Abstract:
:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune hematological disorder characterized by auto antibody-mediated platelet destruction. Although the main cause of ITP remains unclear, but its relationship with some infection was demonstrated. In recent years, many studies have demonstrated improvement of platelet counts in ITP patients after treating Helicobacter pylori infection. The aim of this study was to investigate the effects of H. pylori eradication on platelet count response in Iranian ITP patients.A total of 26 patients diagnosed with both ITP and H. pylori infection. ITP were diagnosed whose platelet counts were less than 100×10(3)/μL. These patients were tested for H. pylori infection by Urea Breath Test and serum H. pylori antibody. All patients received triple therapy for 7 or 14 days to eradicate H. pylori infection. These patients followed for six months.Prevalence of H. pylori was 67.3%. H. pylori eradication achieved in 89.5% (26/29). Of the 26 patients, 15 (57.7%) exhibited a complete response (CR) and 11 (42.3%) were unresponsive. We did not find partial responders. There was a significant difference in the baseline platelet count of responders and non-responders patients (p<0.001). All responders had platelet count ≥50×10(3)/μL and all non-responders had platelet count <50×10(3)/μL.Results of this study revealed that eradication therapy of H. pylori infection can improve platelet counts in ITP patients especially with mild thrombocytopenia and support routine detection and treatment of H. pylori infection in ITP patients in populations with a high prevalence of this infection.
journal_name
Mediterr J Hematol Infect Disauthors
Payandeh M,Sohrabi N,Zare ME,Kansestani AN,Hashemian AHdoi
10.4084/MJHID.2012.056subject
Has Abstractpub_date
2012-01-01 00:00:00pages
e2012056issue
1issn
2035-3006pii
mjhid-4-1-e2012056journal_volume
4pub_type
杂志文章abstract::Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis [corrected], is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20-35 years and in Asian popu...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2014.001
更新日期:2014-01-01 00:00:00
abstract::The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2016.011
更新日期:2016-02-10 00:00:00
abstract::The introduction of newer cytotoxic monoclonal antibodies and chimeric antigen receptor modified T cells is opening a new age in the management of B-lineage adult acute lymphoblastic leukemia. This therapeutic change must be very positively acknowledged because of the limits of intensive chemotherapy programs and allo...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2015.001
更新日期:2015-01-01 00:00:00
abstract::The clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and rosetting are uniq...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2012.061
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Multiple myeloma (MM) is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC). It has been demonstrated that early reduction of FLC can lead to a higher proportion of patients recovering renal function with a bett...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2013.007
更新日期:2013-01-01 00:00:00
abstract::Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, a...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2020.042
更新日期:2020-07-01 00:00:00
abstract::In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. T...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2018.068
更新日期:2018-11-01 00:00:00
abstract::JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2018.058
更新日期:2018-11-01 00:00:00
abstract:Background:β-thalassemia intermedia (TI) spans a wide spectrum of severity and carries higher morbidity than previously recognized, including extramedullary hematopoiesis, leg ulcers, gallstones, thrombosis, secondary heart failure, pulmonary hypertension, skeletal deformity, growth retardation and endocrine abnormalit...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2019.026
更新日期:2019-05-01 00:00:00
abstract::Sickle cell disease (SCD) and ß-thalassemia represent the most common hemoglobinopathies caused, respectively, by the alteration of structural features or deficient production of the ß-chain of the Hb molecule. Other hemoglobinopathies are characterized by different mutations in the α- or ß-globin genes and are associ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2009.008
更新日期:2009-11-13 00:00:00
abstract::The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, wh...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2013.060
更新日期:2013-09-02 00:00:00
abstract::The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (BCS), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis.Risk factors can be local or systemic. A local precipitating factor is rare in BCS, while it is common in patients with portal vein thrombosis. Chronic myeloprolifera...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2011.063
更新日期:2011-01-01 00:00:00
abstract::We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hype...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2012.008
更新日期:2012-01-01 00:00:00
abstract::Patients infected with human immunodeficiency virus (HIV) are at increased risk for developing both non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). Even if this risk has decreased for NHL after the introduction of combination antiretroviral therapy (cART), they remain the most common acquired immune deficien...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2019.004
更新日期:2019-01-01 00:00:00
