Abstract:
BACKGROUND:Sleep facilitates the consolidation of fear extinction memory. Nightmares and insomnia are hallmark symptoms of posttraumatic stress disorder (PTSD), possibly interfering with fear extinction and compromising recovery. A perpetual circle may develop when sleep disturbances increase the risk for PTSD and vice versa. To date, therapeutic options for alleviating sleep disturbances in PTSD are limited. METHODS:WE CONDUCTED THREE STUDIES TO EXAMINE THE RELATIONSHIP BETWEEN SLEEP AND POSTTRAUMATIC SYMPTOMS: (1) a prospective longitudinal cohort study examining the impact of pre-deployment insomnia symptoms and nightmares on the development of PTSD; (2) a cross-sectional study examining subjective sleep measures, polysomnography, endocrinological parameters, and memory in veterans with PTSD, veterans without PTSD, and healthy controls (HCs); (3) a randomized controlled trial (RCT) (n=14) comparing the effect of prazosin and placebo on sleep disturbances in veterans with PTSD. In addition to these studies, we systematically reviewed the literature on treatment options for sleep disturbances in PTSD. RESULTS:Pre-deployment nightmares predicted PTSD symptoms at 6 months post-deployment; however, insomnia symptoms did not. Furthermore, in patients with PTSD, a correlation between the apnea index and PTSD severity was observed, while obstructive sleep apnea syndrome was not more prevalent. We observed a significant increase in awakenings during sleep in patients with PTSD, which were positively correlated with adrenocorticotropic hormone (ACTH) levels, negatively correlated with growth hormone (GH) secretion, and the subjective perception of sleep depth. Also, heart rate was significantly increased in PTSD patients. Interestingly, plasma levels of GH during the night were decreased in PTSD. Furthermore, GH secretion and awakenings were independent predictors for delayed recall, which was lower in PTSD. In our RCT, prazosin was not associated with improvement of any subjective and objective sleep parameters. Only a few RCTs have been published. They show promising results for atypical antipsychotics and prazosin, the latter especially on nightmare reduction. CONCLUSIONS:Disturbed sleep due to nightmares increases the risk for PTSD. PTSD in turn leads to increased sleep fragmentation, decreased GH secretion, and frequent nightmares, which may again compromise fear extinction, synaptic plasticity, and recovery. This suggests that disturbed sleep is a precipitating and perpetuating factor in PTSD symptomatology, creating a perpetual circle. This dissertation suggests that activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system (SNS) is involved in disturbed sleep in patients with PTSD.
journal_name
Eur J Psychotraumatoljournal_title
European journal of psychotraumatologyauthors
van Liempt Sdoi
10.3402/ejpt.v3i0.19142subject
Has Abstractpub_date
2012-01-01 00:00:00issn
2000-8066pii
19142journal_volume
3pub_type
杂志文章abstract:BACKGROUND:The proposal for ICD-11 postulates major changes for posttraumatic stress disorder (PTSD) diagnosis, which needs investigation in different samples. AIMS:To investigate differences of PTSD prevalence and diagnostic agreement between ICD-10 and ICD-11, factor structure of proposed ICD-11 PTSD, and diagnostic...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v7.29700
更新日期:2016-01-21 00:00:00
abstract:BACKGROUND:To date, mental health professionals' attitudes toward posttraumatic stress disorder (PTSD), compared to other psychiatric disorders such as schizophrenia or depression, have rarely been studied. OBJECTIVE:We assessed mental health professionals' attitudes toward patients with PTSD compared to patients suff...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v6.28693
更新日期:2015-10-26 00:00:00
abstract:BACKGROUND:To date there is a lack of studies assessing the psychometric properties of the recently revised PTSD Checklist (PCL), the PTSD Checklist for DSM-5 (PCL-5). The aim of this pilot study was to examine the psychometric properties of the PCL-5 in parents of children with burns. METHODS:The participating parent...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v7.30165
更新日期:2016-04-19 00:00:00
abstract::Background: It is well documented that comorbid post-traumatic stress disorder (PTSD) in chronic pain is associated with a more severe symptom profile with respect to pain, disability and psychological distress. However, very few intervention studies exist targeting both PTSD and pain. The current study is the first r...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2017.1331108
更新日期:2017-05-30 00:00:00
abstract::There is increasing attention for embedding research in mental healthcare. This involves a linkage between scientific research and routine practice, where research is fed by questions from practice and scientific insights are implemented better and faster in clinical practice. This paper illustrates bridging the gap, ...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v3i0.18740
更新日期:2012-01-01 00:00:00
