl GJ,Knafl KA,Grey M,Dixon J,Deatrick JA,Gallo AM

更新日期：2017-03-21 00:00:00

abstract：BACKGROUND:Both scientists and the public routinely refer to randomized controlled trials (RCTs) as being the 'gold standard' of scientific evidence. Although there is no question that placebo-controlled RCTs play a significant role in the evaluation of new pharmaceutical treatments, especially when it is important to ...

journal_title：BMC medical research methodology

authors： Kaplan BJ,Giesbrecht G,Shannon S,McLeod K

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Studies have shown that industry-sponsored meta-analyses of drugs lack scientific rigour and have biased conclusions. However, these studies have been restricted to certain medical specialities. We compared all industry-supported meta-analyses of drug-drug comparisons with those without industry support. ME...

journal_title：BMC medical research methodology

authors： Jørgensen AW,Maric KL,Tendal B,Faurschou A,Gøtzsche PC

更新日期：2008-09-09 00:00:00

abstract：BACKGROUND:Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available but rarely used. This lack of use could be attributed to a lack of need or to a lack of awareness of ...

journal_title：BMC medical research methodology

authors： Farzanfar D,Abumuamar A,Kim J,Sirotich E,Wang Y,Pullenayegum E

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:In many studies the information of patients who are dying in the hospital is censored when examining the change in length of hospital stay (cLOS) due to hospital-acquired infections (HIs). While appropriate estimators of cLOS are available in literature, the existence of the bias due to censoring of deaths w...

journal_title：BMC medical research methodology

authors： Rahman S,von Cube M,Schumacher M,Wolkewitz M

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:While randomised controlled trials (RCTs) provide high-quality evidence to guide practice, much routine care is not based upon available RCTs. This disconnect between evidence and practice is not sufficiently well understood. This case study explores this relationship using a novel approach. Better understan...

journal_title：BMC medical research methodology

authors： Byrne BE,Rooshenas L,Lambert HS,Blazeby JM

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Patient-reported outcomes (PRO) are important as endpoints in clinical trials and epidemiological studies. Guidelines for the development of PRO instruments and analysis of PRO data have emphasized the need to report methods used for sample size planning. The Raschpower procedure has been proposed for sample...

journal_title：BMC medical research methodology

authors： Blanchin M,Guilleux A,Perrot B,Bonnaud-Antignac A,Hardouin JB,Sébille V

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:To accurately predict the response to treatment, we need a stable and effective risk score that can be calculated from patient characteristics. When we evaluate such risks from time-to-event data with right-censoring, Cox's proportional hazards model is the most popular for estimating the linear risk score. ...

journal_title：BMC medical research methodology

authors： Omae K,Eguchi S

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:The collection of individual-level pandemic (H1N1) 2009 influenza immunization data was considered important to facilitate optimal vaccine delivery and accurate assessment of vaccine coverage. These data are also critical for research aimed at evaluating the new vaccine's safety and effectiveness. Systems us...

journal_title：BMC medical research methodology

authors： Pereira JA,Quach S,Heidebrecht C,Foisy J,Quan S,Finkelstein M,Sikora CA,Bettinger JA,Buckeridge DL,McCarthy A,Deeks S,Kwong JC,Public Health Agency of Canada\/Canadian Institutes of Health Research Influenza Research Network Vacc

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the most widely used tool for investigating the methodological quality of SRs and is currently undergoing r...

journal_title：BMC medical research methodology

authors： Wegewitz U,Weikert B,Fishta A,Jacobs A,Pieper D

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Multilevel models for non-normal outcomes are widely used in medical and health sciences research. While methods for interpreting fixed effects are well-developed, methods to quantify and interpret random cluster variation and compare it with other sources of variation are less established. Random cluster va...

journal_title：BMC medical research methodology

authors： Glorioso TJ,Grunwald GK,Ho PM,Maddox TM

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:The choice between paper data collection methods and electronic data collection (EDC) methods has become a key question for clinical researchers. There remains a need to examine potential benefits, efficiencies, and innovations associated with an EDC system in a multi-center medical record review study. MET...

journal_title：BMC medical research methodology

authors： Thwin SS,Clough-Gorr KM,McCarty MC,Lash TL,Alford SH,Buist DS,Enger SM,Field TS,Frost F,Wei F,Silliman RA

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values, it is not known whether it should be imputed. Similarly no clear recommendations exist on: the util...

journal_title：BMC medical research methodology

authors： Kontopantelis E,White IR,Sperrin M,Buchan I

更新日期：2017-01-09 00:00:00

abstract：BACKGROUND:Postal self-completion questionnaires offer one of the least expensive modes of collecting patient based outcomes in health care research. The purpose of this review is to assess the efficacy of methods of increasing response to postal questionnaires in health care studies on patient populations. METHODS:Th...

