The JAK2V617F Point Mutation Increases the Osteoclast Forming Ability of Monocytes in Patients with Chronic Myeloproliferative Neoplasms and Makes their Osteoclasts more Susceptible to JAK2 Inhibition.

abstract：:The B-cell receptor (BCR) signaling inhibitors ibrutinib and idelalisib are revolutionizing the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies. These oral agents, both alone and in combination with other drugs, have shown remarkable clinical activity in relapsed or refractory CLL across ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Falchi L,Baron JM,Orlikowski CA,Ferrajoli A

更新日期：2016-02-10 00:00:00

abstract：:The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, wh...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Randi AM,Laffan MA,Starke RD

更新日期：2013-09-02 00:00:00

abstract：:The clinical presentation of β-thalassemia intermedia phenotypes are influenced by many factors. The persistence of fetal hemoglobin and several polymorphisms located in the promoters of γ- and β-globin genes are some of them. The aim of this study was to evaluate the combined effect of the -158 Gγ (C→T) polymorphism ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Dabke P,Colah R,Ghosh K,Nadkarni A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Homozygous or double heterozygous factor XIII (FXIII) deficiency is characterized by soft tissue hematomas, intracranial and delayed spontaneous bleeding. Alterations of thromboelastography (TEG) parameters in these patients have been reported. The aim of the study was to show results of TEG, TEG Lysis (Lys ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Martinuzzo M,Barrera L,Altuna D,Baña FT,Bieti J,Amigo Q,D'Adamo M,López MS,Oyhamburu J,Otaso JC

更新日期：2016-08-16 00:00:00

abstract：Background:Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The relationship between HbF and SCD severity among affected children is also poorly studied. Methods:In this descriptive cross-sectional study,...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Adeodu OO,Akinlosotu MA,Adegoke SA,Oseni SBA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Iron overload in patients with beta-thalassemia major (BTM) lead to alterations in the arterial structures and the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and relatively quick to perform and may identify children at increased r...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Abdelsamei HA,El-Sherif AM,Ismail AM,Abdel Hakeem GL

更新日期：2015-03-01 00:00:00

abstract：:Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sabatelli M,Laurenti L,Luigetti M

更新日期：2018-09-01 00:00:00

abstract：:The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (BCS), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis.Risk factors can be local or systemic. A local precipitating factor is rare in BCS, while it is common in patients with portal vein thrombosis. Chronic myeloprolifera...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Stefano V,Za T,Ciminello A,Betti S,Rossi E

更新日期：2011-01-01 00:00:00

abstract：:In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. T...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Malara A,Abbonante V,Zingariello M,Migliaccio A,Balduini A

更新日期：2018-11-01 00:00:00

abstract：:The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mineri R,Mariotti J,Sarina B,Morabito L,Crocchiolo R,Bramanti S,Sarno T,Tordato F,Carlo-Stella C,Santoro A,Castagna L

更新日期：2018-02-15 00:00:00

abstract：:Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sorà F,Chiusolo P,Laurenti L,Autore F,Giammarco S,Sica S

更新日期：2016-07-01 00:00:00

abstract：:Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral ax...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sachdeva M,Abdulhaq H

更新日期：2013-04-10 00:00:00

abstract：:MTB ranks as the first worldwide pathogen latently infecting one third of the population and the second leading cause of death from a single infectious agent, after the human immunodeficiency virus (HIV). The development of vigorous and apparently appropriate immune response upon infection with M. tuberculosis in huma...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bozzano F,Marras F,De Maria A

更新日期：2014-04-07 00:00:00

abstract：:Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, a...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Lassandro G,Palladino V,Amoruso A,Palmieri VV,Russo G,Giordano P

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Better survival of thalassemia patients allowed previously unrecognized renal complications to emerge. OBJECTIVES:Assess prevalence and early predictors of renal dysfunction in young β-thalassemia major (β-TM) and intermedia (β-TI) patients. SUBJECTS:66 β-TM (group I), 26 β-TI (group II) Egyptian patients ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Tantawy AA,El Bablawy N,Adly AA,Ebeid FS

更新日期：2014-09-01 00:00:00

abstract：:The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and follo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： do Nascimento EM,de Castro Lobo CL,de Bragança Pereira B,Ballas SK

更新日期：2019-03-01 00:00:00

abstract：:Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We report the case of a 45-year-old woman with chronic HIV infection and personality disorder, who after 12 months of tenofovir, complained of fatigue, diffuse bone pa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Socio GV,Fabbriciani G,Massarotti M,Messina S,Cecchini E,Marasini B

更新日期：2012-01-01 00:00:00

abstract：:The primary objective of this review was to update and discuss the current concepts and the results of the treatment of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA). After a brief consideration of the epidemiologic and clinicobiologic characteristics of ALL in the AYA population, the main r...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ribera JM,Ribera J,Genescà E

更新日期：2014-07-02 00:00:00

abstract：:Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However, there is a paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case series of five patie...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Zonoozi S,Barnard M,Prescott E,Jones R,Shah FT,Tzoulis P

