Effect of Cis Acting Potential Regulators in the β Globin Gene Cluster on the Production of HbF in Thalassemia Patients.

abstract：:Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis [corrected], is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20-35 years and in Asian popu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Deaver D,Naghashpour M,Sokol L

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Bone marrow aspiration and biopsy still remains as one of the vital tests for confirmation of diagnosis of visceral Leishmaniasis. The aim of the present study is to assess the relative frequency of common, uncommon and atypical hematological findings in cases of Visceral Leishmaniasis. MATERIALS #ENTITYS...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Bhatia P,Haldar D,Varma N,Marwaha R,Varma S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to compare polymerase chain reaction (PCR) and IgM detection using enzyme linked immune-sorbent assay (ELISA) in diagnosis of congenital cytomegalovirus (CMV) infection. METHODS:This study was conducted from May 2009 to December 2010. Urine and blood samples were collected from 94 neonates ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Albanna EA,El-Latif RS,Sharaf HA,Gohar MK,Ibrahim BM

更新日期：2013-07-10 00:00:00

abstract：INTRODUCTION:Sickle cell disease (SCD) is one of the leading causes of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time challenging its man...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yassin M,Soliman A,De Sanctis V,Nashwan A,Abusamaan S,Moustafa A,Kohla S,Soliman D

更新日期：2017-06-20 00:00:00

abstract：:Rhodococcus equi is an uncommon Gram positive, variably acid-fast pathogen, that appears as hard to treat mostly owing to the establishment of intracellular niches. Lack of interpretive criteria for susceptibility testing may lead to under-reporting or overestimation of resistances, whereas knowledge about this pathog...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Savini V,Salutari P,Sborgia M,Mancini I,Masciarelli G,Catavitello C,Astolfi D,D'Amario C,Fioritoni G,Spadaro A,D'Antonio D

更新日期：2011-01-01 00:00:00

abstract：:Long-term survival of relapsed/refractory acute myeloid leukemia (AML) remains a major problem, particularly in patients not eligible for transplantation.We hereby evaluated the feasibility and efficacy of adding Gemtuzumab Ozogamicin to salvage chemotherapy (Ara-C, Idarubicine, Peg-Filgrastim) in relapsed/refractory ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Capria S,Trisolini SM,Minotti C,Stefanizzi C,Cardarelli L,Cartoni C,Diverio D,De Propris MS,Mancini M,Micozzi A,Foà R,Meloni G

更新日期：2012-01-01 00:00:00

abstract：:One case of acute panmyelosis with myelofibrosis (APMF) is here reported. A 45 year old male presented with abrupt onset of rapidly progressing low backache, weakness and pancytopenia. On examination there was no organomegaly. Peripheral blood examination revealed normocytic normochromic red blood cells with 10% circu...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Chatterjee T,Gupta S,Sharma A,Sharma S,Gupta D

更新日期：2013-06-04 00:00:00

abstract：:Patients infected with human immunodeficiency virus (HIV) are at increased risk for developing both non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). Even if this risk has decreased for NHL after the introduction of combination antiretroviral therapy (cART), they remain the most common acquired immune deficien...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Re A,Cattaneo C,Rossi G

更新日期：2019-01-01 00:00:00

abstract：Background:Alpha Thalassemia (α-thal) is a heterogeneous group of hereditary alterations caused by deletions that affect alpha regulatory genes, and the 3.7Kb deletion is the most frequent worldwide. The prevalence ranges from 20% and 35% in Brazil, depending mainly on race, predominant in Afro-descendants. Purpose:Th...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Anselmo FC,Soumanou AG,de Aguiar Ferreira C,Sobrinha FMV,Castro ACS,Brito RO,da Mota AJ,de Souza Gonçalves M,de Moura Neto JP

更新日期：2021-01-01 00:00:00

abstract：Objective:This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial. Methods:Patients with non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT), who were unable to pursue conventional therapy with transfusion and chelation, we...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Yang K,Wu Y,Zhou Y,Long B,Lu Q,Zhou T,Wang L,Geng Z,Yin X

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Cardiac iron toxicity is the leading cause of death among β-halassaemia major (TM) patients. Once heart failure becomes overt, it is difficult to reverse. OBJECTIVES:To investigate non-overt cardiac dysfunctions in TM patients using pulsed wave Tissue Doppler Imaging (TD I) and its relation to iron overload...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Ragab SM,Fathy WM,El-Aziz WF,Helal RT

更新日期：2015-08-24 00:00:00

abstract：:Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We report the case of a 45-year-old woman with chronic HIV infection and personality disorder, who after 12 months of tenofovir, complained of fatigue, diffuse bone pa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Socio GV,Fabbriciani G,Massarotti M,Messina S,Cecchini E,Marasini B

更新日期：2012-01-01 00:00:00

abstract：Background:Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The relationship between HbF and SCD severity among affected children is also poorly studied. Methods:In this descriptive cross-sectional study,...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Adeodu OO,Akinlosotu MA,Adegoke SA,Oseni SBA

更新日期：2017-11-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is highly curable with the combination of all-transretinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypic, cytogenetic and molecular characteristics and outcome of APL ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Pagoni M,Garofalaki M,Panitsas F,Manola K,Psarra K,Economopoulos P,Vourtsi A,Antoniades M,Gkirkas K,Tzouvara E,Katis F,Prokopiou C,Tziotziou I,Balta A,Lemissiou E,Tsirigotis P,Repoussis P,Harhalakis N