journal_title：BMC medical research methodology

authors： Nakash RA,Hutton JL,Jørstad-Stein EC,Gates S,Lamb SE

更新日期：2006-02-23 00:00:00

abstract：BACKGROUND:The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is now widely used in health research. The aim of this paper is to describe the experience of using TIDi...

journal_title：BMC medical research methodology

authors： Cotterill S,Knowles S,Martindale AM,Elvey R,Howard S,Coupe N,Wilson P,Spence M

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the pop...

journal_title：BMC medical research methodology

authors： Wahlgren L,Schantz P

更新日期：2011-01-17 00:00:00

abstract：BACKGROUND:Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to calculate the distribution of individual parameters has long limited this approach to linear mixed-effe...

journal_title：BMC medical research methodology

authors： Desmée S,Mentré F,Veyrat-Follet C,Sébastien B,Guedj J

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:Although in health services survey research we strive for a high response rate, this must be balanced against the need to recruit participants ethically and considerately, particularly in surveys with a sensitive nature. In survey research there are no established recommendations to guide recruitment approac...

journal_title：BMC medical research methodology

authors： Hunt KJ,Shlomo N,Addington-Hall J

更新日期：2013-01-11 00:00:00

abstract：BACKGROUND:Bias in adolescent self-reported height and weight is well documented. Given the importance and widespread use of the National Longitudinal Study of Adolescent to Adult Health (Add Health) data for obesity research, we developed and tested the feasibility and validity of an empirically derived statistical co...

journal_title：BMC medical research methodology

authors： Liechty JM,Bi X,Qu A

更新日期：2016-09-22 00:00:00

abstract：BACKGROUND:Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for clustering. These inflation factors are valid under the assumption that randomisation is stratified by...

journal_title：BMC medical research methodology

authors： Martin JT,Hemming K,Girling A

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:In spite of efforts to employ risk-based strategies to increase monitoring efficiency in the academic setting, empirical evidence on their effectiveness remains sparse. This mixed-methods study aimed to evaluate the risk-based on-site monitoring approach currently followed at our academic institution. METHO...

journal_title：BMC medical research methodology

authors： von Niederhäusern B,Orleth A,Schädelin S,Rawi N,Velkopolszky M,Becherer C,Benkert P,Satalkar P,Briel M,Pauli-Magnus C

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:To determine if the search technique that is used to sample randomized controlled trial (RCT) manuscripts from a field of medical science can influence the measurement of the change in quality over time in that field. METHODS:RCT manuscripts in the field of brain injury were identified using two readily-ava...

journal_title：BMC medical research methodology

authors： Borsody MK,Yamada C

更新日期：2005-02-07 00:00:00

abstract：BACKGROUND:One of the main challenges for drug evaluation in rare diseases is the often heterogeneous course of these diseases. Traditional outcome measures may not be applicable for all patients, when they are in different stages of their disease. For instance, in Duchenne Muscular Dystrophy, the Six Minute Walk Test ...

journal_title：BMC medical research methodology

authors： Gaasterland CM,Jansen-van der Weide MC,Weinreich SS,van der Lee JH

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:When investigating subgroup effects in meta-analysis, it is unclear whether accounting in meta-regression for between-trial variation in treatment effects, but not between-trial variation in treatment interaction effects when such effects are present, leads to biased estimates, coverage problems, or wrong st...

journal_title：BMC medical research methodology

authors： da Costa BR,Sutton AJ

更新日期：2019-10-26 00:00:00

abstract：BACKGROUND:Technical advances following the Human Genome Project revealed that high-quality and -quantity DNA may be obtained from whole saliva samples. However, usability of previously collected samples and the effects of environmental conditions on the samples during collection have not been assessed in detail. In fi...

journal_title：BMC medical research methodology

authors： Nemoda Z,Horvat-Gordon M,Fortunato CK,Beltzer EK,Scholl JL,Granger DA

更新日期：2011-12-19 00:00:00

abstract：BACKGROUND:Greater transparency and, in particular, sharing of patient-level data for further scientific research is an increasingly important topic for the pharmaceutical industry and other organisations who sponsor and conduct clinical trials as well as generally in the interests of patients participating in studies....

journal_title：BMC medical research methodology

authors： Tucker K,Branson J,Dilleen M,Hollis S,Loughlin P,Nixon MJ,Williams Z

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:Diagnostic problems in clinical trials are sometimes ordinal. For example, colon tumor staging was performed according to the TNM classification. However, clinical data are limited by markedly small sample sizes in some stage. METHODS:We propose a distribution-free test for detecting ordered alternatives in...

journal_title：BMC medical research methodology

authors： Chang CH,Chin CC,Yu WW,Huang YY

更新日期：2013-12-05 00:00:00