abstract::Background: A crucial but often overlooked impact of early life exposure to trauma is its far-reaching effect on a person's relationship with their body. Several domains of body experience may be negatively influenced or damaged as a result of early childhood trauma. Objective: The aim of this study was to investigate...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2017.1322892
更新日期:2017-05-31 00:00:00
abstract:BACKGROUND:Patients with posttraumatic stress disorder (PTSD) are prone to dissociation, which in theory should interfere with successful treatment. However, most empirical studies do not substantiate this assumption. OBJECTIVE:The primary objective was to test whether state dissociation predicts the success of an ada...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v7.30375
更新日期:2016-07-06 00:00:00
abstract:BACKGROUND:During the past several years, there has been a growing interest in the negative effects that providing therapy may have on therapists. Of special interest is a phenomenon called secondary traumatization, which can arise while working with traumatized clients. To develop a simple screening tool for secondary...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v5.21875
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:The representation of low- and middle-income countries (LMIC) in traumatic stress research is important to establish a global evidence base, build research capacity, and reduce the burden of unmet mental health needs around the world. Reviews of the traumatic stress literature up to 2002 showed trends toward...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v5.23269
更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:Despite robust empirical support for the efficacy of trauma-focused treatments, the dissemination proves difficult, especially in relation to patients with comorbid psychosis. Many therapists endorse negative beliefs about the credibility, burden, and harm of such treatment. OBJECTIVE:This feasibility study...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v7.31712
更新日期:2016-09-06 00:00:00
abstract:Background:Non-pharmacological and non-psychological approaches to the treatment of post-traumatic stress disorder (PTSD) have often been excluded from systematic reviews and meta-analyses. Consequently, we know little regarding their efficacy. Objective:To determine the effect sizes of non-pharmacological and non-psy...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2020.1795361
更新日期:2020-08-24 00:00:00
abstract::Brief eclectic psychotherapy for PTSD (BEPP) is an evidence-based therapeutic approach that combines and integrates elements from psychodynamic, cognitive-behavioral, and directive psychotherapy. Psychoeducation is done jointly with the patient and his or her partner. Exposure, a structured writing task, and memorabil...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v4i0.21369
更新日期:2013-12-20 00:00:00
abstract::Background: Studies that identify children after acute trauma and prospectively track risk/protective factors and trauma responses over time are resource-intensive; small sample sizes often limit power and generalizability. The Prospective studies of Acute Child Trauma and Recovery (PACT/R) Data Archive was created to...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2020.1729025
更新日期:2020-03-10 00:00:00
abstract:BACKGROUND:While there is a considerable amount of literature addressing consequences of trauma in veterans and holocaust survivors, war and postwar civilian populations, particularly children, are still understudied. Evidence regarding intergenerational effects of trauma in families is inconsistent. OBJECTIVE:To shed...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v4i0.21060
更新日期:2013-08-13 00:00:00
abstract::Background: Child maltreatment is a major public problem, associated with enormous consequences on the individual and socioeconomic level. Studies show a clear impact of child maltreatment on long-term physical health. However, there is a lack of analyses comprising a wide variety of subtypes of maltreatment and addre...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2018.1510278
更新日期:2018-09-07 00:00:00
abstract:BACKGROUND:Asylum interviews within the asylum procedure are associated with psychological stress for traumatized asylum seekers. This study investigates the impact of asylum interviews on the mental health in a sample of 40 traumatized asylum seekers. The comparison group consisted of refugees (N=10) that had not been...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v6.26286
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Although there is some evidence of the posttraumatic stress disorder (PTSD) construct's cross cultural validity, trauma-related disorders may vary across cultures, and the same may be true for treatments that address such conditions. Experienced therapists tailor psychotherapy to each patient's particular si...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v7.31179
更新日期:2016-07-28 00:00:00
abstract::Background: Approximately half of all asylum seekers suffer from trauma-related disorders requiring treatment, among them Posttraumatic Stress Disorder (PTSD), depression, anxiety, and somatic symptoms. There is a lack of easily accessible, low-threshold treatments taking the cultural background into account. Cultural...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2017.1390362