更新日期：2011-01-01 00:00:00

abstract：:A 71 year old female with multiple myeloma presented with back pain seven year after autologous stem cell transplant. Skeletal bone survey and magnetic resonance imaging did not show a relapse that was evidenced by CT/PET. Lenalidomide as single agent induced a complete disappearance of the lesions 6 months later and ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Gozzetti A,Rossi V,Cerase A,Papini G,Defina M,Bocchia M

更新日期：2012-01-01 00:00:00

abstract：:The inherited disorders of hemoglobin are by far the commonest monogenic diseases and there is considerable evidence that they have reached their very high frequencies due to heterozygote advantage against malaria. Recent studies have begun to clarify the effect of interactions between malaria and some of the more sev...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Weatherall DJ

更新日期：2009-12-20 00:00:00

abstract：INTRODUCTION:Follicular lymphoma (FL) is an indolent lymphoproliferative disorder of B-cells with variable clinical behavior. It is the second most common subtype of Non-Hodgkin lymphoma in western countries but reported to have a lower incidence in Asia. MATERIALS AND METHODS:Cases of FL diagnosed in the Department o...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Sylvia MT,Dey B,Basu D,Jacob SE,Kar R,Dubashi B

更新日期：2016-11-01 00:00:00

abstract：:This is the report of the clinical case of a patient who presents the association of a JAK-2 positive chronic myeloproliferative neoplasia to a subsequent 5q- myelodysplastic syndrome, developed after about 14 years from the first diagnosis. Patient's symptoms had rapidly worsened, and she became transfusion-dependent...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Vaccarino A,Dogliotti I,Marletto F,Demarchi A,Bazzan M

更新日期：2016-10-20 00:00:00

abstract：Background:Italy has been one of the first European countries hit by the COVID-19 pandemic, with many patients dying from severe respiratory issues, especially frail subjects. Hematology patients are generally thought to be at high risk of developing severe COVID-19-associated complications. The aim of this work was to...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Botti S,Serra N,Castagnetti F,Chiaretti S,Mordini N,Gargiulo G,Orlando L

更新日期：2021-01-01 00:00:00

abstract：:The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian patients with SCA. Data of patients with SCA who were seen and follo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： do Nascimento EM,de Castro Lobo CL,de Bragança Pereira B,Ballas SK

更新日期：2019-03-01 00:00:00

abstract：:JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched nor...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Spanoudakis E,Papoutselis M,Bazdiara I,Lamprianidi E,Kordella X,Tilkeridis C,Tsatalas C,Kotsianidis I

更新日期：2018-11-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelodysplastic syndromes (MDS). Most patients with MDS are older than 60 years and age-associated morbidities limit the patients' options for curative transplant therapy. Since the development of conditioning regimens...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Field T,Anasetti C

更新日期：2010-08-05 00:00:00

abstract：:The introduction of newer cytotoxic monoclonal antibodies and chimeric antigen receptor modified T cells is opening a new age in the management of B-lineage adult acute lymphoblastic leukemia. This therapeutic change must be very positively acknowledged because of the limits of intensive chemotherapy programs and allo...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Maino E,Scattolin AM,Viero P,Sancetta R,Pascarella A,Vespignani M,Bassan R

更新日期：2015-01-01 00:00:00

abstract：:The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significa...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mineri R,Mariotti J,Sarina B,Morabito L,Crocchiolo R,Bramanti S,Sarno T,Tordato F,Carlo-Stella C,Santoro A,Castagna L

更新日期：2018-02-15 00:00:00

abstract：:Acinetobacter baumannii is an important opportunistic pathogen, responsible for approximately 10% of all gram-negative nosocomial infection. The aim of this study was to determine aminoglycoside and quinolone resistance genes and their antimicrobial susceptibility profile in the clinically A. baumannii. In this cross-...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Mirnejad R,Heidary M,Bahramian A,Goudarzi M,Pournajaf A

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:IGF-1 deficiency in TM patients in children and adolescents has been attributed to chronic anemia and hypoxia, chronic liver disease, iron overload and other associated endocrinopathies, e.g. growth hormone deficiency (GHD). Few data are available in the literature regarding adult TM patients and growth di...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： De Sanctis V,Soliman AT,Candini G,Yassin M,Raiola G,Galati MC,Elalaily R,Elsedfy H,Skordis N,Garofalo P,Anastasi S,Campisi S,Karimi M,Kattamis C,Canatan D,Kilinc Y,Sobti P,Fiscina B,El Kholy M

更新日期：2014-11-01 00:00:00

abstract：:Sickle cell disease (SCD) and ß-thalassemia represent the most common hemoglobinopathies caused, respectively, by the alteration of structural features or deficient production of the ß-chain of the Hb molecule. Other hemoglobinopathies are characterized by different mutations in the α- or ß-globin genes and are associ...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Breda L,Gambari R,Rivella S

更新日期：2009-11-13 00:00:00

abstract：:Echinococcosis is an endemic zoonosis in the Mediterranean area, with Albania interested actually to a level that is becoming a public health concern. Authors describe preliminary data from the only tertiary (university) medical facility of Albania, positioned in the capital of the country (Tirana), with 333 new cases...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Pilaca A,Vyshka G,Pepa A,Shytaj K,Shtjefni V,Boçari A,Beqiri A,Kraja D

更新日期：2014-02-16 00:00:00

abstract：:We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. N. paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of dissem...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Monticelli J,Luzzati R,Maurel C,Rosin C,Valentinotti R,Farina C

更新日期：2015-01-01 00:00:00

abstract：:Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, a...

journal_title：Mediterranean journal of hematology and infectious diseases

authors： Lassandro G,Palladino V,Amoruso A,Palmieri VV,Russo G,Giordano P

更新日期：2020-07-01 00:00:00