更新日期：2017-01-01 00:00:00

abstract：:We describe the entire process leading to the start-up of a hematopoietic stem cell transplantation center at the Hiwa Cancer Hospital, in the city of Sulaymaniyah, Kurdistan Iraqi Region. This capacity building project was funded by the Italian Development Cooperation Agency and implemented with the support of the vo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Majolino I,Othman D,Rovelli A,Hassan D,Rasool L,Vacca M,Abdalrahman N,Abdullah C,Ahmed Z,Ali D,Ali K,Broggi C,Calabretta C,Canesi M,Ciabatti G,Del Fante C,De Sapio E,Dore G,Frigato A,Gabriel M,Ipsevich F,Kareem

更新日期：2017-04-15 00:00:00

abstract：:About 95% of cases and 98% of deaths due to tuberculosis (TB) occur in tropical countries while, in temperate low incidence countries, a disproportionate portion of TB cases is diagnosed in immigrants. Urbanization, poverty, poor housing conditions and ventilation, poor nutritional status, low education level, the HIV...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Zammarchi L,Bartalesi F,Bartoloni A

更新日期：2014-06-01 00:00:00

abstract：Background:Although bronchoalveolar lavage (BAL) measurements of galactomannan antigen (GM) seems to be more sensitive than serum testing to detect invasive fungal infection (IFI), a consensus on the most appropriate diagnostic threshold of the BAL GM test is still unclear. Moreover, there is uncertainty as to whether ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Cefalo M,Puxeddu E,Sarmati L,Paterno G,Fontana C,Nasso D,Pane G,De Bellis E,Palmieri R,Buzzati E,Meconi F,Laureana R,Casciani P,Zizzari AG,Rogliani P,de Fabritiis P,Maurillo L,Buccisano F,Cantonetti M,Arcese W,Ven

更新日期：2019-11-01 00:00:00

abstract：Introduction:The aim of the study was to enumerate the clinical, hematological, and molecular spectrum of G6PD deficiency in malaria endemic regions of south west Odisha. Methods:Diagnosis of G6PD deficiency was made by using the Di-chloroindophenol Dye test in two south west districts (Kalahandi and Rayagada) of Odis...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Kumar R,Singh MPSS,Mahapatra S,Chaurasia S,Tripathi MK,Oommen J,Bharti PK,Shanmugam R

更新日期：2020-03-01 00:00:00

abstract：:POEMS syndrome is a rare, chronic and disabling condition. The causes of this condition remain unknown; however, chronic overproduction of proinflammatory cytokines appears to be a major contributor. Early diagnosis is essential to start treatment before the clinical state of the patient becomes compromised. A complet...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Nozza A

更新日期：2017-09-01 00:00:00

abstract：:Nebulized colistin (NC) is used for the treatment of pneumonia due to multidrug- resistant Gram-negative bacteria. In this one-year case-control study, our objective was to evaluate the effect of NC on the ventilator circuit (VC) components. The case group consisted of 25 mechanically-ventilated patients who received ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ghonimat IM,Nazer LH,Aqel F,Mohammad MK,Hawari FI,Le J

更新日期：2015-04-20 00:00:00

abstract：:A 71 year old female with multiple myeloma presented with back pain seven year after autologous stem cell transplant. Skeletal bone survey and magnetic resonance imaging did not show a relapse that was evidenced by CT/PET. Lenalidomide as single agent induced a complete disappearance of the lesions 6 months later and ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Gozzetti A,Rossi V,Cerase A,Papini G,Defina M,Bocchia M

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow microenvironment. Intravenous Bortezomib with or without dexamethasone, is effective and well tolerated in patients with relapsed/refractory multiple myeloma (MM). METHODS:We used Bortezomib without corticosteroids, to avoi...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Gentilini F,Levi A,Federico V,Russo E,Foà R,Petrucci MT

更新日期：2012-01-01 00:00:00

abstract：:We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. N. paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of dissem...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Monticelli J,Luzzati R,Maurel C,Rosin C,Valentinotti R,Farina C

更新日期：2015-01-01 00:00:00

abstract：Background:Alpha Thalassemia (α-thal) is a heterogeneous group of hereditary alterations caused by deletions that affect alpha regulatory genes, and the 3.7Kb deletion is the most frequent worldwide. The prevalence ranges from 20% and 35% in Brazil, depending mainly on race, predominant in Afro-descendants. Purpose:Th...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Anselmo FC,Soumanou AG,de Aguiar Ferreira C,Sobrinha FMV,Castro ACS,Brito RO,da Mota AJ,de Souza Gonçalves M,de Moura Neto JP

更新日期：2021-01-01 00:00:00

abstract：Objective:This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial. Methods:Patients with non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT), who were unable to pursue conventional therapy with transfusion and chelation, we...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yang K,Wu Y,Zhou Y,Long B,Lu Q,Zhou T,Wang L,Geng Z,Yin X

更新日期：2020-05-01 00:00:00