更新日期:2017-11-07 00:00:00
abstract::Background: Pre-sleep cognitive activity and arousal have long been implicated in the maintenance of insomnia. However, despite high comorbidity between insomnia and posttraumatic stress disorder (PTSD), pre-sleep thoughts in PTSD and their associations with disturbed sleep, have not yet been investigated. Objective: ...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2019.1651476
更新日期:2019-08-27 00:00:00
abstract::Background: Dropout from psychotherapy has negative impacts on clients, therapists, and health-care agencies. Research has identified a variety of variables as predictors of dropout, which can be grouped in three domains: socio-demographic, psychological, and treatment-related variables. Objective: In order to further...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2019.1706297
更新日期:2020-01-23 00:00:00
abstract:Background:Due to the one-child policy implemented in China, most families have only one child. When parents experience the death of their only child, these parents receive the label 'Shidu parents'. Shidu is a major public health issue in China. However, the patterns of post-traumatic stress disorder (PTSD) and depres...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2020.1766770
更新日期:2020-07-07 00:00:00
abstract::The present systematic review examined post-migration variables impacting upon mental health outcomes among asylum-seeking and refugee populations in Europe. It focuses on the effects of post-settlement stressors (including length of asylum process and duration of stay, residency status and social integration) and the...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章,评审
doi:10.1080/20008198.2020.1793567
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:To date no validated instrument in the French language exists to screen for posttraumatic stress disorder (PTSD) in survivors of torture and organized violence. OBJECTIVE:The aim of this study is to adapt and validate the Harvard Trauma Questionnaire (HTQ) to this population. METHOD:The adapted version was...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v3i0.19225
更新日期:2012-01-01 00:00:00
abstract::Given the unique context of warzone engagement, which may include chronic threat, multiple and lengthy deployments, and loss, there is a need to understand whether and to what extent knowledge about PTSD derived from studies of civilian trauma exposure is generalizeable to the military. This special issue on PTSD in t...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v5.25322
更新日期:2014-08-14 00:00:00
abstract::Background: Sexual abuse victims often experience symptoms of post-traumatic stress disorder (PTSD), including sleep disturbances. Objective: To investigate whether or not characteristics of sexual abuse are associated with sleep disturbance, and to explore whether correlates of sleep disturbance are distinguishable f...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2019.1581019
更新日期:2019-03-21 00:00:00
abstract:BACKGROUND:In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the symptom profile of posttraumatic stress disorder (PTSD) was expanded to include 20 symptoms. An alternative model of PTSD is outlined in the proposed 11th edition of the International Classification of Diseases (ICD-...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v6.28766
更新日期:2015-10-07 00:00:00
abstract::Background: Emotional abuse and emotional neglect are related to impaired interpersonal functioning. One underlying mechanism could be a developmental delay in mentalizing, the ability to understand other people's thoughts and emotions. Objective: This study investigates the neural correlates of mentalizing and the sp...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.1080/20008198.2016.1272788
更新日期:2017-02-09 00:00:00
abstract:OBJECTIVE:To test the effect of misinformation outside of the laboratory and to explore correlates of the effect, including arousal, cognitive ability, and neuroticism. METHOD:About 2 months before deployment to Afghanistan, 249 soldiers enrolled in this study, which was embedded in a larger project. Two months after ...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v4i0.19864
更新日期:2013-05-02 00:00:00
abstract:BACKGROUND:School killings attract immense media and public attention but psychological studies surrounding these events are rare. OBJECTIVE:To examine the prevalence of posttraumatic stress disorder (PTSD) and possible risk factors of PTSD in 320 Danish high school students (mean age 18 years) 7 months after witnessi...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v4i0.19826
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Single traumatising events are associated with an elevated rate of psychological disorders in children and adolescents. To date, it remains unclear whether early psychological interventions can reduce longer term psychological maladjustment. OBJECTIVE:To systematically review the literature to determine the...
journal_title:European journal of psychotraumatology
pub_type: 杂志文章
doi:10.3402/ejpt.v2i0.7858
更新日期:2011-01-01 00:00:00