abstract:Background:Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The relationship between HbF and SCD severity among affected children is also poorly studied. Methods:In this descriptive cross-sectional study,...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2017.063
更新日期:2017-11-01 00:00:00
abstract:Background:Alpha Thalassemia (α-thal) is a heterogeneous group of hereditary alterations caused by deletions that affect alpha regulatory genes, and the 3.7Kb deletion is the most frequent worldwide. The prevalence ranges from 20% and 35% in Brazil, depending mainly on race, predominant in Afro-descendants. Purpose:Th...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2021.001
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:IGF-1 deficiency in TM patients in children and adolescents has been attributed to chronic anemia and hypoxia, chronic liver disease, iron overload and other associated endocrinopathies, e.g. growth hormone deficiency (GHD). Few data are available in the literature regarding adult TM patients and growth di...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2014.074
更新日期:2014-11-01 00:00:00
abstract::The inherited disorders of hemoglobin are by far the commonest monogenic diseases and there is considerable evidence that they have reached their very high frequencies due to heterozygote advantage against malaria. Recent studies have begun to clarify the effect of interactions between malaria and some of the more sev...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2009.022
更新日期:2009-12-20 00:00:00
abstract::Acinetobacter baumannii is an important opportunistic pathogen, responsible for approximately 10% of all gram-negative nosocomial infection. The aim of this study was to determine aminoglycoside and quinolone resistance genes and their antimicrobial susceptibility profile in the clinically A. baumannii. In this cross-...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2018.044
更新日期:2018-07-01 00:00:00
abstract::Acute promyelocytic leukemia (APL) is highly curable with the combination of all-transretinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypic, cytogenetic and molecular characteristics and outcome of APL ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2011.053
更新日期:2011-01-01 00:00:00
abstract::Nebulized colistin (NC) is used for the treatment of pneumonia due to multidrug- resistant Gram-negative bacteria. In this one-year case-control study, our objective was to evaluate the effect of NC on the ventilator circuit (VC) components. The case group consisted of 25 mechanically-ventilated patients who received ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2015.032
更新日期:2015-04-20 00:00:00
abstract:Objective:This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial. Methods:Patients with non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT), who were unable to pursue conventional therapy with transfusion and chelation, we...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2020.021
更新日期:2020-05-01 00:00:00
abstract::One case of acute panmyelosis with myelofibrosis (APMF) is here reported. A 45 year old male presented with abrupt onset of rapidly progressing low backache, weakness and pancytopenia. On examination there was no organomegaly. Peripheral blood examination revealed normocytic normochromic red blood cells with 10% circu...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2013.042
更新日期:2013-06-04 00:00:00
abstract::Hemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (≥ 16 years of age) were retrospectively analy...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2018.047
更新日期:2018-09-01 00:00:00
abstract::This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2018.033
更新日期:2018-05-01 00:00:00
abstract::Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with ...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type:
doi:10.4084/MJHID.2016.027
更新日期:2016-07-01 00:00:00
abstract:Background:Thrombophilia is a condition that predisposes to a higher incidence of venous thromboembolisms (VTE), some also in atypical sites. Direct oral anticoagulants (DOACs) have proven to be effective in the treatment of deep vein thrombosis (DVT). However, their use can be sometimes challenging in particular setti...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2019.044
更新日期:2019-07-01 00:00:00
abstract::Echinococcosis is an endemic zoonosis in the Mediterranean area, with Albania interested actually to a level that is becoming a public health concern. Authors describe preliminary data from the only tertiary (university) medical facility of Albania, positioned in the capital of the country (Tirana), with 333 new cases...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2014.013
更新日期:2014-02-16 00:00:00
abstract::HIV-associated PBL is an AIDS-defining cancer, classified by WHO as a distinct entity of aggressive DLBCL. To date less than 250 cases have been published, of them 17 are pediatric. The pathogenesis of this rare disease is related to immunodeficiency, chronic immune stimulation and EBV. Clinically is a rapid growing d...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章,评审
doi:10.4084/MJHID.2014.064
更新日期:2014-11-01 00:00:00
abstract::Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelodysplastic syndromes (MDS). Most patients with MDS are older than 60 years and age-associated morbidities limit the patients' options for curative transplant therapy. Since the development of conditioning regimens...
journal_title:Mediterranean journal of hematology and infectious diseases
pub_type: 杂志文章
doi:10.4084/MJHID.2010.019
更新日期:2010-08-05 00:00:00